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The map label for this gene is cah [H]

Identifier: 32266420

GI number: 32266420

Start: 893662

End: 894405

Strand: Direct

Name: cah [H]

Synonym: HH0921

Alternate gene names: 32266420

Gene position: 893662-894405 (Clockwise)

Preceding gene: 32266419

Following gene: 32266421

Centisome position: 49.67

GC content: 36.96

Gene sequence:

>744_bases
ATGAAAAAAAGATTTTTATTGTTCTTTATAACAAGTTTTTTACAAGCAGCTCACTGGGGCTATGGCATAGATGATGGAGC
AGAGAAATGGGCTTCTCTTAGTCCGGACTATGCTCTTTGCAAAACGGGTAAACGCCAATCTCCTATTAATATCACTCGCT
CTCATCTTAAGCCTACCGAAAATCAACTCCGCTTTTTATATAAACATCAAGAAAAGGTAAAAAATATTATAAATAACGGA
CACTCTGTGCAAATTAATTTTCAAAATGGTAGTGCAGTAAGATTGAAAAACACTTATTATTCCCTTGTGCAACTCCATTT
TCATAGTCCTTCTGAGACACAGATTGAGGGCAAAAATTTCCCGATGGAAATGCACATCGTGCATCAAGATAAACAGGGCA
ACACTCTTGTGATTGCAGCACTTTTTGAAGAGGGAAAAGAAAATCCCTCACTTCATAAAATTATTGAATCTATGCCTCAA
AAAGTAAATCAAAGCAAGCCCTTTGGCACACTTAACATTAATAATATTTTGCCCAAGCAAAACGGATATTATGCCTTTGA
TGGGAGCTTAACCACGCCACCTTGTAACGAAAATGTCCAGTGGGTAGTATTTGTTAATCCTATTCAAATCTCCAAAAAAC
AAATTGAAACTTTTCAAGCAGTCCTTCACCATAATGCAAGAAATGTGCAGCCCCTTGGTGATAGGGTAATTGAAGTTGCT
CCACCTCTTCCGATTACGTATTAA

Upstream 100 bases:

>100_bases
CTTGATCTTAAATTGAGCAAATCCCTAGCGTAAAAACCTATTCTAGGCTTTTATCGCTTAAGGATAGGCAAATCTTTTCA
AGCTTATATAAGGAATTTCT

Downstream 100 bases:

>100_bases
GATTCTCTAATGTATTTTAAAATACAATGCATTCTTAAAAAGGAGATATATGCAACTCAAAGGTAAAAATAATTTAAGTC
TTGCCACACCTATATATGCA

Product: carbonic anhydrase

Products: NA

Alternate protein names: Carbonate dehydratase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MKKRFLLFFITSFLQAAHWGYGIDDGAEKWASLSPDYALCKTGKRQSPINITRSHLKPTENQLRFLYKHQEKVKNIINNG
HSVQINFQNGSAVRLKNTYYSLVQLHFHSPSETQIEGKNFPMEMHIVHQDKQGNTLVIAALFEEGKENPSLHKIIESMPQ
KVNQSKPFGTLNINNILPKQNGYYAFDGSLTTPPCNENVQWVVFVNPIQISKKQIETFQAVLHHNARNVQPLGDRVIEVA
PPLPITY

Sequences:

>Translated_247_residues
MKKRFLLFFITSFLQAAHWGYGIDDGAEKWASLSPDYALCKTGKRQSPINITRSHLKPTENQLRFLYKHQEKVKNIINNG
HSVQINFQNGSAVRLKNTYYSLVQLHFHSPSETQIEGKNFPMEMHIVHQDKQGNTLVIAALFEEGKENPSLHKIIESMPQ
KVNQSKPFGTLNINNILPKQNGYYAFDGSLTTPPCNENVQWVVFVNPIQISKKQIETFQAVLHHNARNVQPLGDRVIEVA
PPLPITY
>Mature_247_residues
MKKRFLLFFITSFLQAAHWGYGIDDGAEKWASLSPDYALCKTGKRQSPINITRSHLKPTENQLRFLYKHQEKVKNIINNG
HSVQINFQNGSAVRLKNTYYSLVQLHFHSPSETQIEGKNFPMEMHIVHQDKQGNTLVIAALFEEGKENPSLHKIIESMPQ
KVNQSKPFGTLNINNILPKQNGYYAFDGSLTTPPCNENVQWVVFVNPIQISKKQIETFQAVLHHNARNVQPLGDRVIEVA
PPLPITY

Specific function: Reversible hydration of carbon dioxide [H]

COG id: COG3338

COG function: function code P; Carbonic anhydrase

Gene ontology:

Cell location: Periplasm (Potential) [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the alpha-carbonic anhydrase family [H]

Homologues:

Organism=Homo sapiens, GI4885101, Length=261, Percent_Identity=33.7164750957854, Blast_Score=126, Evalue=2e-29,
Organism=Homo sapiens, GI4502515, Length=266, Percent_Identity=31.9548872180451, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI45935383, Length=266, Percent_Identity=31.9548872180451, Blast_Score=108, Evalue=5e-24,
Organism=Homo sapiens, GI169636420, Length=261, Percent_Identity=32.9501915708812, Blast_Score=107, Evalue=9e-24,
Organism=Homo sapiens, GI4502519, Length=273, Percent_Identity=29.6703296703297, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI4557395, Length=260, Percent_Identity=29.2307692307692, Blast_Score=106, Evalue=2e-23,
Organism=Homo sapiens, GI258679498, Length=264, Percent_Identity=28.4090909090909, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI192447434, Length=264, Percent_Identity=28.4090909090909, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI192447432, Length=264, Percent_Identity=28.4090909090909, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI192447430, Length=264, Percent_Identity=28.4090909090909, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI4502517, Length=264, Percent_Identity=28.4090909090909, Blast_Score=105, Evalue=3e-23,
Organism=Homo sapiens, GI70167127, Length=263, Percent_Identity=31.1787072243346, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI62240989, Length=203, Percent_Identity=32.512315270936, Blast_Score=100, Evalue=1e-21,
Organism=Homo sapiens, GI22027500, Length=257, Percent_Identity=28.4046692607004, Blast_Score=95, Evalue=7e-20,
Organism=Homo sapiens, GI6005723, Length=238, Percent_Identity=27.3109243697479, Blast_Score=93, Evalue=3e-19,
Organism=Homo sapiens, GI38348436, Length=260, Percent_Identity=28.0769230769231, Blast_Score=88, Evalue=6e-18,
Organism=Homo sapiens, GI4885099, Length=262, Percent_Identity=24.0458015267176, Blast_Score=88, Evalue=8e-18,
Organism=Homo sapiens, GI4502521, Length=237, Percent_Identity=27.0042194092827, Blast_Score=87, Evalue=1e-17,
Organism=Homo sapiens, GI130979954, Length=249, Percent_Identity=26.1044176706827, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI130979679, Length=249, Percent_Identity=26.1044176706827, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI9910366, Length=249, Percent_Identity=26.1044176706827, Blast_Score=87, Evalue=2e-17,
Organism=Homo sapiens, GI6912284, Length=259, Percent_Identity=30.1158301158301, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI91208428, Length=234, Percent_Identity=29.0598290598291, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI194097398, Length=270, Percent_Identity=27.7777777777778, Blast_Score=78, Evalue=8e-15,
Organism=Homo sapiens, GI9951923, Length=255, Percent_Identity=23.921568627451, Blast_Score=69, Evalue=4e-12,
Organism=Caenorhabditis elegans, GI17568715, Length=255, Percent_Identity=30.1960784313725, Blast_Score=102, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI17569163, Length=228, Percent_Identity=25.8771929824561, Blast_Score=75, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17569165, Length=226, Percent_Identity=26.1061946902655, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI71995280, Length=266, Percent_Identity=25.187969924812, Blast_Score=65, Evalue=3e-11,
Organism=Drosophila melanogaster, GI24645604, Length=264, Percent_Identity=28.4090909090909, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI21358169, Length=273, Percent_Identity=28.9377289377289, Blast_Score=100, Evalue=7e-22,
Organism=Drosophila melanogaster, GI17737413, Length=261, Percent_Identity=26.8199233716475, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI18858185, Length=263, Percent_Identity=25.8555133079848, Blast_Score=86, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24650523, Length=283, Percent_Identity=27.5618374558304, Blast_Score=83, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28573346, Length=231, Percent_Identity=26.8398268398268, Blast_Score=80, Evalue=2e-15,
Organism=Drosophila melanogaster, GI221329761, Length=264, Percent_Identity=26.8939393939394, Blast_Score=74, Evalue=7e-14,
Organism=Drosophila melanogaster, GI20130189, Length=147, Percent_Identity=27.891156462585, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24649809, Length=240, Percent_Identity=27.0833333333333, Blast_Score=71, Evalue=6e-13,
Organism=Drosophila melanogaster, GI161079350, Length=267, Percent_Identity=26.2172284644195, Blast_Score=70, Evalue=1e-12,
Organism=Drosophila melanogaster, GI18857983, Length=208, Percent_Identity=28.3653846153846, Blast_Score=67, Evalue=9e-12,
Organism=Drosophila melanogaster, GI116008410, Length=272, Percent_Identity=26.4705882352941, Blast_Score=64, Evalue=9e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001148
- InterPro:   IPR018338
- InterPro:   IPR018340 [H]

Pfam domain/function: PF00194 Carb_anhydrase [H]

EC number: =4.2.1.1 [H]

Molecular weight: Translated: 28204; Mature: 28204

Theoretical pI: Translated: 9.77; Mature: 9.77

Prosite motif: PS51144 ALPHA_CA_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.4 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKRFLLFFITSFLQAAHWGYGIDDGAEKWASLSPDYALCKTGKRQSPINITRSHLKPTE
CCCEEHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHCCCCH
NQLRFLYKHQEKVKNIINNGHSVQINFQNGSAVRLKNTYYSLVQLHFHSPSETQIEGKNF
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHEEEEEEEEECCCCCCEECCCCC
PMEMHIVHQDKQGNTLVIAALFEEGKENPSLHKIIESMPQKVNQSKPFGTLNINNILPKQ
CEEEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCC
NGYYAFDGSLTTPPCNENVQWVVFVNPIQISKKQIETFQAVLHHNARNVQPLGDRVIEVA
CCEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
PPLPITY
CCCCCCC
>Mature Secondary Structure
MKKRFLLFFITSFLQAAHWGYGIDDGAEKWASLSPDYALCKTGKRQSPINITRSHLKPTE
CCCEEHHHHHHHHHHHHHCCCCCCHHHHHHHCCCCCHHHHCCCCCCCCCCHHHHHCCCCH
NQLRFLYKHQEKVKNIINNGHSVQINFQNGSAVRLKNTYYSLVQLHFHSPSETQIEGKNF
HHHHHHHHHHHHHHHHHCCCCEEEEEECCCCEEEEEHHEEEEEEEEECCCCCCEECCCCC
PMEMHIVHQDKQGNTLVIAALFEEGKENPSLHKIIESMPQKVNQSKPFGTLNINNILPKQ
CEEEEEEEECCCCCEEEEEEEECCCCCCCHHHHHHHHHHHHHHCCCCCEEEEHHCCCCCC
NGYYAFDGSLTTPPCNENVQWVVFVNPIQISKKQIETFQAVLHHNARNVQPLGDRVIEVA
CCEEEECCCCCCCCCCCCCEEEEEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCEEEEEC
PPLPITY
CCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9811652 [H]