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The map label for this gene is moeA_2

Identifier: 32266242

GI number: 32266242

Start: 728277

End: 729515

Strand: Direct

Name: moeA_2

Synonym: HH0743

Alternate gene names: 32266242

Gene position: 728277-729515 (Clockwise)

Preceding gene: 32266241

Following gene: 32266243

Centisome position: 40.48

GC content: 38.5

Gene sequence:

>1239_bases
ATGACAACCTTTAATCAAGCATTACAAATAGGCATTTCATTACCTCCTACCAAGCACACGCATACTTTGCCTCTTTTTGA
ATCTTATGGCACAATTCTTGCACAAGATATTATCGCTACACGCTCACTTCCTGCATTTGATAACTCTGCAATGGACGGCT
ATGCCATTAGAATGCAAGATTATGGCACACATTGTATATGCGATGGAAGCATTTTAGCAGGAGCTGATAGCAGTGCATTT
GCACTTGCACAAGGACACACATATAAGGTAATGACGGGTTCAATGCTCCCTCAAAACACCCAAGCTGTCGTGCAAATTGA
ATGGGTGCAAGAAGATGAATCAGGTGTGTATATTCCCGCACTAAATTGTAATCAAAACCTTATTCAAGGGCAAAATATCC
GATTTAAAGGCGAAGAAATAGCTCAAGATTCGCTTCTTTTACAAAGAGGCAAACGGCTTAATCACCTTGATTTAAGCGTT
ATCGCTTCCCAAGGCATCAGCGAAGTGCAAAGCTTTGTGCCCTTACGTATAGGGATTTATTCAAGTGGTGATGAAGTTAT
TGAGCCAAATCAGAGTGCCAAAGCACACCAAATTTATAACACAAATGCTACCAGTCTTTACACACTCCTCAAACAACGTG
GCTATGAATGTAGCTATGAAGGCATCTTACAAGATGACAAAAAAGCTCTTTGCGAGGCTATTGAGCAATTTAATAAATAT
GATGTCATTATTACAAGCGGTGGAGCAAGTGTAGGCGATGCAGATTTGATTAAAGAAGTATTGCAAATGCAAGGAGCAAA
AATGCTTTTTGATGGCATTAATGTCAAGCCCGGACGCCATCTTGGATTTGCTACATTAGGAAAAACACTTATTATCTTGC
TGCCGGGTAATCCCCTAGCCTTACTTCTTCATCTACATACACTTATTTTGTCTATTTTGGAATCTTTACAAGGAGGAAGT
GCATTCTATCCTCAAAGTCTTAGCTTAAAGCTTGATGAGGCTTTAAAGCTCAAAGCCAATACAACTTCTATGATTCTAGG
ACGATGTGAAAATGAAACATTTATTCCTCATAATGGCGGAAAAATTGGTTCAAGCTCGCTGACAAATATGTGGAAAAATA
ATGCAATTGCTCTCTTTGATAATGTGCAATTCCTGCCAAAAGGCGCACCTATTAAGGTTATTTCCTATAATGCCGATTTT
TGTGATATAATAGACTTCATTAATTATGAGATTCTTTAA

Upstream 100 bases:

>100_bases
AGTGTAAGTTATATGTATTTAGATTCTATAGAATCTATCGCTCATATACTTGTTCAAGCTTACACTCAACTACGACAATT
TCACACTTAAAGGAACTTTT

Downstream 100 bases:

>100_bases
ATAAATATCTTAAAATAAGGAGTGATTATGACAAAGCTCTTATTCGGAGTAAGCGACACACAAGAATGTCGTAGAGCTAT
TCAGACTATTATCCGTTTTT

Product: molybdopterin biosynthesis enzyme

Products: NA

Alternate protein names: MPT Mo-transferase [H]

Number of amino acids: Translated: 412; Mature: 411

Protein sequence:

>412_residues
MTTFNQALQIGISLPPTKHTHTLPLFESYGTILAQDIIATRSLPAFDNSAMDGYAIRMQDYGTHCICDGSILAGADSSAF
ALAQGHTYKVMTGSMLPQNTQAVVQIEWVQEDESGVYIPALNCNQNLIQGQNIRFKGEEIAQDSLLLQRGKRLNHLDLSV
IASQGISEVQSFVPLRIGIYSSGDEVIEPNQSAKAHQIYNTNATSLYTLLKQRGYECSYEGILQDDKKALCEAIEQFNKY
DVIITSGGASVGDADLIKEVLQMQGAKMLFDGINVKPGRHLGFATLGKTLIILLPGNPLALLLHLHTLILSILESLQGGS
AFYPQSLSLKLDEALKLKANTTSMILGRCENETFIPHNGGKIGSSSLTNMWKNNAIALFDNVQFLPKGAPIKVISYNADF
CDIIDFINYEIL

Sequences:

>Translated_412_residues
MTTFNQALQIGISLPPTKHTHTLPLFESYGTILAQDIIATRSLPAFDNSAMDGYAIRMQDYGTHCICDGSILAGADSSAF
ALAQGHTYKVMTGSMLPQNTQAVVQIEWVQEDESGVYIPALNCNQNLIQGQNIRFKGEEIAQDSLLLQRGKRLNHLDLSV
IASQGISEVQSFVPLRIGIYSSGDEVIEPNQSAKAHQIYNTNATSLYTLLKQRGYECSYEGILQDDKKALCEAIEQFNKY
DVIITSGGASVGDADLIKEVLQMQGAKMLFDGINVKPGRHLGFATLGKTLIILLPGNPLALLLHLHTLILSILESLQGGS
AFYPQSLSLKLDEALKLKANTTSMILGRCENETFIPHNGGKIGSSSLTNMWKNNAIALFDNVQFLPKGAPIKVISYNADF
CDIIDFINYEIL
>Mature_411_residues
TTFNQALQIGISLPPTKHTHTLPLFESYGTILAQDIIATRSLPAFDNSAMDGYAIRMQDYGTHCICDGSILAGADSSAFA
LAQGHTYKVMTGSMLPQNTQAVVQIEWVQEDESGVYIPALNCNQNLIQGQNIRFKGEEIAQDSLLLQRGKRLNHLDLSVI
ASQGISEVQSFVPLRIGIYSSGDEVIEPNQSAKAHQIYNTNATSLYTLLKQRGYECSYEGILQDDKKALCEAIEQFNKYD
VIITSGGASVGDADLIKEVLQMQGAKMLFDGINVKPGRHLGFATLGKTLIILLPGNPLALLLHLHTLILSILESLQGGSA
FYPQSLSLKLDEALKLKANTTSMILGRCENETFIPHNGGKIGSSSLTNMWKNNAIALFDNVQFLPKGAPIKVISYNADFC
DIIDFINYEIL

Specific function: Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP [H]

COG id: COG0303

COG function: function code H; Molybdopterin biosynthesis enzyme

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the moeA family [H]

Homologues:

Organism=Homo sapiens, GI66932975, Length=346, Percent_Identity=28.3236994219653, Blast_Score=143, Evalue=3e-34,
Organism=Homo sapiens, GI10880983, Length=346, Percent_Identity=28.3236994219653, Blast_Score=143, Evalue=4e-34,
Organism=Escherichia coli, GI1787049, Length=309, Percent_Identity=37.2168284789644, Blast_Score=195, Evalue=6e-51,
Organism=Caenorhabditis elegans, GI25147659, Length=340, Percent_Identity=23.5294117647059, Blast_Score=108, Evalue=4e-24,
Organism=Caenorhabditis elegans, GI17562606, Length=341, Percent_Identity=22.5806451612903, Blast_Score=72, Evalue=5e-13,
Organism=Drosophila melanogaster, GI17136978, Length=291, Percent_Identity=27.4914089347079, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI24638841, Length=291, Percent_Identity=27.4914089347079, Blast_Score=111, Evalue=1e-24,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020817
- InterPro:   IPR008284
- InterPro:   IPR005111
- InterPro:   IPR005110
- InterPro:   IPR001453 [H]

Pfam domain/function: PF00994 MoCF_biosynth; PF03454 MoeA_C; PF03453 MoeA_N [H]

EC number: NA

Molecular weight: Translated: 45048; Mature: 44917

Theoretical pI: Translated: 5.36; Mature: 5.36

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.7 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTFNQALQIGISLPPTKHTHTLPLFESYGTILAQDIIATRSLPAFDNSAMDGYAIRMQD
CCCCCCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC
YGTHCICDGSILAGADSSAFALAQGHTYKVMTGSMLPQNTQAVVQIEWVQEDESGVYIPA
CCCEEEECCCEEECCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEEEEECCCCEEEEE
LNCNQNLIQGQNIRFKGEEIAQDSLLLQRGKRLNHLDLSVIASQGISEVQSFVPLRIGIY
ECCCCHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHCCCEEEEEE
SSGDEVIEPNQSAKAHQIYNTNATSLYTLLKQRGYECSYEGILQDDKKALCEAIEQFNKY
CCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCE
DVIITSGGASVGDADLIKEVLQMQGAKMLFDGINVKPGRHLGFATLGKTLIILLPGNPLA
EEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHCCCCEEEEEECCCHHH
LLLHLHTLILSILESLQGGSAFYPQSLSLKLDEALKLKANTTSMILGRCENETFIPHNGG
HHHHHHHHHHHHHHHCCCCCEECCCCCCEEECCEEEEECCCCEEEEEECCCCEECCCCCC
KIGSSSLTNMWKNNAIALFDNVQFLPKGAPIKVISYNADFCDIIDFINYEIL
CCCCHHHHHHHCCCCEEEEECCEECCCCCCEEEEEECCCHHHHHHHHCCCCC
>Mature Secondary Structure 
TTFNQALQIGISLPPTKHTHTLPLFESYGTILAQDIIATRSLPAFDNSAMDGYAIRMQD
CCCCCCCEEEEECCCCCCCEECCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCEEEEEEC
YGTHCICDGSILAGADSSAFALAQGHTYKVMTGSMLPQNTQAVVQIEWVQEDESGVYIPA
CCCEEEECCCEEECCCCCEEEEECCCEEEEEECCCCCCCCCEEEEEEEEEECCCCEEEEE
LNCNQNLIQGQNIRFKGEEIAQDSLLLQRGKRLNHLDLSVIASQGISEVQSFVPLRIGIY
ECCCCHHHCCCCEEECCHHHHHHHHHHHHCCCCCCCHHHHHHHCCHHHHHHCCCEEEEEE
SSGDEVIEPNQSAKAHQIYNTNATSLYTLLKQRGYECSYEGILQDDKKALCEAIEQFNKY
CCCCCCCCCCCCCCEEEEECCCHHHHHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHCCCE
DVIITSGGASVGDADLIKEVLQMQGAKMLFDGINVKPGRHLGFATLGKTLIILLPGNPLA
EEEEECCCCCCCCHHHHHHHHHHCCCEEEECCCCCCCCCCCCHHCCCCEEEEEECCCHHH
LLLHLHTLILSILESLQGGSAFYPQSLSLKLDEALKLKANTTSMILGRCENETFIPHNGG
HHHHHHHHHHHHHHHCCCCCEECCCCCCEEECCEEEEECCCCEEEEEECCCCEECCCCCC
KIGSSSLTNMWKNNAIALFDNVQFLPKGAPIKVISYNADFCDIIDFINYEIL
CCCCHHHHHHHCCCCEEEEECCEECCCCCCEEEEEECCCHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 3045084; 8905232; 9278503; 9515915 [H]