Click here to switch to the map view.

The map label for this gene is gmk

Identifier: 32266206

GI number: 32266206

Start: 687043

End: 687645

Strand: Direct

Name: gmk

Synonym: HH0707

Alternate gene names: 32266206

Gene position: 687043-687645 (Clockwise)

Preceding gene: 32266205

Following gene: 32266207

Centisome position: 38.19

GC content: 35.66

Gene sequence:

>603_bases
ATGAGCAAAGGGGCAGTGCTTATTATCTCTGGACCAAGTGGCTGTGGCAAAAGCACATTAACAAAATCGCTTATAGAATC
TATCCCTAATGTGTATTTTTCTATTTCAACAACTACGCGCCCTATGCGTGAGGGTGAGACTGATGGTGTGCATTATCATT
TTGTGAGCAAAGAACATTTTTTACAAGACATTCACAATAATGTTTTTTTGGAATGGGCAGAAGTGCATACAAATTTTTAT
GGCACTTCACTCAAACCTGTTCAGCAAGCGCTTGAACAAGATAAAATTGTGCTCTTTGATGTTGATGTGCAAGGACATCA
CAGCATTAAAGAATATTTTGGGGATTTTGCCAAGTCTGTATTTATTACAACAAAAAATAAAGATATTCTCCGAGAGCGAC
TTATTTCGCGTCAAACAGATGATCTTCAAACTATTGAATTTCGTCTTATTCAAGCCCATAATGAAATGCAGCATATTCAC
AATTTTGATTATCTTATTATTAATGATGATATTACTACTGCAAAAGAAGCTATGGTTGCCATTGCGCGCTCACTTAAATA
TCAGCAAATTGAGCGTTTGAGTAAGATTATCCAAAAATGGTAA

Upstream 100 bases:

>100_bases
TGCAAAGTAGCATTTCTAGTTTAAGTTCTAATAATCTTAAATCAATGCTTGATGGGCTTGAAGTAACAATCAATATTAGC
TTTAAAGACAAAAGCAAATG

Downstream 100 bases:

>100_bases
GATTGAACGATAAGTTTAAGATTTAAAGACGAGTTTTGGTATAATACCTCAATTTTTATCAAAGGAGATTCTATGCACCC
CCCTAGTATTACACAATTGT

Product: guanylate kinase

Products: NA

Alternate protein names: GMP kinase

Number of amino acids: Translated: 200; Mature: 199

Protein sequence:

>200_residues
MSKGAVLIISGPSGCGKSTLTKSLIESIPNVYFSISTTTRPMREGETDGVHYHFVSKEHFLQDIHNNVFLEWAEVHTNFY
GTSLKPVQQALEQDKIVLFDVDVQGHHSIKEYFGDFAKSVFITTKNKDILRERLISRQTDDLQTIEFRLIQAHNEMQHIH
NFDYLIINDDITTAKEAMVAIARSLKYQQIERLSKIIQKW

Sequences:

>Translated_200_residues
MSKGAVLIISGPSGCGKSTLTKSLIESIPNVYFSISTTTRPMREGETDGVHYHFVSKEHFLQDIHNNVFLEWAEVHTNFY
GTSLKPVQQALEQDKIVLFDVDVQGHHSIKEYFGDFAKSVFITTKNKDILRERLISRQTDDLQTIEFRLIQAHNEMQHIH
NFDYLIINDDITTAKEAMVAIARSLKYQQIERLSKIIQKW
>Mature_199_residues
SKGAVLIISGPSGCGKSTLTKSLIESIPNVYFSISTTTRPMREGETDGVHYHFVSKEHFLQDIHNNVFLEWAEVHTNFYG
TSLKPVQQALEQDKIVLFDVDVQGHHSIKEYFGDFAKSVFITTKNKDILRERLISRQTDDLQTIEFRLIQAHNEMQHIHN
FDYLIINDDITTAKEAMVAIARSLKYQQIERLSKIIQKW

Specific function: Essential for recycling GMP and indirectly, cGMP

COG id: COG0194

COG function: function code F; Guanylate kinase

Gene ontology:

Cell location: Cytoplasm

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 guanylate kinase-like domain

Homologues:

Organism=Homo sapiens, GI226874833, Length=188, Percent_Identity=37.2340425531915, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI4504221, Length=188, Percent_Identity=37.2340425531915, Blast_Score=108, Evalue=3e-24,
Organism=Homo sapiens, GI226874831, Length=188, Percent_Identity=37.2340425531915, Blast_Score=108, Evalue=4e-24,
Organism=Homo sapiens, GI38570142, Length=188, Percent_Identity=29.7872340425532, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI111154074, Length=170, Percent_Identity=34.1176470588235, Blast_Score=81, Evalue=7e-16,
Organism=Homo sapiens, GI14780902, Length=188, Percent_Identity=29.7872340425532, Blast_Score=79, Evalue=4e-15,
Organism=Homo sapiens, GI262118259, Length=171, Percent_Identity=29.8245614035088, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI4505237, Length=171, Percent_Identity=29.8245614035088, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118263, Length=171, Percent_Identity=29.8245614035088, Blast_Score=78, Evalue=6e-15,
Organism=Homo sapiens, GI262118255, Length=171, Percent_Identity=29.8245614035088, Blast_Score=77, Evalue=7e-15,
Organism=Homo sapiens, GI186700629, Length=177, Percent_Identity=31.0734463276836, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI186700627, Length=177, Percent_Identity=31.0734463276836, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI186972120, Length=177, Percent_Identity=31.0734463276836, Blast_Score=75, Evalue=3e-14,
Organism=Homo sapiens, GI21536464, Length=101, Percent_Identity=35.6435643564356, Blast_Score=74, Evalue=8e-14,
Organism=Homo sapiens, GI261862237, Length=97, Percent_Identity=39.1752577319588, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI119943108, Length=97, Percent_Identity=39.1752577319588, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI119943106, Length=135, Percent_Identity=34.0740740740741, Blast_Score=66, Evalue=2e-11,
Organism=Escherichia coli, GI1790080, Length=201, Percent_Identity=39.8009950248756, Blast_Score=132, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI193203132, Length=182, Percent_Identity=37.9120879120879, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI17508835, Length=182, Percent_Identity=37.9120879120879, Blast_Score=115, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI71988041, Length=169, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI71988048, Length=169, Percent_Identity=30.7692307692308, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17557440, Length=172, Percent_Identity=29.6511627906977, Blast_Score=70, Evalue=1e-12,
Organism=Caenorhabditis elegans, GI71984092, Length=89, Percent_Identity=34.8314606741573, Blast_Score=66, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320662, Length=171, Percent_Identity=39.1812865497076, Blast_Score=125, Evalue=4e-30,
Organism=Drosophila melanogaster, GI21356141, Length=195, Percent_Identity=35.8974358974359, Blast_Score=98, Evalue=4e-21,
Organism=Drosophila melanogaster, GI85724806, Length=190, Percent_Identity=27.3684210526316, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI45554481, Length=190, Percent_Identity=27.3684210526316, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI116007136, Length=190, Percent_Identity=27.3684210526316, Blast_Score=73, Evalue=1e-13,
Organism=Drosophila melanogaster, GI24640542, Length=190, Percent_Identity=27.3684210526316, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI45554489, Length=190, Percent_Identity=27.3684210526316, Blast_Score=72, Evalue=2e-13,
Organism=Drosophila melanogaster, GI161077626, Length=190, Percent_Identity=27.3684210526316, Blast_Score=71, Evalue=4e-13,
Organism=Drosophila melanogaster, GI45554813, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=5e-12,
Organism=Drosophila melanogaster, GI45554791, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161077754, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=6e-12,
Organism=Drosophila melanogaster, GI161077752, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=7e-12,
Organism=Drosophila melanogaster, GI45554804, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI281360700, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641282, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI45554818, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24641280, Length=97, Percent_Identity=40.2061855670103, Blast_Score=67, Evalue=1e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): KGUA_HELHP (Q7VIA1)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_860238.1
- ProteinModelPortal:   Q7VIA1
- SMR:   Q7VIA1
- GeneID:   1493761
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0707
- NMPDR:   fig|235279.1.peg.707
- HOGENOM:   HBG671982
- OMA:   EWAEFAG
- ProtClustDB:   PRK00300
- BioCyc:   HHEP235279:HH_0707-MONOMER
- BRENDA:   2.7.4.8
- GO:   GO:0005737
- HAMAP:   MF_00328
- InterPro:   IPR008144
- InterPro:   IPR008145
- InterPro:   IPR020590
- InterPro:   IPR017665
- SMART:   SM00072
- TIGRFAMs:   TIGR03263

Pfam domain/function: PF00625 Guanylate_kin

EC number: =2.7.4.8

Molecular weight: Translated: 23069; Mature: 22937

Theoretical pI: Translated: 6.86; Mature: 6.86

Prosite motif: PS00856 GUANYLATE_KINASE_1; PS50052 GUANYLATE_KINASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKGAVLIISGPSGCGKSTLTKSLIESIPNVYFSISTTTRPMREGETDGVHYHFVSKEHF
CCCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECHHHH
LQDIHNNVFLEWAEVHTNFYGTSLKPVQQALEQDKIVLFDVDVQGHHSIKEYFGDFAKSV
HHHHHHHHEEEHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHEE
FITTKNKDILRERLISRQTDDLQTIEFRLIQAHNEMQHIHNFDYLIINDDITTAKEAMVA
EEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
IARSLKYQQIERLSKIIQKW
HHHHHHHHHHHHHHHHHHCC
>Mature Secondary Structure 
SKGAVLIISGPSGCGKSTLTKSLIESIPNVYFSISTTTRPMREGETDGVHYHFVSKEHF
CCCCEEEEECCCCCCHHHHHHHHHHHCCCEEEEEECCCCCCCCCCCCCEEEEEECHHHH
LQDIHNNVFLEWAEVHTNFYGTSLKPVQQALEQDKIVLFDVDVQGHHSIKEYFGDFAKSV
HHHHHHHHEEEHHHHHHHHCCCCCHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHHEE
FITTKNKDILRERLISRQTDDLQTIEFRLIQAHNEMQHIHNFDYLIINDDITTAKEAMVA
EEEECCHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHCCCCEEEECCCCHHHHHHHHH
IARSLKYQQIERLSKIIQKW
HHHHHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12810954