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The map label for this gene is pepD [H]

Identifier: 32266167

GI number: 32266167

Start: 646362

End: 647729

Strand: Direct

Name: pepD [H]

Synonym: HH0668

Alternate gene names: 32266167

Gene position: 646362-647729 (Clockwise)

Preceding gene: 32266166

Following gene: 161546630

Centisome position: 35.93

GC content: 37.57

Gene sequence:

>1368_bases
ATGAATGACTTTGCCCTCCAAAGCCTACAAGAATTTTATAAACTCTGTGAAATTCCTCATTGTAGCTTTCATACGCAAGA
TATGTTTTCCTATCTTTGCACCACACTCACACACAAAGGCTATGAAGTCCAAAGTGATGAAGCCAAAAACATCTATGCTA
AAAAAGGTAACCCAAGTGTCTGCCTCCAAAGTCATTATGATATGGTATGTGTAGGAGATTCTACACAACACAAAGGAATA
CAAACTATCCAAAAAGATAACTTTTTATGCGCAAAAAATTCTAGCCTTGGTGCAGATAATGGTATTGGTATGGCTTGTAT
GCTAGCCCAAAATGCTCCTGATATTGAGCTTCTTTTTACCAACGACGAAGAAGTAGGTATGATAGGAGCTAATCATCTTG
GACTTAAGATAGAATCTTCCCTTTTGCTCAATCTTGATAGCGAAGATATTAATGAAATTGTTTTAGGTTGCGCTGGCGGA
GTAGATATAGAATGTGAGATTGACCTTAAAGCATTTAACAAACCCCTTGCACAACTCACTTCTAACTACCCTCATATTTA
TCGCATTACAAGTAAAGGCTTTTTGGGAGGACATAGTGGCATTGATATACATAAAAATAAAGAAAATGTCATTACAGAAT
TTGGTTTTTTCCTTGCCTCGCTTGATGTATATATTCTTATGCTTCAAGCAGGAGAAAAACGCAATTCAATCCCCACAGGA
TTAGATTCTATAATTGCTTGTGCCACGCCTCTAAATGAAACTTTTACTACACCACAGGGTGCTATTTTTGACATTACGCC
AATTAAAGACAATATTACTTCTTATCAATATGCTTACCACAAAAATGCAATTATCCCGCTTATATGCGGTATCCATAGTG
GTATATATGCCGCGTCTTCTCAAGGCACACTCTCTTCACTTAATCTCTCACTCCTTGCCCAACAAGAAGAAACGCTTAAA
CTCATTATGATGGCACGTGCTAATACTGATATACTTTTGCAACGCACAATCAATCGGCTACAAAATAGCGTAGCCTTTCT
TAATCCTCATTGCTCTTTGCATACAAGCGGATTTTATAGTCCGTGGGAAAAAAGCATAGATGATAATCACCCGGCACTCA
CGCTTTTGCAAACACTCTATACATCTCATCATATTACACCCCATATCGCACAAATCCACGCAGGTCTAGAATGTGGAATT
CTCAAAAGGCAACTCCTCTCACTTGGCTCACATACAAACCTTGATGTTATTTCTATTGGACCGACAATTCATACTCCACA
TAGTCTTAATGAATGCCTTGATATGCGCGATTTTGAAATCTTTTGTGCTATTTTGCACGATTTTATTATCTCTTATAAGG
GCTTATAA

Upstream 100 bases:

>100_bases
ATTGCTCTTATTGAAAATTCGTGTAAAATCTTACATTATAATGCAAGTTTGCACGAAAGATGTCAAGATAAATCCCAAAT
ATAATTTTTAAGGATCAGGA

Downstream 100 bases:

>100_bases
TGTTAGCGCAACATATCAATGTCGGAATCATCGGAGTGAGTGGCTATACGGGCTTAGAACTTGTTAAGCTTATTCTTGCT
CACCCGATTTTTAAATTAAG

Product: hypothetical protein

Products: NA

Alternate protein names: Beta-alanyl-histidine dipeptidase; Carnosinase; Cysteinylglycinase; Peptidase D; Xaa-His dipeptidase; X-His dipeptidase [H]

Number of amino acids: Translated: 455; Mature: 455

Protein sequence:

>455_residues
MNDFALQSLQEFYKLCEIPHCSFHTQDMFSYLCTTLTHKGYEVQSDEAKNIYAKKGNPSVCLQSHYDMVCVGDSTQHKGI
QTIQKDNFLCAKNSSLGADNGIGMACMLAQNAPDIELLFTNDEEVGMIGANHLGLKIESSLLLNLDSEDINEIVLGCAGG
VDIECEIDLKAFNKPLAQLTSNYPHIYRITSKGFLGGHSGIDIHKNKENVITEFGFFLASLDVYILMLQAGEKRNSIPTG
LDSIIACATPLNETFTTPQGAIFDITPIKDNITSYQYAYHKNAIIPLICGIHSGIYAASSQGTLSSLNLSLLAQQEETLK
LIMMARANTDILLQRTINRLQNSVAFLNPHCSLHTSGFYSPWEKSIDDNHPALTLLQTLYTSHHITPHIAQIHAGLECGI
LKRQLLSLGSHTNLDVISIGPTIHTPHSLNECLDMRDFEIFCAILHDFIISYKGL

Sequences:

>Translated_455_residues
MNDFALQSLQEFYKLCEIPHCSFHTQDMFSYLCTTLTHKGYEVQSDEAKNIYAKKGNPSVCLQSHYDMVCVGDSTQHKGI
QTIQKDNFLCAKNSSLGADNGIGMACMLAQNAPDIELLFTNDEEVGMIGANHLGLKIESSLLLNLDSEDINEIVLGCAGG
VDIECEIDLKAFNKPLAQLTSNYPHIYRITSKGFLGGHSGIDIHKNKENVITEFGFFLASLDVYILMLQAGEKRNSIPTG
LDSIIACATPLNETFTTPQGAIFDITPIKDNITSYQYAYHKNAIIPLICGIHSGIYAASSQGTLSSLNLSLLAQQEETLK
LIMMARANTDILLQRTINRLQNSVAFLNPHCSLHTSGFYSPWEKSIDDNHPALTLLQTLYTSHHITPHIAQIHAGLECGI
LKRQLLSLGSHTNLDVISIGPTIHTPHSLNECLDMRDFEIFCAILHDFIISYKGL
>Mature_455_residues
MNDFALQSLQEFYKLCEIPHCSFHTQDMFSYLCTTLTHKGYEVQSDEAKNIYAKKGNPSVCLQSHYDMVCVGDSTQHKGI
QTIQKDNFLCAKNSSLGADNGIGMACMLAQNAPDIELLFTNDEEVGMIGANHLGLKIESSLLLNLDSEDINEIVLGCAGG
VDIECEIDLKAFNKPLAQLTSNYPHIYRITSKGFLGGHSGIDIHKNKENVITEFGFFLASLDVYILMLQAGEKRNSIPTG
LDSIIACATPLNETFTTPQGAIFDITPIKDNITSYQYAYHKNAIIPLICGIHSGIYAASSQGTLSSLNLSLLAQQEETLK
LIMMARANTDILLQRTINRLQNSVAFLNPHCSLHTSGFYSPWEKSIDDNHPALTLLQTLYTSHHITPHIAQIHAGLECGI
LKRQLLSLGSHTNLDVISIGPTIHTPHSLNECLDMRDFEIFCAILHDFIISYKGL

Specific function: Dipeptidase with broad substrate specificity. Requires dipeptide substrates with an unblocked N-terminus and the amino group in the alpha or beta position. Non-protein amino acids and proline are not accepted in the C-terminal position, whereas some dipep

COG id: COG2195

COG function: function code E; Di- and tripeptidases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase M20C family [H]

Homologues:

Organism=Escherichia coli, GI1786432, Length=481, Percent_Identity=29.9376299376299, Blast_Score=168, Evalue=7e-43,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR002933
- InterPro:   IPR011650
- InterPro:   IPR001160 [H]

Pfam domain/function: PF07687 M20_dimer; PF01546 Peptidase_M20 [H]

EC number: =3.4.13.3 [H]

Molecular weight: Translated: 50252; Mature: 50252

Theoretical pI: Translated: 5.81; Mature: 5.81

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.3 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
3.3 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNDFALQSLQEFYKLCEIPHCSFHTQDMFSYLCTTLTHKGYEVQSDEAKNIYAKKGNPSV
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCEEEECCCCCE
CLQSHYDMVCVGDSTQHKGIQTIQKDNFLCAKNSSLGADNGIGMACMLAQNAPDIELLFT
EEECCCCEEEECCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEE
NDEEVGMIGANHLGLKIESSLLLNLDSEDINEIVLGCAGGVDIECEIDLKAFNKPLAQLT
CCCCEEEEECCCCCEEEECEEEEECCHHHHHHHHHCCCCCCEEEEEEEHHHHCCHHHHHH
SNYPHIYRITSKGFLGGHSGIDIHKNKENVITEFGFFLASLDVYILMLQAGEKRNSIPTG
CCCCEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
LDSIIACATPLNETFTTPQGAIFDITPIKDNITSYQYAYHKNAIIPLICGIHSGIYAASS
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEEHHCCCCEEECC
QGTLSSLNLSLLAQQEETLKLIMMARANTDILLQRTINRLQNSVAFLNPHCSLHTSGFYS
CCCHHHCCEEEECCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHEEECCCCEEECCCCCC
PWEKSIDDNHPALTLLQTLYTSHHITPHIAQIHAGLECGILKRQLLSLGSHTNLDVISIG
CHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEC
PTIHTPHSLNECLDMRDFEIFCAILHDFIISYKGL
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
>Mature Secondary Structure
MNDFALQSLQEFYKLCEIPHCSFHTQDMFSYLCTTLTHKGYEVQSDEAKNIYAKKGNPSV
CCHHHHHHHHHHHHHHCCCCCCCCHHHHHHHHHHHHHCCCCEECCCCCCCEEEECCCCCE
CLQSHYDMVCVGDSTQHKGIQTIQKDNFLCAKNSSLGADNGIGMACMLAQNAPDIELLFT
EEECCCCEEEECCCCCCCCHHHHHCCCEEEECCCCCCCCCCCCEEEEEECCCCCEEEEEE
NDEEVGMIGANHLGLKIESSLLLNLDSEDINEIVLGCAGGVDIECEIDLKAFNKPLAQLT
CCCCEEEEECCCCCEEEECEEEEECCHHHHHHHHHCCCCCCEEEEEEEHHHHCCHHHHHH
SNYPHIYRITSKGFLGGHSGIDIHKNKENVITEFGFFLASLDVYILMLQAGEKRNSIPTG
CCCCEEEEEECCCCCCCCCCCEEECCCHHHHHHHHHHHHHHHHHEEEEECCCCCCCCCCC
LDSIIACATPLNETFTTPQGAIFDITPIKDNITSYQYAYHKNAIIPLICGIHSGIYAASS
HHHHHHHCCCCCCCCCCCCCCEEEEECCCCCCCCEEEECCCCCCEEEEEHHCCCCEEECC
QGTLSSLNLSLLAQQEETLKLIMMARANTDILLQRTINRLQNSVAFLNPHCSLHTSGFYS
CCCHHHCCEEEECCHHHHEEEEEEECCCCHHHHHHHHHHHHHHHEEECCCCEEECCCCCC
PWEKSIDDNHPALTLLQTLYTSHHITPHIAQIHAGLECGILKRQLLSLGSHTNLDVISIG
CHHHCCCCCCHHHHHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHCCCCCCEEEEEEC
PTIHTPHSLNECLDMRDFEIFCAILHDFIISYKGL
CCCCCCHHHHHHHCCCHHHHHHHHHHHHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 1695895; 9278503; 2651887 [H]