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The map label for this gene is atpA

Identifier: 32265926

GI number: 32265926

Start: 410430

End: 411944

Strand: Direct

Name: atpA

Synonym: HH0427

Alternate gene names: 32265926

Gene position: 410430-411944 (Clockwise)

Preceding gene: 32265925

Following gene: 32265927

Centisome position: 22.81

GC content: 38.09

Gene sequence:

>1515_bases
GTGACAACAAAAATCAAATCAGAAGAAATTAGCTCAATTATCAAAGAGAGAATTGAGAACTTTAATATCAACATTGACAT
CAGTGAAACAGGTAAAGTTATTGCTTATGCTGATGGTGTAGCAAAGGTATATGGGCTTAACAATGTTATGTATTATGAGA
TGGTAGAATTTGATACAGGTGATACAGGCATTGCTTTTAATCTTGAAGAAAGCAGTGTAGGTGTGGTTGTGCTTGGTTCT
GGACGCACAATCAAAGAAGGAACTTCTGTTAAGCGTCTCAAAAAACTGATGAAAGTGCCAGTAGGAGATGCAATAGTTGG
ACGTGTTATTAATACATTAGGGGAACCTATTGACGGAAAAGGGGCAATTGAAGCAAATGAATATCGCTTTGTTGAAGAAA
AGGCTCCAGGCATTATGGCACGTAAATCTGTTCACCAACCTCTTCAAACAGGACTTAAGGCTATTGACGCACTTGTACCA
ATCGGACGAGGACAAAGAGAACTTATTATAGGTGATAGACAAACAGGTAAAACAACCGTTGCAATAGATACAATTATCAA
TCAAAAAGGGCAAGATGTTATTTGTATTTATGTTGCTGTAGGACAAAAAGAATCAACTGTTGCTCAAGTTGTGCGCAAAC
TCGAAGAGCACGGAGCTATGGATTATACAGTTGTAGTTAATGCTCCTGCTTCTTTCTCTGCGGCAATGCAGTTTCTTGCC
CCATATACAGGTGTTACAATTGGAGAATATTTTAGAGATAATGCACGACATGCTCTTATCATCTATGATGATTTAAGTAA
ACACGCTGTGGCATATCGCGAAATGTCTCTTATCCTAAGAAGACCTCCCGGGCGTGAAGCATTTCCCGGTGATGTATTTT
ATCTCCATTCTCGTCTCCTTGAAAGAGCAGCGAAGCTTAATGATGAGCTTGGTGCAGGTTCTCTTACTGCATTGCCTATT
ATTGAAACACAAGCTGGAGATGTGGCTGCTTATATTCCAACAAATGTTATTTCAATTACTGATGGACAGATATTTCTTGA
AACAGACTTATTTAACTCTGGTATTCGTCCTGCCATTAACGTGGGATTATCTGTATCACGTGTAGGAGGAGCTGCTCAAA
TTAAAGCTACAAAACAAGTGGCAGGAACTCTACGCCTTGATTTGGCTCAATATAGAGAGCTTCAAGCATTTTCTCAATTT
GCATCTGACCTTGATGAATCAAGTCGTAAACAACTTGAACGAGGACAAAGAATGGTGGAAATCCTTAAACAGCCTCCCTA
CTCTCCTCTTTCAATTGAAAAACAGGTAATCATTATTTATGCTGGAGCAAATGGATACCTTGATAATATTCCAGCCAATA
AAGTTATAAAATTTGAATCAGAGCTTTATCCATTCCTTGAAGCAAAATATCCCAAAATTTTTGAAGATATTAGCGTAAAA
AAGGCAATTGATAAAGAAACTGAGGCTGAGCTTAGCAAGGCTCTTGAAGAGTTTAAAATTAACTTTGGGGCATAA

Upstream 100 bases:

>100_bases
GGATTTAGGTATTGAGGTGTCTTTTTCCAAAGAGCGCTTTAGTAATGATTTAAAGCATCATATCCTCAAAGCACTTTAAT
TTTAACATAAGGAGAGAAAA

Downstream 100 bases:

>100_bases
TGAGGAGCTATTATGGGTGGCAACCTTAAAAATATAAAAAGACAAATCAGTAGTACTAAAAATACACAGAAAACAACTAA
GGCTATGAAACTTGTCTCTA

Product: F0F1 ATP synthase subunit alpha

Products: NA

Alternate protein names: ATP synthase F1 sector subunit alpha; F-ATPase subunit alpha

Number of amino acids: Translated: 504; Mature: 503

Protein sequence:

>504_residues
MTTKIKSEEISSIIKERIENFNINIDISETGKVIAYADGVAKVYGLNNVMYYEMVEFDTGDTGIAFNLEESSVGVVVLGS
GRTIKEGTSVKRLKKLMKVPVGDAIVGRVINTLGEPIDGKGAIEANEYRFVEEKAPGIMARKSVHQPLQTGLKAIDALVP
IGRGQRELIIGDRQTGKTTVAIDTIINQKGQDVICIYVAVGQKESTVAQVVRKLEEHGAMDYTVVVNAPASFSAAMQFLA
PYTGVTIGEYFRDNARHALIIYDDLSKHAVAYREMSLILRRPPGREAFPGDVFYLHSRLLERAAKLNDELGAGSLTALPI
IETQAGDVAAYIPTNVISITDGQIFLETDLFNSGIRPAINVGLSVSRVGGAAQIKATKQVAGTLRLDLAQYRELQAFSQF
ASDLDESSRKQLERGQRMVEILKQPPYSPLSIEKQVIIIYAGANGYLDNIPANKVIKFESELYPFLEAKYPKIFEDISVK
KAIDKETEAELSKALEEFKINFGA

Sequences:

>Translated_504_residues
MTTKIKSEEISSIIKERIENFNINIDISETGKVIAYADGVAKVYGLNNVMYYEMVEFDTGDTGIAFNLEESSVGVVVLGS
GRTIKEGTSVKRLKKLMKVPVGDAIVGRVINTLGEPIDGKGAIEANEYRFVEEKAPGIMARKSVHQPLQTGLKAIDALVP
IGRGQRELIIGDRQTGKTTVAIDTIINQKGQDVICIYVAVGQKESTVAQVVRKLEEHGAMDYTVVVNAPASFSAAMQFLA
PYTGVTIGEYFRDNARHALIIYDDLSKHAVAYREMSLILRRPPGREAFPGDVFYLHSRLLERAAKLNDELGAGSLTALPI
IETQAGDVAAYIPTNVISITDGQIFLETDLFNSGIRPAINVGLSVSRVGGAAQIKATKQVAGTLRLDLAQYRELQAFSQF
ASDLDESSRKQLERGQRMVEILKQPPYSPLSIEKQVIIIYAGANGYLDNIPANKVIKFESELYPFLEAKYPKIFEDISVK
KAIDKETEAELSKALEEFKINFGA
>Mature_503_residues
TTKIKSEEISSIIKERIENFNINIDISETGKVIAYADGVAKVYGLNNVMYYEMVEFDTGDTGIAFNLEESSVGVVVLGSG
RTIKEGTSVKRLKKLMKVPVGDAIVGRVINTLGEPIDGKGAIEANEYRFVEEKAPGIMARKSVHQPLQTGLKAIDALVPI
GRGQRELIIGDRQTGKTTVAIDTIINQKGQDVICIYVAVGQKESTVAQVVRKLEEHGAMDYTVVVNAPASFSAAMQFLAP
YTGVTIGEYFRDNARHALIIYDDLSKHAVAYREMSLILRRPPGREAFPGDVFYLHSRLLERAAKLNDELGAGSLTALPII
ETQAGDVAAYIPTNVISITDGQIFLETDLFNSGIRPAINVGLSVSRVGGAAQIKATKQVAGTLRLDLAQYRELQAFSQFA
SDLDESSRKQLERGQRMVEILKQPPYSPLSIEKQVIIIYAGANGYLDNIPANKVIKFESELYPFLEAKYPKIFEDISVKK
AIDKETEAELSKALEEFKINFGA

Specific function: Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit

COG id: COG0056

COG function: function code C; F0F1-type ATP synthase, alpha subunit

Gene ontology:

Cell location: Cell inner membrane; Peripheral membrane protein

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATPase alpha/beta chains family

Homologues:

Organism=Homo sapiens, GI50345984, Length=509, Percent_Identity=59.9214145383104, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI4757810, Length=509, Percent_Identity=59.9214145383104, Blast_Score=622, Evalue=1e-178,
Organism=Homo sapiens, GI19913428, Length=299, Percent_Identity=28.4280936454849, Blast_Score=115, Evalue=9e-26,
Organism=Homo sapiens, GI19913426, Length=299, Percent_Identity=26.7558528428094, Blast_Score=107, Evalue=3e-23,
Organism=Homo sapiens, GI32189394, Length=409, Percent_Identity=25.1833740831296, Blast_Score=102, Evalue=1e-21,
Organism=Homo sapiens, GI19913424, Length=256, Percent_Identity=28.90625, Blast_Score=82, Evalue=8e-16,
Organism=Escherichia coli, GI1790172, Length=507, Percent_Identity=55.6213017751479, Blast_Score=585, Evalue=1e-168,
Organism=Escherichia coli, GI1788251, Length=291, Percent_Identity=29.553264604811, Blast_Score=117, Evalue=1e-27,
Organism=Escherichia coli, GI1790170, Length=413, Percent_Identity=24.455205811138, Blast_Score=116, Evalue=4e-27,
Organism=Caenorhabditis elegans, GI71988063, Length=502, Percent_Identity=61.1553784860558, Blast_Score=626, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71988080, Length=502, Percent_Identity=61.1553784860558, Blast_Score=625, Evalue=1e-179,
Organism=Caenorhabditis elegans, GI71988074, Length=502, Percent_Identity=58.1673306772908, Blast_Score=577, Evalue=1e-165,
Organism=Caenorhabditis elegans, GI17570191, Length=289, Percent_Identity=27.681660899654, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI17510931, Length=296, Percent_Identity=26.3513513513513, Blast_Score=106, Evalue=2e-23,
Organism=Caenorhabditis elegans, GI25144756, Length=377, Percent_Identity=23.342175066313, Blast_Score=93, Evalue=4e-19,
Organism=Caenorhabditis elegans, GI71988068, Length=74, Percent_Identity=50, Blast_Score=79, Evalue=4e-15,
Organism=Caenorhabditis elegans, GI17565854, Length=247, Percent_Identity=28.3400809716599, Blast_Score=77, Evalue=2e-14,
Organism=Caenorhabditis elegans, GI17509265, Length=50, Percent_Identity=66, Blast_Score=75, Evalue=6e-14,
Organism=Saccharomyces cerevisiae, GI6319370, Length=509, Percent_Identity=59.9214145383104, Blast_Score=631, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319603, Length=307, Percent_Identity=29.3159609120521, Blast_Score=117, Evalue=5e-27,
Organism=Saccharomyces cerevisiae, GI6322581, Length=417, Percent_Identity=25.6594724220624, Blast_Score=108, Evalue=2e-24,
Organism=Drosophila melanogaster, GI24658560, Length=505, Percent_Identity=59.8019801980198, Blast_Score=614, Evalue=1e-176,
Organism=Drosophila melanogaster, GI281361666, Length=291, Percent_Identity=27.8350515463918, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI24646341, Length=291, Percent_Identity=27.8350515463918, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI17136796, Length=291, Percent_Identity=27.8350515463918, Blast_Score=117, Evalue=1e-26,
Organism=Drosophila melanogaster, GI28574560, Length=409, Percent_Identity=24.9388753056235, Blast_Score=102, Evalue=9e-22,
Organism=Drosophila melanogaster, GI24638766, Length=409, Percent_Identity=24.9388753056235, Blast_Score=99, Evalue=1e-20,
Organism=Drosophila melanogaster, GI20129479, Length=257, Percent_Identity=29.9610894941634, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI24583992, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583988, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583986, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24583984, Length=256, Percent_Identity=28.515625, Blast_Score=79, Evalue=1e-14,

Paralogues:

None

Copy number: 9,000 Molecules/Cell In: Glucose minimal media [C]

Swissprot (AC and ID): ATPA_HELHP (Q7VJ23)

Other databases:

- EMBL:   AE017125
- RefSeq:   NP_859958.1
- ProteinModelPortal:   Q7VJ23
- SMR:   Q7VJ23
- GeneID:   1493481
- GenomeReviews:   AE017125_GR
- KEGG:   hhe:HH0427
- NMPDR:   fig|235279.1.peg.427
- HOGENOM:   HBG565875
- OMA:   EMALTLW
- ProtClustDB:   PRK09281
- BioCyc:   HHEP235279:HH_0427-MONOMER
- BRENDA:   3.6.3.14
- HAMAP:   MF_01346
- InterPro:   IPR020003
- InterPro:   IPR000194
- InterPro:   IPR005294
- InterPro:   IPR017458
- InterPro:   IPR018118
- InterPro:   IPR000793
- InterPro:   IPR004100
- PANTHER:   PTHR15184:SF3
- TIGRFAMs:   TIGR00962

Pfam domain/function: PF00006 ATP-synt_ab; PF00306 ATP-synt_ab_C; PF02874 ATP-synt_ab_N; SSF47917 ATPase_a/b_C; SSF50615 ATPase_a/b_N

EC number: =3.6.3.14

Molecular weight: Translated: 55288; Mature: 55157

Theoretical pI: Translated: 5.63; Mature: 5.63

Prosite motif: PS00152 ATPASE_ALPHA_BETA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTKIKSEEISSIIKERIENFNINIDISETGKVIAYADGVAKVYGLNNVMYYEMVEFDTG
CCCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCHHEEHCCCCEEEEEEEEECCC
DTGIAFNLEESSVGVVVLGSGRTIKEGTSVKRLKKLMKVPVGDAIVGRVINTLGEPIDGK
CCCEEEEECCCCCCEEEEECCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
GAIEANEYRFVEEKAPGIMARKSVHQPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTTV
CCEECCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEE
AIDTIINQKGQDVICIYVAVGQKESTVAQVVRKLEEHGAMDYTVVVNAPASFSAAMQFLA
EEEHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
PYTGVTIGEYFRDNARHALIIYDDLSKHAVAYREMSLILRRPPGREAFPGDVFYLHSRLL
CCCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHH
ERAAKLNDELGAGSLTALPIIETQAGDVAAYIPTNVISITDGQIFLETDLFNSGIRPAIN
HHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCCCCCCCHHHH
VGLSVSRVGGAAQIKATKQVAGTLRLDLAQYRELQAFSQFASDLDESSRKQLERGQRMVE
CCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKQPPYSPLSIEKQVIIIYAGANGYLDNIPANKVIKFESELYPFLEAKYPKIFEDISVK
HHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHH
KAIDKETEAELSKALEEFKINFGA
HHHCHHHHHHHHHHHHHHHCCCCC
>Mature Secondary Structure 
TTKIKSEEISSIIKERIENFNINIDISETGKVIAYADGVAKVYGLNNVMYYEMVEFDTG
CCCCCHHHHHHHHHHHHHCCEEEEEECCCCCEEEEECCHHEEHCCCCEEEEEEEEECCC
DTGIAFNLEESSVGVVVLGSGRTIKEGTSVKRLKKLMKVPVGDAIVGRVINTLGEPIDGK
CCCEEEEECCCCCCEEEEECCCEECCCCHHHHHHHHHHCCCCHHHHHHHHHHHCCCCCCC
GAIEANEYRFVEEKAPGIMARKSVHQPLQTGLKAIDALVPIGRGQRELIIGDRQTGKTTV
CCEECCCEEEEHHCCCCHHHHHHHHHHHHHHHHHHHHHHCCCCCCEEEEEECCCCCCEEE
AIDTIINQKGQDVICIYVAVGQKESTVAQVVRKLEEHGAMDYTVVVNAPASFSAAMQFLA
EEEHHHCCCCCEEEEEEEEECCCHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHH
PYTGVTIGEYFRDNARHALIIYDDLSKHAVAYREMSLILRRPPGREAFPGDVFYLHSRLL
CCCCCCHHHHHHCCCCEEEEEEECCCHHHHHHHHHHHHEECCCCCCCCCCHHHHHHHHHH
ERAAKLNDELGAGSLTALPIIETQAGDVAAYIPTNVISITDGQIFLETDLFNSGIRPAIN
HHHHHCCCCCCCCCEEEEEEEECCCCCEEEECCCCEEEEECCEEEEEECCCCCCCCHHHH
VGLSVSRVGGAAQIKATKQVAGTLRLDLAQYRELQAFSQFASDLDESSRKQLERGQRMVE
CCEEEECCCCCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
ILKQPPYSPLSIEKQVIIIYAGANGYLDNIPANKVIKFESELYPFLEAKYPKIFEDISVK
HHHCCCCCCCCCCCEEEEEEECCCCCCCCCCCCCEEEEHHHHHHHHHCCCCHHHHHHHHH
KAIDKETEAELSKALEEFKINFGA
HHHCHHHHHHHHHHHHHHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 12810954