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The map label for this gene is mutS

Identifier: 32265874

GI number: 32265874

Start: 366104

End: 368326

Strand: Direct

Name: mutS

Synonym: HH0375

Alternate gene names: 32265874

Gene position: 366104-368326 (Clockwise)

Preceding gene: 32265873

Following gene: 32265875

Centisome position: 20.35

GC content: 36.8

Gene sequence:

>2223_bases
GTGCAAAACCATAATGAAAGGCTCATTGCCAAGCTTGACTTATCTGATTTTCTCGCAGTTTTTTTAACATATTTTGCACG
CGAAAAATCCTTTATTTTTGAAGGAGATAGGCATTTTTATGCCATACTTTTGCAAGAGCTTGATAACCACCCATTGAATC
CACCTCCGCCACTTGAAAATCTCAATGAACCCTTAAGGCTTTTGCAAAAATATGGCACTCTAAGATTGTATGAAATCTTT
GCATTTATCAAGCTGATGCGATATTTTGCTTATCTCAAAAAAAATATATCCGAATCTACTCCTCGCACCAAAGAATGGCT
TGATAAGATTCTTATCCCTGATGGATTACAAGAGATTGATAATGTATTTGATGATAAAGGAGAGATTAAAGAGGGCGTGT
ATAACGAAATTGACACGCTTAAATCTCACATTTCACGCACTAAAATGCACATTGATGAGCATATATCGCGTATTTTGCAC
TCTTCTAGCCTTGCTCCTTATCTTGTAGATTCTTCTGTGCATTATATCAATCAAAACGAATGTCTTTTGCTTAAGGCGGG
ATATAATCATATCATCAAAGGTATGGTGCTTGAACGCTCTCATAGCGGATTTTTCTATCTTGTGCCAGAGAGTATTATAA
CACTTAAAGAAAAGCAAAATGAGCTCAAAGATAGTCTTGAACAAAGTCTCTATAATATTTGCAAATCTCTTTCAAACACA
CTTCATAAACACGAGCGATTTTTGCATTTTCTTAACAAAGCCTTTGATACTTTTGACCATATCTATGCGCGATTGAGTTT
TGCCAAAGCTCACAATCTCTCTTTTATATATGAAATGACACGCGAAAAAAACATTATCTTATCTGAATTTTCCCACCCTG
CCTTACAATCCCCAAAACCTATAAATTTTGCATATAAAGGTGATGTTTTGATGATTACAGGTGTAAATGCTGGAGGAAAA
ACAATGCTTTTAAAATCTCTTCTTAGCGCGTGTTTTTTAAGTAAATTTCTTATCCCGCTTAAAATCAACGCTTACCACTC
AAAGATTCCATATTTTAAGCATATTATAGCTATTATCTCTGACCCTCAAAATAGCAAAAATGATATTTCCACTTTTGCAG
GACGTATGCTTGAGTTTAAGCAGATTCTTAATACCTCTGATTTGTTGCTTGGCATTGATGAAATTGAGTTAGGCACAGAC
GCAGATGAGGCAGCCAGCCTTTATAAAGTATTACTTGAGTATTTGCTCCAACATCACGCTAAAATCCTCCTTACCACGCA
TCATAAACATCTTGCCGCACTTATGGCACATAATCCCAAAGTCCAACTCTGTGCGGCAATGTATGACATTCAAGCTCAAG
TGCCACTCTTTGAGTTTCTTGATGGAAGCATTGGGAAAAGCTACGCATTTGAAAGTGCGCAAAGATATGGAATCCCCGCT
TCCCTTATCTCTCAAGCCAAAGCTGTATATGGCGAAGATAAAGAGCGATTAAATGAGCTTATTGAACGCTCAAGTGAATT
AGAAATCACGCTTGAACAAAAGCGACTTGAATTAGAATCACTTATTGCAGAATATGAGCGCAAGATTCTCTCCCTCAATG
AACGCTCCAATGCGCAAAAAGAAGAATTTGAGCTGCTCAAACACAATTTACAATCTACCTATAACCAAGCCACACAAACG
CTCAAATCTGCCCTCAAATCGCAAGAAAGCAAGGAAATGCACAAAGCTTTTAATCAATCTCATAAGATTCTTCATACTGC
ACCCTCTCTCCAAAAAACCACACAAAATCCTCATACATTTAAAGTTGGTGATAAAATAAAATATAAAAATGCAAAAGGAC
ATATTTTAAGTATAAAGGGTGAAATGTGTGTAATAGAGCTTGAAGGCGGATTTAAGTTTAAAGAAAAGCTAGAGAATCTT
AAGCCTTCTTTTGCGCCTTCTCCCACACCAAAATCTCATATTACATTTGAGCAAAGCAAAAGTGTAAGTGTAAGCCTAGA
TTTACACGGAATGCGTGGAGAAGAGGCAATAGAGAAACTTGATGAGTTTTTATCAAATGCACTCATTGCTGGATATGATG
AAGTGCTTGTATATCACGGCATTGGCAGCGGAATCTTAAGTAAACTTGTGCGAGACTATCTGCTTACTCACCCTAAGATT
CTCTCTTTTAGTGATGCACCTGCAAATATGGGTGGCTTTGGAGCAAAAATCATAAAGCTATAA

Upstream 100 bases:

>100_bases
CAAGATTGTAAAATAAATGATATAGATGATGCAGATAAAGATTCTATACAAAAAGCTACACAAGATAAAAACAAAGATGA
CACTCTAGCGGATATGCCTA

Downstream 100 bases:

>100_bases
ATTCAAATAAAATTTAAATTAATGTGATAGAATGCACACTTTTAAAATTAAAAAAGGAGAAGAGAAATGGCTTTGTTTGA
AGTTAATATGCCGCCAATCC

Product: recombination and DNA strand exchange inhibitor protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 740; Mature: 740

Protein sequence:

>740_residues
MQNHNERLIAKLDLSDFLAVFLTYFAREKSFIFEGDRHFYAILLQELDNHPLNPPPPLENLNEPLRLLQKYGTLRLYEIF
AFIKLMRYFAYLKKNISESTPRTKEWLDKILIPDGLQEIDNVFDDKGEIKEGVYNEIDTLKSHISRTKMHIDEHISRILH
SSSLAPYLVDSSVHYINQNECLLLKAGYNHIIKGMVLERSHSGFFYLVPESIITLKEKQNELKDSLEQSLYNICKSLSNT
LHKHERFLHFLNKAFDTFDHIYARLSFAKAHNLSFIYEMTREKNIILSEFSHPALQSPKPINFAYKGDVLMITGVNAGGK
TMLLKSLLSACFLSKFLIPLKINAYHSKIPYFKHIIAIISDPQNSKNDISTFAGRMLEFKQILNTSDLLLGIDEIELGTD
ADEAASLYKVLLEYLLQHHAKILLTTHHKHLAALMAHNPKVQLCAAMYDIQAQVPLFEFLDGSIGKSYAFESAQRYGIPA
SLISQAKAVYGEDKERLNELIERSSELEITLEQKRLELESLIAEYERKILSLNERSNAQKEEFELLKHNLQSTYNQATQT
LKSALKSQESKEMHKAFNQSHKILHTAPSLQKTTQNPHTFKVGDKIKYKNAKGHILSIKGEMCVIELEGGFKFKEKLENL
KPSFAPSPTPKSHITFEQSKSVSVSLDLHGMRGEEAIEKLDEFLSNALIAGYDEVLVYHGIGSGILSKLVRDYLLTHPKI
LSFSDAPANMGGFGAKIIKL

Sequences:

>Translated_740_residues
MQNHNERLIAKLDLSDFLAVFLTYFAREKSFIFEGDRHFYAILLQELDNHPLNPPPPLENLNEPLRLLQKYGTLRLYEIF
AFIKLMRYFAYLKKNISESTPRTKEWLDKILIPDGLQEIDNVFDDKGEIKEGVYNEIDTLKSHISRTKMHIDEHISRILH
SSSLAPYLVDSSVHYINQNECLLLKAGYNHIIKGMVLERSHSGFFYLVPESIITLKEKQNELKDSLEQSLYNICKSLSNT
LHKHERFLHFLNKAFDTFDHIYARLSFAKAHNLSFIYEMTREKNIILSEFSHPALQSPKPINFAYKGDVLMITGVNAGGK
TMLLKSLLSACFLSKFLIPLKINAYHSKIPYFKHIIAIISDPQNSKNDISTFAGRMLEFKQILNTSDLLLGIDEIELGTD
ADEAASLYKVLLEYLLQHHAKILLTTHHKHLAALMAHNPKVQLCAAMYDIQAQVPLFEFLDGSIGKSYAFESAQRYGIPA
SLISQAKAVYGEDKERLNELIERSSELEITLEQKRLELESLIAEYERKILSLNERSNAQKEEFELLKHNLQSTYNQATQT
LKSALKSQESKEMHKAFNQSHKILHTAPSLQKTTQNPHTFKVGDKIKYKNAKGHILSIKGEMCVIELEGGFKFKEKLENL
KPSFAPSPTPKSHITFEQSKSVSVSLDLHGMRGEEAIEKLDEFLSNALIAGYDEVLVYHGIGSGILSKLVRDYLLTHPKI
LSFSDAPANMGGFGAKIIKL
>Mature_740_residues
MQNHNERLIAKLDLSDFLAVFLTYFAREKSFIFEGDRHFYAILLQELDNHPLNPPPPLENLNEPLRLLQKYGTLRLYEIF
AFIKLMRYFAYLKKNISESTPRTKEWLDKILIPDGLQEIDNVFDDKGEIKEGVYNEIDTLKSHISRTKMHIDEHISRILH
SSSLAPYLVDSSVHYINQNECLLLKAGYNHIIKGMVLERSHSGFFYLVPESIITLKEKQNELKDSLEQSLYNICKSLSNT
LHKHERFLHFLNKAFDTFDHIYARLSFAKAHNLSFIYEMTREKNIILSEFSHPALQSPKPINFAYKGDVLMITGVNAGGK
TMLLKSLLSACFLSKFLIPLKINAYHSKIPYFKHIIAIISDPQNSKNDISTFAGRMLEFKQILNTSDLLLGIDEIELGTD
ADEAASLYKVLLEYLLQHHAKILLTTHHKHLAALMAHNPKVQLCAAMYDIQAQVPLFEFLDGSIGKSYAFESAQRYGIPA
SLISQAKAVYGEDKERLNELIERSSELEITLEQKRLELESLIAEYERKILSLNERSNAQKEEFELLKHNLQSTYNQATQT
LKSALKSQESKEMHKAFNQSHKILHTAPSLQKTTQNPHTFKVGDKIKYKNAKGHILSIKGEMCVIELEGGFKFKEKLENL
KPSFAPSPTPKSHITFEQSKSVSVSLDLHGMRGEEAIEKLDEFLSNALIAGYDEVLVYHGIGSGILSKLVRDYLLTHPKI
LSFSDAPANMGGFGAKIIKL

Specific function: This Protein Is Involved In The Repair Of Mismatches In DNA. It Is Possible That It Carries Out The Mismatch Recognition Step. This Protein Has A Weak Atpase Activity. [C]

COG id: COG1193

COG function: function code L; Mismatch repair ATPase (MutS family)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 Smr domain [H]

Homologues:

Organism=Homo sapiens, GI36949366, Length=299, Percent_Identity=27.4247491638796, Blast_Score=67, Evalue=6e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005747
- InterPro:   IPR000432
- InterPro:   IPR007696
- InterPro:   IPR002625 [H]

Pfam domain/function: PF00488 MutS_V; PF01713 Smr [H]

EC number: NA

Molecular weight: Translated: 84413; Mature: 84413

Theoretical pI: Translated: 7.56; Mature: 7.56

Prosite motif: PS50828 SMR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.7 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
2.6 %Cys+Met (Translated Protein)
0.7 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQNHNERLIAKLDLSDFLAVFLTYFAREKSFIFEGDRHFYAILLQELDNHPLNPPPPLEN
CCCCCCCEEEEECHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC
LNEPLRLLQKYGTLRLYEIFAFIKLMRYFAYLKKNISESTPRTKEWLDKILIPDGLQEID
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHH
NVFDDKGEIKEGVYNEIDTLKSHISRTKMHIDEHISRILHSSSLAPYLVDSSVHYINQNE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEECCCC
CLLLKAGYNHIIKGMVLERSHSGFFYLVPESIITLKEKQNELKDSLEQSLYNICKSLSNT
EEEEECCHHHHHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHKHERFLHFLNKAFDTFDHIYARLSFAKAHNLSFIYEMTREKNIILSEFSHPALQSPKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEHCCCCCCCCCCCCC
INFAYKGDVLMITGVNAGGKTMLLKSLLSACFLSKFLIPLKINAYHSKIPYFKHIIAIIS
CCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEECHHHHCCHHHHHHHHHHC
DPQNSKNDISTFAGRMLEFKQILNTSDLLLGIDEIELGTDADEAASLYKVLLEYLLQHHA
CCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCHHCCCCCHHHHHHHHHHHHHHHHHHCC
KILLTTHHKHLAALMAHNPKVQLCAAMYDIQAQVPLFEFLDGSIGKSYAFESAQRYGIPA
EEEEEECHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCH
SLISQAKAVYGEDKERLNELIERSSELEITLEQKRLELESLIAEYERKILSLNERSNAQK
HHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EEFELLKHNLQSTYNQATQTLKSALKSQESKEMHKAFNQSHKILHTAPSLQKTTQNPHTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHCCCCCEE
KVGDKIKYKNAKGHILSIKGEMCVIELEGGFKFKEKLENLKPSFAPSPTPKSHITFEQSK
ECCCCEEEECCCCCEEEEECCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCEEEECCC
SVSVSLDLHGMRGEEAIEKLDEFLSNALIAGYDEVLVYHGIGSGILSKLVRDYLLTHPKI
CEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHHHCCCCE
LSFSDAPANMGGFGAKIIKL
EECCCCCCCCCCCCCEEECC
>Mature Secondary Structure
MQNHNERLIAKLDLSDFLAVFLTYFAREKSFIFEGDRHFYAILLQELDNHPLNPPPPLEN
CCCCCCCEEEEECHHHHHHHHHHHHHHCCCEEEECCCHHHHHHHHHHCCCCCCCCCCCCC
LNEPLRLLQKYGTLRLYEIFAFIKLMRYFAYLKKNISESTPRTKEWLDKILIPDGLQEID
CHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHCCCCHHHHHH
NVFDDKGEIKEGVYNEIDTLKSHISRTKMHIDEHISRILHSSSLAPYLVDSSVHYINQNE
HHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCEEEECCCC
CLLLKAGYNHIIKGMVLERSHSGFFYLVPESIITLKEKQNELKDSLEQSLYNICKSLSNT
EEEEECCHHHHHHHHHEEECCCCEEEECCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LHKHERFLHFLNKAFDTFDHIYARLSFAKAHNLSFIYEMTREKNIILSEFSHPALQSPKP
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHCCCCEEHCCCCCCCCCCCCC
INFAYKGDVLMITGVNAGGKTMLLKSLLSACFLSKFLIPLKINAYHSKIPYFKHIIAIIS
CCEEEECCEEEEEECCCCCHHHHHHHHHHHHHHHHHHHHEEECHHHHCCHHHHHHHHHHC
DPQNSKNDISTFAGRMLEFKQILNTSDLLLGIDEIELGTDADEAASLYKVLLEYLLQHHA
CCCCCHHHHHHHHHHHHHHHHHHCCCHHEEECCHHCCCCCHHHHHHHHHHHHHHHHHHCC
KILLTTHHKHLAALMAHNPKVQLCAAMYDIQAQVPLFEFLDGSIGKSYAFESAQRYGIPA
EEEEEECHHHHHHHHHCCCCHHHHHHHHHHHCCCCHHHHHCCCCCCHHHHHHHHHCCCCH
SLISQAKAVYGEDKERLNELIERSSELEITLEQKRLELESLIAEYERKILSLNERSNAQK
HHHHHHHHHHCCCHHHHHHHHHCCCCEEEEHHHHHHHHHHHHHHHHHHHHHCCCCCCCHH
EEFELLKHNLQSTYNQATQTLKSALKSQESKEMHKAFNQSHKILHTAPSLQKTTQNPHTF
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCEEECCCCHHHHCCCCCEE
KVGDKIKYKNAKGHILSIKGEMCVIELEGGFKFKEKLENLKPSFAPSPTPKSHITFEQSK
ECCCCEEEECCCCCEEEEECCEEEEEECCCCCHHHHHHHCCCCCCCCCCCCCCEEEECCC
SVSVSLDLHGMRGEEAIEKLDEFLSNALIAGYDEVLVYHGIGSGILSKLVRDYLLTHPKI
CEEEEEEECCCCCHHHHHHHHHHHHHHHHCCHHHEEEEECCCHHHHHHHHHHHHHCCCCE
LSFSDAPANMGGFGAKIIKL
EECCCCCCCCCCCCCEEECC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9923682 [H]