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The map label for this gene is ntpA [H]

Identifier: 30995367

GI number: 30995367

Start: 347265

End: 347729

Strand: Reverse

Name: ntpA [H]

Synonym: HI0316

Alternate gene names: 30995367

Gene position: 347729-347265 (Counterclockwise)

Preceding gene: 16272271

Following gene: 16272269

Centisome position: 19.0

GC content: 35.91

Gene sequence:

>465_bases
TTGACCGCATTTTTAATGATGCAATACAAAAATAATCAATCTGTTCTCGTTGTAATTTACACTAAAGATACAAACAGAGT
TTTAATGCTCCAACGCCAAGATGATCCTGATTTTTGGCAGTCTGTTACTGGCACTATTGAAAGTGATGAGACACCAAAAA
AAACAGCAATTCGTGAGCTATGGGAAGAAGTGCGGTTAGACATTTCGGAAAATTCCACCGCACTTTTTGATTGCAATGAG
AGCATAGAATTTGAAATTTTTCCACATTTCCGCTATAAATACGCACCGAATATTACTCACTGCAAAGAACATTGGTTTTT
GTGTGAGGTGGAAAAAGAATTTATTCCAGTATTGAGTGAGCATTTAGATTTTTGCTGGGTGTCGGCGAAAAAAGCAGTAG
AAATGACGAAATCCCAGAATAATGCGGAAGCTATTAAAAAATATCTTTTTAATCTCCGTAGGTAA

Upstream 100 bases:

>100_bases
AGCCCCGAGTTTTGCAAATCCGCAAGCATTGGAAGAGTTGGCAATTTCTGTCGTTAAAGCAGAATAAGTTTGAAATATTA
GGAATGAAGTGCGGTCAGAT

Downstream 100 bases:

>100_bases
GTATAATCACAGCTAATTATGGTGATAGCGGTTCTCTTTTGGGAAAAGCTACATCCACTCCCAACGGGGTAACACTTTTA
CTAACCTAGGCTATACCTAG

Product: dATP pyrophosphohydrolase

Products: dAMP; pyrophosphate [C]

Alternate protein names: dATP pyrophosphohydrolase [H]

Number of amino acids: Translated: 154; Mature: 153

Protein sequence:

>154_residues
MTAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESDETPKKTAIRELWEEVRLDISENSTALFDCNE
SIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFIPVLSEHLDFCWVSAKKAVEMTKSQNNAEAIKKYLFNLRR

Sequences:

>Translated_154_residues
MTAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESDETPKKTAIRELWEEVRLDISENSTALFDCNE
SIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFIPVLSEHLDFCWVSAKKAVEMTKSQNNAEAIKKYLFNLRR
>Mature_153_residues
TAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESDETPKKTAIRELWEEVRLDISENSTALFDCNES
IEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFIPVLSEHLDFCWVSAKKAVEMTKSQNNAEAIKKYLFNLRR

Specific function: Catalyzes the hydrolysis of dihydroneopterin triphosphate to dihydroneopterin monophosphate and pyrophosphate. Required for efficient folate biosynthesis. Can also hydrolyze nucleoside triphosphates with a preference for dATP [H]

COG id: COG0494

COG function: function code LR; NTP pyrophosphohydrolases including oxidative damage repair enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 nudix hydrolase domain [H]

Homologues:

Organism=Escherichia coli, GI1788172, Length=143, Percent_Identity=48.951048951049, Blast_Score=153, Evalue=4e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003564
- InterPro:   IPR020084
- InterPro:   IPR000086
- InterPro:   IPR015797 [H]

Pfam domain/function: PF00293 NUDIX [H]

EC number: 3.6.1.- [C]

Molecular weight: Translated: 18355; Mature: 18224

Theoretical pI: Translated: 5.31; Mature: 5.31

Prosite motif: PS00893 NUDIX

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
5.8 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
2.6 %Met     (Mature Protein)
5.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESDETPKKTAIREL
CCEEEEEEEECCCEEEEEEEECCCCEEEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHH
WEEVRLDISENSTALFDCNESIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFIPVLSE
HHHHCCCCCCCCEEEEECCCCCEEEEECCEEEEECCCCCCHHHCEEEEEECHHHHHHHHH
HLDFCWVSAKKAVEMTKSQNNAEAIKKYLFNLRR
HHHEEEHHHHHHHHHHCCCCCHHHHHHHHHHCCC
>Mature Secondary Structure 
TAFLMMQYKNNQSVLVVIYTKDTNRVLMLQRQDDPDFWQSVTGTIESDETPKKTAIREL
CEEEEEEEECCCEEEEEEEECCCCEEEEEEECCCHHHHHHHCCCCCCCCCCHHHHHHHH
WEEVRLDISENSTALFDCNESIEFEIFPHFRYKYAPNITHCKEHWFLCEVEKEFIPVLSE
HHHHCCCCCCCCEEEEECCCCCEEEEECCEEEEECCCCCCHHHCEEEEEECHHHHHHHHH
HLDFCWVSAKKAVEMTKSQNNAEAIKKYLFNLRR
HHHEEEHHHHHHHHHHCCCCCHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: deoxy-ATP; H2O [C]

Specific reaction: deoxy-ATP + H2O = dAMP + pyrophosphate [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7542800 [H]