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The map label for this gene is sseL [H]

Identifier: 308065958

GI number: 308065958

Start: 2394726

End: 2395748

Strand: Direct

Name: sseL [H]

Synonym: NA

Alternate gene names: 308065958

Gene position: 2394726-2395748 (Clockwise)

Preceding gene: 16765613

Following gene: 16765622

Centisome position: 49.3

GC content: 38.32

Gene sequence:

>1023_bases
ATGAATATATGTGTAAATTCACTTTACCGATTGAGCATACCGCAATTTCACAGCTTATATACAGAAGAGGTGAGCGATGA
GGCGCTTACATTGTTGTTTAGCGCCGTAGAGAACGGTGATCAGAATTGTATTGATCTGTTATGCAATCTTGCGTTACGCA
ACGATGACCTGGGGCATAGAGTTGAGAAATTTCTTTTTGATCTCTTTAGCGGGAAAAGAACGGGATCATCAGATATAGAC
AAAAAAATCAATCAGGCTTGCCTTGTATTACATCAAATCGCCAATAACGATATAACAAAAGATAATACTGAGTGGAAAAA
GCTACATGCCCCTTCCAGATTACTTTATATGGCAGGTTCCGCGACAACCGACCTTTCTAAAAAAATAGGAATAGCACATA
AAATTATGGGCGACCAGTTCGCTCAGACAGATCAAGAACAGGTAGGAGTTGAAAATCTTTGGTGTGGTGCGCGAATGTTG
TCGTCAGATGAGCTAGCAGCTGCAACGCAAGGTCTGGTTCAAGAATCACCTCTTCTCTCGGTAAACTATCCTATTGGGCT
GATTCATCCTACCACCAAAGAAAATATATTAAGCACTCAGCTACTTGAAAAGATTGCTCAATCAGGATTATCTCACAATG
AAGTCTTCCTGGTAAATACAGGAGATCACTGGCTTCTCTGTTTATTTTATAAACTTGCAGAAAAAATAAAATGCCTTATA
TTTAATACTTATTATGATTTAAATGAAAATACTAAGCAAGAGATTATAGAAGCAGCAAAAATTGCAGGCATATCAGAAAG
CGATGAGGTTAATTTTATTGAAATGAATTTACAGAACAATGTACCCAACGGCTGTGGTCTATTTTGTTACCATACAATTC
AACTCTTATCGAATGCCGGACAAAACGATCCTGCTACCACACTACGAGAATTTGCGGAAAATTTCTTAACGCTTTCAGTA
GAGGAACAAGCACTATTTAACACCCAAACCCGGCGGCAAATATATGAATACAGTCTCCAGTAA

Upstream 100 bases:
NA

Downstream 100 bases:
NA

Product: deubiquitinase

Products: NA

Alternate protein names: Deubiquitinating enzyme; DUB; Deubiquitinating protease; Salmonella secreted effector L [H]

Number of amino acids: Translated: 340; Mature: 340

Protein sequence:
NA

Sequences:

>Translated_340_residues
MNICVNSLYRLSIPQFHSLYTEEVSDEALTLLFSAVENGDQNCIDLLCNLALRNDDLGHRVEKFLFDLFSGKRTGSSDID
KKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGSATTDLSKKIGIAHKIMGDQFAQTDQEQVGVENLWCGARML
SSDELAAATQGLVQESPLLSVNYPIGLIHPTTKENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLI
FNTYYDLNENTKQEIIEAAKIAGISESDEVNFIEMNLQNNVPNGCGLFCYHTIQLLSNAGQNDPATTLREFAENFLTLSV
EEQALFNTQTRRQIYEYSLQ
>Mature_340_residues
MNICVNSLYRLSIPQFHSLYTEEVSDEALTLLFSAVENGDQNCIDLLCNLALRNDDLGHRVEKFLFDLFSGKRTGSSDID
KKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGSATTDLSKKIGIAHKIMGDQFAQTDQEQVGVENLWCGARML
SSDELAAATQGLVQESPLLSVNYPIGLIHPTTKENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLI
FNTYYDLNENTKQEIIEAAKIAGISESDEVNFIEMNLQNNVPNGCGLFCYHTIQLLSNAGQNDPATTLREFAENFLTLSV
EEQALFNTQTRRQIYEYSLQ

Specific function: Effector proteins function to alter host cell physiology and promote bacterial survival in host tissues. This protease targets the host cell ubiquitin pathway by acting as a deubiquitinase in infected host cells [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Secreted. Host cytoplasm (By similarity). Note=Secreted via type III secretion system 2 (SPI-2 TTSS), and delivered into the host cytoplasm. In phagocytic cells localizes to the Salmonella-containing vacuole (SCV). In epithelial cells localizes to the Sal

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase C79 family [H]

Homologues:

Organism=Escherichia coli, GI1788604, Length=366, Percent_Identity=28.9617486338798, Blast_Score=117, Evalue=8e-28,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

NA

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 38222; Mature: 38222

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.6 %Cys     (Translated Protein)
1.5 %Met     (Translated Protein)
4.1 %Cys+Met (Translated Protein)
2.6 %Cys     (Mature Protein)
1.5 %Met     (Mature Protein)
4.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNICVNSLYRLSIPQFHSLYTEEVSDEALTLLFSAVENGDQNCIDLLCNLALRNDDLGHR
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
VEKFLFDLFSGKRTGSSDIDKKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECC
ATTDLSKKIGIAHKIMGDQFAQTDQEQVGVENLWCGARMLSSDELAAATQGLVQESPLLS
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEE
VNYPIGLIHPTTKENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLI
EECCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHEEEE
FNTYYDLNENTKQEIIEAAKIAGISESDEVNFIEMNLQNNVPNGCGLFCYHTIQLLSNAG
EEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
QNDPATTLREFAENFLTLSVEEQALFNTQTRRQIYEYSLQ
CCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNICVNSLYRLSIPQFHSLYTEEVSDEALTLLFSAVENGDQNCIDLLCNLALRNDDLGHR
CCCHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHCCCCHHHH
VEKFLFDLFSGKRTGSSDIDKKINQACLVLHQIANNDITKDNTEWKKLHAPSRLLYMAGS
HHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHCCCCCCCCCHHHHHCCCCEEEEEECC
ATTDLSKKIGIAHKIMGDQFAQTDQEQVGVENLWCGARMLSSDELAAATQGLVQESPLLS
CCHHHHHHHHHHHHHHHHHHHCCCHHHCCHHHHHHHHHHCCCHHHHHHHHHHHHCCCEEE
VNYPIGLIHPTTKENILSTQLLEKIAQSGLSHNEVFLVNTGDHWLLCLFYKLAEKIKCLI
EECCEEEECCCCHHHHHHHHHHHHHHHCCCCCCEEEEEECCCHHHHHHHHHHHHHHEEEE
FNTYYDLNENTKQEIIEAAKIAGISESDEVNFIEMNLQNNVPNGCGLFCYHTIQLLSNAG
EEEEECCCCCHHHHHHHHHHHCCCCCCCCCEEEEEEECCCCCCCCHHHHHHHHHHHHCCC
QNDPATTLREFAENFLTLSVEEQALFNTQTRRQIYEYSLQ
CCCHHHHHHHHHHHHEEEEEHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: NA