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The map label for this gene is ytcI [H]

Identifier: 30264719

GI number: 30264719

Start: 4448149

End: 4449717

Strand: Reverse

Name: ytcI [H]

Synonym: BA_4896

Alternate gene names: 30264719

Gene position: 4449717-4448149 (Counterclockwise)

Preceding gene: 30264720

Following gene: 30264718

Centisome position: 85.12

GC content: 40.6

Gene sequence:

>1569_bases
TTGGCACCACCGTCTTATAATTTAGTTTCTGAAATAGAGAAATATACAGGTGATAAAGAGAAGCTTGCTTTAATTTGGCA
AGATGATAAAGGGAATCGACGAGAAGTTACATACGCTGAGCTAATGAAAGGTGCAAATAAAATTGGAAACGCTTTTATAA
AGAGTGGTCTGCAAAAAGGGGACAAGCTCCTCATTATGATGCCGCGTTTAATTGAAGCGTACATGACGTATATCGCAGCG
ATTAAAGCAGGATTTGTCGTAATTCCGAGTTCGGAAATGTTACGCAAAAAGGATATCGAATATCGCATTGGACACGGGGA
AGTAAAAGCAATCGTAAGTTATGAGCCTTACATTGGACAGTTTGATGATATAGAAGCGATGGAATCCCTTCAAAAGTTCG
TTCTGAGCGAGCGGTCAGTAGATGGATGGATCAATTTAAAAACAGCGTTAGAAACAGAAAGTGACATGTTAGAAATGGCG
AAGACAGATAAAGAAGATATGGTCTTTTTATCTTACACGTCAGGAACGACAGGAAATCCAAAAGGTGTTGTTCATACGCA
TGCGTGGGCATACGCTCATTTACGTACAAGCGCTCCGAATTGGCTCGGAATTGAAGAGAATGATGTTGTATGGGCAACAG
CTAGTCCAGGCTGGCAGAAGTGGATTTGGAGCCCGTTTTTAGCAACTCTAGGCTCGGGGGCAACAGGATTTGTATACCAC
GGTAAGTTTGAACCAAAAACGTATTTAAATTTATTAGACGATAATAAGGTGAATGTACTTTGTTGTACGCCAACTGAGTA
TAGATTAATGGCAAAAGTAGAAAATTTAAGCGAGTACAATTTAGAAGCGTTACATAGCGCTGTATCCGCAGGTGAGCCGT
TAAATAGAGAAGTCATTGAAACGTTCCAAAAGCACTTTCATATTACAGTGAGAGACGGCTATGGGCAAACGGAAAATACA
TTGCTTGTTGGTGTAATGAAAGGGATGGATATTAGACCAGGATCAATGGGGAAACCGACGCCAGGCAACCACGTTGATAT
TGTAGATGAGGAAGGGATGCCAGTAAGGGTAGGCGAAGTTGGTGATATTGCGGTTCATATTGAAACACCAGCCCTCTTTA
AACAATACTATAAAGACGATGAGCGCACAGCGATGCAATTCCGCGGTGATTATTATATTACCGGTGATAAAGCAAAGAAA
GATGAAGACGGCTATTTCTGGTTTGAAGGGCGCGGTGATGATATTATTATTAGCTCTGGTTATACAATCGGGCCGTTTGA
AGTAGAAGATGCGCTCGTAAAGCACCCTTATGTAAGAGAATGTGCGGTTGTCGCAAGTCCTGATGAAATTCGCGGAAGTG
TCGTGAAGGCATTTATCGTATTAAGAGAGAATATAGAAAAGAACGAAGAAACATTAATTCCAATACTCCAACAACACGTC
AAGGAACTTACTGCACCATATAAATACCCTCGCAAAATTGAATTTGTAGATGAACTACCAAAAACGATTTCTGGAAAAAT
CCGCCGTATTGAACTTAGAAAACAAGAGATGGAGATTCCGTCAAAATAA

Upstream 100 bases:

>100_bases
AATTTGTCAAAAGATGAGGGTTCAAAATTGACAGAAAATTCTTTATTATATAAGGGAGGCATAAAGAAAAAGGAGGATGT
TTATGAAGAGAGAGGAATTG

Downstream 100 bases:

>100_bases
ATTTGAAAACAGTGAAGGAAATAGTTGAATGAAATGGCAAACAATGATAATATAAAAACGAACACAAGTTCGATTTTATA
AATTGAAAAAAGAGGTGTCC

Product: acetyl-CoA synthetase, putative

Products: AMP; diphosphate; acetyl-CoA

Alternate protein names: NA

Number of amino acids: Translated: 522; Mature: 521

Protein sequence:

>522_residues
MAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAYMTYIAA
IKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQFDDIEAMESLQKFVLSERSVDGWINLKTALETESDMLEMA
KTDKEDMVFLSYTSGTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGATGFVYH
GKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIETFQKHFHITVRDGYGQTENT
LLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYITGDKAKK
DEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEETLIPILQQHV
KELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK

Sequences:

>Translated_522_residues
MAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAYMTYIAA
IKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQFDDIEAMESLQKFVLSERSVDGWINLKTALETESDMLEMA
KTDKEDMVFLSYTSGTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGATGFVYH
GKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIETFQKHFHITVRDGYGQTENT
LLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYITGDKAKK
DEDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEETLIPILQQHV
KELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK
>Mature_521_residues
APPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKGDKLLIMMPRLIEAYMTYIAAI
KAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQFDDIEAMESLQKFVLSERSVDGWINLKTALETESDMLEMAK
TDKEDMVFLSYTSGTTGNPKGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGATGFVYHG
KFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIETFQKHFHITVRDGYGQTENTL
LVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEVGDIAVHIETPALFKQYYKDDERTAMQFRGDYYITGDKAKKD
EDGYFWFEGRGDDIIISSGYTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEETLIPILQQHVK
ELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK

Specific function: Enables The Cell To Use Acetate During Aerobic Growth To Generate Energy Via The Tca Cycle, And Biosynthetic Compounds Via The Glyoxylate Shunt. Acetylates Chey, The Response Regulator Involved In Flagellar Movement And Chemotaxis. [C]

COG id: COG0365

COG function: function code I; Acyl-coenzyme A synthetases/AMP-(fatty) acid ligases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ATP-dependent AMP-binding enzyme family [H]

Homologues:

Organism=Homo sapiens, GI42544132, Length=529, Percent_Identity=40.4536862003781, Blast_Score=401, Evalue=1e-112,
Organism=Homo sapiens, GI38505220, Length=502, Percent_Identity=41.2350597609562, Blast_Score=377, Evalue=1e-104,
Organism=Homo sapiens, GI122937307, Length=529, Percent_Identity=38.3742911153119, Blast_Score=360, Evalue=2e-99,
Organism=Homo sapiens, GI157311624, Length=535, Percent_Identity=37.0093457943925, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI157311622, Length=535, Percent_Identity=37.0093457943925, Blast_Score=353, Evalue=2e-97,
Organism=Homo sapiens, GI58082049, Length=535, Percent_Identity=37.0093457943925, Blast_Score=352, Evalue=4e-97,
Organism=Homo sapiens, GI115511026, Length=530, Percent_Identity=36.4150943396226, Blast_Score=327, Evalue=2e-89,
Organism=Homo sapiens, GI42544134, Length=357, Percent_Identity=32.4929971988796, Blast_Score=211, Evalue=1e-54,
Organism=Homo sapiens, GI195947378, Length=421, Percent_Identity=28.7410926365796, Blast_Score=191, Evalue=2e-48,
Organism=Homo sapiens, GI13375727, Length=552, Percent_Identity=28.9855072463768, Blast_Score=186, Evalue=6e-47,
Organism=Homo sapiens, GI28416953, Length=534, Percent_Identity=28.6516853932584, Blast_Score=182, Evalue=5e-46,
Organism=Homo sapiens, GI253970489, Length=577, Percent_Identity=27.209705372617, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI8923896, Length=567, Percent_Identity=27.5132275132275, Blast_Score=170, Evalue=3e-42,
Organism=Homo sapiens, GI156151445, Length=543, Percent_Identity=25.9668508287293, Blast_Score=123, Evalue=3e-28,
Organism=Homo sapiens, GI187761345, Length=529, Percent_Identity=25.8979206049149, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI187761343, Length=529, Percent_Identity=25.8979206049149, Blast_Score=115, Evalue=8e-26,
Organism=Homo sapiens, GI31982927, Length=542, Percent_Identity=20.8487084870849, Blast_Score=77, Evalue=5e-14,
Organism=Escherichia coli, GI1790505, Length=531, Percent_Identity=28.6252354048964, Blast_Score=203, Evalue=2e-53,
Organism=Escherichia coli, GI1788107, Length=491, Percent_Identity=26.2729124236253, Blast_Score=159, Evalue=3e-40,
Organism=Escherichia coli, GI221142682, Length=504, Percent_Identity=24.8015873015873, Blast_Score=153, Evalue=2e-38,
Organism=Escherichia coli, GI1786529, Length=541, Percent_Identity=26.9870609981516, Blast_Score=147, Evalue=2e-36,
Organism=Escherichia coli, GI145693145, Length=500, Percent_Identity=26.4, Blast_Score=141, Evalue=9e-35,
Organism=Escherichia coli, GI1786810, Length=504, Percent_Identity=25.1984126984127, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1789201, Length=369, Percent_Identity=24.9322493224932, Blast_Score=97, Evalue=3e-21,
Organism=Caenorhabditis elegans, GI71983001, Length=558, Percent_Identity=27.9569892473118, Blast_Score=157, Evalue=2e-38,
Organism=Caenorhabditis elegans, GI71982997, Length=558, Percent_Identity=27.9569892473118, Blast_Score=156, Evalue=3e-38,
Organism=Caenorhabditis elegans, GI17559526, Length=535, Percent_Identity=25.981308411215, Blast_Score=155, Evalue=5e-38,
Organism=Caenorhabditis elegans, GI17558820, Length=521, Percent_Identity=26.1036468330134, Blast_Score=152, Evalue=6e-37,
Organism=Caenorhabditis elegans, GI32563687, Length=513, Percent_Identity=26.1208576998051, Blast_Score=147, Evalue=1e-35,
Organism=Caenorhabditis elegans, GI17557194, Length=528, Percent_Identity=26.3257575757576, Blast_Score=145, Evalue=5e-35,
Organism=Caenorhabditis elegans, GI17538037, Length=526, Percent_Identity=25.6653992395437, Blast_Score=137, Evalue=1e-32,
Organism=Caenorhabditis elegans, GI71994690, Length=522, Percent_Identity=26.2452107279693, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71994703, Length=522, Percent_Identity=26.2452107279693, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI71994694, Length=522, Percent_Identity=26.2452107279693, Blast_Score=130, Evalue=2e-30,
Organism=Caenorhabditis elegans, GI17560308, Length=536, Percent_Identity=25.1865671641791, Blast_Score=121, Evalue=1e-27,
Organism=Caenorhabditis elegans, GI17531443, Length=513, Percent_Identity=23.5867446393762, Blast_Score=110, Evalue=2e-24,
Organism=Caenorhabditis elegans, GI71985884, Length=380, Percent_Identity=26.3157894736842, Blast_Score=107, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17560140, Length=529, Percent_Identity=23.8185255198488, Blast_Score=103, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI71996755, Length=495, Percent_Identity=23.2323232323232, Blast_Score=100, Evalue=1e-21,
Organism=Caenorhabditis elegans, GI115534440, Length=542, Percent_Identity=23.8007380073801, Blast_Score=79, Evalue=7e-15,
Organism=Saccharomyces cerevisiae, GI6319264, Length=559, Percent_Identity=28.2647584973166, Blast_Score=176, Evalue=8e-45,
Organism=Saccharomyces cerevisiae, GI6323182, Length=561, Percent_Identity=26.0249554367201, Blast_Score=167, Evalue=3e-42,
Organism=Saccharomyces cerevisiae, GI6319699, Length=353, Percent_Identity=27.4787535410765, Blast_Score=116, Evalue=7e-27,
Organism=Drosophila melanogaster, GI24667955, Length=559, Percent_Identity=28.4436493738819, Blast_Score=188, Evalue=6e-48,
Organism=Drosophila melanogaster, GI62472339, Length=527, Percent_Identity=28.842504743833, Blast_Score=186, Evalue=5e-47,
Organism=Drosophila melanogaster, GI24667959, Length=365, Percent_Identity=33.1506849315069, Blast_Score=175, Evalue=7e-44,
Organism=Drosophila melanogaster, GI21355225, Length=536, Percent_Identity=27.0522388059701, Blast_Score=166, Evalue=3e-41,
Organism=Drosophila melanogaster, GI24581924, Length=511, Percent_Identity=27.3972602739726, Blast_Score=152, Evalue=7e-37,
Organism=Drosophila melanogaster, GI21355181, Length=519, Percent_Identity=26.3969171483622, Blast_Score=147, Evalue=1e-35,
Organism=Drosophila melanogaster, GI18859661, Length=508, Percent_Identity=26.9685039370079, Blast_Score=139, Evalue=5e-33,
Organism=Drosophila melanogaster, GI19922652, Length=505, Percent_Identity=23.960396039604, Blast_Score=113, Evalue=3e-25,
Organism=Drosophila melanogaster, GI24656500, Length=505, Percent_Identity=23.5643564356436, Blast_Score=111, Evalue=1e-24,
Organism=Drosophila melanogaster, GI21356947, Length=483, Percent_Identity=22.1532091097308, Blast_Score=101, Evalue=2e-21,
Organism=Drosophila melanogaster, GI24648260, Length=355, Percent_Identity=26.7605633802817, Blast_Score=99, Evalue=7e-21,
Organism=Drosophila melanogaster, GI24653035, Length=364, Percent_Identity=24.4505494505494, Blast_Score=93, Evalue=5e-19,
Organism=Drosophila melanogaster, GI20130357, Length=355, Percent_Identity=26.1971830985915, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648257, Length=504, Percent_Identity=23.2142857142857, Blast_Score=89, Evalue=1e-17,
Organism=Drosophila melanogaster, GI161076582, Length=368, Percent_Identity=23.6413043478261, Blast_Score=82, Evalue=6e-16,
Organism=Drosophila melanogaster, GI21356441, Length=386, Percent_Identity=22.020725388601, Blast_Score=81, Evalue=2e-15,
Organism=Drosophila melanogaster, GI281365686, Length=318, Percent_Identity=21.0691823899371, Blast_Score=79, Evalue=5e-15,
Organism=Drosophila melanogaster, GI20130353, Length=543, Percent_Identity=21.9152854511971, Blast_Score=79, Evalue=7e-15,
Organism=Drosophila melanogaster, GI28573631, Length=543, Percent_Identity=21.9152854511971, Blast_Score=79, Evalue=8e-15,
Organism=Drosophila melanogaster, GI24648253, Length=376, Percent_Identity=22.0744680851064, Blast_Score=70, Evalue=4e-12,
Organism=Drosophila melanogaster, GI24648255, Length=388, Percent_Identity=21.6494845360825, Blast_Score=69, Evalue=7e-12,
Organism=Drosophila melanogaster, GI21358303, Length=457, Percent_Identity=20.7877461706783, Blast_Score=69, Evalue=8e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR020845
- InterPro:   IPR000873 [H]

Pfam domain/function: PF00501 AMP-binding [H]

EC number: 6.2.1.1

Molecular weight: Translated: 59050; Mature: 58919

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00455 AMP_BINDING

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.8 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAPPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKG
CCCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DKLLIMMPRLIEAYMTYIAAIKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQ
CEEEEEHHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCCEEECCCCEEEEEEECCCCCC
FDDIEAMESLQKFVLSERSVDGWINLKTALETESDMLEMAKTDKEDMVFLSYTSGTTGNP
CCCHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
KGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGATGFVYH
CCEEEECCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEE
GKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIE
CCCCCHHHHEEECCCCEEEEEECCCCHHHHHHHHCCHHCCHHHHHHHHHCCCCCCHHHHH
TFQKHFHITVRDGYGQTENTLLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEV
HHHHCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCC
GDIAVHIETPALFKQYYKDDERTAMQFRGDYYITGDKAKKDEDGYFWFEGRGDDIIISSG
CEEEEEEECHHHHHHHHCCCCHHEEEECCCEEEECCCCCCCCCCEEEEECCCCEEEEECC
YTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEETLIPILQQHV
CEECCCHHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK
HHHHCCCCCCCEEHHHHHCCHHHCCCEEEEEEEHHHCCCCCC
>Mature Secondary Structure 
APPSYNLVSEIEKYTGDKEKLALIWQDDKGNRREVTYAELMKGANKIGNAFIKSGLQKG
CCCCCHHHHHHHHHCCCCCEEEEEEECCCCCCCCCHHHHHHHHHHHHHHHHHHHHHCCC
DKLLIMMPRLIEAYMTYIAAIKAGFVVIPSSEMLRKKDIEYRIGHGEVKAIVSYEPYIGQ
CEEEEEHHHHHHHHHHHHHHHHCCEEEECCHHHHHHCCCCEEECCCCEEEEEEECCCCCC
FDDIEAMESLQKFVLSERSVDGWINLKTALETESDMLEMAKTDKEDMVFLSYTSGTTGNP
CCCHHHHHHHHHHHHHCCCCCCEEEEEEHHCCHHHHHHHHHCCCCCEEEEEECCCCCCCC
KGVVHTHAWAYAHLRTSAPNWLGIEENDVVWATASPGWQKWIWSPFLATLGSGATGFVYH
CCEEEECCEEEEEEECCCCCCCCCCCCCEEEEECCCCHHHHHHHHHHHHHCCCCCEEEEE
GKFEPKTYLNLLDDNKVNVLCCTPTEYRLMAKVENLSEYNLEALHSAVSAGEPLNREVIE
CCCCCHHHHEEECCCCEEEEEECCCCHHHHHHHHCCHHCCHHHHHHHHHCCCCCCHHHHH
TFQKHFHITVRDGYGQTENTLLVGVMKGMDIRPGSMGKPTPGNHVDIVDEEGMPVRVGEV
HHHHCEEEEEECCCCCCCCEEEEEEECCCCCCCCCCCCCCCCCEEEEECCCCCCEEECCC
GDIAVHIETPALFKQYYKDDERTAMQFRGDYYITGDKAKKDEDGYFWFEGRGDDIIISSG
CEEEEEEECHHHHHHHHCCCCHHEEEECCCEEEECCCCCCCCCCEEEEECCCCEEEEECC
YTIGPFEVEDALVKHPYVRECAVVASPDEIRGSVVKAFIVLRENIEKNEETLIPILQQHV
CEECCCHHHHHHHCCCCHHHEEEECCCHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHH
KELTAPYKYPRKIEFVDELPKTISGKIRRIELRKQEMEIPSK
HHHHCCCCCCCEEHHHHHCCHHHCCCEEEEEEEHHHCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; acetate; CoA

Specific reaction: ATP + acetate + CoA = AMP + diphosphate + acetyl-CoA

General reaction: Acid-thiol ligation [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9387221; 9384377 [H]