Click here to switch to the map view.

The map label for this gene is uppS

Identifier: 30263827

GI number: 30263827

Start: 3638874

End: 3639650

Strand: Reverse

Name: uppS

Synonym: BA_3961

Alternate gene names: 30263827

Gene position: 3639650-3638874 (Counterclockwise)

Preceding gene: 30263828

Following gene: 30263826

Centisome position: 69.63

GC content: 37.97

Gene sequence:

>777_bases
ATGATGTTTAAAAACTTTCCTTTTTTTAAAGGTAAAAAGGACACATCGTTTGATCATCTCGTTGAAGAAGTAAAAAAAGG
ATATATCCCAGAACATATTGCGATCATTATGGATGGTAATGGAAGATGGGCGAAGAGGAGAGCAATGCCTCGTATTGCGG
GACATCATGAAGGTATGCAAGTTGTAAAGAAAATTACAAAATTTGCAAGTAAACTTAATGTGAAAGTGTTAACTCTCTAT
GCTTTTTCGACTGAGAACTGGAAAAGACCGAAAAAGGAAGTTGATTATTTAATGCAGCTTCCAGAAGAATTTTTAGGTAC
ATTTTTACCAGAATTGATTGAAGAAAACGTACAAGTCCGAGTAATAGGGCAACAAGATCGTCTTCCTACGCATACACGCA
GAGCGATGGAGAAGGCCATGGAAGAAACGAAAGAGAATACGGGATTAATTCTTAATTTCGCGTTAAACTATGGAAGTCGA
GATGAAATCGTTTCTGCTGTGCAACATATGATGAAAGATAGTGAGGAAGGAAAAGTTCGTGTTGAAGATGTAAGTGAAGA
AATGCTTTCTTCCTACTTAATGACGAGTTCTTTACCTGACCCAGAGTTGTTAATCCGTACGAGCGGAGAGCTACGTATTA
GTAATTTCATGTTATGGCAAATTGCATATTCGGAATTTTGGTTTACAGATGTGTATTGGCCAGATTTTACCGAGGAACAT
TTGCTAAATGCGATTACAGACTTTCAACATAGAGGGCGCAGATTCGGAGGCGTGTAG

Upstream 100 bases:

>100_bases
ATCATGGAAGTGTAATAGCGATACCTTCGCAAATATGACCCTCTTCTTAAGGGGGTCTTTTTACACTTTTAGGCATACGT
CTGCTTGCTGGAGGGTATGA

Downstream 100 bases:

>100_bases
AAAGAGAGGGTTTGGTAGTGAAACAGAGAATTATTACTGGAGTGGTTGCTGCCGCGCTATTCATTCCCATCGTAATTTAC
GGTGGCGTGCCTTTTACGGT

Product: undecaprenyl pyrophosphate synthase

Products: NA

Alternate protein names: UPP synthase; Di-trans,poly-cis-decaprenylcistransferase; Undecaprenyl diphosphate synthase; UDS

Number of amino acids: Translated: 258; Mature: 258

Protein sequence:

>258_residues
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLY
AFSTENWKRPKKEVDYLMQLPEEFLGTFLPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
LLNAITDFQHRGRRFGGV

Sequences:

>Translated_258_residues
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLY
AFSTENWKRPKKEVDYLMQLPEEFLGTFLPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
LLNAITDFQHRGRRFGGV
>Mature_258_residues
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQVVKKITKFASKLNVKVLTLY
AFSTENWKRPKKEVDYLMQLPEEFLGTFLPELIEENVQVRVIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSR
DEIVSAVQHMMKDSEEGKVRVEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
LLNAITDFQHRGRRFGGV

Specific function: Generates undecaprenyl pyrophosphate (UPP) from isopentenyl pyrophosphate (IPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide

COG id: COG0020

COG function: function code I; Undecaprenyl pyrophosphate synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the UPP synthase family

Homologues:

Organism=Homo sapiens, GI45580742, Length=229, Percent_Identity=39.3013100436681, Blast_Score=168, Evalue=4e-42,
Organism=Homo sapiens, GI45580738, Length=229, Percent_Identity=39.3013100436681, Blast_Score=168, Evalue=4e-42,
Organism=Escherichia coli, GI1786371, Length=227, Percent_Identity=44.9339207048458, Blast_Score=211, Evalue=3e-56,
Organism=Caenorhabditis elegans, GI71993029, Length=232, Percent_Identity=35.3448275862069, Blast_Score=152, Evalue=2e-37,
Organism=Saccharomyces cerevisiae, GI6323748, Length=227, Percent_Identity=32.15859030837, Blast_Score=125, Evalue=9e-30,
Organism=Saccharomyces cerevisiae, GI6319474, Length=213, Percent_Identity=31.924882629108, Blast_Score=119, Evalue=7e-28,
Organism=Drosophila melanogaster, GI18857969, Length=226, Percent_Identity=38.4955752212389, Blast_Score=168, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): UPPS_BACAN (Q81WL2)

Other databases:

- EMBL:   AE016879
- EMBL:   AE017334
- EMBL:   AE017225
- RefSeq:   NP_846204.1
- RefSeq:   YP_020600.2
- RefSeq:   YP_029925.1
- ProteinModelPortal:   Q81WL2
- SMR:   Q81WL2
- EnsemblBacteria:   EBBACT00000010705
- EnsemblBacteria:   EBBACT00000014419
- EnsemblBacteria:   EBBACT00000024485
- GeneID:   1086839
- GeneID:   2819577
- GeneID:   2849350
- GenomeReviews:   AE016879_GR
- GenomeReviews:   AE017225_GR
- GenomeReviews:   AE017334_GR
- KEGG:   ban:BA_3961
- KEGG:   bar:GBAA_3961
- KEGG:   bat:BAS3674
- TIGR:   BA_3961
- TIGR:   GBAA_3961
- GeneTree:   EBGT00050000002230
- HOGENOM:   HBG627837
- OMA:   RVRWAGR
- ProtClustDB:   PRK14830
- BioCyc:   BANT260799:BAS3674-MONOMER
- BioCyc:   BANT261594:GBAA3961-MONOMER
- BRENDA:   2.5.1.31
- HAMAP:   MF_01139
- InterPro:   IPR001441
- InterPro:   IPR018520
- Gene3D:   G3DSA:3.40.1180.10
- PANTHER:   PTHR10291
- TIGRFAMs:   TIGR00055

Pfam domain/function: PF01255 Prenyltransf; SSF64005 UPP_synth

EC number: =2.5.1.31

Molecular weight: Translated: 30161; Mature: 30161

Theoretical pI: Translated: 6.74; Mature: 6.74

Prosite motif: PS01066 UPP_SYNTHASE

Important sites: ACT_SITE 38-38

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
5.0 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
5.0 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQ
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHHCCHHHHH
VVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMQLPEEFLGTFLPELIEENVQVR
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
VIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQHMMKDSEEGKVR
EECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEE
VEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHEEHHEEHHHHHHEEECCCCCCCHHH
LLNAITDFQHRGRRFGGV
HHHHHHHHHHCCHHCCCC
>Mature Secondary Structure
MMFKNFPFFKGKKDTSFDHLVEEVKKGYIPEHIAIIMDGNGRWAKRRAMPRIAGHHEGMQ
CCCCCCCCCCCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCHHHHHCCCHHHCCHHHHH
VVKKITKFASKLNVKVLTLYAFSTENWKRPKKEVDYLMQLPEEFLGTFLPELIEENVQVR
HHHHHHHHHHHCCEEEEEEEEECCCCCCCCHHHHHHHHHCHHHHHHHHHHHHHHCCCEEE
VIGQQDRLPTHTRRAMEKAMEETKENTGLILNFALNYGSRDEIVSAVQHMMKDSEEGKVR
EECCCCCCCHHHHHHHHHHHHHHHCCCCEEEEEEECCCCHHHHHHHHHHHHCCCCCCCEE
VEDVSEEMLSSYLMTSSLPDPELLIRTSGELRISNFMLWQIAYSEFWFTDVYWPDFTEEH
HHHHHHHHHHHHHHHCCCCCCCEEEECCCCEEEHHEEHHEEHHHHHHEEECCCCCCCHHH
LLNAITDFQHRGRRFGGV
HHHHHHHHHHCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12721629