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The map label for this gene is tkt-2 [H]

Identifier: 30263628

GI number: 30263628

Start: 3443715

End: 3445715

Strand: Reverse

Name: tkt-2 [H]

Synonym: BA_3744

Alternate gene names: 30263628

Gene position: 3445715-3443715 (Counterclockwise)

Preceding gene: 30263629

Following gene: 30263627

Centisome position: 65.92

GC content: 40.98

Gene sequence:

>2001_bases
ATGTCACATTCAATCGAACAACTTTCTATCAACACGATTCGCACATTATCCATCGATGCGATTGAAAAAGCAAACTCTGG
TCACCCAGGAATGCCAATGGGTGCAGCACCAATGGCTTATACATTATGGACTCAATTTATGAAACACAATCCAAATAACC
CAACGTGGTTTAACCGTGATCGTTTCGTATTATCTGCAGGTCATGGTTCAATGTTATTATACAGCCTACTTCACCTATCT
GGTTATGATGTAACAATGGATGACTTAAAGAACTTCCGTCAATGGGGAAGCAAAACTCCAGGGCATCCTGAGTACGGTCA
TACAGCTGGTGTAGATGCAACTACTGGTCCACTTGGACAAGGTATTGCAACTGCTGTAGGTATGGCAATGGCAGAAAGAC
ATTTAGCTGCTAAATATAACCGTGATGCGTATAATATAGTAGATCATTATACATACGCTATTTGTGGTGATGGAGATTTA
ATGGAAGGCGTTTCTGCTGAAGCATCTTCATTAGCTGCTCATTTACAATTAGGTCGTCTTGTTGTGCTTTATGATTCAAA
CGATATTTCATTAGATGGCGATTTAAATCGTTCATTCTCTGAAAGTGTAGAAGATCGTTACAAAGCATACGGATGGCAAG
TAATCCGTGTTGAGGATGGAAACGATATTGAAGCTATCGCGAAAGCAATCGAAGAAGCGAAAGCTGACGAAAAACGCCCA
ACGCTAATTGAAGTAAGAACGACAATTGGTTTCGGTTCTCCAAACAAATCAGGAAAATCAGCTTCACATGGTTCTCCACT
TGGTGTAGAAGAAACAAAGTTAACGAAAGAAGCATACGCTTGGACTGCTGAACAAGACTTCCATGTAGCAGAAGAAGTAT
ATGAAAACTTCCGTAAAACAGTACAAGATGTTGGTGAAACTGCACAAGCTGAGTGGAATACTATGCTAGGTGAATATGCA
CAAGCATATCCAGAATTAGCAAACGAACTGCAAGCAGCAATGAACGGTCTTCTTCCAGAAGGTTGGGAGCAAAACTTACC
AACTTATGAATTAGGATCAAAAGCAGCAACTCGTAATTCTTCAGGTGCTGTAATTAATGCAATTGCAGAGTCTGTACCAT
CATTCTTCGGTGGATCTGCTGACCTTGCTGGTTCTAACAAAACATACATGAATAACGAAAAAGACTTTACAAGAGATGAT
TACAGCGGTAAAAACATTTGGTACGGTGTACGTGAGTTCGCAATGGGTGCAGCAATGAACGGTATTGCACTACATGGTGG
TTTAAAAACTTACGGTGGTACGTTCTTCGTATTCTCTGACTACTTACGCCCAGCAATTCGTCTTGCAGCATTAATGCAAT
TGCCGGTAACGTATGTATTCACACACGACAGTATCGCTGTTGGTGAAGATGGTCCAACACATGAACCAATCGAGCAATTA
GCAGCGCTACGTGCAATGCCAAATGTATCTGTTATTCGTCCAGCTGACGGTAACGAATCTGTTGCAGCTTGGAGACTAGC
TCTAGAATCTACAAACAAACCAACTGCTTTAGTATTAACTCGTCAAGATCTTCCAACATTAGAAGGTGCAAAAGACGATA
CGTATGAAAAAGTAGCAAAAGGTGCGTATGTAGTTTCTGCAAGCAAGAAAGAAACAGCTGATGTAATCTTACTTGCAACT
GGATCTGAAGTAAGTCTAGCTGTTGAAGCTCAAAAAGCATTAGCAGTAGACGGCGTTGATGCATCTGTTGTCAGCATGCC
ATCTATGGATCGCTTTGAAGCTCAAACAGCTGAGTACAAAGAATCTGTATTACCAAAAGCAGTAACAAAACGTTTCGCAA
TCGAAATGGGTGCTACATTCGGATGGCACCGTTACGTAGGTCTTGAAGGAGATGTGTTAGGTATCGATACATTCGGTGCT
TCTGCTCCTGGTGAGAAGATTATGGAAGAGTATGGATTTACTGTAGAGAACGTTGTTCGTAAAGTAAAAGAAATGCTTTA
A

Upstream 100 bases:

>100_bases
ACATCAACATATTTGTCGATACATGTTGTATAATCTTGCGTGGGAAGCTATCATATAAATGTATAAAACGTTTACTAATA
TAAGCGAAGGGAAGAATAGC

Downstream 100 bases:

>100_bases
TGATTTTAGAAAAATCTCTCCGGCATGGAGAGGTTTTTCTATGTAAATGAGTTTTTTCGACAGAAAAAGTTTTTTCTCTC
TCCGCAGTCAGACAATCATT

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 666; Mature: 665

Protein sequence:

>666_residues
MSHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRDRFVLSAGHGSMLLYSLLHLS
GYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQGIATAVGMAMAERHLAAKYNRDAYNIVDHYTYAICGDGDL
MEGVSAEASSLAAHLQLGRLVVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYENFRKTVQDVGETAQAEWNTMLGEYA
QAYPELANELQAAMNGLLPEGWEQNLPTYELGSKAATRNSSGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDD
YSGKNIWYGVREFAMGAAMNGIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAKGAYVVSASKKETADVILLAT
GSEVSLAVEAQKALAVDGVDASVVSMPSMDRFEAQTAEYKESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGA
SAPGEKIMEEYGFTVENVVRKVKEML

Sequences:

>Translated_666_residues
MSHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRDRFVLSAGHGSMLLYSLLHLS
GYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQGIATAVGMAMAERHLAAKYNRDAYNIVDHYTYAICGDGDL
MEGVSAEASSLAAHLQLGRLVVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYENFRKTVQDVGETAQAEWNTMLGEYA
QAYPELANELQAAMNGLLPEGWEQNLPTYELGSKAATRNSSGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDD
YSGKNIWYGVREFAMGAAMNGIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAKGAYVVSASKKETADVILLAT
GSEVSLAVEAQKALAVDGVDASVVSMPSMDRFEAQTAEYKESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGA
SAPGEKIMEEYGFTVENVVRKVKEML
>Mature_665_residues
SHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRDRFVLSAGHGSMLLYSLLHLSG
YDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQGIATAVGMAMAERHLAAKYNRDAYNIVDHYTYAICGDGDLM
EGVSAEASSLAAHLQLGRLVVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRPT
LIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYENFRKTVQDVGETAQAEWNTMLGEYAQ
AYPELANELQAAMNGLLPEGWEQNLPTYELGSKAATRNSSGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDDY
SGKNIWYGVREFAMGAAMNGIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQLA
ALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAKGAYVVSASKKETADVILLATG
SEVSLAVEAQKALAVDGVDASVVSMPSMDRFEAQTAEYKESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGAS
APGEKIMEEYGFTVENVVRKVKEML

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=498, Percent_Identity=27.3092369477912, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI4507521, Length=498, Percent_Identity=27.3092369477912, Blast_Score=161, Evalue=2e-39,
Organism=Homo sapiens, GI133778974, Length=589, Percent_Identity=25.6366723259762, Blast_Score=142, Evalue=7e-34,
Organism=Homo sapiens, GI225637459, Length=675, Percent_Identity=20.8888888888889, Blast_Score=104, Evalue=2e-22,
Organism=Homo sapiens, GI225637463, Length=577, Percent_Identity=21.6637781629116, Blast_Score=100, Evalue=9e-21,
Organism=Homo sapiens, GI225637461, Length=577, Percent_Identity=21.6637781629116, Blast_Score=99, Evalue=2e-20,
Organism=Escherichia coli, GI48994911, Length=661, Percent_Identity=51.1346444780635, Blast_Score=673, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=661, Percent_Identity=49.7730711043873, Blast_Score=651, Evalue=0.0,
Organism=Caenorhabditis elegans, GI17539652, Length=668, Percent_Identity=24.7005988023952, Blast_Score=150, Evalue=2e-36,
Organism=Saccharomyces cerevisiae, GI6325331, Length=670, Percent_Identity=48.955223880597, Blast_Score=634, Evalue=0.0,
Organism=Saccharomyces cerevisiae, GI6319593, Length=671, Percent_Identity=47.8390461997019, Blast_Score=609, Evalue=1e-175,
Organism=Drosophila melanogaster, GI24666278, Length=573, Percent_Identity=27.5741710296684, Blast_Score=166, Evalue=6e-41,
Organism=Drosophila melanogaster, GI45551847, Length=670, Percent_Identity=24.4776119402985, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI45550715, Length=670, Percent_Identity=24.4776119402985, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI24645119, Length=641, Percent_Identity=23.7129485179407, Blast_Score=149, Evalue=7e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 72410; Mature: 72279

Theoretical pI: Translated: 4.71; Mature: 4.71

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2 ; PS00237 G_PROTEIN_RECEP_F1_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRD
CCCCCHHEECCEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
GIATAVGMAMAERHLAAKYNRDAYNIVDHYTYAICGDGDLMEGVSAEASSLAAHLQLGRL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHCCE
VVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
EEEECCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYENFRKT
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
VQDVGETAQAEWNTMLGEYAQAYPELANELQAAMNGLLPEGWEQNLPTYELGSKAATRNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCHHCCCC
SGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDDYSGKNIWYGVREFAMGAAMN
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
CEEEECCHHHCCCEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHH
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAK
HHHHCCCCCEEEECCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHC
GAYVVSASKKETADVILLATGSEVSLAVEAQKALAVDGVDASVVSMPSMDRFEAQTAEYK
CEEEEECCCCCCCCEEEEEECCCEEEEEEHHHHHEECCCCCHHCCCCCCHHHHHHHHHHH
ESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGASAPGEKIMEEYGFTVENVVR
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHH
KVKEML
HHHHHC
>Mature Secondary Structure 
SHSIEQLSINTIRTLSIDAIEKANSGHPGMPMGAAPMAYTLWTQFMKHNPNNPTWFNRD
CCCCHHEECCEEEEEEHHHHHHCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCCCCCC
RFVLSAGHGSMLLYSLLHLSGYDVTMDDLKNFRQWGSKTPGHPEYGHTAGVDATTGPLGQ
EEEEECCCCHHHHHHHHHHCCCCEEHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCH
GIATAVGMAMAERHLAAKYNRDAYNIVDHYTYAICGDGDLMEGVSAEASSLAAHLQLGRL
HHHHHHHHHHHHHHHHHHCCCCHHHHHHCEEEEEECCCHHHHCCCHHHHHHHHHHHHCCE
VVLYDSNDISLDGDLNRSFSESVEDRYKAYGWQVIRVEDGNDIEAIAKAIEEAKADEKRP
EEEECCCCEEECCCCCCHHHHHHHHHHHHCCEEEEEEECCCCHHHHHHHHHHHHCCCCCC
TLIEVRTTIGFGSPNKSGKSASHGSPLGVEETKLTKEAYAWTAEQDFHVAEEVYENFRKT
CEEEEEEEECCCCCCCCCCCCCCCCCCCCCHHHHHHHHHEECCCCCHHHHHHHHHHHHHH
VQDVGETAQAEWNTMLGEYAQAYPELANELQAAMNGLLPEGWEQNLPTYELGSKAATRNS
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCHHCCCCCCCCCCCHHCCCC
SGAVINAIAESVPSFFGGSADLAGSNKTYMNNEKDFTRDDYSGKNIWYGVREFAMGAAMN
CCHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHHCC
GIALHGGLKTYGGTFFVFSDYLRPAIRLAALMQLPVTYVFTHDSIAVGEDGPTHEPIEQL
CEEEECCHHHCCCEEEEHHHHHHHHHHHHHHHHCCEEEEEECCCEEECCCCCCHHHHHHH
AALRAMPNVSVIRPADGNESVAAWRLALESTNKPTALVLTRQDLPTLEGAKDDTYEKVAK
HHHHCCCCCEEEECCCCCCCCEEEEEEHHCCCCCEEEEEECCCCCCCCCCCCHHHHHHHC
GAYVVSASKKETADVILLATGSEVSLAVEAQKALAVDGVDASVVSMPSMDRFEAQTAEYK
CEEEEECCCCCCCCEEEEEECCCEEEEEEHHHHHEECCCCCHHCCCCCCHHHHHHHHHHH
ESVLPKAVTKRFAIEMGATFGWHRYVGLEGDVLGIDTFGASAPGEKIMEEYGFTVENVVR
HHHHHHHHHHHHHHHHCCCCCCEEEECCCCCEEEEECCCCCCCHHHHHHHHCCCHHHHHH
KVKEML
HHHHHC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]