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The map label for this gene is tkt-1 [H]

Identifier: 30263339

GI number: 30263339

Start: 3154028

End: 3156052

Strand: Reverse

Name: tkt-1 [H]

Synonym: BA_3432

Alternate gene names: 30263339

Gene position: 3156052-3154028 (Counterclockwise)

Preceding gene: 270000545

Following gene: 30263338

Centisome position: 60.38

GC content: 40.1

Gene sequence:

>2025_bases
ATGACACAAAACATAAATCAATTAGCAGTGAATACAATTCGTACGTTATCAATTGATGCTATTAATGCGGCAAATTCAGG
TCATCCAGGTCTTCCGATGGGAGCAGCGCCAATGGCTTATGCATTATGGGCGAATCATTTAAATCATAATCCTAATCATC
CAAAATGGTTTAACCGTGATCGCTTCGTTTTATCGGCGGGGCATGGATCTAGCTTATTATATAGCCTACTTCATTTAGCT
GGATATGACGTTTCAATTGATGACTTGAAAAACTTCAGAAAGTTAAATAGTAAAACACCAGGACATCCTGAGTTTGGTCA
TACTTCTGGAGTTGAAGCGACGACAGGCCCGTTAGGACAAGGGATTGCCAATGCTGTCGGAATGGCAATGGCAGAAGCGC
ATTTAGCAGCGAAGTTTAATAAGGATGGTCACTCTATTATAGATCACAATACGTACGCTTTAGTCGGAGACGGTGATTTA
ATGGAAGGTGTCGCTTATGAAGCGATGTCAATGGAAGGTGTCGCTTATGAAGCGATGTCAATGGCAGGACATATGAAACT
TGGCAAGTTAATTGTGCTGTATGATTCAAATGAAATTTCACTTGATGGTGAATTAAACATTGCTTTCTCTGAAGATATGC
AGAAAAGGGTAGAATCTGCACATTGGCAATATGTAAGAGTTGAAGATGGAAACGATGTTGATGCGATTACAAAAGCGATT
CAATTAGCGAAAGATAATACGGACCAACCTACTCTTATAGAGATTAGAACCGTTATAGGTTACGGAAGTCCAAAAGTTGC
TGGAACGAACAAAGCACATGGTAACCCGCTTGGATTAGAAGAAGCGACAGCGACAAAACAAGTGTATGGTTGGCATTATG
AAGAAGACTTCTTTGTACCTGAAGAAGTAACAGCTCATTTTAATGAACTGAAACAAAAAGGTATTGAAAAAGAACGTGGC
TGGAATGAGCAGTTCAACTTATACAGAGAGTCAAATCCTGCACTAGCAGATGAATTAGAAAAAGCAATTATAGGTGAAGT
TTTAATCGAAGCGAAAGACATTCTATCCTTTGATAGTGAAAAAACGATTTCAACTCGTGTTGCAAGTGGGGAAGCTATTA
ATCATTATGTGAAATCGATTCCTTCTATTTTCGGTGGAAGTGCGGATCTTTCTCATTCTACGATGACAGATATAAAAGGG
GAAGCAGTGTATGCGGTAGAATCGTATGCTGGCCGAAATATATACTTTGGTGTACGTGAACATGCAATGGGCGCAGCAGC
GAATGGACTGGCTCTTCATGGAGGAGTAAAACCGTTCGTGAGTACATTCTTTGTATTTAATGACTATCTTCGTCCATCTA
TTCGACTGGCTGCATTGCAAAAGTTACCTGTTACGTACGTATTTACACATGATTCAATTGCTGTAGGAGAAGATGGTCCA
ACGCATGAACCTATTGAACATTTAGCAGCTCTTCGGGCAATCCCTGGTTTAACAGTTATCCGTCCGTCAGATGCAAATGA
AACAGCAAGTGCGTGGGCGTATGCTTTACAGCAAACGGAAGGTCCAGTCGTTTTAGTACTGAGCCGTCAAAATTTACCGG
TGTTTCATGAAACGAAAGCAAACATAGAGAATCTTTCTAAAGGGGCTTACGTATTAACACAAACGAATGAAAATCCGGAT
GTAATTTTAATTGCGACAGGTTCTGAAGTATCCTTAGCTGCTAGTGCGAAAGCGAAACTAGAAGAAGACAATGTCTCTGT
TCGCATCGTTGCAATGCCAAGCTGGGAGTTATTCGATCGCCAATCGAAAGAATATAAAGAATCCGTTCTTCCGTCTTCTG
TAACGAAACGAGTATCTCTTGAGATGGGTGTATCTCTCGGCTGGGAGCGTTATGTAGGACAAGAAGGAAACATATTATCG
ATTGAAACATTTGGAGCTTCAGGAACTGGGGCTGAAGTCATGAATCTATTTGGATTTACGACAGAAAATGTTGTTCAAAT
TACAAAAAATGTATTAAATTCTTAA

Upstream 100 bases:

>100_bases
TAATGAATTATTGCAAGAAAGTGGATTTAAATGGTGGTTAGATCAAGAAACGAAAAAATAAGTACTTTCTTTCATGAAAG
CATGTAGGGGGACGATTACT

Downstream 100 bases:

>100_bases
GCTATGACTGTGAATACCTTTCCGTACATATCAGTGCTGCAAGGTATTCCAGATTGTAGTGATATGAATTTTTAATAAAA
GATGATTTGAGGAGGAATTA

Product: transketolase

Products: NA

Alternate protein names: TK [H]

Number of amino acids: Translated: 674; Mature: 673

Protein sequence:

>674_residues
MTQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRDRFVLSAGHGSSLLYSLLHLA
GYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDL
MEGVAYEAMSMEGVAYEAMSMAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAI
QLAKDNTDQPTLIEIRTVIGYGSPKVAGTNKAHGNPLGLEEATATKQVYGWHYEEDFFVPEEVTAHFNELKQKGIEKERG
WNEQFNLYRESNPALADELEKAIIGEVLIEAKDILSFDSEKTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKG
EAVYAVESYAGRNIYFGVREHAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGP
THEPIEHLAALRAIPGLTVIRPSDANETASAWAYALQQTEGPVVLVLSRQNLPVFHETKANIENLSKGAYVLTQTNENPD
VILIATGSEVSLAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILS
IETFGASGTGAEVMNLFGFTTENVVQITKNVLNS

Sequences:

>Translated_674_residues
MTQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRDRFVLSAGHGSSLLYSLLHLA
GYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDL
MEGVAYEAMSMEGVAYEAMSMAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAI
QLAKDNTDQPTLIEIRTVIGYGSPKVAGTNKAHGNPLGLEEATATKQVYGWHYEEDFFVPEEVTAHFNELKQKGIEKERG
WNEQFNLYRESNPALADELEKAIIGEVLIEAKDILSFDSEKTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKG
EAVYAVESYAGRNIYFGVREHAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGP
THEPIEHLAALRAIPGLTVIRPSDANETASAWAYALQQTEGPVVLVLSRQNLPVFHETKANIENLSKGAYVLTQTNENPD
VILIATGSEVSLAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILS
IETFGASGTGAEVMNLFGFTTENVVQITKNVLNS
>Mature_673_residues
TQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRDRFVLSAGHGSSLLYSLLHLAG
YDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQGIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDLM
EGVAYEAMSMEGVAYEAMSMAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAIQ
LAKDNTDQPTLIEIRTVIGYGSPKVAGTNKAHGNPLGLEEATATKQVYGWHYEEDFFVPEEVTAHFNELKQKGIEKERGW
NEQFNLYRESNPALADELEKAIIGEVLIEAKDILSFDSEKTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKGE
AVYAVESYAGRNIYFGVREHAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGPT
HEPIEHLAALRAIPGLTVIRPSDANETASAWAYALQQTEGPVVLVLSRQNLPVFHETKANIENLSKGAYVLTQTNENPDV
ILIATGSEVSLAASAKAKLEEDNVSVRIVAMPSWELFDRQSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILSI
ETFGASGTGAEVMNLFGFTTENVVQITKNVLNS

Specific function: Unknown

COG id: COG0021

COG function: function code G; Transketolase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the transketolase family [H]

Homologues:

Organism=Homo sapiens, GI205277463, Length=680, Percent_Identity=25.8823529411765, Blast_Score=179, Evalue=9e-45,
Organism=Homo sapiens, GI4507521, Length=680, Percent_Identity=25.8823529411765, Blast_Score=179, Evalue=9e-45,
Organism=Homo sapiens, GI133778974, Length=672, Percent_Identity=25.297619047619, Blast_Score=154, Evalue=2e-37,
Organism=Homo sapiens, GI225637459, Length=690, Percent_Identity=21.8840579710145, Blast_Score=122, Evalue=9e-28,
Organism=Homo sapiens, GI225637463, Length=606, Percent_Identity=22.2772277227723, Blast_Score=120, Evalue=6e-27,
Organism=Homo sapiens, GI225637461, Length=606, Percent_Identity=22.2772277227723, Blast_Score=119, Evalue=8e-27,
Organism=Escherichia coli, GI48994911, Length=668, Percent_Identity=47.3053892215569, Blast_Score=628, Evalue=0.0,
Organism=Escherichia coli, GI1788808, Length=676, Percent_Identity=46.7455621301775, Blast_Score=616, Evalue=1e-177,
Organism=Caenorhabditis elegans, GI17539652, Length=670, Percent_Identity=25.2238805970149, Blast_Score=167, Evalue=2e-41,
Organism=Saccharomyces cerevisiae, GI6325331, Length=684, Percent_Identity=45.4678362573099, Blast_Score=575, Evalue=1e-164,
Organism=Saccharomyces cerevisiae, GI6319593, Length=682, Percent_Identity=43.6950146627566, Blast_Score=546, Evalue=1e-156,
Organism=Drosophila melanogaster, GI45551847, Length=591, Percent_Identity=29.1032148900169, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI45550715, Length=591, Percent_Identity=29.1032148900169, Blast_Score=201, Evalue=2e-51,
Organism=Drosophila melanogaster, GI24645119, Length=552, Percent_Identity=28.804347826087, Blast_Score=185, Evalue=1e-46,
Organism=Drosophila melanogaster, GI24666278, Length=592, Percent_Identity=27.5337837837838, Blast_Score=179, Evalue=7e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009014
- InterPro:   IPR015941
- InterPro:   IPR005475
- InterPro:   IPR005478
- InterPro:   IPR020826
- InterPro:   IPR005476
- InterPro:   IPR005474 [H]

Pfam domain/function: PF02779 Transket_pyr; PF02780 Transketolase_C; PF00456 Transketolase_N [H]

EC number: =2.2.1.1 [H]

Molecular weight: Translated: 73317; Mature: 73186

Theoretical pI: Translated: 5.08; Mature: 5.08

Prosite motif: PS00801 TRANSKETOLASE_1 ; PS00802 TRANSKETOLASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.5 %Met     (Translated Protein)
2.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRD
CCCCHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
RFVLSAGHGSSLLYSLLHLAGYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQ
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
GIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDLMEGVAYEAMSMEGVAYEAMS
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHH
MAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAI
HHCCEEECCEEEEECCCEEEECCEEEEEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHH
QLAKDNTDQPTLIEIRTVIGYGSPKVAGTNKAHGNPLGLEEATATKQVYGWHYEEDFFVP
HHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEECCCCCCCH
EEVTAHFNELKQKGIEKERGWNEQFNLYRESNPALADELEKAIIGEVLIEAKDILSFDSE
HHHHHHHHHHHHHCCHHHCCCCCHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
KTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKGEAVYAVESYAGRNIYFGVRE
CHHHHECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCEEEEEEHH
HAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGP
HHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCEEECCCCC
THEPIEHLAALRAIPGLTVIRPSDANETASAWAYALQQTEGPVVLVLSRQNLPVFHETKA
CHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCC
NIENLSKGAYVLTQTNENPDVILIATGSEVSLAASAKAKLEEDNVSVRIVAMPSWELFDR
CHHHCCCCEEEEEECCCCCCEEEEECCCCEEEEECCHHHCCCCCEEEEEEEECCHHHHHH
QSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILSIETFGASGTGAEVMNLFGFT
HHHHHHHHCCCHHHHHHEEEECCCCCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCC
TENVVQITKNVLNS
HHHHHHHHHHHHCC
>Mature Secondary Structure 
TQNINQLAVNTIRTLSIDAINAANSGHPGLPMGAAPMAYALWANHLNHNPNHPKWFNRD
CCCHHHHHHHHHHEEEEEEEECCCCCCCCCCCCCHHHHHHHHHHHCCCCCCCCCCCCCC
RFVLSAGHGSSLLYSLLHLAGYDVSIDDLKNFRKLNSKTPGHPEFGHTSGVEATTGPLGQ
EEEEECCCCHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCHH
GIANAVGMAMAEAHLAAKFNKDGHSIIDHNTYALVGDGDLMEGVAYEAMSMEGVAYEAMS
HHHHHHHHHHHHHHHHHHCCCCCCEEECCCCEEEEECCHHHHHHHHHHHCCCCHHHHHHH
MAGHMKLGKLIVLYDSNEISLDGELNIAFSEDMQKRVESAHWQYVRVEDGNDVDAITKAI
HHCCEEECCEEEEECCCEEEECCEEEEEEHHHHHHHHHHCCEEEEEEECCCCHHHHHHHH
QLAKDNTDQPTLIEIRTVIGYGSPKVAGTNKAHGNPLGLEEATATKQVYGWHYEEDFFVP
HHHCCCCCCCEEEEEEEEEECCCCCCCCCCCCCCCCCCCCHHHHHHHHHCEECCCCCCCH
EEVTAHFNELKQKGIEKERGWNEQFNLYRESNPALADELEKAIIGEVLIEAKDILSFDSE
HHHHHHHHHHHHHCCHHHCCCCCHHCEEECCCCCHHHHHHHHHHHHHHHHHHHHHCCCCC
KTISTRVASGEAINHYVKSIPSIFGGSADLSHSTMTDIKGEAVYAVESYAGRNIYFGVRE
CHHHHECCCCHHHHHHHHHHHHHHCCCCCCCCCHHHCCCCCEEEEEECCCCCEEEEEEHH
HAMGAAANGLALHGGVKPFVSTFFVFNDYLRPSIRLAALQKLPVTYVFTHDSIAVGEDGP
HHCCCCCCCEEEECCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEECCCEEECCCCC
THEPIEHLAALRAIPGLTVIRPSDANETASAWAYALQQTEGPVVLVLSRQNLPVFHETKA
CHHHHHHHHHHHHCCCCEEECCCCCCCHHHHHHHHHHCCCCCEEEEEECCCCCEEECCCC
NIENLSKGAYVLTQTNENPDVILIATGSEVSLAASAKAKLEEDNVSVRIVAMPSWELFDR
CHHHCCCCEEEEEECCCCCCEEEEECCCCEEEEECCHHHCCCCCEEEEEEEECCHHHHHH
QSKEYKESVLPSSVTKRVSLEMGVSLGWERYVGQEGNILSIETFGASGTGAEVMNLFGFT
HHHHHHHHCCCHHHHHHEEEECCCCCCHHHHCCCCCCEEEEEECCCCCCCHHHHHHHCCC
TENVVQITKNVLNS
HHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11058132 [H]