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The map label for this gene is fimB

Identifier: 30065433

GI number: 30065433

Start: 4374872

End: 4375357

Strand: Reverse

Name: fimB

Synonym: S4467

Alternate gene names: 30065433

Gene position: 4375357-4374872 (Counterclockwise)

Preceding gene: 30065437

Following gene: 30065432

Centisome position: 95.13

GC content: 40.74

Gene sequence:

>486_bases
ATGAGGAATAAGGCTGATAACAAAAAAAGGAACTTCCTTACCCATAGTGAAATCGAGTCACTCCTTAAAGCAGCAAATAC
CGGGCCTCATGCAACACGTAATTATTGTCTGATTTTGCTTTGTTTTATTCATGGTTTCCGGGCGAGTGAAATTTGTCGAT
TGAGGATTTCGGATATTGATCTTAAAGCAAAGTGTATATATATCCATCGATTAAAAAAAGGCTTTTCAACAACGCACCCG
CTATTGAACAAAGAAGTTCAGGCTTTAAAAAACTGGTTGAGTATCCGTACTTCTTATCCGCATGCTGAGAGCGAGTGGGT
ATTTTTATCACGTAAGGGGAATCCGCTTTCTCGGCAACAGTTTTACCATATTATCTCGACTTCTGGTGGTAATGCCGGGT
TGTCACTGGAGATTCATCCGCACATGTTACGCTATTCGTGTGGTTTTGCTTTGGCGAATATGGGAATAGATACGCGACTT
ATCTAG

Upstream 100 bases:

>100_bases
TAAGCAAACGTTCGCTTTTATAAACATAATCAGGATAAAAATGTTGGATTATTGCTAACCCAGCACAGCTAGTGCGCGTC
TGTAATTATAAGGGAAAACG

Downstream 100 bases:

>100_bases
GATTATCTTGGGCATCGCAATATTCGTCATACTGTCTGGTATACCGCCAGCAATGCAGGGCGTTTTTACGGCATCTGGGA
TAGAGCCAGAGGACGACAGC

Product: recombinase; regulator for fimA

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 161; Mature: 161

Protein sequence:

>161_residues
MRNKADNKKRNFLTHSEIESLLKAANTGPHATRNYCLILLCFIHGFRASEICRLRISDIDLKAKCIYIHRLKKGFSTTHP
LLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQFYHIISTSGGNAGLSLEIHPHMLRYSCGFALANMGIDTRL
I

Sequences:

>Translated_161_residues
MRNKADNKKRNFLTHSEIESLLKAANTGPHATRNYCLILLCFIHGFRASEICRLRISDIDLKAKCIYIHRLKKGFSTTHP
LLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQFYHIISTSGGNAGLSLEIHPHMLRYSCGFALANMGIDTRL
I
>Mature_161_residues
MRNKADNKKRNFLTHSEIESLLKAANTGPHATRNYCLILLCFIHGFRASEICRLRISDIDLKAKCIYIHRLKKGFSTTHP
LLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQFYHIISTSGGNAGLSLEIHPHMLRYSCGFALANMGIDTRL
I

Specific function: FimB is one of the 2 regulatory proteins which control the phase variation of type 1 fimbriae in E.coli. These proteins mediate the periodic inversion of a 300bp DNA segment that harbors the promoter for the fimbrial structural gene, fimA. FimB switches f

COG id: COG0582

COG function: function code L; Integrase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the 'phage' integrase family [H]

Homologues:

Organism=Escherichia coli, GI1790767, Length=161, Percent_Identity=97.5155279503106, Blast_Score=327, Evalue=2e-91,
Organism=Escherichia coli, GI1790768, Length=154, Percent_Identity=46.1038961038961, Blast_Score=146, Evalue=6e-37,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011010
- InterPro:   IPR013762
- InterPro:   IPR002104 [H]

Pfam domain/function: PF00589 Phage_integrase [H]

EC number: NA

Molecular weight: Translated: 18409; Mature: 18409

Theoretical pI: Translated: 10.34; Mature: 10.34

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.1 %Cys     (Translated Protein)
1.9 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
3.1 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MRNKADNKKRNFLTHSEIESLLKAANTGPHATRNYCLILLCFIHGFRASEICRLRISDID
CCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
LKAKCIYIHRLKKGFSTTHPLLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQ
CEEHHHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHH
FYHIISTSGGNAGLSLEIHPHMLRYSCGFALANMGIDTRLI
HEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEECC
>Mature Secondary Structure
MRNKADNKKRNFLTHSEIESLLKAANTGPHATRNYCLILLCFIHGFRASEICRLRISDID
CCCCCCCCHHHCCCHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCC
LKAKCIYIHRLKKGFSTTHPLLNKEVQALKNWLSIRTSYPHAESEWVFLSRKGNPLSRQQ
CEEHHHHEEHHHHCCCCCCHHHHHHHHHHHHHHHHHCCCCCCCCCEEEEECCCCCCCHHH
FYHIISTSGGNAGLSLEIHPHMLRYSCGFALANMGIDTRLI
HEEEEECCCCCCCEEEEECHHHHHHHHHHHHHHCCCCEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]