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The map label for this gene is ggt

Identifier: 30065275

GI number: 30065275

Start: 4216590

End: 4218332

Strand: Direct

Name: ggt

Synonym: S4298

Alternate gene names: 30065275

Gene position: 4216590-4218332 (Clockwise)

Preceding gene: 30065273

Following gene: 30065277

Centisome position: 91.68

GC content: 55.08

Gene sequence:

>1743_bases
ATGATAAAACCGACGTTTTTACGCCGGGTGGCCATTGCTGCTCTGCTCTCAGGAAGTTGTTTTAGCGCCGCCGCCGCGCC
TCCTGCGCCGCCCGTCTCGTATGGTGTGGAGGAAGATGTCTTCCATCCGGTACGCGCGAAACAGGGAATGGTAGCGTCTG
TGGACGCCACTGCCACTCAGGTGGGGGTGGATATCCTCAAGGAGGGCGGGAATGCCGTTGATGCCGCCGTGGCGGTGGGC
TACGCGCTGGCGGTAACGCATCCGCAGGCAGGGAATCTGGGCGGTGGTGGTTTTATGTTAATCCGCTCGAAAAATGGCAA
TACCACGGCTATCGATTTCCGCGAAATGGCACCCGCCAAAGCGACCCGCGATATGTTCCTCGATGATCAGGGCAACCCGG
ACAGCAAAAAATCACTCACTTCGCATCTGGCTTCCGGCACACCGGGTACGGTAGCAGGTTTCTCGCTGGCGCTGGATAAA
TACGGCACCATGCCGCTGAACAAAGTCGTGCAGCCCGCGTTTAAACTGGCACGCGATGGTTTTATCGTTAACGACGCGCT
GGCTGACGATCTCAAAACCTACGGTAGCGAAGTGTTGCCGAATCACGAAAACAGTAAAGCTATCTTCTGGAAAGAGGGCG
AGCCGCTGAAAAAGGGCGACACGCTGGTGCAGGCGAACCTGGCAAAGAGCCTGGAGATGATTGCTGAAAACGGCCCGGAC
GAATTCTATAAAGGCACGATTGCGGAACAGATCGCCCAGGAGATGCAGAAAAACGGTGGCTTGATCACTAAAGAAGATTT
AGCGGCCTATAAAGCGGTCGAACGCACTCCGATAAGCGGCGATTATCGCGGGTATCAGGTTTACTCCATGCCACCGCCAT
CCTCCGGCGGGATCCATATCGTACAAATCCTCAATATTCTGGAAAACTTCGATATGAAGAAATACGGCTTTGGCAGCGCC
GATGCGATGCAAATCATGGCAGAAGCGGAGAAATACGCCTACGCCGACCGCTCGGAATATCTTGGCGACCCGGATTTTGT
CAAAGTCCCGTGGCAGGCACTGACCAATAAAGCCTATGCCAAATCCATTGCCGATCAAATTGATATCAAAAAAGCGAAGC
CGTCCAGTGAGATTCGCCCTGGCAAGCTTGCGCCTTATGAGAGTAATCAAACTACCCATTACTCTGTAGTGGATAAAGAC
GGTAACGCGGTGGCGGTGACCTATACGCTGAACACCACCTTCGGTACGGGTATTGTCGCGGGTGAGAGCGGTATTCTGCT
TAATAACCAGATGGATGATTTCTCCGCCAAACCGGGCGTACCGAACGTTTACGGGCTGGTGGGCGGTGATGCCAACGCCG
TCGGGCCGAACAAACGCCCGCTGTCGTCGATGTCGCCGACCATTGTGGTGAAAGACGGTAAAACCTGGCTGGTTACCGGT
AGCCCAGGCGGTAGCCGGATTATCACCACGGTGCTGCAAATGGTGGTGAATAGCATCGATTATGGCATGAACGTCGCCGA
AGCGACCAATGCGCCGCGTTTCCACCATCAGTGGTTGCCGGACGAGCTGCGTGTCGAAAAAGGGTTTAGCCCGGATACGC
TCAAGCTGCTGGAAGCAAAAGGTCAGAAAGTGGCGCTGAAAGAGGCGATGGGCAGCACACAAAGCATTATGGTTGGGCCG
GACGGTGAGTTGTACGGCGCATCCGACCCGCGCTCGGTGGATGATTTAACGGCGGGGTATTAA

Upstream 100 bases:

>100_bases
ATATCCTTTAAGTTTACTCGCTTCCCGACAAAACGATGATTAATTCAGAGTTATATACCAGGCTTAGCTGGGGTTGCCCC
TTAATCTCTGGAGAATAACG

Downstream 100 bases:

>100_bases
TATCTTAAGCCCTCCCGGTAGGTGAGGGCTTAAATGACAAACTTAGATTGCAAATTCTCTATTTCACCCGCGCCATATAA
TACGCATCGACATATTCACC

Product: gamma-glutamyltranspeptidase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 580; Mature: 580

Protein sequence:

>580_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDK
YGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDIKKAKPSSEIRPGKLAPYESNQTTHYSVVDKD
GNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Sequences:

>Translated_580_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDK
YGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDIKKAKPSSEIRPGKLAPYESNQTTHYSVVDKD
GNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY
>Mature_580_residues
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQVGVDILKEGGNAVDAAVAVG
YALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAKATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDK
YGTMPLNKVVQPAFKLARDGFIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHIVQILNILENFDMKKYGFGSA
DAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYAKSIADQIDIKKAKPSSEIRPGKLAPYESNQTTHYSVVDKD
GNAVAVTYTLNTTFGTGIVAGESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAKGQKVALKEAMGSTQSIMVGP
DGELYGASDPRSVDDLTAGY

Specific function: GGT PLAYS A KEY ROLE IN THE GAMMA-GLUTAMYL CYCLE, A PATHWAY FOR THE SYNTHESIS AND DEGRADATION OF GLUTATHIONE. [C]

COG id: COG0405

COG function: function code E; Gamma-glutamyltransferase

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the gamma-glutamyltransferase family [H]

Homologues:

Organism=Homo sapiens, GI73915092, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915090, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915096, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI73915094, Length=533, Percent_Identity=32.2701688555347, Blast_Score=259, Evalue=4e-69,
Organism=Homo sapiens, GI113429324, Length=521, Percent_Identity=31.6698656429942, Blast_Score=241, Evalue=2e-63,
Organism=Homo sapiens, GI113429326, Length=525, Percent_Identity=31.047619047619, Blast_Score=234, Evalue=1e-61,
Organism=Homo sapiens, GI109148539, Length=549, Percent_Identity=31.6939890710383, Blast_Score=200, Evalue=4e-51,
Organism=Homo sapiens, GI153266901, Length=549, Percent_Identity=28.5974499089253, Blast_Score=174, Evalue=2e-43,
Organism=Homo sapiens, GI153266885, Length=550, Percent_Identity=28.5454545454545, Blast_Score=173, Evalue=3e-43,
Organism=Homo sapiens, GI153266907, Length=546, Percent_Identity=27.1062271062271, Blast_Score=159, Evalue=6e-39,
Organism=Homo sapiens, GI30581157, Length=219, Percent_Identity=33.7899543378995, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI30581155, Length=219, Percent_Identity=33.7899543378995, Blast_Score=123, Evalue=5e-28,
Organism=Homo sapiens, GI218505805, Length=219, Percent_Identity=32.4200913242009, Blast_Score=107, Evalue=2e-23,
Organism=Homo sapiens, GI310124095, Length=219, Percent_Identity=30.5936073059361, Blast_Score=94, Evalue=4e-19,
Organism=Escherichia coli, GI1789856, Length=580, Percent_Identity=99.6551724137931, Blast_Score=1182, Evalue=0.0,
Organism=Caenorhabditis elegans, GI72000294, Length=573, Percent_Identity=34.3804537521815, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI212646519, Length=573, Percent_Identity=34.3804537521815, Blast_Score=262, Evalue=4e-70,
Organism=Caenorhabditis elegans, GI193208245, Length=561, Percent_Identity=32.9768270944742, Blast_Score=248, Evalue=9e-66,
Organism=Caenorhabditis elegans, GI193208247, Length=561, Percent_Identity=32.9768270944742, Blast_Score=247, Evalue=1e-65,
Organism=Caenorhabditis elegans, GI17542894, Length=499, Percent_Identity=36.0721442885772, Blast_Score=244, Evalue=1e-64,
Organism=Caenorhabditis elegans, GI17506189, Length=557, Percent_Identity=30.8797127468582, Blast_Score=235, Evalue=4e-62,
Organism=Caenorhabditis elegans, GI17564448, Length=443, Percent_Identity=27.765237020316, Blast_Score=117, Evalue=2e-26,
Organism=Caenorhabditis elegans, GI72001495, Length=232, Percent_Identity=25.8620689655172, Blast_Score=84, Evalue=2e-16,
Organism=Caenorhabditis elegans, GI72001497, Length=233, Percent_Identity=27.0386266094421, Blast_Score=84, Evalue=2e-16,
Organism=Saccharomyces cerevisiae, GI6323330, Length=496, Percent_Identity=29.0322580645161, Blast_Score=159, Evalue=1e-39,
Organism=Drosophila melanogaster, GI45551474, Length=513, Percent_Identity=32.943469785575, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161077880, Length=513, Percent_Identity=32.943469785575, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642670, Length=513, Percent_Identity=32.943469785575, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI24642666, Length=513, Percent_Identity=32.943469785575, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161077878, Length=513, Percent_Identity=32.943469785575, Blast_Score=253, Evalue=2e-67,
Organism=Drosophila melanogaster, GI161077496, Length=524, Percent_Identity=31.2977099236641, Blast_Score=234, Evalue=1e-61,
Organism=Drosophila melanogaster, GI18859893, Length=518, Percent_Identity=30.6949806949807, Blast_Score=224, Evalue=1e-58,
Organism=Drosophila melanogaster, GI18859741, Length=551, Percent_Identity=28.4936479128857, Blast_Score=192, Evalue=5e-49,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000101 [H]

Pfam domain/function: PF01019 G_glu_transpept [H]

EC number: =2.3.2.2 [H]

Molecular weight: Translated: 61801; Mature: 61801

Theoretical pI: Translated: 5.39; Mature: 5.39

Prosite motif: PS00013 PROKAR_LIPOPROTEIN ; PS00462 G_GLU_TRANSPEPTIDASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.3 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
3.1 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQ
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHHH
VGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAK
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCCH
ATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDG
HHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCCH
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KSIADQIDIKKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
CCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC
>Mature Secondary Structure
MIKPTFLRRVAIAALLSGSCFSAAAAPPAPPVSYGVEEDVFHPVRAKQGMVASVDATATQ
CCCHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCHHHCCCHHHCCCCEEECCCHHHH
VGVDILKEGGNAVDAAVAVGYALAVTHPQAGNLGGGGFMLIRSKNGNTTAIDFREMAPAK
HHHHHHHCCCCHHHHHHHHHEEEEEECCCCCCCCCCEEEEEECCCCCEEEEEHHHCCCCH
ATRDMFLDDQGNPDSKKSLTSHLASGTPGTVAGFSLALDKYGTMPLNKVVQPAFKLARDG
HHHHHEECCCCCCCHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCHHHHHHHHHHHHHCC
FIVNDALADDLKTYGSEVLPNHENSKAIFWKEGEPLKKGDTLVQANLAKSLEMIAENGPD
EEEEHHHHHHHHHHCHHHCCCCCCCCEEEEECCCCCCCCCCEEHHHHHHHHHHHHCCCCH
EFYKGTIAEQIAQEMQKNGGLITKEDLAAYKAVERTPISGDYRGYQVYSMPPPSSGGIHI
HHHHHHHHHHHHHHHHHCCCCEEHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCHH
VQILNILENFDMKKYGFGSADAMQIMAEAEKYAYADRSEYLGDPDFVKVPWQALTNKAYA
HHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHCCHHHHCCCCCEEECCHHHHHHHHHH
KSIADQIDIKKAKPSSEIRPGKLAPYESNQTTHYSVVDKDGNAVAVTYTLNTTFGTGIVA
HHHHHHHHCCCCCCCCCCCCCCCCCCCCCCCEEEEEEECCCCEEEEEEEEECCCCCEEEE
GESGILLNNQMDDFSAKPGVPNVYGLVGGDANAVGPNKRPLSSMSPTIVVKDGKTWLVTG
CCCCEEECCCCCCCCCCCCCCCEEEEECCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEC
SPGGSRIITTVLQMVVNSIDYGMNVAEATNAPRFHHQWLPDELRVEKGFSPDTLKLLEAK
CCCCHHHHHHHHHHHHHHHHCCCCHHHHCCCCCHHHCCCCHHHHHHCCCCCHHHHHHHHC
GQKVALKEAMGSTQSIMVGPDGELYGASDPRSVDDLTAGY
CCEEEHHHHCCCCCEEEECCCCCEECCCCCCCCCHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 2570061; 9278503; 8041620; 1360205 [H]