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The map label for this gene is sulII

Identifier: 30063882

GI number: 30063882

Start: 2598850

End: 2599665

Strand: Direct

Name: sulII

Synonym: S2703

Alternate gene names: 30063882

Gene position: 2598850-2599665 (Clockwise)

Preceding gene: 30063881

Following gene: 30063883

Centisome position: 56.5

GC content: 60.78

Gene sequence:

>816_bases
ATGAATAAATCGCTCATCATTTTCGGCATCGTCAACATAACCTCGGACAGTTTCTCCGATGGAGGCCGGTATCTGGCGCC
AGACGCAGCCATTGCGCAGGCGCGTAAGCTGATGGCCGAGGGGGCAGATGTGATCGACCTCGGTCCGGCATCCAGCAATC
CCGACGCCGCGCCTGTTTCGTCCGACACAGAAATCGCGCGTATCGCGCCGGTGCTGGACGCGCTCAAGGCAGATGGCATT
CCCGTCTCGCTCGACAGTTATCAACCCGCGACGCAAGCCTATGCCTTGTCGCGTGGTGTGGCCTATCTCAATGATATTCG
CGGTTTTCCAGACGCTGCGTTCTATCCGCAATTGGCGAAATCATCTGCCAAACTCGTCGTTATGCATTCGGTGCAAGACG
GGCAGGCAGATCGGCGCGAGGCACCCGCTGGCGACATCATGGATCACATTGCGGCGTTCTTTGACGCGCGCATCGCGGCG
CTGACGGGTGCCGGTATCAAACGCAACCGCCTTGTCCTTGATCCCGGCATGGGGTTTTTTCTGGGGGCTGCTCCCGAAAC
CTCGCTCTCGGTGCTGGCGCGGTTCGATGAATTGCGGCTGCGCTTCGATTTGCCGGTGCTTCTGTCTGTTTCGCGCAAAT
CCTTTCTGCGCGCGCTCACAGGCCGTGGTCCGGGGGATGTCGGGGCCGCGACACTCGCTGCAGAGCTTGCCGCCGCCGCA
GGTGGAGCTGACTTCATCCGCACACACGAGCCGCGCCCCTTGCGCGACGGGCTGGCGGTATTGGCGGCGCTGAAAGAAAC
CGCAAGAATTCGTTAA

Upstream 100 bases:

>100_bases
TAATGGATCACCGCAAACAGGTTACTCGCCTGGGGATTCCCTTTCGACCCGAGCATCCGTATGAGACTCATGCTCGATTA
TTATTATTATAGAAGCCCCC

Downstream 100 bases:

>100_bases
CTGCACATTCGGGATATTTCTCTATATTCGCGGTTCAGCAGGCATGTCCCCTTTGAGGGCGACCCGACGACAGGATAATC
GACCTTATGGTGCGCAAATA

Product: dihydropteroate synthase

Products: NA

Alternate protein names: Dihydropteroate pyrophosphorylase type II; Dihydropteroate synthase type II; DHPS

Number of amino acids: Translated: 271; Mature: 271

Protein sequence:

>271_residues
MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIARIAPVLDALKADGI
PVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAA
LTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAA
GGADFIRTHEPRPLRDGLAVLAALKETARIR

Sequences:

>Translated_271_residues
MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIARIAPVLDALKADGI
PVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAA
LTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAA
GGADFIRTHEPRPLRDGLAVLAALKETARIR
>Mature_271_residues
MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVSSDTEIARIAPVLDALKADGI
PVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAKSSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAA
LTGAGIKRNRLVLDPGMGFFLGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAA
GGADFIRTHEPRPLRDGLAVLAALKETARIR

Specific function: DHPS catalyzes the formation of the immediate precursor of folic acid. It is implicated in resistance to sulfonamide. The type II enzyme is stable whereas type I DHPS loses its activity rapidly

COG id: COG0294

COG function: function code H; Dihydropteroate synthase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 pterin-binding domain

Homologues:

Organism=Escherichia coli, GI87082224, Length=268, Percent_Identity=33.2089552238806, Blast_Score=139, Evalue=2e-34,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DHP2_ECOLX (P0AC11)

Other databases:

- EMBL:   M36657
- PIR:   A34950
- RefSeq:   NP_957531.1
- RefSeq:   YP_002455756.1
- RefSeq:   YP_002891091.1
- RefSeq:   YP_002894395.1
- RefSeq:   YP_002995721.1
- RefSeq:   YP_794145.1
- RefSeq:   YP_891140.1
- ProteinModelPortal:   P0AC11
- SMR:   P0AC11
- GeneID:   2716515
- GeneID:   4397525
- GeneID:   4525479
- GeneID:   7205328
- GeneID:   7872496
- GeneID:   7872620
- GeneID:   8094934
- ProtClustDB:   CLSK862171
- BRENDA:   2.5.1.15
- InterPro:   IPR006390
- InterPro:   IPR011005
- InterPro:   IPR000489
- Gene3D:   G3DSA:3.20.20.20
- PANTHER:   PTHR20941:SF1
- TIGRFAMs:   TIGR01496

Pfam domain/function: PF00809 Pterin_bind; SSF51717 DHP_synth_like

EC number: =2.5.1.15

Molecular weight: Translated: 28470; Mature: 28470

Theoretical pI: Translated: 6.29; Mature: 6.29

Prosite motif: PS00792 DHPS_1; PS00793 DHPS_2; PS50972 PTERIN_BINDING

Important sites: BINDING 20-20 BINDING 85-85 BINDING 104-104 BINDING 174-174 BINDING 213-213 BINDING 247-247 BINDING 249-249

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
1.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.8 %Met     (Mature Protein)
1.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVS
CCCCEEEEEEEEECCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
SDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAK
CCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
SSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFF
CCCEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
LGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAA
ECCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
GGADFIRTHEPRPLRDGLAVLAALKETARIR
CCHHHHHCCCCCCHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MNKSLIIFGIVNITSDSFSDGGRYLAPDAAIAQARKLMAEGADVIDLGPASSNPDAAPVS
CCCCEEEEEEEEECCCCCCCCCCEECCHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCC
SDTEIARIAPVLDALKADGIPVSLDSYQPATQAYALSRGVAYLNDIRGFPDAAFYPQLAK
CCCHHHHHHHHHHHHHCCCCEEEECCCCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHC
SSAKLVVMHSVQDGQADRREAPAGDIMDHIAAFFDARIAALTGAGIKRNRLVLDPGMGFF
CCCEEEEEECCCCCCCHHHCCCHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEE
LGAAPETSLSVLARFDELRLRFDLPVLLSVSRKSFLRALTGRGPGDVGAATLAAELAAAA
ECCCCCHHHHHHHHHHHHHEEECCHHHHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHC
GGADFIRTHEPRPLRDGLAVLAALKETARIR
CCHHHHHCCCCCCHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 3075438