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The map label for this gene is bisZ

Identifier: 30063320

GI number: 30063320

Start: 1924738

End: 1927167

Strand: Reverse

Name: bisZ

Synonym: S2003

Alternate gene names: 30063320

Gene position: 1927167-1924738 (Counterclockwise)

Preceding gene: 30063321

Following gene: 30063316

Centisome position: 41.9

GC content: 52.06

Gene sequence:

>2430_bases
ATGGCATTAACAAGACGTGAATTTATTAAACACAGCGGTATTGCCGCTGGAGCGCTGGTGGTGACATCGGCAGCACCGCT
CCCCGCATGGGCAGAAGAGAAGGGCGGTAAAATCCTCACCGCGGGACGTTGGGGAGCGATGAGCGTAGAAGTGAAGGACG
GCAAGATTGTTTCTTCGACAGGCGCGCTGGCGAAAACCATACCGAACTCCTTACAGTCTACGGCGGCGGATCAGGTACAC
ACCACGGCGCGTATTCAGCATCCGATGGTGAGAAAAAGCTATCTCGACAATCCACTGCAACCGGCGAAAGGTCGTGGCGA
AGATACCTATGTACAGGTGAGCTGGGAACAGGCATTAAAACTGATTCATGAGCAACATGAGCGTATTCGTAAAGCTAACG
GACCATCGGCCATTTTTGCCGGATCTTACGGCTGGCGCTCTTCTGGCGTGTTGCATAAAGCGCAAACCTTACTGCAACGT
TATATGAACCTGGCGGGCGGTTATTCCGGGCATAGCGGCGATTATTCAACCGGGGCAGCACAGGTGATCATGCCGCATGT
GGTCGGTTCTGTAGAGGTGTATGAACAGCAGGCCTCCTGGCCGCTGATTCTGGAAAACAGCCAGGTTGTGGTGCTGTGGG
GAATGAACCCGCTGAATACCTTAAAAATTGCCTGGAGCAGTACCGATGAGCAAGGGCTGGAATACTTCCATCAGCTGAAA
AAATCTGGCAAACCAGTGATTGCCATTGATCCTATCCGCTCCGAAACCATCGAATTCTTTGGCGATAATGCCACCTGGAT
CGCGCCGAATATGGGCACCGACGTGGCACTGATGTTAGGGATTGCGCATACCCTGATGACACAAGGCAAACACGATAAAG
TGTTCCTTGAAAAATACACTACCGGGTATCCGCAGTTTGAAGAGTATCTGACAGGTAAGAGCGATAATACGCCGAAGAGC
GCGGTCTGGACGGCGGAAATTACTGGCGTACCGGAAGCGCAGATAGTCAAACTCGCTGAACTGATGGCGGCGAATCGCAC
AATGCTGATGGCAGGCTGGGGAATTCAGCGCCAGCAATATGGTGAACAGAAACACTGGATGCTGGTGACGCTGGCGGCGA
TGTTAGGGCAGATTGGTACACCGGGCGGCGGTTTTGGTTTCTCTTATCATTACTCCAATGGTGGCAACCCGACGCGTGTT
GGCGGCGTGCTGCCGGAAATGTCTGCGGCGATTGCCGGACAGGCCAGCGAGGCCGCTGATGATGGCGGAATGACGGCGAT
TCCTGTTGCCCGTATCGTCGATGCGCTGGAAAATCCTGGCGGCAAATATCAGCATAACGGTAAAGAACAAACGTATCCGA
ATATCAAAATGATCTGGTGGGCGGGTGGCGGTAACTTTACCCATCACCAGGATACTAATCGTCTGATCAAAGCCTGGCAG
AAACCGGAGATGATCGTCGTTTCTGAATGCTACTGGACCGCAGCAGCCAAACACGCAGATATCGTATTACCGATCACCAC
ATCGTTTGAGCGCAATGACTTGACGATGACCGGTGATTACAGCAACCAGCATATTGTGCCGATGAAGCAGGCTGTTGCTC
CGCAATTTGAAGCGCGTAACGATTTTGACGTGTTTGCCGATCTTGCGGAATTACTCAAACCTGGCGGAAAAGAGATCTAT
ACCGAAGGTAAAGATGAAATGGCGTGGCTGAAATTTTTCTATGATGCCGCTCAGAAAGGGGCCCGTGCGCAACGCGTCAC
TATGCCAATGTTTAATGCCTTCTGGCAGCAAAATAAACTGATCGAAATGCGCCGCAGCGAGAAGAACGAACAGTACGTTC
GTTATGGTGATTTCCGCGCCGATCCGGTGAAAAATGCGCTGGGTACGCCAAGCGGCAAAATTGAGATTTACTCCAAAACG
CTGGAAAAATTTGGCTATAAGGATTGCCCGGCACACCCAACCTGGCTTGCGCCTGATGAGTGGAAGGGTACCGCCGACGA
GAAGCAGTTGCAGCTTCTGACCGCACATCCGGCACACCGTTTACACAGTCAGCTTAACTATGCGGAACTGCGTAAAAAAT
ATGCGGTTGCCGATCGTGAACCGATCACTATTCACACCGAAGATGCTGCTCGATTTGGTATTGCGAATGGCGATCTGGTG
CGTGTCTGGAACAAACGTGGTCAGATTTTGACAGGCGCGGTGGTGACTGACGGGATCAAAAAAGGCGTGGTATGCGTGCA
TGAAGGTGCATGGCCAGATCTGGAAAACGGCTTGTGTAAAAACGGCAGTGCGAACGTGTTAACGGCGGATATCCCCAGCT
CGCAGCGGGCAAATGCCTGTGCCGGTAACTCTGCGCTGGTGTATATCGAAAAATATACGGGTAACGCACCGAAGTTAACG
GCATTTGATAAGCCTGCTGTTCAGGCGTAA

Upstream 100 bases:

>100_bases
CATGAGCGAAAACGAACCGGACATTTTAACGCGGTATTTCCAGTACAACGCCAAAGATATTACCGAGAAACAGTGATCCT
CGTTGATCAGGGAGGAAGTT

Downstream 100 bases:

>100_bases
GAAGTGAATAGCGCCCGGAAACGGGCGCTGAGGTTATGCAAACGTAAAACTGCCTGATGCGCTATGCTTATCAGGCCTAC
ATAGTCCCTGCAATAGATTG

Product: biotin sulfoxide reductase 2

Products: NA

Alternate protein names: TMAO reductase 2; Trimethylamine oxidase 2 [H]

Number of amino acids: Translated: 809; Mature: 808

Protein sequence:

>809_residues
MALTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSSTGALAKTIPNSLQSTAADQVH
TTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQR
YMNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQASWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
KSGKPVIAIDPIRSETIEFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKSDNTPKS
AVWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRV
GGVLPEMSAAIAGQASEAADDGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFADLAELLKPGGKEIY
TEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKT
LEKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGIANGDLV
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQRANACAGNSALVYIEKYTGNAPKLT
AFDKPAVQA

Sequences:

>Translated_809_residues
MALTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSSTGALAKTIPNSLQSTAADQVH
TTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQR
YMNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQASWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
KSGKPVIAIDPIRSETIEFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKSDNTPKS
AVWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRV
GGVLPEMSAAIAGQASEAADDGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFADLAELLKPGGKEIY
TEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKT
LEKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGIANGDLV
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQRANACAGNSALVYIEKYTGNAPKLT
AFDKPAVQA
>Mature_808_residues
ALTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSSTGALAKTIPNSLQSTAADQVHT
TARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALKLIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRY
MNLAGGYSGHSGDYSTGAAQVIMPHVVGSVEVYEQQASWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLKK
SGKPVIAIDPIRSETIEFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYTTGYPQFEEYLTGKSDNTPKSA
VWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQYGEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVG
GVLPEMSAAIAGQASEAADDGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQK
PEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARNDFDVFADLAELLKPGGKEIYT
EGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKLIEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTL
EKFGYKDCPAHPTWLAPDEWKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGIANGDLVR
VWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQRANACAGNSALVYIEKYTGNAPKLTA
FDKPAVQA

Specific function: Reduces trimethylamine-N-oxide (TMAO) into trimethylamine; an anaerobic reaction coupled to energy-yielding reactions. Can also reduce other N- and S-oxide compounds such as 4-methylmorpholine-N-oxide and biotin sulfoxide (BSO), but with a lower catalytic

COG id: COG0243

COG function: function code C; Anaerobic dehydrogenases, typically selenocysteine-containing

Gene ontology:

Cell location: Periplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the prokaryotic molybdopterin-containing oxidoreductase family [H]

Homologues:

Organism=Escherichia coli, GI87081994, Length=809, Percent_Identity=98.6402966625464, Blast_Score=1664, Evalue=0.0,
Organism=Escherichia coli, GI145693196, Length=773, Percent_Identity=63.5187580853816, Blast_Score=1060, Evalue=0.0,
Organism=Escherichia coli, GI1787231, Length=786, Percent_Identity=45.1653944020356, Blast_Score=644, Evalue=0.0,
Organism=Escherichia coli, GI87081797, Length=752, Percent_Identity=30.9840425531915, Blast_Score=271, Evalue=2e-73,
Organism=Escherichia coli, GI1787870, Length=850, Percent_Identity=28.7058823529412, Blast_Score=266, Evalue=3e-72,
Organism=Escherichia coli, GI171474008, Length=840, Percent_Identity=28.3333333333333, Blast_Score=235, Evalue=7e-63,
Organism=Escherichia coli, GI3868721, Length=719, Percent_Identity=22.8094575799722, Blast_Score=110, Evalue=3e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR009010
- InterPro:   IPR006658
- InterPro:   IPR006657
- InterPro:   IPR006656
- InterPro:   IPR006655
- InterPro:   IPR006311 [H]

Pfam domain/function: PF00384 Molybdopterin; PF01568 Molydop_binding [H]

EC number: =1.7.2.3 [H]

Molecular weight: Translated: 88903; Mature: 88772

Theoretical pI: Translated: 8.01; Mature: 8.01

Prosite motif: PS00490 MOLYBDOPTERIN_PROK_2 ; PS00932 MOLYBDOPTERIN_PROK_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
3.0 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.8 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MALTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSST
CCCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCEEEEECCCCEEEEEECCCEEEECC
GALAKTIPNSLQSTAADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHH
LIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRYMNLAGGYSGHSGDYSTGAA
HHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
QVIMPHVVGSVEVYEQQASWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
HHHHHHHHCCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHH
KSGKPVIAIDPIRSETIEFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYT
HCCCCEEEECCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHC
TGYPQFEEYLTGKSDNTPKSAVWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQY
CCCCCHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHH
GEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVGGVLPEMSAAIAGQASEAAD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCC
DGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHC
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARN
CCCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCCEECCHHHHHCCCCCCCC
DFDVFADLAELLKPGGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKL
CHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHH
IEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTLEKFGYKDCPAHPTWLAPDE
HHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCC
WKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGIANGDLV
CCCCCCHHHEEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEE
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQRANAC
EEECCCCCEEEEHHHHCCHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AGNSALVYIEKYTGNAPKLTAFDKPAVQA
CCCCEEEEEEECCCCCCEEEECCCCCCCC
>Mature Secondary Structure 
ALTRREFIKHSGIAAGALVVTSAAPLPAWAEEKGGKILTAGRWGAMSVEVKDGKIVSST
CCCHHHHHHHCCCCCCEEEEECCCCCCCCHHHCCCEEEEECCCCEEEEEECCCEEEECC
GALAKTIPNSLQSTAADQVHTTARIQHPMVRKSYLDNPLQPAKGRGEDTYVQVSWEQALK
CHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHCCCCCCCCCCCCCCCEEEEEHHHHHH
LIHEQHERIRKANGPSAIFAGSYGWRSSGVLHKAQTLLQRYMNLAGGYSGHSGDYSTGAA
HHHHHHHHHHHCCCCCEEEECCCCCCCCCHHHHHHHHHHHHHHHHCCCCCCCCCCCCCHH
QVIMPHVVGSVEVYEQQASWPLILENSQVVVLWGMNPLNTLKIAWSSTDEQGLEYFHQLK
HHHHHHHHCCHHHHHHCCCCCEEEECCCEEEEECCCCCCEEEEEECCCCHHHHHHHHHHH
KSGKPVIAIDPIRSETIEFFGDNATWIAPNMGTDVALMLGIAHTLMTQGKHDKVFLEKYT
HCCCCEEEECCCCCHHHHHCCCCCEEECCCCCCHHHHHHHHHHHHHHCCCCCEEEEEHHC
TGYPQFEEYLTGKSDNTPKSAVWTAEITGVPEAQIVKLAELMAANRTMLMAGWGIQRQQY
CCCCCHHHHHCCCCCCCCCCEEEEEEECCCCHHHHHHHHHHHHCCCEEEEECCCCCHHHH
GEQKHWMLVTLAAMLGQIGTPGGGFGFSYHYSNGGNPTRVGGVLPEMSAAIAGQASEAAD
CCCCCHHHHHHHHHHHCCCCCCCCCCEEEEECCCCCCCCCCCCCHHHHHHHCCCCCCCCC
DGGMTAIPVARIVDALENPGGKYQHNGKEQTYPNIKMIWWAGGGNFTHHQDTNRLIKAWQ
CCCCEEHHHHHHHHHHHCCCCCCCCCCCCCCCCCEEEEEEECCCCCCCCCHHHHHHHHHC
KPEMIVVSECYWTAAAKHADIVLPITTSFERNDLTMTGDYSNQHIVPMKQAVAPQFEARN
CCCEEEEECCHHHHHCCCCEEEEEEECCCCCCCCEEECCCCCCEECCHHHHHCCCCCCCC
DFDVFADLAELLKPGGKEIYTEGKDEMAWLKFFYDAAQKGARAQRVTMPMFNAFWQQNKL
CHHHHHHHHHHHCCCCCEEECCCCHHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHCCHH
IEMRRSEKNEQYVRYGDFRADPVKNALGTPSGKIEIYSKTLEKFGYKDCPAHPTWLAPDE
HHHHHCCCCCCEEEECCCCCCHHHHHHCCCCCCEEEHHHHHHHCCCCCCCCCCCCCCCCC
WKGTADEKQLQLLTAHPAHRLHSQLNYAELRKKYAVADREPITIHTEDAARFGIANGDLV
CCCCCCHHHEEEEECCCHHHHHHCCCHHHHHHHHHCCCCCCEEEEECCHHHCCCCCCCEE
RVWNKRGQILTGAVVTDGIKKGVVCVHEGAWPDLENGLCKNGSANVLTADIPSSQRANAC
EEECCCCCEEEEHHHHCCHHCCEEEEECCCCCCCCCCCCCCCCCCEEEECCCCCCCCCCC
AGNSALVYIEKYTGNAPKLTAFDKPAVQA
CCCCEEEEEEECCCCCCEEEECCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]