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The map label for this gene is safA

Identifier: 30063040

GI number: 30063040

Start: 1608707

End: 1608910

Strand: Reverse

Name: safA

Synonym: S1655

Alternate gene names: 30063040

Gene position: 1608910-1608707 (Counterclockwise)

Preceding gene: 30063041

Following gene: 30063039

Centisome position: 34.98

GC content: 35.29

Gene sequence:

>204_bases
ATGCATGCGACCACAGTGAAAAACAAAATCACGCAAAGAGATAACTATAAAGAAATCATGTCTGTAATTGTGGTTGTCTT
ATTACTGACACTTACGTTGATAGCCATTTTTTCGGCAATTGATCAGCTGAGTATTTCAGAAATGGGTCGCATTGCAAGAG
ATCTTACACATTTCATTATCAATAGTTTGCAAGACTGGAAATAA

Upstream 100 bases:

>100_bases
TACTGAAGCACCAGTCCTATTTCTTCTTTTCTCCAGCCTGTTATATTAAGCATACTGATTAACGACTTTTAACGTTATCC
GCTAAATAAACATATTTGAA

Downstream 100 bases:

>100_bases
ACAGCAAATTATAAATGTGAAATGTTTAAAAGGTATCGATAAAACTTTATTGTTTTAAGGAGATAAAATGTCGCTCGTTT
GTTCTGTTATATTTATTCAT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 67; Mature: 67

Protein sequence:

>67_residues
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFIINSLQDWK

Sequences:

>Translated_67_residues
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFIINSLQDWK
>Mature_67_residues
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFIINSLQDWK

Specific function: Connects the signal transduction between the two- component systems EvgS/EvgA and PhoQ/PhoP, by directly interacting with PhoQ and thus activating the PhoQ/PhoP system, in response to acid stress conditions

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cell inner membrane; Single-pass type II membrane protein

Metaboloic importance: Non Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the SafA family

Homologues:

Organism=Escherichia coli, GI1787777, Length=64, Percent_Identity=98.4375, Blast_Score=125, Evalue=6e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): SAFA_SHIFL (Q7UCH6)

Other databases:

- EMBL:   AE005674
- EMBL:   AE014073
- RefSeq:   NP_837211.1
- EnsemblBacteria:   EBESCT00000086232
- EnsemblBacteria:   EBESCT00000092608
- GeneID:   1078015
- GenomeReviews:   AE005674_GR
- GenomeReviews:   AE014073_GR
- KEGG:   sfx:S1655
- GeneTree:   EBGT00050000011225
- HOGENOM:   HBG467795
- ProtClustDB:   CLSK512219

Pfam domain/function: NA

EC number: NA

Molecular weight: Translated: 7672; Mature: 7672

Theoretical pI: Translated: 9.19; Mature: 9.19

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0x10a79b98)-;

Cys/Met content:

0.0 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
4.5 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
4.5 %Met     (Mature Protein)
4.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFII
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSLQDWK
HHHHCCH
>Mature Secondary Structure
MHATTVKNKITQRDNYKEIMSVIVVVLLLTLTLIAIFSAIDQLSISEMGRIARDLTHFII
CCCHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NSLQDWK
HHHHCCH

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 12384590; 12704152