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The map label for this gene is yeaP

Identifier: 30062947

GI number: 30062947

Start: 1505400

End: 1506425

Strand: Reverse

Name: yeaP

Synonym: S1545

Alternate gene names: 30062947

Gene position: 1506425-1505400 (Counterclockwise)

Preceding gene: 30062949

Following gene: 30062944

Centisome position: 32.75

GC content: 47.86

Gene sequence:

>1026_bases
GTGTCAGATCAGATTATCGCCCGCGTCTCGCAATCCCTTGCCAAAGAACAGTCACTGGAAAGTCTGGTCCGACAGCTTCT
GGAGATGCTGGAAATGGTCACTGATATGGAATCAACCTACCTGACCAAAGTGGATGTCGAAGCGCGCCTGCAGCATATTA
TGTTTGCCCGTAACAGCCAGAAAATGCACATCCCGGAGAATTTTACCGTCTTGTGGGATTACTCGTTATGCAAACGCGCC
ATTGATGAAAACTGCTTTTTCAGCGATGAAGTCCCTGACCGTTGGGGCGACTGTATTGCGGCACGCAATCTTGGCATCAC
CACATTTCTGAGCACGCCAATTCACTTACCGGATGGATCATTCTATGGCACGCTTTGCGCCGCCAGCAGTGAGAAGCGCC
AGTGGAGTGAACGCGCGGAACAGGTTTTACAGTTATTCGCCGGACTGATTGCACAATATATTCAAAAAGAGGCACTGGTT
GAACAGCTGCACGAAGCCAATGCTGCGCTGATTGCGCAATCGTATACCGACTCGTTAACCGGGCTACCGAATCGGCGGGC
GATTTTTGAAAATCTGACGACGCTGTTTTCCCTCGCCCGGCATCTTAACCATAAGATAATGATCGCGTTTATCGATCTGG
ATAACTTCAAATTAATCAATGATCGTTTTGGTCATAATAGTGGCGATCTGTTTCTCATTCAGGTTGGCGAGCGCCTTAAT
ACGCTCCAGCAAAATGGCGAAGTTATTGGTCGTCTCGGTGGTGATGAGTTTTTGGTTGTTTCACTAAACAACGAGAATGC
GGATATTTCGTCGCTGCGAGAACGTATTCAACAGCAAATACGTGGAGAATATCACTTAGGTGATGTTGATTTGTATTATC
CCGGTGCCAGTCTTGGCATAGTAGAAGTCGATCCTGAAACAACCGATGCAGACAGTGCCCTGCATGCTGCCGATATTGCG
ATGTATCAGGAGAAAAAACACAAACAGAAAACACCTTTTGTCGCGCATCCAGCGCTACATTCCTGA

Upstream 100 bases:

>100_bases
AAAACATATTACGTCTTGTTTCATCTTTGTTGATGATGTTTTATCATGCCTGCAAAGATTAAATAATCAGCACTTACCCG
CCGTATCCTGGAGTTGTTCC

Downstream 100 bases:

>100_bases
GGCGTATTCACATCCTTTTGATTGGTGATAACATGCGAATCGGTATTATTTTTCCGGTTGTAATCTTCATTACAGCGGTC
GTATTTTTAGCATGGTTTTT

Product: hypothetical protein

Products: NA

Alternate protein names: DGC [H]

Number of amino acids: Translated: 341; Mature: 340

Protein sequence:

>341_residues
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVLWDYSLCKRA
IDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALV
EQLHEANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIA
MYQEKKHKQKTPFVAHPALHS

Sequences:

>Translated_341_residues
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVLWDYSLCKRA
IDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALV
EQLHEANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIA
MYQEKKHKQKTPFVAHPALHS
>Mature_340_residues
SDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQKMHIPENFTVLWDYSLCKRAI
DENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGSFYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVE
QLHEANAALIAQSYTDSLTGLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLNT
LQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGIVEVDPETTDADSALHAADIAM
YQEKKHKQKTPFVAHPALHS

Specific function: Catalyzes the condensation of two GTP molecules to the cyclic dinucleotide di-GMP (c-di-GMP), which acts as a secondary messenger (Probable). Cyclic-di-GMP is a second messenger which controls cell surface-associated traits in bacteria [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 GGDEF domain [H]

Homologues:

Organism=Escherichia coli, GI87081977, Length=341, Percent_Identity=99.1202346041056, Blast_Score=702, Evalue=0.0,
Organism=Escherichia coli, GI1787541, Length=165, Percent_Identity=32.7272727272727, Blast_Score=94, Evalue=2e-20,
Organism=Escherichia coli, GI87082007, Length=164, Percent_Identity=32.9268292682927, Blast_Score=79, Evalue=3e-16,
Organism=Escherichia coli, GI1788381, Length=184, Percent_Identity=29.8913043478261, Blast_Score=78, Evalue=7e-16,
Organism=Escherichia coli, GI1786584, Length=165, Percent_Identity=29.6969696969697, Blast_Score=77, Evalue=1e-15,
Organism=Escherichia coli, GI1788956, Length=101, Percent_Identity=41.5841584158416, Blast_Score=66, Evalue=3e-12,
Organism=Escherichia coli, GI1787816, Length=162, Percent_Identity=31.4814814814815, Blast_Score=65, Evalue=4e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001054
- InterPro:   IPR000160
- InterPro:   IPR003018 [H]

Pfam domain/function: PF01590 GAF; PF00990 GGDEF [H]

EC number: =2.7.7.65 [H]

Molecular weight: Translated: 38527; Mature: 38396

Theoretical pI: Translated: 4.91; Mature: 4.91

Prosite motif: PS50887 GGDEF

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.2 %Cys     (Translated Protein)
2.3 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.2 %Cys     (Mature Protein)
2.1 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCC
KMHIPENFTVLWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
CEECCCCCEEEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEECCCCC
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
CEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEHHHCCCCCCCEEEEEECHHHH
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
HHHHCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEE
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC
>Mature Secondary Structure 
SDQIIARVSQSLAKEQSLESLVRQLLEMLEMVTDMESTYLTKVDVEARLQHIMFARNSQ
CCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEECHHHHHHHHHHHCCCC
KMHIPENFTVLWDYSLCKRAIDENCFFSDEVPDRWGDCIAARNLGITTFLSTPIHLPDGS
CEECCCCCEEEECHHHHHHHHCCCCCCCCCCCHHHHHHHHHCCCCEEEEECCCEECCCCC
FYGTLCAASSEKRQWSERAEQVLQLFAGLIAQYIQKEALVEQLHEANAALIAQSYTDSLT
CEEHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
GLPNRRAIFENLTTLFSLARHLNHKIMIAFIDLDNFKLINDRFGHNSGDLFLIQVGERLN
CCCCHHHHHHHHHHHHHHHHHCCCEEEEEEEECCCEEEEHHHCCCCCCCEEEEEECHHHH
TLQQNGEVIGRLGGDEFLVVSLNNENADISSLRERIQQQIRGEYHLGDVDLYYPGASLGI
HHHHCCCEEEEECCCCEEEEEECCCCCCHHHHHHHHHHHHCCCCCCCCEEEEECCCCEEE
VEVDPETTDADSALHAADIAMYQEKKHKQKTPFVAHPALHS
EEECCCCCCCHHHHHHHHHHHHHHHHHHCCCCEECCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]