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The map label for this gene is adrB [H]

Identifier: 30062931

GI number: 30062931

Start: 1487193

End: 1488791

Strand: Reverse

Name: adrB [H]

Synonym: S1528

Alternate gene names: 30062931

Gene position: 1488791-1487193 (Counterclockwise)

Preceding gene: 30062932

Following gene: 30062929

Centisome position: 32.37

GC content: 50.09

Gene sequence:

>1599_bases
ATGCAAAAAGCACAACGGATCATTAAAACCTATCGCCGTAATCGAATGATTGTTTGTACGATTTGCGCACTCGTTACGCT
CGCTTCGACCCTGAGCGTGCGATTTATTTCACAGCGTAACTTAAATCAACAACGGGTAGTACAATTCGCCAATCACGCTG
TAGAGGAATTAGATAAAGTACTGCTTCCCCTACAGGCAGGTAGCAAAGTCTTGCTTCCGCTGATTGGTCTGCCCTGCTCT
GTCGCCCATTTGCCATTACGTAAACAGGCGGCAAAACTCCAAACTGTGCGATCCATTGGCCTGGTGCAAGACGGCACACT
TTATTGCTCCAGCATTTTTGGTTATCGCAATGTGCCCGTCGTGGACATTCTGGCTGAACTTCCTGCACCGCAACCACTTT
TACGCCTGACGATCGACCGTGCCCTGATTAAAGGCAGTCCGGTTTTGATTCAATGGACGCCTGCAGCGGGCAGTAGCAAT
GCTGGGGTCATAGAGATGATTAACATCGACTTACTGACGGCAATGCTCCTTGAGCCACAACTGCCGCAAATCAGTAGCGC
CAGCCTGACGGTGGACAAACGGCATTTGCTCTATGGTAATGGGCTGGTAGATTCCCTTCCGCAACCTGAAGACAATGAAA
ACTATCAGGTTTCTTCGCAAAGCTTTCCTTTTACCATTAACGTAAATGGTCCGGGGGCTACGGCGCTGGCATGGCACTAT
CTTCCAACACAATTACCGCTGGCGGTGCTGCTAAGTTTACTGGTGGGCTATATCGCCTGGCTGGCGACCGCTTACCGGAT
GAGCTTTTCCCGCGAAATTAATCTGGGCCTGGCGCAACATGAGTTCGAATTGTTCTGTCAGCCTTTGCTTAATGCGCGCA
GCCAGCAATGTATTGGTGTAGAGATTTTGCTGCGCTGGAATAATCCGCGTCAGGGCTGGATTTCACCGGATGTGTTTATT
CCTATCGCGGAAGAACATCATTTAATTGTGCCACTGACCCACTATGTGATGGCAGAAACCATTCGTCAGCACCATGTTTT
CCCGATGAGTAGTCAGTTTCATGTTGGCATTAACGTCGCACCCAGCCATTTTCGCCGTGGTGTGCTGATAAAAGATCTCA
ATCAGTACTGGTTTAGCGCTCACCCGATTCAGCAACTGATCCTCGAAATCACCGAACGCGATGCCTTACTGGATGTTGAT
TATCGGATTGCCCGCGAGCTGCATCGTAAAAACGTCAAACTGGCGATTGATGACTTCGGCACCGGCAACAGCTCGTTTTC
CTGGCTTGAAACATTACGTCCTGACGTGCTGAAAATTGATAAGTCATTTACCGCAGCTATAGGTTCTGACGCGGTTAACT
CGACGGTGACCGATATCATCATCGCGCTGGGGCAAAGACTGAATATTGAACTGGTGGCGGAGGGCGTGGAAACGCAAGAA
CAGGCGAAGTATTTGCGCCGTCATGGCGTGCATATTTTGCAAGGGTATTTGTACGCACAGCCGATGCCGCTACGTGATTT
TCCCAAATGGCTGGCGGGCAGCCAACCGCCGCCCGCCCGGCATAATGGACATATCACGCCCATTATGTCGTTACGTTAA

Upstream 100 bases:

>100_bases
GGCGAATTTATACCCGCTTTCTCGTCTGCTGTAATATTCCCCACTACACTTCCACTGTTGCGTCAGGCGTTTGTCGCCAT
ACGCTTACAGGGTGGCCCGC

Downstream 100 bases:

>100_bases
CGCTTACTCATCTTCATCGTGCGCCGGTTGCTCTTTAACAATGCGAACCAGATCAACACGATAATCATTGGCTTCAAAGA
TGGTGATATGCAGTGGCCCT

Product: hypothetical protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 532; Mature: 532

Protein sequence:

>532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSKVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSN
AGVIEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQSFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTHYVMAETIRQHHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMSLR

Sequences:

>Translated_532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSKVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSN
AGVIEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQSFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTHYVMAETIRQHHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMSLR
>Mature_532_residues
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKVLLPLQAGSKVLLPLIGLPCS
VAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPVVDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSN
AGVIEMINIDLLTAMLLEPQLPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQSFPFTINVNGPGATALAWHY
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGVEILLRWNNPRQGWISPDVFI
PIAEEHHLIVPLTHYVMAETIRQHHVFPMSSQFHVGINVAPSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVD
YRIARELHRKNVKLAIDDFGTGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMSLR

Specific function: May serve as a negative regulator of cellulose synthesis (as has been suggested for S.typhimurium); over-expression inhibits cell aggregation in strains able to produce adhesive curli fimbriae. Cyclic-di-GMP is a second messenger which controls cell surfa

COG id: COG2200

COG function: function code T; FOG: EAL domain

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 EAL domain [H]

Homologues:

Organism=Escherichia coli, GI87081980, Length=532, Percent_Identity=98.8721804511278, Blast_Score=1077, Evalue=0.0,
Organism=Escherichia coli, GI1788502, Length=520, Percent_Identity=28.8461538461538, Blast_Score=228, Evalue=5e-61,
Organism=Escherichia coli, GI87081845, Length=531, Percent_Identity=28.060263653484, Blast_Score=167, Evalue=1e-42,
Organism=Escherichia coli, GI1786507, Length=247, Percent_Identity=38.8663967611336, Blast_Score=164, Evalue=2e-41,
Organism=Escherichia coli, GI1790496, Length=259, Percent_Identity=35.1351351351351, Blast_Score=154, Evalue=1e-38,
Organism=Escherichia coli, GI87081743, Length=327, Percent_Identity=31.4984709480122, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI87081921, Length=261, Percent_Identity=32.9501915708812, Blast_Score=134, Evalue=2e-32,
Organism=Escherichia coli, GI226510982, Length=262, Percent_Identity=31.6793893129771, Blast_Score=120, Evalue=1e-28,
Organism=Escherichia coli, GI1787541, Length=259, Percent_Identity=30.1158301158301, Blast_Score=114, Evalue=1e-26,
Organism=Escherichia coli, GI1787055, Length=254, Percent_Identity=30.3149606299213, Blast_Score=104, Evalue=1e-23,
Organism=Escherichia coli, GI87082096, Length=242, Percent_Identity=29.7520661157025, Blast_Score=102, Evalue=7e-23,
Organism=Escherichia coli, GI1788849, Length=236, Percent_Identity=31.3559322033898, Blast_Score=100, Evalue=2e-22,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001633 [H]

Pfam domain/function: PF00563 EAL [H]

EC number: =3.1.4.52 [H]

Molecular weight: Translated: 59576; Mature: 59576

Theoretical pI: Translated: 8.74; Mature: 8.74

Prosite motif: PS50883 EAL

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
LLPLQAGSKVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPV
HHHHCCCCEEEHHHHCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCH
VDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGVIEMINIDLLTAMLLEPQ
HHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHCCC
LPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQSFPFTINVNGPGATALAWHY
CCCCCCCEEEEECCEEEEECCHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEC
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
EILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTHYVMAETIRQHHVFPMSSQFHVGINVA
EEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCC
TGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
CCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMSLR
HHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCC
>Mature Secondary Structure
MQKAQRIIKTYRRNRMIVCTICALVTLASTLSVRFISQRNLNQQRVVQFANHAVEELDKV
CCHHHHHHHHHHCCCEEEHHHHHHHHHHHHHHHEEHHHCCCCHHHHHHHHHHHHHHHHHH
LLPLQAGSKVLLPLIGLPCSVAHLPLRKQAAKLQTVRSIGLVQDGTLYCSSIFGYRNVPV
HHHHCCCCEEEHHHHCCCCCHHCCCHHHHHHHHHHHHHHCCCCCCCHHHHHHCCCCCCCH
VDILAELPAPQPLLRLTIDRALIKGSPVLIQWTPAAGSSNAGVIEMINIDLLTAMLLEPQ
HHHHHHCCCCCHHHHHHHHHHHHCCCCEEEEEECCCCCCCCCEEEEEHHHHHHHHHHCCC
LPQISSASLTVDKRHLLYGNGLVDSLPQPEDNENYQVSSQSFPFTINVNGPGATALAWHY
CCCCCCCEEEEECCEEEEECCHHHCCCCCCCCCCEEEECCCCCEEEEECCCCCCEEEEEC
LPTQLPLAVLLSLLVGYIAWLATAYRMSFSREINLGLAQHEFELFCQPLLNARSQQCIGV
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCEECCCCHHHHHHHHHHHHHCCCCCCCEEE
EILLRWNNPRQGWISPDVFIPIAEEHHLIVPLTHYVMAETIRQHHVFPMSSQFHVGINVA
EEEEEECCCCCCCCCCCEEEEECCCCEEEEHHHHHHHHHHHHHHCCCCCCCCEEEEEEEC
PSHFRRGVLIKDLNQYWFSAHPIQQLILEITERDALLDVDYRIARELHRKNVKLAIDDFG
HHHHHCCCHHHHHHHHHCCCCHHHHHHHHHHHCCCEEECHHHHHHHHHHCCCEEEEECCC
TGNSSFSWLETLRPDVLKIDKSFTAAIGSDAVNSTVTDIIIALGQRLNIELVAEGVETQE
CCCCCHHHHHHCCCHHEECCCHHHHHHCCHHHHHHHHHHHHHHCCCCCEEEEECCCCHHH
QAKYLRRHGVHILQGYLYAQPMPLRDFPKWLAGSQPPPARHNGHITPIMSLR
HHHHHHHCCHHHHHHHHHCCCCCHHHHHHHHCCCCCCCCCCCCCCCEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503 [H]