| Definition | Shigella flexneri 2a str. 2457T, complete genome. |
|---|---|
| Accession | NC_004741 |
| Length | 4,599,354 |
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The map label for this gene is entA
Identifier: 30062053
GI number: 30062053
Start: 527806
End: 528552
Strand: Direct
Name: entA
Synonym: S0516
Alternate gene names: 30062053
Gene position: 527806-528552 (Clockwise)
Preceding gene: 30062052
Following gene: 30062054
Centisome position: 11.48
GC content: 57.56
Gene sequence:
>747_bases ATGGATTTCAGCGGTAAAAATGTCTGGGTAACCGGCGCAGGTAAAGGTATCGGCTACGCCACGGCGCTGACGTTTGTTGA GGCGGGAGCGAAAGTTACAGGTTTTGATCAAGCGTTCACTCAGGAGCAATATCCCTTTGCGACCGAAGTAATGGATGTTG CCGACGCCGGGCAGGTGGCGCAGGTATGTCAGCGACTGTTAGCTGAAACGGAGCGACTGGACGTGCTGATCAATGCGGCG GGAATTTTGCGCATGGGCGCGACCGATCAGCTCAGTAAAGAGGACTGGCAGCAGACTTTTGCGGTTAACGTCGGCGGTGC GTTTAACCTGTTCCAGCAAACCATGAACCAGTTTCGCCGTCAGCGGGGCGGGGCGATTGTCACTGTGGCGTCCGACGCCG CACACACGGCGCGTATTGGTATGAGTGCTTATGGCGCATCGAAAGCGGCGCTGAAAAGCCTGGCGTTGAGCGTCGGGCTG GAACTGGCGGGTAGCGGCGTGCGCTGTAATGTGGTTTCGCCTGGCTCCACCGACACCGATATGCAACGCACGCTGTGGGT GAGCGATGACGCCGAAGAACAGCGTATTCGCGGCTTTGGCGAGCAGTTTAAACTCGGCATTCCGCTGGGGAAAATCGCCC GTCCACAAGAGATCGCCAACACGATTTTGTTCCTCGCCTCTGACCTCGCCAGCCATATCACCCTACAGGATATTGTGGTC GATGGCGGCTCAACGCTGGGGGCATAA
Upstream 100 bases:
>100_bases CGCGCTGGCGCAAAGTGCATGGTGATATCGACTTTGTCATGCTGGCGAAAAACCCGACCATCGACGCCTGGTGGAAGCTA CTCTCCCGCGAGGTGAAATA
Downstream 100 bases:
>100_bases GCATGATCTGGAAACGCCATTTAACGCTCGACGAACTGAACGCCACCAGCGATAACACAATGGTGGCGCATCTGGGAATT GTGTATACCCTTCTGGGAGA
Product: 2,3-dihydroxybenzoate-2,3-dehydrogenase
Products: NA
Alternate protein names: NA
Number of amino acids: Translated: 248; Mature: 248
Protein sequence:
>248_residues MDFSGKNVWVTGAGKGIGYATALTFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAGQVAQVCQRLLAETERLDVLINAA GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTARIGMSAYGASKAALKSLALSVGL ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV DGGSTLGA
Sequences:
>Translated_248_residues MDFSGKNVWVTGAGKGIGYATALTFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAGQVAQVCQRLLAETERLDVLINAA GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTARIGMSAYGASKAALKSLALSVGL ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV DGGSTLGA >Mature_248_residues MDFSGKNVWVTGAGKGIGYATALTFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAGQVAQVCQRLLAETERLDVLINAA GILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRRQRGGAIVTVASDAAHTARIGMSAYGASKAALKSLALSVGL ELAGSGVRCNVVSPGSTDTDMQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV DGGSTLGA
Specific function: Siderophore biosynthesis; enterobactin biosynthesis. [C]
COG id: COG1028
COG function: function code IQR; Dehydrogenases with different specificities (related to short-chain alcohol dehydrogenases)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Non_Essential [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family [H]
Homologues:
Organism=Homo sapiens, GI66933014, Length=251, Percent_Identity=32.2709163346614, Blast_Score=107, Evalue=9e-24, Organism=Homo sapiens, GI32483357, Length=259, Percent_Identity=30.5019305019305, Blast_Score=100, Evalue=8e-22, Organism=Homo sapiens, GI7705925, Length=248, Percent_Identity=29.4354838709677, Blast_Score=92, Evalue=6e-19, Organism=Homo sapiens, GI5031737, Length=247, Percent_Identity=29.5546558704453, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI40254992, Length=195, Percent_Identity=32.8205128205128, Blast_Score=89, Evalue=5e-18, Organism=Homo sapiens, GI15277342, Length=256, Percent_Identity=30.078125, Blast_Score=86, Evalue=2e-17, Organism=Homo sapiens, GI4504505, Length=208, Percent_Identity=28.3653846153846, Blast_Score=82, Evalue=6e-16, Organism=Homo sapiens, GI19923817, Length=256, Percent_Identity=24.21875, Blast_Score=80, Evalue=2e-15, Organism=Homo sapiens, GI126723750, Length=265, Percent_Identity=26.4150943396226, Blast_Score=78, Evalue=7e-15, Organism=Homo sapiens, GI10190704, Length=256, Percent_Identity=25, Blast_Score=78, Evalue=9e-15, Organism=Homo sapiens, GI33667109, Length=189, Percent_Identity=30.1587301587302, Blast_Score=74, Evalue=1e-13, Organism=Homo sapiens, GI31542939, Length=248, Percent_Identity=28.6290322580645, Blast_Score=69, Evalue=3e-12, Organism=Homo sapiens, GI59889578, Length=231, Percent_Identity=26.8398268398268, Blast_Score=69, Evalue=4e-12, Organism=Homo sapiens, GI4503817, Length=236, Percent_Identity=24.5762711864407, Blast_Score=66, Evalue=2e-11, Organism=Escherichia coli, GI1786812, Length=248, Percent_Identity=97.9838709677419, Blast_Score=494, Evalue=1e-141, Organism=Escherichia coli, GI1787335, Length=250, Percent_Identity=36, Blast_Score=130, Evalue=7e-32, Organism=Escherichia coli, GI87082100, Length=256, Percent_Identity=31.25, Blast_Score=117, Evalue=7e-28, Organism=Escherichia coli, GI1790717, Length=253, Percent_Identity=25.6916996047431, Blast_Score=92, Evalue=3e-20, Organism=Escherichia coli, GI1788459, Length=197, Percent_Identity=30.9644670050761, Blast_Score=91, Evalue=1e-19, Organism=Escherichia coli, GI1789208, Length=250, Percent_Identity=27.6, Blast_Score=90, Evalue=1e-19, Organism=Escherichia coli, GI2367175, Length=254, Percent_Identity=31.1023622047244, Blast_Score=89, Evalue=4e-19, Organism=Escherichia coli, GI1787905, Length=254, Percent_Identity=27.9527559055118, Blast_Score=87, Evalue=8e-19, Organism=Escherichia coli, GI1789378, Length=264, Percent_Identity=27.2727272727273, Blast_Score=83, Evalue=2e-17, Organism=Escherichia coli, GI87082160, Length=262, Percent_Identity=26.7175572519084, Blast_Score=80, Evalue=2e-16, Organism=Escherichia coli, GI2367365, Length=247, Percent_Identity=28.7449392712551, Blast_Score=77, Evalue=1e-15, Organism=Escherichia coli, GI1787820, Length=176, Percent_Identity=28.9772727272727, Blast_Score=68, Evalue=5e-13, Organism=Escherichia coli, GI1787526, Length=202, Percent_Identity=26.2376237623762, Blast_Score=62, Evalue=3e-11, Organism=Caenorhabditis elegans, GI193204405, Length=266, Percent_Identity=35.3383458646617, Blast_Score=115, Evalue=2e-26, Organism=Caenorhabditis elegans, GI17560150, Length=262, Percent_Identity=34.7328244274809, Blast_Score=114, Evalue=5e-26, Organism=Caenorhabditis elegans, GI17562990, Length=261, Percent_Identity=33.7164750957854, Blast_Score=111, Evalue=3e-25, Organism=Caenorhabditis elegans, GI115534694, Length=250, Percent_Identity=32, Blast_Score=110, Evalue=6e-25, Organism=Caenorhabditis elegans, GI72000259, Length=262, Percent_Identity=34.7328244274809, Blast_Score=109, Evalue=1e-24, Organism=Caenorhabditis elegans, GI17561402, Length=255, Percent_Identity=30.1960784313725, Blast_Score=106, Evalue=8e-24, Organism=Caenorhabditis elegans, GI17563726, Length=262, Percent_Identity=32.824427480916, Blast_Score=106, Evalue=9e-24, Organism=Caenorhabditis elegans, GI17562908, Length=268, Percent_Identity=34.7014925373134, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17560220, Length=267, Percent_Identity=34.0823970037453, Blast_Score=102, Evalue=2e-22, Organism=Caenorhabditis elegans, GI17531453, Length=266, Percent_Identity=33.4586466165414, Blast_Score=101, Evalue=3e-22, Organism=Caenorhabditis elegans, GI17562904, Length=264, Percent_Identity=31.8181818181818, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17562906, Length=264, Percent_Identity=32.5757575757576, Blast_Score=99, Evalue=2e-21, Organism=Caenorhabditis elegans, GI17544670, Length=267, Percent_Identity=29.5880149812734, Blast_Score=98, Evalue=4e-21, Organism=Caenorhabditis elegans, GI25147288, Length=256, Percent_Identity=28.515625, Blast_Score=93, Evalue=1e-19, Organism=Caenorhabditis elegans, GI17538480, Length=264, Percent_Identity=30.3030303030303, Blast_Score=88, Evalue=3e-18, Organism=Caenorhabditis elegans, GI17555706, Length=251, Percent_Identity=29.0836653386454, Blast_Score=87, Evalue=1e-17, Organism=Caenorhabditis elegans, GI17562910, Length=266, Percent_Identity=29.6992481203008, Blast_Score=86, Evalue=2e-17, Organism=Caenorhabditis elegans, GI71994604, Length=250, Percent_Identity=30.8, Blast_Score=84, Evalue=6e-17, Organism=Caenorhabditis elegans, GI17560676, Length=245, Percent_Identity=29.3877551020408, Blast_Score=83, Evalue=1e-16, Organism=Caenorhabditis elegans, GI17560332, Length=270, Percent_Identity=30.3703703703704, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI17551412, Length=264, Percent_Identity=29.5454545454545, Blast_Score=82, Evalue=2e-16, Organism=Caenorhabditis elegans, GI71994600, Length=172, Percent_Identity=33.1395348837209, Blast_Score=81, Evalue=6e-16, Organism=Caenorhabditis elegans, GI17508651, Length=194, Percent_Identity=30.4123711340206, Blast_Score=80, Evalue=7e-16, Organism=Caenorhabditis elegans, GI17565030, Length=264, Percent_Identity=31.0606060606061, Blast_Score=80, Evalue=9e-16, Organism=Caenorhabditis elegans, GI17559104, Length=268, Percent_Identity=29.1044776119403, Blast_Score=79, Evalue=3e-15, Organism=Caenorhabditis elegans, GI17536651, Length=260, Percent_Identity=30, Blast_Score=77, Evalue=9e-15, Organism=Caenorhabditis elegans, GI212645366, Length=247, Percent_Identity=31.1740890688259, Blast_Score=76, Evalue=1e-14, Organism=Caenorhabditis elegans, GI17568967, Length=205, Percent_Identity=31.219512195122, Blast_Score=75, Evalue=3e-14, Organism=Caenorhabditis elegans, GI17538486, Length=263, Percent_Identity=28.5171102661597, Blast_Score=75, Evalue=4e-14, Organism=Caenorhabditis elegans, GI17538182, Length=229, Percent_Identity=29.2576419213974, Blast_Score=74, Evalue=5e-14, Organism=Caenorhabditis elegans, GI17508895, Length=194, Percent_Identity=28.8659793814433, Blast_Score=74, Evalue=1e-13, Organism=Caenorhabditis elegans, GI193207185, Length=147, Percent_Identity=36.0544217687075, Blast_Score=72, Evalue=3e-13, Organism=Caenorhabditis elegans, GI17561272, Length=201, Percent_Identity=25.8706467661692, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17564282, Length=190, Percent_Identity=30, Blast_Score=69, Evalue=3e-12, Organism=Caenorhabditis elegans, GI17536025, Length=262, Percent_Identity=30.1526717557252, Blast_Score=67, Evalue=6e-12, Organism=Saccharomyces cerevisiae, GI6323882, Length=222, Percent_Identity=29.2792792792793, Blast_Score=76, Evalue=6e-15, Organism=Saccharomyces cerevisiae, GI6322227, Length=197, Percent_Identity=28.4263959390863, Blast_Score=72, Evalue=8e-14, Organism=Saccharomyces cerevisiae, GI6322861, Length=191, Percent_Identity=27.7486910994764, Blast_Score=71, Evalue=2e-13, Organism=Saccharomyces cerevisiae, GI6324126, Length=255, Percent_Identity=23.1372549019608, Blast_Score=67, Evalue=3e-12, Organism=Drosophila melanogaster, GI24644339, Length=256, Percent_Identity=33.203125, Blast_Score=105, Evalue=2e-23, Organism=Drosophila melanogaster, GI21357041, Length=252, Percent_Identity=32.9365079365079, Blast_Score=103, Evalue=1e-22, Organism=Drosophila melanogaster, GI24643142, Length=250, Percent_Identity=31.6, Blast_Score=102, Evalue=2e-22, Organism=Drosophila melanogaster, GI28571526, Length=253, Percent_Identity=32.0158102766798, Blast_Score=102, Evalue=3e-22, Organism=Drosophila melanogaster, GI23397609, Length=249, Percent_Identity=33.3333333333333, Blast_Score=100, Evalue=6e-22, Organism=Drosophila melanogaster, GI24639444, Length=253, Percent_Identity=32.0158102766798, Blast_Score=99, Evalue=2e-21, Organism=Drosophila melanogaster, GI21355319, Length=255, Percent_Identity=28.6274509803922, Blast_Score=93, Evalue=2e-19, Organism=Drosophila melanogaster, GI24644337, Length=260, Percent_Identity=33.0769230769231, Blast_Score=92, Evalue=4e-19, Organism=Drosophila melanogaster, GI18859837, Length=190, Percent_Identity=32.6315789473684, Blast_Score=82, Evalue=4e-16, Organism=Drosophila melanogaster, GI21356301, Length=190, Percent_Identity=29.4736842105263, Blast_Score=71, Evalue=7e-13, Organism=Drosophila melanogaster, GI17737361, Length=236, Percent_Identity=28.8135593220339, Blast_Score=67, Evalue=8e-12, Organism=Drosophila melanogaster, GI45554248, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI24640117, Length=207, Percent_Identity=28.5024154589372, Blast_Score=65, Evalue=5e-11, Organism=Drosophila melanogaster, GI24665243, Length=216, Percent_Identity=26.8518518518519, Blast_Score=64, Evalue=7e-11, Organism=Drosophila melanogaster, GI221331218, Length=216, Percent_Identity=26.8518518518519, Blast_Score=64, Evalue=7e-11,
Paralogues:
None
Copy number: NA
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR002198 - InterPro: IPR003560 - InterPro: IPR016040 - InterPro: IPR020904 [H]
Pfam domain/function: PF00106 adh_short [H]
EC number: =1.3.1.28 [H]
Molecular weight: Translated: 26282; Mature: 26282
Theoretical pI: Translated: 4.74; Mature: 4.74
Prosite motif: PS00061 ADH_SHORT
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
0.8 %Cys (Translated Protein) 2.4 %Met (Translated Protein) 3.2 %Cys+Met (Translated Protein) 0.8 %Cys (Mature Protein) 2.4 %Met (Mature Protein) 3.2 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MDFSGKNVWVTGAGKGIGYATALTFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAGQVA CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEECCHHHHCCCCCCHHHHHHHHHCCCHHH QVCQRLLAETERLDVLINAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRR HHHHHHHHHHHHHHEEEECCHHEEECCCCCCCHHHHHHHEEEECCCHHHHHHHHHHHHHH QRGGAIVTVASDAAHTARIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTD HHCCEEEEEECCCCHHHHHCHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC MQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV CHHEEEECCCHHHHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCHHHEEE DGGSTLGA ECCCCCCC >Mature Secondary Structure MDFSGKNVWVTGAGKGIGYATALTFVEAGAKVTGFDQAFTQEQYPFATEVMDVADAGQVA CCCCCCEEEEEECCCCCHHHHHHHHHHCCCCEECCHHHHCCCCCCHHHHHHHHHCCCHHH QVCQRLLAETERLDVLINAAGILRMGATDQLSKEDWQQTFAVNVGGAFNLFQQTMNQFRR HHHHHHHHHHHHHHEEEECCHHEEECCCCCCCHHHHHHHEEEECCCHHHHHHHHHHHHHH QRGGAIVTVASDAAHTARIGMSAYGASKAALKSLALSVGLELAGSGVRCNVVSPGSTDTD HHCCEEEEEECCCCHHHHHCHHHHCCHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCC MQRTLWVSDDAEEQRIRGFGEQFKLGIPLGKIARPQEIANTILFLASDLASHITLQDIVV CHHEEEECCCHHHHHHHCCCCCEEECCCHHCCCCHHHHHHHHHHHHHHHHHHCCHHHEEE DGGSTLGA ECCCCCCC
PDB accession: NA
Resolution: NA
Structure class: Alpha Beta
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 10.0
TargetDB status: NA
Availability: NA
References: 2521622; 2521621; 9278503 [H]