Click here to switch to the map view.

The map label for this gene is ldcC

Identifier: 30061743

GI number: 30061743

Start: 200110

End: 202251

Strand: Direct

Name: ldcC

Synonym: S0179

Alternate gene names: 30061743

Gene position: 200110-202251 (Clockwise)

Preceding gene: 30061742

Following gene: 161486543

Centisome position: 4.35

GC content: 50.79

Gene sequence:

>2142_bases
ATGAACATCATTGCCATTATGGGACCGCATGGCGTCTTTTATAAAGATGAGCCCATCAAAGAACTGGAGTCGGCGCTGGT
GGCGCAAGGCTTTCAGATTATCTGGCCACAAAACAGCGTTGATTTGCTGAAATTTATCGAACATAACCCTCGAATTTGCG
GCGTGATTTTTGACTGGGATGAGTACAGTCTCGATTTATGCAGCGATATCAATCAACTTAATGAATATCTCCCGCTTTAT
GCCTTCATCAACACCCACTCGACGATGGATGTCAGCGTGCAGGATATGCGGATGGCGCTCTGGTTTTTTGAATATGCGCT
GGGGCAGGCGGAAGATATCGCCATTCGTATGCGTCAGTACACCAACGAATATCTTGATAACATTACGCCGCCGTTCACGA
AAGCCTTGTTTACCTACGTCAAAGAGCGGAAGTACACCTTTTGTACGCCGGGGCATATGGGCGGCACCGCATATCAAAAA
AGCCCGGTTGGCTGTCTGTTTTATGATTTTTTCGGCGGGAATACCCTTAAGGCTGATGTCTCTATTTCGGTCACCGAGCT
TGGTTCGTTGCTTGACCACACCGGGCCACACCTGGAAGCGGAAGAGTACATCGCGCGGACTTTTGGCGCGGAACAGAGTT
ATATCGTTACCAACGGAATATCGACGTCGAACAAAATTGTGGGTATGTACGCCGCGCCATCCGGCAGTACGCTGTTGATC
GACCGCAACTGCCATAAATCACTGGCGCATCTGTTGATGATGAACGATGTAGTGCCAGTCTGGCTGAAACCGACGCGTAA
TGCGTTGGGGATTCTGGGGGGGATCCCGCGCCGTGAATTTACTCGCGACAGCATCGAAGAGAAAGTCGCTGCCACTACGC
AAGCACAATGGCCGGTTCATGCGGTGATCACCAACTCCACCTATGATGGTTTGCTCTACAACACCGACTGGATCAAACAG
ACGCTGGATGTCCCGTCGATCCACTTCGATTCCGCCTGGGTGCCGTATACTCATTTTCATCCAATCTACCAGGGTAAAAG
TGGTATGAGCGGCGAGCGTGTTGCGGGAAAAGTTTTCTTCGAAACGCAATCGACCCACAAAATGCTGGCGGCGTTATCGC
AGGCTTCACTGATCCACATTAAAGGCGAGTATGACGAAGAGGCGTTTAACGAAGCCTTTATGATGCATACCACCACCTCG
CCCAGTTATCCCATTGTTGCTTCGGTTAAGACGGCGGCGGCGATGCTGCGTGGTAATCCGGGCAAACGGCTGATTAACCG
TTCGGTGGAGCGGGCGCTGCATTTTCGCAAAGAGGTCCAGCGGCTGCGGGAAGAGTCTGACGGTTGGTTTTTCGATATCT
GGCAACCGCCGCAGGTGGATGAAGCCGAATGCAGGCCCGTTGCGCCTGGCGAACAATGGCACGGCTTTAACGATGCGGAT
GCCGATCATATGTTTCTCGATCCGGTTAAAGTCACTATTTTGACACCGGGGATGGACGAACAGGGCAATATGAGTGAGGA
GGGGATCCCGGCGGCGCTGGTAGCAAAATTCCTCGACGAACGTGGGATCGTAGTAGAGAAAACCGGCCCTTATAACCTGC
TGTTTCTCTTTAGTATTGGCATCGATAAAACCAAAGCAATGGGATTATTGCGTGGGTTGACGGAATTTAAGCGCTCTTAC
GATCTCAACCTGCGGATCAAAAATATGCTGCCCGATCTCTATGCTGAAGATCCCGATTTCTACCGCAATATGCGTATTCA
GGATCTGGCGCAAGGGATCCATAAGCTGATTCGTAAACACGATCTTTCCGGTTTGATGTTGCGGGCATTCGATACTTTGC
CGGAAATGATCATGACGCCACATCAGGCATGGCAGAGACAGATTAAAGGTGAAGTAGAAACCATTGCGCTGGAACAACTG
GTCGGTAGAGTATCGGCAAATATGATCCTGCCTTATCCACCGGGCGTACCGCTGTTGATGCCAGGAGAAATGCTGACCAA
AGAGAGCCGCACGGTACTCGATTTTCTACTGATGCTTTGTTCCGTAGGGCAACATTACCCCGGTTTTGAAACGGATATTC
ACGGCGCGAAACAGGACGAAGACGGCGTTTACCGCGTACGAGTCCTAAAAATGGCGGGATAA

Upstream 100 bases:

>100_bases
AATTCGCAAAAGTTCTGAAAAAGGGTCACTTCGGTGGCCCTTTTTTATCGCCACGGTTTGAGCAGGCTATGATTAAGGAA
GGATTTTCCAGGAGGAACAC

Downstream 100 bases:

>100_bases
CTTGCCAGAGCGGCTTCCGGGCGAGTAACGTGCTGTTAACAAATAAAGGAGACGTTATGCTGGGTTTAAAACAGGTTCAC
CATATTGCGATTATTGCGAC

Product: lysine decarboxylase 2

Products: NA

Alternate protein names: LDC [H]

Number of amino acids: Translated: 713; Mature: 713

Protein sequence:

>713_residues
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSDINQLNEYLPLY
AFINTHSTMDVSVQDMRMALWFFEYALGQAEDIAIRMRQYTNEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGISTSNKIVGMYAAPSGSTLLI
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVHAVITNSTYDGLLYNTDWIKQ
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVFFETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTS
PSYPIVASVKTAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECRPVAPGEQWHGFNDAD
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIGIDKTKAMGLLRGLTEFKRSY
DLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKHDLSGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQL
VGRVSANMILPYPPGVPLLMPGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG

Sequences:

>Translated_713_residues
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSDINQLNEYLPLY
AFINTHSTMDVSVQDMRMALWFFEYALGQAEDIAIRMRQYTNEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGISTSNKIVGMYAAPSGSTLLI
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVHAVITNSTYDGLLYNTDWIKQ
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVFFETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTS
PSYPIVASVKTAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECRPVAPGEQWHGFNDAD
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIGIDKTKAMGLLRGLTEFKRSY
DLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKHDLSGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQL
VGRVSANMILPYPPGVPLLMPGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG
>Mature_713_residues
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWDEYSLDLCSDINQLNEYLPLY
AFINTHSTMDVSVQDMRMALWFFEYALGQAEDIAIRMRQYTNEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQK
SPVGCLFYDFFGGNTLKADVSISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGISTSNKIVGMYAAPSGSTLLI
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVHAVITNSTYDGLLYNTDWIKQ
TLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVFFETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTS
PSYPIVASVKTAAAMLRGNPGKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECRPVAPGEQWHGFNDAD
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIGIDKTKAMGLLRGLTEFKRSY
DLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKHDLSGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQL
VGRVSANMILPYPPGVPLLMPGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG

Specific function: LDC is constitutively but weakly expressed under various conditions [H]

COG id: COG1982

COG function: function code E; Arginine/lysine/ornithine decarboxylases

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the Orn/Lys/Arg decarboxylase class-I family [H]

Homologues:

Organism=Escherichia coli, GI1786384, Length=713, Percent_Identity=99.1584852734923, Blast_Score=1478, Evalue=0.0,
Organism=Escherichia coli, GI1790573, Length=710, Percent_Identity=68.5915492957746, Blast_Score=1073, Evalue=0.0,
Organism=Escherichia coli, GI221142684, Length=735, Percent_Identity=34.6938775510204, Blast_Score=450, Evalue=1e-127,
Organism=Escherichia coli, GI87082193, Length=626, Percent_Identity=33.8658146964856, Blast_Score=322, Evalue=5e-89,
Organism=Escherichia coli, GI1786909, Length=692, Percent_Identity=30.9248554913295, Blast_Score=297, Evalue=1e-81,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005308
- InterPro:   IPR011193
- InterPro:   IPR000310
- InterPro:   IPR008286
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF01276 OKR_DC_1; PF03711 OKR_DC_1_C; PF03709 OKR_DC_1_N [H]

EC number: =4.1.1.18 [H]

Molecular weight: Translated: 80595; Mature: 80595

Theoretical pI: Translated: 5.66; Mature: 5.66

Prosite motif: PS00703 OKR_DC_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.0 %Cys     (Translated Protein)
4.1 %Met     (Translated Protein)
5.0 %Cys+Met (Translated Protein)
1.0 %Cys     (Mature Protein)
4.1 %Met     (Mature Protein)
5.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSDINQLNEYLPLYAFINTHSTMDVSVQDMRMALWFFEYALGQAEDIAIRMRQY
CCCHHHHHHHHHHHHHCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TNEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQKSPVGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGISTSNKIVGMYAAPSGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCEEEE
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVH
ECCHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEE
AVITNSTYDGLLYNTDWIKQTLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVFF
EEEECCCCCCEEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
ETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTSPSYPIVASVKTAAAMLRGNP
ECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEHHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECRPVAPGEQWHGFNDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHCCCCCCCC
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKAMGLLRGLTEFKRSYDLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKH
CCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLSGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQLVGRVSANMILPYPPGVPLLM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEC
PGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC
>Mature Secondary Structure
MNIIAIMGPHGVFYKDEPIKELESALVAQGFQIIWPQNSVDLLKFIEHNPRICGVIFDWD
CCEEEEECCCCCCCCCCHHHHHHHHHHHCCCEEEECCCCHHHHHHHHCCCCEEEEEECCC
EYSLDLCSDINQLNEYLPLYAFINTHSTMDVSVQDMRMALWFFEYALGQAEDIAIRMRQY
CCCHHHHHHHHHHHHHCEEEEEEECCCEEEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHH
TNEYLDNITPPFTKALFTYVKERKYTFCTPGHMGGTAYQKSPVGCLFYDFFGGNTLKADV
HHHHHHCCCCHHHHHHHHHHHHCCCEEECCCCCCCCCCCCCCCCEEEEEECCCCEEEEEE
SISVTELGSLLDHTGPHLEAEEYIARTFGAEQSYIVTNGISTSNKIVGMYAAPSGSTLLI
EEEHHHHHHHHHCCCCCCCHHHHHHHHHCCCCCEEEECCCCCCCCEEEEEECCCCCEEEE
DRNCHKSLAHLLMMNDVVPVWLKPTRNALGILGGIPRREFTRDSIEEKVAATTQAQWPVH
ECCHHHHHHHHHHHHCCCEEEECCCCCHHHHHCCCCCCHHHHHHHHHHHHHHCCCCCCEE
AVITNSTYDGLLYNTDWIKQTLDVPSIHFDSAWVPYTHFHPIYQGKSGMSGERVAGKVFF
EEEECCCCCCEEEEHHHHHHHCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEEEE
ETQSTHKMLAALSQASLIHIKGEYDEEAFNEAFMMHTTTSPSYPIVASVKTAAAMLRGNP
ECCHHHHHHHHHCCCCEEEEECCCCHHHHCCEEEEEECCCCCCCEEEHHHHHHHHHCCCC
GKRLINRSVERALHFRKEVQRLREESDGWFFDIWQPPQVDEAECRPVAPGEQWHGFNDAD
HHHHHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCCCCCCCCCCCCCHHCCCCCCCC
ADHMFLDPVKVTILTPGMDEQGNMSEEGIPAALVAKFLDERGIVVEKTGPYNLLFLFSIG
CCCEEECCEEEEEECCCCCCCCCCCCCCCCHHHHHHHHHCCCEEEECCCCCEEEEEEEEC
IDKTKAMGLLRGLTEFKRSYDLNLRIKNMLPDLYAEDPDFYRNMRIQDLAQGIHKLIRKH
CCHHHHHHHHHHHHHHHHCCCCCEEEHHHCCHHHCCCCHHHHCCCHHHHHHHHHHHHHHC
DLSGLMLRAFDTLPEMIMTPHQAWQRQIKGEVETIALEQLVGRVSANMILPYPPGVPLLM
CCCHHHHHHHHHHHHHHCCHHHHHHHHHCCHHHHHHHHHHHHHHCCCEEEECCCCCCEEC
PGEMLTKESRTVLDFLLMLCSVGQHYPGFETDIHGAKQDEDGVYRVRVLKMAG
CCHHHHHHHHHHHHHHHHHHHCCCCCCCCCCCCCCCCCCCCCEEEEEEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9226257; 9339543; 9278503; 9723924 [H]