Click here to switch to the map view.

The map label for this gene is murC

Identifier: 30061658

GI number: 30061658

Start: 98870

End: 100345

Strand: Direct

Name: murC

Synonym: S0090

Alternate gene names: 30061658

Gene position: 98870-100345 (Clockwise)

Preceding gene: 30061657

Following gene: 30061659

Centisome position: 2.15

GC content: 54.4

Gene sequence:

>1476_bases
ATGAATACACAACAATTGGCAAAACTGCGTTCCATCGTGCCCGAAATGCGTCGCGTTCGGCACATACATTTTGTCGGCAT
TGGTGGTGCCGGTATGGGCGGTATTGCCGAAGTTCTGGCCAATGAAGGTTATCAGATCAGTGGTTCCGATTTAGCGCCAA
ATCCGGTCACGCAGCAGTTACTGAATCTGGGTGCGACGATTTATTTCAACCATCGCCCGGAAAACGTACGTGATGCCAGC
GTGGTCGTTGTTTCCAGCGCCATTTCTGCCGACAACCCGGAAATTGTCGCAGCTCATGAAGCGCGTATTCCGGTGATCCG
TCGTGCCGAAATGCTGGCTGAGTTAATGCGTTTTCGTCATGGCATCGCCATTGCAGGAACGCACGGCAAAACGACAACTA
CCGCGATGGTTTCCAGCATCTACGCAGAAGCGGGGCTCGACCCAACCTTCGTTAACGGCGGGCTGGTAAAAGCGGCGGGG
GTTCATGCGCGTTTGGGGCATGGTCGGTACCTGATTGCCGAAGCAGATGAGAGTGATGCATCGTTCCTGCATCTGCAACC
GATGGTGGCGATTGTCACCAATATCGAAGCCGACCACATGGATACCTACCAGGGCGACTTTGAGAATTTAAAACAGACCT
TTATTAATTTTCTGCACAACCTGCCTTTTTACGGTCGTGCGGTGATGTGTGTTGATGATCCGGTGATCCGCGAATTGTTA
CCGCGTGTGGGACGTCAGACCACAACTTACGGCTTCAGCGAAGATGCCGACGTGCGTGTAGAAGATTATCAGCAGATTGG
CCCGCAGGGGCACTTTACGCTGCTGCGTCAGGACAAAGAGCCGATGTGCGTCACCCTGAATGCGCCAGGCCGTCATAACG
CGCTGAACGCCGCAGCTGCGGTTGCGGTTGCTACGGAAGAGGGAATTGACGACGAGGCTATTTTGCGTGCGCTGGAGAGC
TTCCAGGGGACTGGTCGCCGTTTTGATTTCCTCGGTGAATTCCCGCTGGAGCCAGTGAATGGTAAAAGCGGTACGGCAAT
GCTGGTCGATGACTACGGCCACCACCCGACGGAAGTTGACGCCACCATTAAAGCGGCGCGCGCAGGCTGGCCGGATAAAA
ACCTGGTAATGCTGTTTCAGCCGCACCGTTTTACCCGTACGCGCGACCTGTATGATGATTTCGCCAATGTGCTGACGCAG
GTTGATACCCTGTTGATGCTGGAAGTGTATCCGGCTGGCGAAGCGCCAATTCCGGGAGCGGACAGCCGTTCGCTGTGTCG
CACAATTCGTGGACGTGGGAAAATTGATCCCATTCTGGTGCCGGACCCTGCGCAGGTAGCCGAGATGCTGGCACCGGTAT
TAACCGGTAACGACCTGATTCTCGTTCAGGGGGCTGGTAATATCGGAAAAATTGCCCGTTCTTTAGCTGAAATCAAACTG
AAGCCGCAAACTCCGGAGGAAGAACAACATGACTGA

Upstream 100 bases:

>100_bases
CCACCGAGCGAGTGGCAAATGAAGTGAGCCGGGCTGCCCGGGCGTAATTGTAGCGATGCCTTTTGCATCGTATGAATTTA
AGAAGTTAATGGCGTAAAGA

Downstream 100 bases:

>100_bases
TAAAATCGCGGTCCTGTTGGGCGGGACTTCCGCTGAGCGGGAAGTTTCTCTGAATTCTGGCGCAGCGGTGTTAGCCGGGC
TGCGTGAAGGCGGTATTGAT

Product: UDP-N-acetylmuramate--L-alanine ligase

Products: NA

Alternate protein names: UDP-N-acetylmuramoyl-L-alanine synthetase [H]

Number of amino acids: Translated: 491; Mature: 491

Protein sequence:

>491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLLNLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMCVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALES
FQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQ
VDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
KPQTPEEEQHD

Sequences:

>Translated_491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLLNLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMCVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALES
FQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQ
VDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
KPQTPEEEQHD
>Mature_491_residues
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQLLNLGATIYFNHRPENVRDAS
VVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRHGIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAG
VHARLGHGRYLIAEADESDASFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMCVTLNAPGRHNALNAAAAVAVATEEGIDDEAILRALES
FQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVDATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQ
VDTLLMLEVYPAGEAPIPGADSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
KPQTPEEEQHD

Specific function: Cell wall formation [H]

COG id: COG0773

COG function: function code M; UDP-N-acetylmuramate-alanine ligase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the MurCDEF family [H]

Homologues:

Organism=Escherichia coli, GI1786279, Length=491, Percent_Identity=99.3890020366599, Blast_Score=999, Evalue=0.0,
Organism=Escherichia coli, GI1790680, Length=479, Percent_Identity=27.9749478079332, Blast_Score=143, Evalue=2e-35,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004101
- InterPro:   IPR013221
- InterPro:   IPR000713
- InterPro:   IPR016040
- InterPro:   IPR005758 [H]

Pfam domain/function: PF01225 Mur_ligase; PF02875 Mur_ligase_C; PF08245 Mur_ligase_M [H]

EC number: =6.3.2.8 [H]

Molecular weight: Translated: 53528; Mature: 53528

Theoretical pI: Translated: 5.42; Mature: 5.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
LNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCEEEECCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMCVTLNAPGRHNALNAAAA
HHCCCCCEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCC
DSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
CHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHEEE
KPQTPEEEQHD
CCCCCCCCCCC
>Mature Secondary Structure
MNTQQLAKLRSIVPEMRRVRHIHFVGIGGAGMGGIAEVLANEGYQISGSDLAPNPVTQQL
CCHHHHHHHHHHHHHHHHHEEEEEEEECCCCHHHHHHHHHCCCCEECCCCCCCCHHHHHH
LNLGATIYFNHRPENVRDASVVVVSSAISADNPEIVAAHEARIPVIRRAEMLAELMRFRH
HHCCCEEEECCCCCCCCCCEEEEEEECCCCCCCCEEEECCCCCCHHHHHHHHHHHHHHHC
GIAIAGTHGKTTTTAMVSSIYAEAGLDPTFVNGGLVKAAGVHARLGHGRYLIAEADESDA
CEEEEECCCCHHHHHHHHHHHHHCCCCCEEECCCEEEECCCEEEECCCEEEEEECCCCCC
SFLHLQPMVAIVTNIEADHMDTYQGDFENLKQTFINFLHNLPFYGRAVMCVDDPVIRELL
CEEEHHHHHHHHHCCCCCCCCCCCCHHHHHHHHHHHHHHCCCCCCEEEEEECCHHHHHHH
PRVGRQTTTYGFSEDADVRVEDYQQIGPQGHFTLLRQDKEPMCVTLNAPGRHNALNAAAA
HHCCCCCEECCCCCCCCCCHHHHHHCCCCCCEEEEECCCCCEEEEECCCCCCCHHHHHHH
VAVATEEGIDDEAILRALESFQGTGRRFDFLGEFPLEPVNGKSGTAMLVDDYGHHPTEVD
EEEEHHCCCCHHHHHHHHHHHCCCCCEEEECCCCCCCCCCCCCCCEEEEECCCCCCCCHH
ATIKAARAGWPDKNLVMLFQPHRFTRTRDLYDDFANVLTQVDTLLMLEVYPAGEAPIPGA
HHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCCCCC
DSRSLCRTIRGRGKIDPILVPDPAQVAEMLAPVLTGNDLILVQGAGNIGKIARSLAEIKL
CHHHHHHHHHCCCCCCCEECCCHHHHHHHHHHHHCCCCEEEEECCCCHHHHHHHHHHEEE
KPQTPEEEQHD
CCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA