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The map label for this gene is kefC

Identifier: 30061614

GI number: 30061614

Start: 46574

End: 48436

Strand: Direct

Name: kefC

Synonym: S0046

Alternate gene names: 30061614

Gene position: 46574-48436 (Clockwise)

Preceding gene: 30061613

Following gene: 30061615

Centisome position: 1.01

GC content: 55.29

Gene sequence:

>1863_bases
ATGGATAGTCATACGCTGGTTCAGGCGCTGATCTACCTCGGATCGGCGGCGCTGATTGTACCCATTGCGGTACGTCTTGG
TCTGGGATCGGTACTTGGCTACCTGATCGCCGGCTGCATTATTGGCCCGTGGGGGCTGCGACTGGTGACCGATGCCGAAT
CTATTCTGCACTTTGCCGAGATTGGGGTGGTGCTGATGCTGTTTATTATCGGCCTCGAACTCGATCCACAAAGGCTGTGG
AAGCTGCGTGCGGCAGTGTTCGGCGGTGGCGCATTGCAGATGGTGATTTGCGGTGGCCTGCTGGGGCTGTTCTGTATGTT
ACTTGGGCTGCGCTGGCAGGTCGCGGAATTGATCGGTATGACGCTGGCGCTCTCATCAACGGCGATTGCCATGCAGGCGA
TGAATGAACGCAATCTGATGGTGACGCAAATGGGCCGCAGTGCCTTTGCAGTGCTGCTGTTCCAGGATATCGCGGCAATC
CCGCTGGTGGCGATGATCCCGCTACTGGCGGCGAGCAGTGCCTCGACGACGATGGGCGCATTTGCTCTCTCGGCGTTAAA
AGTGGCGGGTGCGCTGGTACTGGTGGTATTGCTGGGGCGCTATGTTACGCGTCCGGCGCTGCGTTTTGTTGCCCGCTCTG
GCTTGCGGGAAGTGTTTAGTGCCGTGGCGTTATTCCTTGTGTTTGGCTTTGGTTTGCTGCTGGAAGAGGTCGGCTTGTCG
ATGGCGATGGGCGCGTTTCTGGCGGGCGTACTGCTGGCAAGCTCGGAATACCGTCATGCGTTGGAAAGCGATATCGAACC
GTTTAAAGGTTTGCTGTTGGGGCTGTTTTTCATCGGTGTTGGCATGTCGATAGACTTTGGCACGCTGATTGAAAACCCAT
TGCGCATTGTCATTTTGCTGCTCGGTTTCCTCATCATCAAAATCGCCATGCTGTGGCTGATTGCCCGACCGTTGCAGGTG
CCAAATAAACAGCGTCGCTGGTTTGCGGTGTTGTTAGGGCAGGGCAGTGAGTTTGCCTTTGTGGTATTTGGTGCGGCGCA
GATGGCGAATGTGCTGGAGCCGGAGTGGGCGAAATCGCTGACCCTGGCGGTGGCGCTGTCGATGGCAGCAACGCCGATTC
TGCTGGTGATCCTCAATCGCCTTGAGCAATCTTCTACGGAGGAGGCGCGTGAAGCCGATGAGATCGATGAAGAACAGCCG
CGCGTGATTATCGCCGGATTCGGTCGTTTTGGACAGATTACCGGACGTTTACTGCTCTCCAGCGGGGTGAAAATGGTGGT
GCTCGATCACGATCCGGACCATATCGAAACGCTGCGTAAATTTGGTATGAAAGTGTTTTATGGCGATGCCACGCGGATGG
ATTTACTGGAATCTGCCGGAGCGGCGAAAGCGGAAGTGCTGATTAACGCTATTGACGATCCGCAAACCAACCTGCAACTG
ACGGAGATGGTGAAAGAACATTTCCCGCATTTGCAGATTATTGCCCGCGCCCGCGATGTCGATCACTACATTCGTTTGCG
TCAGGCAGGCGTTGAAAAGCCGGAGCGTGAAACCTTTGAAGGTGCGCTGAAAACCGGGCGTCTGGCGCTGGAAAGTTTAG
GTCTGGGGCCGTATGAAGCGCGAGAACGTGCCGATGTGTTCCGCCGCTTTAATATTCAGATGGTGGAAGAGATGGCAATG
GTTGAGAATGACACCAAAGCCCGCGCGGCGGTCTATAAACGCACCAGCGCGATGTTAAGTGAGATCATCACCGAGGACCG
CGAACATCTGTCATTAATTCAACGACATGGCTGGCAGGGAACAGAAGAAGGTAAACATACCGGCAACATGGCGGATGAAC
CGGAAACGAAACCCTCATCTTAA

Upstream 100 bases:

>100_bases
CCGTTTGCCATGCACTGCACCTTTATTTGTGACGACGAAACCCTCGAAGGGCAGGCGCGCCACTATAAGCAACGTCTGCT
GGAATGGCAGGAGGCCCATC

Downstream 100 bases:

>100_bases
TAAAGAGTGACGTAAATCACACTTTACAGCTAACTGTTTGTTTTTGTTTCATTGTAATGCGGCGAGTCCAGGGGGAGAGC
GTGGACTCGCCAGCAGAATA

Product: glutathione-regulated potassium-efflux system protein KefC

Products: Proton [Cytoplasm]; K (I) [Periplasm] [C]

Alternate protein names: K(+)/H(+) antiporter [H]

Number of amino acids: Translated: 620; Mature: 620

Protein sequence:

>620_residues
MDSHTLVQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLW
KLRAAVFGGGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLIENPLRIVILLLGFLIIKIAMLWLIARPLQV
PNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQP
RVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
TEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAM
VENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS

Sequences:

>Translated_620_residues
MDSHTLVQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLW
KLRAAVFGGGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLIENPLRIVILLLGFLIIKIAMLWLIARPLQV
PNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQP
RVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
TEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAM
VENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS
>Mature_620_residues
MDSHTLVQALIYLGSAALIVPIAVRLGLGSVLGYLIAGCIIGPWGLRLVTDAESILHFAEIGVVLMLFIIGLELDPQRLW
KLRAAVFGGGALQMVICGGLLGLFCMLLGLRWQVAELIGMTLALSSTAIAMQAMNERNLMVTQMGRSAFAVLLFQDIAAI
PLVAMIPLLAASSASTTMGAFALSALKVAGALVLVVLLGRYVTRPALRFVARSGLREVFSAVALFLVFGFGLLLEEVGLS
MAMGAFLAGVLLASSEYRHALESDIEPFKGLLLGLFFIGVGMSIDFGTLIENPLRIVILLLGFLIIKIAMLWLIARPLQV
PNKQRRWFAVLLGQGSEFAFVVFGAAQMANVLEPEWAKSLTLAVALSMAATPILLVILNRLEQSSTEEAREADEIDEEQP
RVIIAGFGRFGQITGRLLLSSGVKMVVLDHDPDHIETLRKFGMKVFYGDATRMDLLESAGAAKAEVLINAIDDPQTNLQL
TEMVKEHFPHLQIIARARDVDHYIRLRQAGVEKPERETFEGALKTGRLALESLGLGPYEARERADVFRRFNIQMVEEMAM
VENDTKARAAVYKRTSAMLSEIITEDREHLSLIQRHGWQGTEEGKHTGNMADEPETKPSS

Specific function: Transport system that facilitates potassium-efflux, possibly by potassium-proton antiport [H]

COG id: COG0475

COG function: function code P; Kef-type K+ transport systems, membrane components

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 RCK N-terminal domain [H]

Homologues:

Organism=Homo sapiens, GI157388921, Length=383, Percent_Identity=25.5874673629243, Blast_Score=90, Evalue=5e-18,
Organism=Escherichia coli, GI1786232, Length=620, Percent_Identity=99.3548387096774, Blast_Score=1231, Evalue=0.0,
Organism=Escherichia coli, GI1789749, Length=607, Percent_Identity=43.8220757825371, Blast_Score=464, Evalue=1e-132,
Organism=Escherichia coli, GI1786685, Length=519, Percent_Identity=29.2870905587669, Blast_Score=158, Evalue=1e-39,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR006153
- InterPro:   IPR004771
- InterPro:   IPR006036
- InterPro:   IPR016040
- InterPro:   IPR003148 [H]

Pfam domain/function: PF00999 Na_H_Exchanger; PF02254 TrkA_N [H]

EC number: NA

Molecular weight: Translated: 67707; Mature: 67707

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.5 %Cys     (Translated Protein)
4.2 %Met     (Translated Protein)
4.7 %Cys+Met (Translated Protein)
0.5 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
4.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure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CCCCCCCCCCCCCCCCCCCC
>Mature Secondary Structure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CCCCCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; K (I) [Cytoplasm] [C]

Specific reaction: Proton [Periplasm] + K (I) [Cytoplasm] = Proton [Cytoplasm] + K (I) [Periplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: NA