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The map label for this gene is cytR [H]

Identifier: 29349021

GI number: 29349021

Start: 4681882

End: 4682925

Strand: Reverse

Name: cytR [H]

Synonym: BT_3613

Alternate gene names: 29349021

Gene position: 4682925-4681882 (Counterclockwise)

Preceding gene: 29349026

Following gene: 29349017

Centisome position: 74.8

GC content: 46.46

Gene sequence:

>1044_bases
ATGGAAAACCGGAAACATACTTCACTCAAAGACCTCGCCCAAGCATTAGGCGTATCCATCCCTACTGTATCCCGAGCGCT
GAAAGACAGCCCGGAAATCAGCCGTGAACTTTGCGCCAAAGCCAAGAAGCTGGCCAAAGAGATGAATTATCGTCCCAATC
CTTTCGCTATGAGTCTGCGAAAGAATGCGCCGCGCATCATCGGAGTGATCGTTCCGGATATTGTCACTCATTTCTTTGCC
TCCATTCTGAACGGGATAGAGAACATGGCGATCGATAACGGATATTTCGTCATTATCACGACATCGCACGAGTCTTTCGA
GCATGAAAAAAGGAATATAGAGAATCTGGTCAATATGCGGGTAGAGGGGATTATCGCCTGCCTGTCTCAGGAAACAACTG
ACTTTTCTCATTTTGCCGCATTGAAAGAGATCAATATGCCGCTGATTCTGTTCGACCGTGTTTGCCTGACCGATCAATTC
TCGTCAGTAATAGCAGACGGAGCACAATCCGCACAAATGGCTACCCAGCATCTGCTGGACAATGGAAGTAAACGGGTGGC
TTTTATCGGCGGTGCCAATCATCTGGATATTGTAAAAAGAAGGAAGCACGGTTATCTGGAAGCCTTGCGCGATAATCGGA
TTCCGATTGAAAAGGAATTAGTTGTCTGCCGGAAAATTGATTATGAGGAAGGACAGATTGCTACGGAAACATTATTATCT
CTCCCCCAGCCTCCCGATGCCATCCTTGCCATGAATGACACATTGGCTTTTGCCGCCATGGAAGTAATCAAAAGGCACGG
ACTTCGTATTCCCGACGATATCGCCATCATCGGATACACGGATGAGCAGCACGCCAATTATGTGGAACCCAAGTTATCTG
CCGTATCGCATCAGACTTATAAGATGGGGGAAACAGCGTGTCAACTGCTGATTGATCAAATTAAGGGAGACAGGACGGTC
AAGCAAGTGGTGATTCCGACACATTTGCAGATAAGGGAGAGTAGCATTAAGGAGAATAATAAAAAAAATGCTGTATCTAC
GTAA

Upstream 100 bases:

>100_bases
AAGCTACGTAACGGTTTACGTAAAAAATATTTCTTTAAATGCGGAGATTTATCAGGGAATATGCTTTCTTTGCAGATAAA
TCTAAGTTGGAGACCTTCAG

Downstream 100 bases:

>100_bases
TATAGATACAGCACCTTTTACATATAGAGAGTTTTATCTTATTATTTCAACTCCGCTTCAGTATTAGCAAAATCAAGCAA
TGTGATATCAAAGACAAGAG

Product: LacI family transcriptional regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 347; Mature: 347

Protein sequence:

>347_residues
MENRKHTSLKDLAQALGVSIPTVSRALKDSPEISRELCAKAKKLAKEMNYRPNPFAMSLRKNAPRIIGVIVPDIVTHFFA
SILNGIENMAIDNGYFVIITTSHESFEHEKRNIENLVNMRVEGIIACLSQETTDFSHFAALKEINMPLILFDRVCLTDQF
SSVIADGAQSAQMATQHLLDNGSKRVAFIGGANHLDIVKRRKHGYLEALRDNRIPIEKELVVCRKIDYEEGQIATETLLS
LPQPPDAILAMNDTLAFAAMEVIKRHGLRIPDDIAIIGYTDEQHANYVEPKLSAVSHQTYKMGETACQLLIDQIKGDRTV
KQVVIPTHLQIRESSIKENNKKNAVST

Sequences:

>Translated_347_residues
MENRKHTSLKDLAQALGVSIPTVSRALKDSPEISRELCAKAKKLAKEMNYRPNPFAMSLRKNAPRIIGVIVPDIVTHFFA
SILNGIENMAIDNGYFVIITTSHESFEHEKRNIENLVNMRVEGIIACLSQETTDFSHFAALKEINMPLILFDRVCLTDQF
SSVIADGAQSAQMATQHLLDNGSKRVAFIGGANHLDIVKRRKHGYLEALRDNRIPIEKELVVCRKIDYEEGQIATETLLS
LPQPPDAILAMNDTLAFAAMEVIKRHGLRIPDDIAIIGYTDEQHANYVEPKLSAVSHQTYKMGETACQLLIDQIKGDRTV
KQVVIPTHLQIRESSIKENNKKNAVST
>Mature_347_residues
MENRKHTSLKDLAQALGVSIPTVSRALKDSPEISRELCAKAKKLAKEMNYRPNPFAMSLRKNAPRIIGVIVPDIVTHFFA
SILNGIENMAIDNGYFVIITTSHESFEHEKRNIENLVNMRVEGIIACLSQETTDFSHFAALKEINMPLILFDRVCLTDQF
SSVIADGAQSAQMATQHLLDNGSKRVAFIGGANHLDIVKRRKHGYLEALRDNRIPIEKELVVCRKIDYEEGQIATETLLS
LPQPPDAILAMNDTLAFAAMEVIKRHGLRIPDDIAIIGYTDEQHANYVEPKLSAVSHQTYKMGETACQLLIDQIKGDRTV
KQVVIPTHLQIRESSIKENNKKNAVST

Specific function: This protein negatively controls the transcription initiation of genes such as deoCABD, udp, and cdd encoding catabolizing enzymes and nupC, nupG, and tsx encoding transporting and pore-forming proteins. Binds cytidine and adenosine as effectors [H]

COG id: COG1609

COG function: function code K; Transcriptional regulators

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH lacI-type DNA-binding domain [H]

Homologues:

Organism=Escherichia coli, GI1790369, Length=310, Percent_Identity=31.2903225806452, Blast_Score=176, Evalue=2e-45,
Organism=Escherichia coli, GI1790194, Length=308, Percent_Identity=29.2207792207792, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1788474, Length=335, Percent_Identity=28.3582089552239, Blast_Score=142, Evalue=4e-35,
Organism=Escherichia coli, GI1787948, Length=319, Percent_Identity=25.705329153605, Blast_Score=137, Evalue=1e-33,
Organism=Escherichia coli, GI1789202, Length=295, Percent_Identity=26.1016949152542, Blast_Score=132, Evalue=5e-32,
Organism=Escherichia coli, GI1789068, Length=319, Percent_Identity=26.0188087774295, Blast_Score=116, Evalue=2e-27,
Organism=Escherichia coli, GI48994940, Length=327, Percent_Identity=26.2996941896024, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1787580, Length=333, Percent_Identity=25.5255255255255, Blast_Score=111, Evalue=6e-26,
Organism=Escherichia coli, GI1786540, Length=343, Percent_Identity=26.530612244898, Blast_Score=109, Evalue=2e-25,
Organism=Escherichia coli, GI1786268, Length=316, Percent_Identity=24.0506329113924, Blast_Score=105, Evalue=6e-24,
Organism=Escherichia coli, GI1787906, Length=340, Percent_Identity=24.4117647058824, Blast_Score=99, Evalue=3e-22,
Organism=Escherichia coli, GI1790715, Length=317, Percent_Identity=24.6056782334385, Blast_Score=92, Evalue=5e-20,
Organism=Escherichia coli, GI1789456, Length=346, Percent_Identity=23.121387283237, Blast_Score=77, Evalue=2e-15,
Organism=Escherichia coli, GI1790689, Length=352, Percent_Identity=24.7159090909091, Blast_Score=68, Evalue=1e-12,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000843
- InterPro:   IPR010982
- InterPro:   IPR001761 [H]

Pfam domain/function: PF00356 LacI; PF00532 Peripla_BP_1 [H]

EC number: NA

Molecular weight: Translated: 38807; Mature: 38807

Theoretical pI: Translated: 7.38; Mature: 7.38

Prosite motif: PS50932 HTH_LACI_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.9 %Met     (Translated Protein)
4.3 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MENRKHTSLKDLAQALGVSIPTVSRALKDSPEISRELCAKAKKLAKEMNYRPNPFAMSLR
CCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEHHH
KNAPRIIGVIVPDIVTHFFASILNGIENMAIDNGYFVIITTSHESFEHEKRNIENLVNMR
CCCCEEEEEHHHHHHHHHHHHHHHHHHHCEECCCEEEEEECCCHHHHHHHHHHHHHHHHH
VEGIIACLSQETTDFSHFAALKEINMPLILFDRVCLTDQFSSVIADGAQSAQMATQHLLD
HHHHHHHHHCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
NGSKRVAFIGGANHLDIVKRRKHGYLEALRDNRIPIEKELVVCRKIDYEEGQIATETLLS
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHC
LPQPPDAILAMNDTLAFAAMEVIKRHGLRIPDDIAIIGYTDEQHANYVEPKLSAVSHQTY
CCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
KMGETACQLLIDQIKGDRTVKQVVIPTHLQIRESSIKENNKKNAVST
HHHHHHHHHHHHHHCCCCHHHHEECCCHHHHHHHHHHCCCCCCCCCC
>Mature Secondary Structure
MENRKHTSLKDLAQALGVSIPTVSRALKDSPEISRELCAKAKKLAKEMNYRPNPFAMSLR
CCCCCCCCHHHHHHHHCCCCHHHHHHHCCCHHHHHHHHHHHHHHHHHCCCCCCCCEEHHH
KNAPRIIGVIVPDIVTHFFASILNGIENMAIDNGYFVIITTSHESFEHEKRNIENLVNMR
CCCCEEEEEHHHHHHHHHHHHHHHHHHHCEECCCEEEEEECCCHHHHHHHHHHHHHHHHH
VEGIIACLSQETTDFSHFAALKEINMPLILFDRVCLTDQFSSVIADGAQSAQMATQHLLD
HHHHHHHHHCCCCCHHHHHHHHHCCCCEEEHHHHHHHHHHHHHHHCCHHHHHHHHHHHHC
NGSKRVAFIGGANHLDIVKRRKHGYLEALRDNRIPIEKELVVCRKIDYEEGQIATETLLS
CCCCEEEEEECCCHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHCCCCCCCHHHHHHHC
LPQPPDAILAMNDTLAFAAMEVIKRHGLRIPDDIAIIGYTDEQHANYVEPKLSAVSHQTY
CCCCCCCEEEECHHHHHHHHHHHHHCCCCCCCCEEEEECCCCCCCCCCCHHHHHHHHHHH
KMGETACQLLIDQIKGDRTVKQVVIPTHLQIRESSIKENNKKNAVST
HHHHHHHHHHHHHHCCCCHHHHEECCCHHHHHHHHHHCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]