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The map label for this gene is ptpA [H]

Identifier: 29348663

GI number: 29348663

Start: 4153514

End: 4155712

Strand: Reverse

Name: ptpA [H]

Synonym: BT_3254

Alternate gene names: 29348663

Gene position: 4155712-4153514 (Counterclockwise)

Preceding gene: 29348664

Following gene: 29348662

Centisome position: 66.38

GC content: 51.57

Gene sequence:

>2199_bases
ATGAGTAAAATTGGAAAAAGAGCCATTCTGATATTGCTGGCGCTACCAATCGGATTCAATGTTATGGCACAGGAAATCAA
AAAGCTGACACTGGAAGACTTGATTCCGGGCGGCGAGACCTACCGTTATGCAGAAAACCTCTACGGTCTGCAATGGTGGG
GAGACGTGTGTATCAAACCAAGTACCGACACCATCTACACTGTTCAACCCAGAACAGGGAAAGAGACAGTGCTGACTACC
CTCGGACAAATCAACAAAGTACTGGCAGACAATAAAGCAGGGAAACTGCCGACCCCGTACTCAATCCGCTACCCGTGGGC
GGACAAACCGCAAATGTTACTGAAAGTATCCGGTAAGTACATCGTATACGATTTCGAGAACAACCGGATTGTCAGCACAC
TGAAGTTGAAAGATAAAGCAGCCAACGAAGATTATTGCGTCGCCAACGGAAACGTAGCCTACACAGTCAACAACAACCTG
TATGTGAACGAACAGGCAATCACCGACGAACCCGAAGGCATCGTCTGCGGGCAATCCGTCCACCGCAATGAGTTCGGCAT
CAACAAAGGCACCTTCTGGAGCCCGAAAGGCAACCTGCTCGCTTTCTACCGCATGGACGAAAGCATGGTGACGCAATACC
CGCTTGTAGACATCACGGCACGTGTAGGAGAAGTGAATAACGTCCGTTACCCGATGGCAGGAATGACCAGCCACCAAGTA
AAAGTAGGCGTCTACAACCCCTCCACCGGTAAGACCATCTATCTGAATGCAGGTGATCCGACCGACCGTTACTTCACCAA
TATCAGCTGGTCACCGGACGAAAAGAGCATCTACCTTATCGAACTGAACCGCGACCAGAACCACGCCGTACTTTGCCAAT
ATGACGCAACGACAGGCAAGTTACTGAGCAAACTGCTGGAAGAAACGCACCCCAAATATGTAGAGCCTCAGCACCCCATC
GTATTCTTACCGTGGGACAGCAGCAAATTCATCTACCAGAGCCAGCGTGACGGATATAACCATCTATATTTATGCGACCT
CACCTCCAGCCTCAAAGGCGAATGGAAAAGCGATGCCGCAGGCGGCAAGCACATCGAATACATCCCGACGAAGCAACTGA
CCGAGGGCAAATGGCTGGTAGGCGACATTCTGGGCTTCAACGCCAAGAGGAAAGAAGTCATCTTCCAAGGAGTAGATGGC
ACAGGCTCCAATAACTTTGCAGTAAATGTCAACACAGGAAAGTGCAGCCTCCCGTTCAGCTTCCGTTCTATCACAGAAGG
AGAACATAACGGAATGCTCAGCGCATCGGGAAGCTACCTCATCGACCGTTATTCGACTCCCACCCTTCCGCGCCGCATTG
ACATCGTGGATACCAAAAGCCTGAAAACAGTCAACCTGCTGACAGCCAAAGACCCATACGAAGGCTACGAGATGCCGACC
ATCGAAACCGGTACTATCAAAGCCGACGACGGAACGACCGACCTATACTACCGCCTCACCAAACCCGCAGATTTCGACCC
GAACAAAAAGTATCCGGTCATCGTCTACGTATACGGCGGCCCGCACGCACAACTCGTCACCGGTGGTTGGCTGAACGGCT
CCCGCGGATGGGATATCTATATGGCTAACAAAGGCTATATCATGTTCACCCTCGACAACCGCGGCAGTGCCAACCGTGGA
CTGGAATTCGAAAACGCCACCTTCCGCCGCCTCGGCATCGAAGAAGGCAAAGACCAGGTGAAAGGCATTGAATTTCTGAA
ATCCCTCCCCTACATAGACGGAAACCGCATCGGTGTACACGGATGGAGCTTCGGAGGCCACATGACCACTGCCCTGCTGC
TCCGCTACCCCGAAATATTCAAGGTAGGCGTAGCAGGCGGACCTGTCATCGACTGGGGATATTACGAAGTGATGTACGGC
GAACGTTACATGGACACTCCGGAAAGCAATCCGGAAGGCTACAAAGAATGTAATCTGAAGAACCTTGCCGGACAGCTGAA
AGGTCATCTGCTCATTATCCATGACGACCACGATGACACTTGCGTACCGCAGCACACACTGTCGTTCATGAAAGCCTGTG
TAGATGCCCGCACCTACCCCGACCTGTTTATCTATCCGTGCCACAAGCACAACGTATCAGGCCGCGACCGTGTACATCTG
CACGAAAAAATCACCCGATACTTTGAGCAGAACCTATAG

Upstream 100 bases:

>100_bases
TGAATATCTCGAAAAAGACGTATCATCCGACAGAGAAAGACAACTCTCCTGAACAGGGTAAAATAGAAGGATTTAAAACC
AATAAAGATAAATAAAAGCA

Downstream 100 bases:

>100_bases
CAATCTATAGTTGACAGCTCACAGCATCATACCGAAAAACTCATAACTGAAAACTCATAACTTAATACTCATTATGAAGA
TATTATTACTAGGCTCGGGC

Product: dipeptidyl peptidase IV

Products: NA

Alternate protein names: PTP; Prolyl tripeptidyl peptidase A [H]

Number of amino acids: Translated: 732; Mature: 731

Protein sequence:

>732_residues
MSKIGKRAILILLALPIGFNVMAQEIKKLTLEDLIPGGETYRYAENLYGLQWWGDVCIKPSTDTIYTVQPRTGKETVLTT
LGQINKVLADNKAGKLPTPYSIRYPWADKPQMLLKVSGKYIVYDFENNRIVSTLKLKDKAANEDYCVANGNVAYTVNNNL
YVNEQAITDEPEGIVCGQSVHRNEFGINKGTFWSPKGNLLAFYRMDESMVTQYPLVDITARVGEVNNVRYPMAGMTSHQV
KVGVYNPSTGKTIYLNAGDPTDRYFTNISWSPDEKSIYLIELNRDQNHAVLCQYDATTGKLLSKLLEETHPKYVEPQHPI
VFLPWDSSKFIYQSQRDGYNHLYLCDLTSSLKGEWKSDAAGGKHIEYIPTKQLTEGKWLVGDILGFNAKRKEVIFQGVDG
TGSNNFAVNVNTGKCSLPFSFRSITEGEHNGMLSASGSYLIDRYSTPTLPRRIDIVDTKSLKTVNLLTAKDPYEGYEMPT
IETGTIKADDGTTDLYYRLTKPADFDPNKKYPVIVYVYGGPHAQLVTGGWLNGSRGWDIYMANKGYIMFTLDNRGSANRG
LEFENATFRRLGIEEGKDQVKGIEFLKSLPYIDGNRIGVHGWSFGGHMTTALLLRYPEIFKVGVAGGPVIDWGYYEVMYG
ERYMDTPESNPEGYKECNLKNLAGQLKGHLLIIHDDHDDTCVPQHTLSFMKACVDARTYPDLFIYPCHKHNVSGRDRVHL
HEKITRYFEQNL

Sequences:

>Translated_732_residues
MSKIGKRAILILLALPIGFNVMAQEIKKLTLEDLIPGGETYRYAENLYGLQWWGDVCIKPSTDTIYTVQPRTGKETVLTT
LGQINKVLADNKAGKLPTPYSIRYPWADKPQMLLKVSGKYIVYDFENNRIVSTLKLKDKAANEDYCVANGNVAYTVNNNL
YVNEQAITDEPEGIVCGQSVHRNEFGINKGTFWSPKGNLLAFYRMDESMVTQYPLVDITARVGEVNNVRYPMAGMTSHQV
KVGVYNPSTGKTIYLNAGDPTDRYFTNISWSPDEKSIYLIELNRDQNHAVLCQYDATTGKLLSKLLEETHPKYVEPQHPI
VFLPWDSSKFIYQSQRDGYNHLYLCDLTSSLKGEWKSDAAGGKHIEYIPTKQLTEGKWLVGDILGFNAKRKEVIFQGVDG
TGSNNFAVNVNTGKCSLPFSFRSITEGEHNGMLSASGSYLIDRYSTPTLPRRIDIVDTKSLKTVNLLTAKDPYEGYEMPT
IETGTIKADDGTTDLYYRLTKPADFDPNKKYPVIVYVYGGPHAQLVTGGWLNGSRGWDIYMANKGYIMFTLDNRGSANRG
LEFENATFRRLGIEEGKDQVKGIEFLKSLPYIDGNRIGVHGWSFGGHMTTALLLRYPEIFKVGVAGGPVIDWGYYEVMYG
ERYMDTPESNPEGYKECNLKNLAGQLKGHLLIIHDDHDDTCVPQHTLSFMKACVDARTYPDLFIYPCHKHNVSGRDRVHL
HEKITRYFEQNL
>Mature_731_residues
SKIGKRAILILLALPIGFNVMAQEIKKLTLEDLIPGGETYRYAENLYGLQWWGDVCIKPSTDTIYTVQPRTGKETVLTTL
GQINKVLADNKAGKLPTPYSIRYPWADKPQMLLKVSGKYIVYDFENNRIVSTLKLKDKAANEDYCVANGNVAYTVNNNLY
VNEQAITDEPEGIVCGQSVHRNEFGINKGTFWSPKGNLLAFYRMDESMVTQYPLVDITARVGEVNNVRYPMAGMTSHQVK
VGVYNPSTGKTIYLNAGDPTDRYFTNISWSPDEKSIYLIELNRDQNHAVLCQYDATTGKLLSKLLEETHPKYVEPQHPIV
FLPWDSSKFIYQSQRDGYNHLYLCDLTSSLKGEWKSDAAGGKHIEYIPTKQLTEGKWLVGDILGFNAKRKEVIFQGVDGT
GSNNFAVNVNTGKCSLPFSFRSITEGEHNGMLSASGSYLIDRYSTPTLPRRIDIVDTKSLKTVNLLTAKDPYEGYEMPTI
ETGTIKADDGTTDLYYRLTKPADFDPNKKYPVIVYVYGGPHAQLVTGGWLNGSRGWDIYMANKGYIMFTLDNRGSANRGL
EFENATFRRLGIEEGKDQVKGIEFLKSLPYIDGNRIGVHGWSFGGHMTTALLLRYPEIFKVGVAGGPVIDWGYYEVMYGE
RYMDTPESNPEGYKECNLKNLAGQLKGHLLIIHDDHDDTCVPQHTLSFMKACVDARTYPDLFIYPCHKHNVSGRDRVHLH
EKITRYFEQNL

Specific function: Serine proteinase. Releases tripeptides from the free amino terminus of proteins. Has a requirement for Pro in the P1 position, but is inactivated by Pro in the P1' position [H]

COG id: COG1506

COG function: function code E; Dipeptidyl aminopeptidases/acylaminoacyl-peptidases

Gene ontology:

Cell location: Cytoplasmic

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S9B family [H]

Homologues:

Organism=Homo sapiens, GI18450280, Length=633, Percent_Identity=26.6982622432859, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI37577089, Length=633, Percent_Identity=26.6982622432859, Blast_Score=176, Evalue=6e-44,
Organism=Homo sapiens, GI18765694, Length=667, Percent_Identity=26.2368815592204, Blast_Score=170, Evalue=6e-42,
Organism=Homo sapiens, GI85787627, Length=651, Percent_Identity=25.0384024577573, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI295842403, Length=651, Percent_Identity=25.0384024577573, Blast_Score=165, Evalue=1e-40,
Organism=Homo sapiens, GI295842359, Length=651, Percent_Identity=25.0384024577573, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI52426756, Length=651, Percent_Identity=25.0384024577573, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI295849272, Length=651, Percent_Identity=25.0384024577573, Blast_Score=165, Evalue=2e-40,
Organism=Homo sapiens, GI16933540, Length=788, Percent_Identity=24.746192893401, Blast_Score=162, Evalue=8e-40,
Organism=Homo sapiens, GI194394146, Length=421, Percent_Identity=29.2161520190024, Blast_Score=158, Evalue=2e-38,
Organism=Homo sapiens, GI86792863, Length=561, Percent_Identity=25.4901960784314, Blast_Score=141, Evalue=2e-33,
Organism=Homo sapiens, GI86792778, Length=561, Percent_Identity=25.4901960784314, Blast_Score=141, Evalue=3e-33,
Organism=Homo sapiens, GI86792774, Length=561, Percent_Identity=25.4901960784314, Blast_Score=140, Evalue=3e-33,
Organism=Homo sapiens, GI37577091, Length=632, Percent_Identity=23.4177215189873, Blast_Score=108, Evalue=1e-23,
Organism=Caenorhabditis elegans, GI17508019, Length=245, Percent_Identity=33.0612244897959, Blast_Score=153, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17508017, Length=245, Percent_Identity=33.0612244897959, Blast_Score=153, Evalue=4e-37,
Organism=Caenorhabditis elegans, GI17550672, Length=668, Percent_Identity=24.1017964071856, Blast_Score=123, Evalue=4e-28,
Organism=Caenorhabditis elegans, GI17564632, Length=282, Percent_Identity=31.5602836879433, Blast_Score=118, Evalue=1e-26,
Organism=Caenorhabditis elegans, GI17564634, Length=282, Percent_Identity=31.5602836879433, Blast_Score=118, Evalue=1e-26,
Organism=Saccharomyces cerevisiae, GI6321817, Length=660, Percent_Identity=24.0909090909091, Blast_Score=151, Evalue=3e-37,
Organism=Saccharomyces cerevisiae, GI6324793, Length=580, Percent_Identity=24.1379310344828, Blast_Score=134, Evalue=4e-32,
Organism=Drosophila melanogaster, GI45550825, Length=641, Percent_Identity=24.6489859594384, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45553511, Length=641, Percent_Identity=24.6489859594384, Blast_Score=163, Evalue=3e-40,
Organism=Drosophila melanogaster, GI45551969, Length=650, Percent_Identity=24.7692307692308, Blast_Score=163, Evalue=4e-40,
Organism=Drosophila melanogaster, GI17933704, Length=632, Percent_Identity=25.6329113924051, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI221331178, Length=632, Percent_Identity=25.6329113924051, Blast_Score=150, Evalue=3e-36,
Organism=Drosophila melanogaster, GI161083744, Length=634, Percent_Identity=25.7097791798107, Blast_Score=149, Evalue=9e-36,
Organism=Drosophila melanogaster, GI24582257, Length=259, Percent_Identity=33.5907335907336, Blast_Score=138, Evalue=1e-32,
Organism=Drosophila melanogaster, GI24582032, Length=607, Percent_Identity=25.5354200988468, Blast_Score=120, Evalue=3e-27,
Organism=Drosophila melanogaster, GI221372266, Length=308, Percent_Identity=25, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI45551475, Length=224, Percent_Identity=26.7857142857143, Blast_Score=100, Evalue=6e-21,
Organism=Drosophila melanogaster, GI221372263, Length=303, Percent_Identity=25.0825082508251, Blast_Score=100, Evalue=6e-21,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001375
- InterPro:   IPR002469 [H]

Pfam domain/function: PF00930 DPPIV_N; PF00326 Peptidase_S9 [H]

EC number: =3.4.14.12 [H]

Molecular weight: Translated: 82595; Mature: 82464

Theoretical pI: Translated: 7.03; Mature: 7.03

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.4 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.4 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
3.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKIGKRAILILLALPIGFNVMAQEIKKLTLEDLIPGGETYRYAENLYGLQWWGDVCIKP
CCCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCEEEEC
STDTIYTVQPRTGKETVLTTLGQINKVLADNKAGKLPTPYSIRYPWADKPQMLLKVSGKY
CCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEEECCCE
IVYDFENNRIVSTLKLKDKAANEDYCVANGNVAYTVNNNLYVNEQAITDEPEGIVCGQSV
EEEECCCCEEEEEEEEECCCCCCCEEEECCCEEEEECCCEEECCCCCCCCCCCEEECCCC
HRNEFGINKGTFWSPKGNLLAFYRMDESMVTQYPLVDITARVGEVNNVRYPMAGMTSHQV
CCCCCCCCCCCEECCCCCEEEEEECCHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCEE
KVGVYNPSTGKTIYLNAGDPTDRYFTNISWSPDEKSIYLIELNRDQNHAVLCQYDATTGK
EEEEECCCCCCEEEEECCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEEECCCHHH
LLSKLLEETHPKYVEPQHPIVFLPWDSSKFIYQSQRDGYNHLYLCDLTSSLKGEWKSDAA
HHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCEEEEEECCHHHCCCCCCCCC
GGKHIEYIPTKQLTEGKWLVGDILGFNAKRKEVIFQGVDGTGSNNFAVNVNTGKCSLPFS
CCCEEEEECCCCCCCCCEEEEHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCEEECCCC
FRSITEGEHNGMLSASGSYLIDRYSTPTLPRRIDIVDTKSLKTVNLLTAKDPYEGYEMPT
HHHCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCE
IETGTIKADDGTTDLYYRLTKPADFDPNKKYPVIVYVYGGPHAQLVTGGWLNGSRGWDIY
EECCEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEE
MANKGYIMFTLDNRGSANRGLEFENATFRRLGIEEGKDQVKGIEFLKSLPYIDGNRIGVH
EECCCEEEEEECCCCCCCCCEEECCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
GWSFGGHMTTALLLRYPEIFKVGVAGGPVIDWGYYEVMYGERYMDTPESNPEGYKECNLK
EECCCCHHHHHHHHCCCCCEEEECCCCCEEECCEEEEEECCEECCCCCCCCCCHHHCCHH
NLAGQLKGHLLIIHDDHDDTCVPQHTLSFMKACVDARTYPDLFIYPCHKHNVSGRDRVHL
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEHH
HEKITRYFEQNL
HHHHHHHHHHCC
>Mature Secondary Structure 
SKIGKRAILILLALPIGFNVMAQEIKKLTLEDLIPGGETYRYAENLYGLQWWGDVCIKP
CCCHHHEEEEEEECCCCHHHHHHHHHHHHHHHCCCCCCCCHHHHHCCCEEEECCEEEEC
STDTIYTVQPRTGKETVLTTLGQINKVLADNKAGKLPTPYSIRYPWADKPQMLLKVSGKY
CCCCEEEECCCCCCHHHHHHHHHHHHHHHCCCCCCCCCCEEEECCCCCCCCEEEEECCCE
IVYDFENNRIVSTLKLKDKAANEDYCVANGNVAYTVNNNLYVNEQAITDEPEGIVCGQSV
EEEECCCCEEEEEEEEECCCCCCCEEEECCCEEEEECCCEEECCCCCCCCCCCEEECCCC
HRNEFGINKGTFWSPKGNLLAFYRMDESMVTQYPLVDITARVGEVNNVRYPMAGMTSHQV
CCCCCCCCCCCEECCCCCEEEEEECCHHHHHCCCEEEEEEECCCCCCEECCCCCCCCCEE
KVGVYNPSTGKTIYLNAGDPTDRYFTNISWSPDEKSIYLIELNRDQNHAVLCQYDATTGK
EEEEECCCCCCEEEEECCCCCCCEEEECCCCCCCCEEEEEEECCCCCCEEEEEECCCHHH
LLSKLLEETHPKYVEPQHPIVFLPWDSSKFIYQSQRDGYNHLYLCDLTSSLKGEWKSDAA
HHHHHHHHCCCCCCCCCCCEEEEECCCCCEEEECCCCCCCEEEEEECCHHHCCCCCCCCC
GGKHIEYIPTKQLTEGKWLVGDILGFNAKRKEVIFQGVDGTGSNNFAVNVNTGKCSLPFS
CCCEEEEECCCCCCCCCEEEEHHHCCCCCCCEEEEEECCCCCCCCEEEEEECCEEECCCC
FRSITEGEHNGMLSASGSYLIDRYSTPTLPRRIDIVDTKSLKTVNLLTAKDPYEGYEMPT
HHHCCCCCCCCEEECCCCEEEEECCCCCCCCEEEEEECCCCEEEEEEEECCCCCCCCCCE
IETGTIKADDGTTDLYYRLTKPADFDPNKKYPVIVYVYGGPHAQLVTGGWLNGSRGWDIY
EECCEEECCCCCCEEEEEECCCCCCCCCCCCCEEEEEECCCCEEEEECCCCCCCCCEEEE
MANKGYIMFTLDNRGSANRGLEFENATFRRLGIEEGKDQVKGIEFLKSLPYIDGNRIGVH
EECCCEEEEEECCCCCCCCCEEECCCCEEECCCCCCHHHHHHHHHHHHCCCCCCCEEEEE
GWSFGGHMTTALLLRYPEIFKVGVAGGPVIDWGYYEVMYGERYMDTPESNPEGYKECNLK
EECCCCHHHHHHHHCCCCCEEEECCCCCEEECCEEEEEECCEECCCCCCCCCCHHHCCHH
NLAGQLKGHLLIIHDDHDDTCVPQHTLSFMKACVDARTYPDLFIYPCHKHNVSGRDRVHL
HHHHHCCCCEEEEECCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCCCCCEEHH
HEKITRYFEQNL
HHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA