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The map label for this gene is ispD [H]

Identifier: 29348290

GI number: 29348290

Start: 3601234

End: 3601950

Strand: Reverse

Name: ispD [H]

Synonym: BT_2881

Alternate gene names: 29348290

Gene position: 3601950-3601234 (Counterclockwise)

Preceding gene: 29348291

Following gene: 29348289

Centisome position: 57.54

GC content: 39.33

Gene sequence:

>717_bases
ATGAATATAGCATTGATTATTGCAGGGGGATCCGGCAACCGGATGGGACAAGATATTCCAAAACAGTTTATTCATGTGGA
TAATTGTCCGGTTATTGTACATACAATGTTAGCTTTCCAAAGACATCCGGACATAACTGCTGTTGCTGTTGTTTGTTTAG
GTGGATGGGAAACTGTGTTGTCTTCATACGCTCATCAGTATAATGTATCAAAGTTACGTTGGATATTTGCTGGGGGGATA
AATGGTCAGGAATCAATTAGTAACGGCATATACGGTTTAAAAAAGAACGGTGTCAAAAAGGATGATCTGGTTTTGATTCA
TGATGCGGTTCGTCCACTGGTATCTCAGAGTATTATATCTTCCAATATCGCAATTTGTAAGCAGTATGGTTATGCTATCA
CTGGTATTCAGTGTAGGGAGGCTATTTTGGAAAGTGATGATGGCTTTTGTTCTGTGACAAGTATTCCGCGTGATAAATTG
ATAAGAACGCAGACACCCCAGACTTTTCGGTTAGAAAATATTATAAATGTCCATGAGCAGGCAAAATCAAAAGGTATCAT
AAACTCAGTATCTTCTTGTACTCTTTTGGCGGAATTGGGCGGATATGAAATGCATATAGTTCCGGGAGAGGAGCGAAATA
TAAAGATTACGACTACGGAAGACCTGGAGATTTTCAAGGTTTTGAGGCAAACGTCAAAAGAAGACTGGCTGAAATGA

Upstream 100 bases:

>100_bases
AAAGTTGTGCGTGAATGAGTTTTATCAGATAAAGGATTTCTGCAAAAGAAAGAAGAATGGATAACATTATAATAGTATTA
AATTCAAATCTGTTACTAAA

Downstream 100 bases:

>100_bases
TGACTTATTATGACGATATCAGAAAAGTGCAGGATTTGCATCTGCCGTGGGAAATTCTGACTGATATAAATATTCTGATT
GTGGGGGCCTCAGGTCTGAT

Product: 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase

Products: NA

Alternate protein names: 4-diphosphocytidyl-2C-methyl-D-erythritol synthase; MEP cytidylyltransferase; MCT [H]

Number of amino acids: Translated: 238; Mature: 238

Protein sequence:

>238_residues
MNIALIIAGGSGNRMGQDIPKQFIHVDNCPVIVHTMLAFQRHPDITAVAVVCLGGWETVLSSYAHQYNVSKLRWIFAGGI
NGQESISNGIYGLKKNGVKKDDLVLIHDAVRPLVSQSIISSNIAICKQYGYAITGIQCREAILESDDGFCSVTSIPRDKL
IRTQTPQTFRLENIINVHEQAKSKGIINSVSSCTLLAELGGYEMHIVPGEERNIKITTTEDLEIFKVLRQTSKEDWLK

Sequences:

>Translated_238_residues
MNIALIIAGGSGNRMGQDIPKQFIHVDNCPVIVHTMLAFQRHPDITAVAVVCLGGWETVLSSYAHQYNVSKLRWIFAGGI
NGQESISNGIYGLKKNGVKKDDLVLIHDAVRPLVSQSIISSNIAICKQYGYAITGIQCREAILESDDGFCSVTSIPRDKL
IRTQTPQTFRLENIINVHEQAKSKGIINSVSSCTLLAELGGYEMHIVPGEERNIKITTTEDLEIFKVLRQTSKEDWLK
>Mature_238_residues
MNIALIIAGGSGNRMGQDIPKQFIHVDNCPVIVHTMLAFQRHPDITAVAVVCLGGWETVLSSYAHQYNVSKLRWIFAGGI
NGQESISNGIYGLKKNGVKKDDLVLIHDAVRPLVSQSIISSNIAICKQYGYAITGIQCREAILESDDGFCSVTSIPRDKL
IRTQTPQTFRLENIINVHEQAKSKGIINSVSSCTLLAELGGYEMHIVPGEERNIKITTTEDLEIFKVLRQTSKEDWLK

Specific function: Catalyzes the formation of 4-diphosphocytidyl-2-C- methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4- phosphate (MEP) [H]

COG id: COG1211

COG function: function code I; 4-diphosphocytidyl-2-methyl-D-erithritol synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ispD family [H]

Homologues:

Organism=Homo sapiens, GI157412259, Length=223, Percent_Identity=26.0089686098655, Blast_Score=79, Evalue=3e-15,
Organism=Homo sapiens, GI157671913, Length=131, Percent_Identity=32.0610687022901, Blast_Score=72, Evalue=6e-13,
Organism=Escherichia coli, GI1789104, Length=236, Percent_Identity=25.8474576271186, Blast_Score=69, Evalue=2e-13,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001228 [H]

Pfam domain/function: PF01128 IspD [H]

EC number: =2.7.7.60 [H]

Molecular weight: Translated: 26324; Mature: 26324

Theoretical pI: Translated: 7.50; Mature: 7.50

Prosite motif: PS01295 ISPD

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.5 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
4.2 %Cys+Met (Translated Protein)
2.5 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
4.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNIALIIAGGSGNRMGQDIPKQFIHVDNCPVIVHTMLAFQRHPDITAVAVVCLGGWETVL
CEEEEEEECCCCCCCCHHHHHHHEECCCCHHHHHHHHHHHCCCCHHEEHHHHHCCHHHHH
SSYAHQYNVSKLRWIFAGGINGQESISNGIYGLKKNGVKKDDLVLIHDAVRPLVSQSIIS
HHHHHHCCHHHEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHH
SNIAICKQYGYAITGIQCREAILESDDGFCSVTSIPRDKLIRTQTPQTFRLENIINVHEQ
HHHHHHHHCCCEECCHHHHHHHHCCCCCEEEECCCCHHHHEECCCCCEEEHHHHHHHHHH
AKSKGIINSVSSCTLLAELGGYEMHIVPGEERNIKITTTEDLEIFKVLRQTSKEDWLK
HHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCHHHCCC
>Mature Secondary Structure
MNIALIIAGGSGNRMGQDIPKQFIHVDNCPVIVHTMLAFQRHPDITAVAVVCLGGWETVL
CEEEEEEECCCCCCCCHHHHHHHEECCCCHHHHHHHHHHHCCCCHHEEHHHHHCCHHHHH
SSYAHQYNVSKLRWIFAGGINGQESISNGIYGLKKNGVKKDDLVLIHDAVRPLVSQSIIS
HHHHHHCCHHHEEEEEECCCCCHHHHHCCCCCCCCCCCCCCCEEEEHHHHHHHHHHHHHH
SNIAICKQYGYAITGIQCREAILESDDGFCSVTSIPRDKLIRTQTPQTFRLENIINVHEQ
HHHHHHHHCCCEECCHHHHHHHHCCCCCEEEECCCCHHHHEECCCCCEEEHHHHHHHHHH
AKSKGIINSVSSCTLLAELGGYEMHIVPGEERNIKITTTEDLEIFKVLRQTSKEDWLK
HHHCCHHHHHHHHHHHHHCCCEEEEEECCCCCCEEEEECCCHHHHHHHHHCCHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA