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The map label for this gene is yjhH [H]

Identifier: 29348223

GI number: 29348223

Start: 3495718

End: 3496647

Strand: Reverse

Name: yjhH [H]

Synonym: BT_2814

Alternate gene names: 29348223

Gene position: 3496647-3495718 (Counterclockwise)

Preceding gene: 29348235

Following gene: 29348222

Centisome position: 55.85

GC content: 45.59

Gene sequence:

>930_bases
ATGAATAACAAAATGAATATTCCTTTATCAGGAATTATTCCTCCGTTGGTAACTCCCTTGTTGGACGATGATGTGTTGGA
TGTGGAAGGTTTGCAAAGATTGATCGAACATCTGATAGCAGGGGGAGTACATGCTCTTTTTGTGTTGGGAACTACCGGTG
AATCACAGAGCCTCAGTTATAAATTGAGGATGGAAATGATTAAAAATACCTGCCGTATAGCGAAAGGACGGTTGCCGGTA
TTGGTATGTATTTCCGATACTTCGATTGTGGAGAGTGTGAACCTTGCCTGCCTTGCGGCAGATCATGGAGCCGATGCCGT
CGTTTCCGCTCCTCCTTACTACTTTGCGACAGGTCAGCCCGAACTGATCGAGTTTTATGAGCATCTGCTGCCTCAGTTGC
CGTTACCATTATTCTTGTATAATATGCCGACTCATACAAAGGTGAACTTTGCACCGGCTACGATTCAGCGGATAGCGGAG
AATCCCGGCGTAATCGGTTTTAAAGACAGTTCGGCAAATACGGTTTATTTCCAGTCGGTGATGTATGCCATGAAAGATAA
TCCGGATTTCTCGATGCTGGTGGGACCGGAAGAAATTATGGCGGAATCCGTACTGCTGGGGGCTCATGGCGGCGTAAACG
GTGGTGCGAATATGTTCCCCGAATTGTATGTGAGCTTATACAACGCTGCGAAGAATGCAGATATGGAAGAAGTGAGACGT
TTGCAGGAAAAAGTAATGCAAATCAGTGCTACGATATATACGGTAGGGCAACATGGGTCCAGTTACCTGAAAGGTCTGAA
ATGTGCTCTCAGTCTACTCGGAATATGCAGCGATTATGTGGCTGCGCCTTTCCATAAGTTCGAACAACGGGAAAGAGGAA
AAATATGGAAGGCACTTCAAAATTTGGGAGTTGATGTAGTGCTCAGGTAA

Upstream 100 bases:

>100_bases
CTTTTCTTCAGATATGGAATAATGTGATTACAAAATGCTAAATACCCCGTCTTATTAGTATCATTAATAACAATCATATA
CAAATTAAAAGAATCAGACT

Downstream 100 bases:

>100_bases
TTAATCAAGAAAAAATGAACGGCTATGTCTATTCTCGACATTATTATCTTTTTATTCTTCACGGGGGGAGTTGTTGTCTT
CGGCTGCTCTTTCTTCAACA

Product: dihydrodipicolinate synthase

Products: dihydrodipicolinate; H2O

Alternate protein names: NA

Number of amino acids: Translated: 309; Mature: 309

Protein sequence:

>309_residues
MNNKMNIPLSGIIPPLVTPLLDDDVLDVEGLQRLIEHLIAGGVHALFVLGTTGESQSLSYKLRMEMIKNTCRIAKGRLPV
LVCISDTSIVESVNLACLAADHGADAVVSAPPYYFATGQPELIEFYEHLLPQLPLPLFLYNMPTHTKVNFAPATIQRIAE
NPGVIGFKDSSANTVYFQSVMYAMKDNPDFSMLVGPEEIMAESVLLGAHGGVNGGANMFPELYVSLYNAAKNADMEEVRR
LQEKVMQISATIYTVGQHGSSYLKGLKCALSLLGICSDYVAAPFHKFEQRERGKIWKALQNLGVDVVLR

Sequences:

>Translated_309_residues
MNNKMNIPLSGIIPPLVTPLLDDDVLDVEGLQRLIEHLIAGGVHALFVLGTTGESQSLSYKLRMEMIKNTCRIAKGRLPV
LVCISDTSIVESVNLACLAADHGADAVVSAPPYYFATGQPELIEFYEHLLPQLPLPLFLYNMPTHTKVNFAPATIQRIAE
NPGVIGFKDSSANTVYFQSVMYAMKDNPDFSMLVGPEEIMAESVLLGAHGGVNGGANMFPELYVSLYNAAKNADMEEVRR
LQEKVMQISATIYTVGQHGSSYLKGLKCALSLLGICSDYVAAPFHKFEQRERGKIWKALQNLGVDVVLR
>Mature_309_residues
MNNKMNIPLSGIIPPLVTPLLDDDVLDVEGLQRLIEHLIAGGVHALFVLGTTGESQSLSYKLRMEMIKNTCRIAKGRLPV
LVCISDTSIVESVNLACLAADHGADAVVSAPPYYFATGQPELIEFYEHLLPQLPLPLFLYNMPTHTKVNFAPATIQRIAE
NPGVIGFKDSSANTVYFQSVMYAMKDNPDFSMLVGPEEIMAESVLLGAHGGVNGGANMFPELYVSLYNAAKNADMEEVRR
LQEKVMQISATIYTVGQHGSSYLKGLKCALSLLGICSDYVAAPFHKFEQRERGKIWKALQNLGVDVVLR

Specific function: Unknown

COG id: COG0329

COG function: function code EM; Dihydrodipicolinate synthase/N-acetylneuraminate lyase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the DHDPS family [H]

Homologues:

Organism=Homo sapiens, GI31543060, Length=289, Percent_Identity=23.8754325259516, Blast_Score=84, Evalue=1e-16,
Organism=Homo sapiens, GI13540533, Length=215, Percent_Identity=26.9767441860465, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI87082415, Length=299, Percent_Identity=29.7658862876254, Blast_Score=152, Evalue=2e-38,
Organism=Escherichia coli, GI1786463, Length=242, Percent_Identity=30.5785123966942, Blast_Score=135, Evalue=5e-33,
Organism=Escherichia coli, GI1789620, Length=274, Percent_Identity=27.007299270073, Blast_Score=114, Evalue=8e-27,
Organism=Escherichia coli, GI1788823, Length=301, Percent_Identity=24.5847176079734, Blast_Score=109, Evalue=2e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013785
- InterPro:   IPR002220
- InterPro:   IPR020625
- InterPro:   IPR020624 [H]

Pfam domain/function: PF00701 DHDPS [H]

EC number: 4.2.1.52

Molecular weight: Translated: 33844; Mature: 33844

Theoretical pI: Translated: 5.85; Mature: 5.85

Prosite motif: PS00666 DHDPS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
5.5 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
5.5 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNNKMNIPLSGIIPPLVTPLLDDDVLDVEGLQRLIEHLIAGGVHALFVLGTTGESQSLSY
CCCCCCCCHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHH
KLRMEMIKNTCRIAKGRLPVLVCISDTSIVESVNLACLAADHGADAVVSAPPYYFATGQP
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCEEEEEECCCCCCEEECCCEEEECCCH
ELIEFYEHLLPQLPLPLFLYNMPTHTKVNFAPATIQRIAENPGVIGFKDSSANTVYFQSV
HHHHHHHHHHCCCCCCEEEECCCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCHHHHHH
MYAMKDNPDFSMLVGPEEIMAESVLLGAHGGVNGGANMFPELYVSLYNAAKNADMEEVRR
HHHHCCCCCEEEEECHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
LQEKVMQISATIYTVGQHGSSYLKGLKCALSLLGICSDYVAAPFHKFEQRERGKIWKALQ
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLGVDVVLR
HCCEEEEEC
>Mature Secondary Structure
MNNKMNIPLSGIIPPLVTPLLDDDVLDVEGLQRLIEHLIAGGVHALFVLGTTGESQSLSY
CCCCCCCCHHHCHHHHHHHHCCCCCCCHHHHHHHHHHHHHCCCEEEEEEECCCCCCCHHH
KLRMEMIKNTCRIAKGRLPVLVCISDTSIVESVNLACLAADHGADAVVSAPPYYFATGQP
HHHHHHHHHHHHHHCCCCCEEEEECCCHHHHHCCEEEEEECCCCCCEEECCCEEEECCCH
ELIEFYEHLLPQLPLPLFLYNMPTHTKVNFAPATIQRIAENPGVIGFKDSSANTVYFQSV
HHHHHHHHHHCCCCCCEEEECCCCCCEEEECHHHHHHHHCCCCEEEEECCCCCCHHHHHH
MYAMKDNPDFSMLVGPEEIMAESVLLGAHGGVNGGANMFPELYVSLYNAAKNADMEEVRR
HHHHCCCCCEEEEECHHHHHHHHHHEECCCCCCCCHHHHHHHHHHHHHHHCCCCHHHHHH
LQEKVMQISATIYTVGQHGSSYLKGLKCALSLLGICSDYVAAPFHKFEQRERGKIWKALQ
HHHHHHHHHHHEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
NLGVDVVLR
HCCEEEEEC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: L-aspartate 4-semialdehyde; pyruvate

Specific reaction: L-aspartate 4-semialdehyde + pyruvate = dihydrodipicolinate + 2 H2O

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 7610040; 9278503 [H]