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The map label for this gene is ahcY [H]

Identifier: 29348206

GI number: 29348206

Start: 3470274

End: 3471704

Strand: Reverse

Name: ahcY [H]

Synonym: BT_2797

Alternate gene names: 29348206

Gene position: 3471704-3470274 (Counterclockwise)

Preceding gene: 29348207

Following gene: 29348205

Centisome position: 55.46

GC content: 47.38

Gene sequence:

>1431_bases
ATGATTTACAATATGTCTACAGAATTATTCTCTACTCTGCCTTATAAAGTGGCAGATATTACACTTGCTGATTTCGGACG
CAAGGAAATCGATTTGGCAGAAAAAGAAATGCCCGGCCTGATGGCTCTACGCGAAAAGTATGGAGAATCCAAACCGTTAA
AAGGTGCCCGTATCATGGGATCATTACATATGACCATCCAGACCGCCGTACTGATTGAAACACTGGTTGCATTGGGAGCT
GAAGTCCGCTGGTGCTCTTGTAATATATATTCAACGCAGGATCATGCTGCTGCTGCGATTGCTGCTTCCGGTGTTGCGGT
ATTTGCATGGAAAGGCGAGAATCTTGCCGACTACTGGTGGTGCACATTGCAGGCATTGAACTTCCCCGGCGGAAAAGGTC
CGAATGTGATTGTAGACGATGGTGGTGACGCTACAATGATGATTCATGTCGGTTATGATGCCGAGAATGATGCTGCCGTA
TTGGACAAGGAAGTGCATGCGGAGGATGAAATCGAACTGAATGCCATTCTGAAAAAAGTATTGGCTGAGGATAAGACTCG
CTGGCATCGTGTGGCTGAGGAAATGCGCGGCGTATCGGAAGAGACAACGACCGGTGTACACCGTTTGTATCAGATGCAGG
AAGAAGGCAAATTGCTGTTCCCGGCATTTAATGTGAACGATTCGGTTACCAAGTCTAAGTTTGATAATCTCTACGGATGT
CGTGAGTCACTGGCTGACGGTATCAAGAGAGCGACCGATGTGATGATTGCCGGTAAGGTAGTGGTGGTATGTGGTTACGG
TGATGTGGGCAAGGGATGTTCGCATTCAATGCGCTCTTATGGTGCGCGTGTGCTTGTGACGGAAGTCGATCCGATTTGTG
CGTTGCAGGCTGCTATGGAAGGTTTCGAAGTCGTAACGATGGAAGATGCCTGCACCGAAGGTAATATCTTCGTGACTACT
ACGGGGAATATCGATATCATTCGCATTGACCACATGGAGAAAATGAAAGATCAGGCGATCGTATGTAACATCGGCCACTT
TGATAATGAAATCCAGGTGGATGCGTTGAAACATTATTCGGGCATCAAATGTGTAAACATCAAGCCGCAGGTAGACCGCT
ATTATTTCCCGGATGGTCACAGCATTCTTTTGCTGGCTGACGGTCGTCTGGTGAATTTGGGATGTGCGACAGGCCATCCG
TCATTCGTGATGAGTAACTCATTTACCAATCAGACGCTGGCCCAGATCGAGTTGTTCAACAAGAAATACGAAGTAAATGT
ATACCGCTTGCCGAAGCACCTGGATGAAGAAGTGGCTCGCCTGCATCTCGAAAAGATCGGGGTGAAACTGACGAAGCTGA
CTCCGGAACAGGCCGCTTATATCGGTGTATCGGTAGACGGACCTTATAAGGCTGAACATTATAGATACTAA

Upstream 100 bases:

>100_bases
GCCAATGGGAGCCCGGTGTAAGTGTTTTTTTTATAAAAAAGAAGGATAGCTTTTGCCCTACTAATCAGAATGTTCTATCT
TTGCATCAATTACATTTTAA

Downstream 100 bases:

>100_bases
TTTAATTGACAATTGACAGTTGACAAATGACAATGAACAGCTATATGGAACGAGTGATCTGCCGGGCTGTTATTGTTGAC
CATCAATTGTCAATTGTCAA

Product: S-adenosyl-L-homocysteine hydrolase

Products: NA

Alternate protein names: S-adenosyl-L-homocysteine hydrolase; AdoHcyase [H]

Number of amino acids: Translated: 476; Mature: 476

Protein sequence:

>476_residues
MIYNMSTELFSTLPYKVADITLADFGRKEIDLAEKEMPGLMALREKYGESKPLKGARIMGSLHMTIQTAVLIETLVALGA
EVRWCSCNIYSTQDHAAAAIAASGVAVFAWKGENLADYWWCTLQALNFPGGKGPNVIVDDGGDATMMIHVGYDAENDAAV
LDKEVHAEDEIELNAILKKVLAEDKTRWHRVAEEMRGVSEETTTGVHRLYQMQEEGKLLFPAFNVNDSVTKSKFDNLYGC
RESLADGIKRATDVMIAGKVVVVCGYGDVGKGCSHSMRSYGARVLVTEVDPICALQAAMEGFEVVTMEDACTEGNIFVTT
TGNIDIIRIDHMEKMKDQAIVCNIGHFDNEIQVDALKHYSGIKCVNIKPQVDRYYFPDGHSILLLADGRLVNLGCATGHP
SFVMSNSFTNQTLAQIELFNKKYEVNVYRLPKHLDEEVARLHLEKIGVKLTKLTPEQAAYIGVSVDGPYKAEHYRY

Sequences:

>Translated_476_residues
MIYNMSTELFSTLPYKVADITLADFGRKEIDLAEKEMPGLMALREKYGESKPLKGARIMGSLHMTIQTAVLIETLVALGA
EVRWCSCNIYSTQDHAAAAIAASGVAVFAWKGENLADYWWCTLQALNFPGGKGPNVIVDDGGDATMMIHVGYDAENDAAV
LDKEVHAEDEIELNAILKKVLAEDKTRWHRVAEEMRGVSEETTTGVHRLYQMQEEGKLLFPAFNVNDSVTKSKFDNLYGC
RESLADGIKRATDVMIAGKVVVVCGYGDVGKGCSHSMRSYGARVLVTEVDPICALQAAMEGFEVVTMEDACTEGNIFVTT
TGNIDIIRIDHMEKMKDQAIVCNIGHFDNEIQVDALKHYSGIKCVNIKPQVDRYYFPDGHSILLLADGRLVNLGCATGHP
SFVMSNSFTNQTLAQIELFNKKYEVNVYRLPKHLDEEVARLHLEKIGVKLTKLTPEQAAYIGVSVDGPYKAEHYRY
>Mature_476_residues
MIYNMSTELFSTLPYKVADITLADFGRKEIDLAEKEMPGLMALREKYGESKPLKGARIMGSLHMTIQTAVLIETLVALGA
EVRWCSCNIYSTQDHAAAAIAASGVAVFAWKGENLADYWWCTLQALNFPGGKGPNVIVDDGGDATMMIHVGYDAENDAAV
LDKEVHAEDEIELNAILKKVLAEDKTRWHRVAEEMRGVSEETTTGVHRLYQMQEEGKLLFPAFNVNDSVTKSKFDNLYGC
RESLADGIKRATDVMIAGKVVVVCGYGDVGKGCSHSMRSYGARVLVTEVDPICALQAAMEGFEVVTMEDACTEGNIFVTT
TGNIDIIRIDHMEKMKDQAIVCNIGHFDNEIQVDALKHYSGIKCVNIKPQVDRYYFPDGHSILLLADGRLVNLGCATGHP
SFVMSNSFTNQTLAQIELFNKKYEVNVYRLPKHLDEEVARLHLEKIGVKLTKLTPEQAAYIGVSVDGPYKAEHYRY

Specific function: May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine [H]

COG id: COG0499

COG function: function code H; S-adenosylhomocysteine hydrolase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: NA

Operon status: Not Known

Operon components: None

Similarity: Belongs to the adenosylhomocysteinase family [H]

Homologues:

Organism=Homo sapiens, GI9951915, Length=466, Percent_Identity=63.0901287553648, Blast_Score=567, Evalue=1e-161,
Organism=Homo sapiens, GI239937451, Length=442, Percent_Identity=62.6696832579185, Blast_Score=533, Evalue=1e-151,
Organism=Homo sapiens, GI298286489, Length=465, Percent_Identity=48.6021505376344, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI195539337, Length=465, Percent_Identity=48.6021505376344, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI24308043, Length=465, Percent_Identity=48.6021505376344, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI195539349, Length=465, Percent_Identity=48.6021505376344, Blast_Score=447, Evalue=1e-125,
Organism=Homo sapiens, GI21361647, Length=465, Percent_Identity=47.741935483871, Blast_Score=430, Evalue=1e-120,
Organism=Caenorhabditis elegans, GI17506425, Length=467, Percent_Identity=61.4561027837259, Blast_Score=559, Evalue=1e-159,
Organism=Saccharomyces cerevisiae, GI6320882, Length=479, Percent_Identity=61.1691022964509, Blast_Score=545, Evalue=1e-156,
Organism=Drosophila melanogaster, GI24642172, Length=469, Percent_Identity=63.1130063965885, Blast_Score=565, Evalue=1e-161,
Organism=Drosophila melanogaster, GI24656245, Length=455, Percent_Identity=48.7912087912088, Blast_Score=442, Evalue=1e-124,
Organism=Drosophila melanogaster, GI45553387, Length=464, Percent_Identity=48.0603448275862, Blast_Score=422, Evalue=1e-118,
Organism=Drosophila melanogaster, GI45553385, Length=463, Percent_Identity=47.9481641468683, Blast_Score=419, Evalue=1e-117,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000043
- InterPro:   IPR015878
- InterPro:   IPR020082 [H]

Pfam domain/function: PF05221 AdoHcyase; PF00670 AdoHcyase_NAD [H]

EC number: =3.3.1.1 [H]

Molecular weight: Translated: 52740; Mature: 52740

Theoretical pI: Translated: 5.24; Mature: 5.24

Prosite motif: PS00738 ADOHCYASE_1 ; PS00739 ADOHCYASE_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

2.3 %Cys     (Translated Protein)
3.6 %Met     (Translated Protein)
5.9 %Cys+Met (Translated Protein)
2.3 %Cys     (Mature Protein)
3.6 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIYNMSTELFSTLPYKVADITLADFGRKEIDLAEKEMPGLMALREKYGESKPLKGARIMG
CEECCCHHHHHHCCCEEEEEEHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEE
SLHMTIQTAVLIETLVALGAEVRWCSCNIYSTQDHAAAAIAASGVAVFAWKGENLADYWW
EEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHEECCEEEEEECCCCCCHHEE
CTLQALNFPGGKGPNVIVDDGGDATMMIHVGYDAENDAAVLDKEVHAEDEIELNAILKKV
EEEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
LAEDKTRWHRVAEEMRGVSEETTTGVHRLYQMQEEGKLLFPAFNVNDSVTKSKFDNLYGC
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
RESLADGIKRATDVMIAGKVVVVCGYGDVGKGCSHSMRSYGARVLVTEVDPICALQAAME
HHHHHHHHHHHHHEEEECEEEEEECCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHC
GFEVVTMEDACTEGNIFVTTTGNIDIIRIDHMEKMKDQAIVCNIGHFDNEIQVDALKHYS
CCEEEEEECCCCCCCEEEEECCCEEEEEECCHHHCCCCEEEEEECCCCCEEEEEEHHCCC
GIKCVNIKPQVDRYYFPDGHSILLLADGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFN
CEEEEECCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCHHHHHHHEEC
KKYEVNVYRLPKHLDEEVARLHLEKIGVKLTKLTPEQAAYIGVSVDGPYKAEHYRY
CEEEEEEEECCHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEECCCCCCCCCCCC
>Mature Secondary Structure
MIYNMSTELFSTLPYKVADITLADFGRKEIDLAEKEMPGLMALREKYGESKPLKGARIMG
CEECCCHHHHHHCCCEEEEEEHHHCCCCCCCHHHHCCCHHHHHHHHHCCCCCCCCCEEEE
SLHMTIQTAVLIETLVALGAEVRWCSCNIYSTQDHAAAAIAASGVAVFAWKGENLADYWW
EEHHHHHHHHHHHHHHHCCCCEEEEEEEEECCCCHHHHHHEECCEEEEEECCCCCCHHEE
CTLQALNFPGGKGPNVIVDDGGDATMMIHVGYDAENDAAVLDKEVHAEDEIELNAILKKV
EEEEEEECCCCCCCEEEEECCCCEEEEEEECCCCCCCHHHHHHHCCCCCCHHHHHHHHHH
LAEDKTRWHRVAEEMRGVSEETTTGVHRLYQMQEEGKLLFPAFNVNDSVTKSKFDNLYGC
HHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHCCCCEEEEEECCCCCHHHHHHHHHHHH
RESLADGIKRATDVMIAGKVVVVCGYGDVGKGCSHSMRSYGARVLVTEVDPICALQAAME
HHHHHHHHHHHHHEEEECEEEEEECCCCCCCCHHHHHHHCCCEEEEEECCHHHHHHHHHC
GFEVVTMEDACTEGNIFVTTTGNIDIIRIDHMEKMKDQAIVCNIGHFDNEIQVDALKHYS
CCEEEEEECCCCCCCEEEEECCCEEEEEECCHHHCCCCEEEEEECCCCCEEEEEEHHCCC
GIKCVNIKPQVDRYYFPDGHSILLLADGRLVNLGCATGHPSFVMSNSFTNQTLAQIELFN
CEEEEECCCCCCEEECCCCCEEEEEECCEEEEEEECCCCCCEEEECCCCCHHHHHHHEEC
KKYEVNVYRLPKHLDEEVARLHLEKIGVKLTKLTPEQAAYIGVSVDGPYKAEHYRY
CEEEEEEEECCHHHHHHHHHHHHHHHCEEEEEECCCCCEEEEEECCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA