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The map label for this gene is atoC [H]

Identifier: 29347843

GI number: 29347843

Start: 3046175

End: 3047515

Strand: Reverse

Name: atoC [H]

Synonym: BT_2433

Alternate gene names: 29347843

Gene position: 3047515-3046175 (Counterclockwise)

Preceding gene: 29347846

Following gene: 29347842

Centisome position: 48.68

GC content: 45.34

Gene sequence:

>1341_bases
ATGAGTAAAATTCTTATCATTGACGATGAGGTTCAGATTCGTAGCCTGTTGGCTCGTATGCTCGGACTGGAGGGTTATGA
GGTGTGTCAGGCGGGTGATTGCAAGGCAGCTATCAGGCAGTTGGAAATTCAACAGCCGGATGTGGCTTTGTGTGATGTCT
TTCTTCCCGATGGAAACGGGGTCGATCTGGTGTTGAACATTAAAAAGACAGCTCCGAATGTGGAAGTCATTCTTCTTACC
GCTCACGGTAATATACCCGACGGAGTGCAGGCAATCAAGAACGGTGCATTTGATTATATAACCAAAGGGGACGATAATAA
TAAGATTATCCCTCTGATCAGTCGTGCCGTTGAGAAGGCTAAGATGAATGTCCGGTTAGAGAAACTGGAAAAGAAAGTCA
GTCAGCTATATTCTTTTGATTCCATTCTGGGAGAATCGAAAGTGCTGAAAGAAGCTGTTATGCTGGCACAGAAGGTTTCG
GTGACTGATGTTCCGGTGTTGTTGACCGGAGAAACGGGGACCGGAAAAGAAGTATTTGCACAAGCCATACATTATAATAG
TAAGCGGAGCAAACAGAGCTTTGTTGCCGTGAACTGTTCGTCTTTCAGTAAGGAACTGCTGGAGAGTGAAATGTTCGGGC
ATAAAGCCGGGTCCTTCACCGGAGCTTTGAAGGACAAGAAAGGACTCTTCGAAGAAGCCAACAACGGTACGATCTTTTTG
GATGAAATCGGAGAAATGGCTTTTGAACTACAGGCCAAATTGCTGCGTATTCTCGAAACAGGCGAATATATAAAGATAGG
AGATACGAAACCGACGCACGTGAATGTTCGTATTATTGCTGCTACCAACCGCAATCTGACAGAGGAAATCAAAGCGGGAC
GTTTCCGTGAAGACCTGTTTTATCGTCTTTCGGTATTTCAGGTACATCTGCCGGCACTTCGCGAACGTACCGGTGATATC
AGAATTCTTGCCACTGCCTTTGCAAAGAGCTTTTCCGAGAAACTTTCGTATACGGTCAATGAGATGACTCCTGCTTTTCT
TCATGCGTTGGAACAGCAACCCTGGAAAGGAAATATCCGTGAATTGCGGAATGTGATAGAACGGAGTCTGATTGTCTGCG
AAGGCGGGCATCTGGATGTGTGCGATCTTCCGTTGGAGATTCAGAATACTCATTATGAATGTTCGGATGATAATATCGGT
AGTTTTGAACTGGCTGCTATGGAACGAAGGCATATTGCCCGCGTCCTGGAATATACGAAAGGCAACAAGACGGAAACTGC
CCGCTTGCTGAAGATCGGTCTTACCACTTTGTACAGGAAGATAGAGGAATACAAAATATAA

Upstream 100 bases:

>100_bases
GGAAATAACAATAAAGTAGGGAGAATTGTTCTCGGATCATAGAAAAAAGACTTATATTTGCGCACCCTGTTTGTCTTTCT
TCATTTTTTATAAATTAATT

Downstream 100 bases:

>100_bases
TAATATGACTATCTGATTTCTTTTTTAGGGGTATATGAGCGATTAATCGTTCATATACTGATCTGTAATGTGAAAAAGAA
ATAGAAGATATGAATATTTG

Product: two-component system response regulator

Products: NA

Alternate protein names: Ornithine decarboxylase antizyme; Ornithine/arginine decarboxylase inhibitor [H]

Number of amino acids: Translated: 446; Mature: 445

Protein sequence:

>446_residues
MSKILIIDDEVQIRSLLARMLGLEGYEVCQAGDCKAAIRQLEIQQPDVALCDVFLPDGNGVDLVLNIKKTAPNVEVILLT
AHGNIPDGVQAIKNGAFDYITKGDDNNKIIPLISRAVEKAKMNVRLEKLEKKVSQLYSFDSILGESKVLKEAVMLAQKVS
VTDVPVLLTGETGTGKEVFAQAIHYNSKRSKQSFVAVNCSSFSKELLESEMFGHKAGSFTGALKDKKGLFEEANNGTIFL
DEIGEMAFELQAKLLRILETGEYIKIGDTKPTHVNVRIIAATNRNLTEEIKAGRFREDLFYRLSVFQVHLPALRERTGDI
RILATAFAKSFSEKLSYTVNEMTPAFLHALEQQPWKGNIRELRNVIERSLIVCEGGHLDVCDLPLEIQNTHYECSDDNIG
SFELAAMERRHIARVLEYTKGNKTETARLLKIGLTTLYRKIEEYKI

Sequences:

>Translated_446_residues
MSKILIIDDEVQIRSLLARMLGLEGYEVCQAGDCKAAIRQLEIQQPDVALCDVFLPDGNGVDLVLNIKKTAPNVEVILLT
AHGNIPDGVQAIKNGAFDYITKGDDNNKIIPLISRAVEKAKMNVRLEKLEKKVSQLYSFDSILGESKVLKEAVMLAQKVS
VTDVPVLLTGETGTGKEVFAQAIHYNSKRSKQSFVAVNCSSFSKELLESEMFGHKAGSFTGALKDKKGLFEEANNGTIFL
DEIGEMAFELQAKLLRILETGEYIKIGDTKPTHVNVRIIAATNRNLTEEIKAGRFREDLFYRLSVFQVHLPALRERTGDI
RILATAFAKSFSEKLSYTVNEMTPAFLHALEQQPWKGNIRELRNVIERSLIVCEGGHLDVCDLPLEIQNTHYECSDDNIG
SFELAAMERRHIARVLEYTKGNKTETARLLKIGLTTLYRKIEEYKI
>Mature_445_residues
SKILIIDDEVQIRSLLARMLGLEGYEVCQAGDCKAAIRQLEIQQPDVALCDVFLPDGNGVDLVLNIKKTAPNVEVILLTA
HGNIPDGVQAIKNGAFDYITKGDDNNKIIPLISRAVEKAKMNVRLEKLEKKVSQLYSFDSILGESKVLKEAVMLAQKVSV
TDVPVLLTGETGTGKEVFAQAIHYNSKRSKQSFVAVNCSSFSKELLESEMFGHKAGSFTGALKDKKGLFEEANNGTIFLD
EIGEMAFELQAKLLRILETGEYIKIGDTKPTHVNVRIIAATNRNLTEEIKAGRFREDLFYRLSVFQVHLPALRERTGDIR
ILATAFAKSFSEKLSYTVNEMTPAFLHALEQQPWKGNIRELRNVIERSLIVCEGGHLDVCDLPLEIQNTHYECSDDNIGS
FELAAMERRHIARVLEYTKGNKTETARLLKIGLTTLYRKIEEYKI

Specific function: Member of the two-component regulatory system AtoS/AtoC involved in the transcriptional regulation of the ato genes for acetoacetate metabolism. Also an inhibitor of polyamine biosynthesis [H]

COG id: COG2204

COG function: function code T; Response regulator containing CheY-like receiver, AAA-type ATPase, and DNA-binding domains

Gene ontology:

Cell location: Cytoplasm (Probable) [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1788550, Length=453, Percent_Identity=39.0728476821192, Blast_Score=336, Evalue=2e-93,
Organism=Escherichia coli, GI1790299, Length=465, Percent_Identity=35.4838709677419, Blast_Score=299, Evalue=2e-82,
Organism=Escherichia coli, GI1790437, Length=438, Percent_Identity=36.7579908675799, Blast_Score=290, Evalue=1e-79,
Organism=Escherichia coli, GI1788905, Length=452, Percent_Identity=35.6194690265487, Blast_Score=280, Evalue=1e-76,
Organism=Escherichia coli, GI1789233, Length=322, Percent_Identity=40.6832298136646, Blast_Score=234, Evalue=8e-63,
Organism=Escherichia coli, GI87082117, Length=239, Percent_Identity=43.9330543933054, Blast_Score=218, Evalue=5e-58,
Organism=Escherichia coli, GI1789087, Length=242, Percent_Identity=43.3884297520661, Blast_Score=216, Evalue=2e-57,
Organism=Escherichia coli, GI87082152, Length=295, Percent_Identity=38.6440677966102, Blast_Score=210, Evalue=1e-55,
Organism=Escherichia coli, GI1786524, Length=347, Percent_Identity=38.0403458213257, Blast_Score=208, Evalue=6e-55,
Organism=Escherichia coli, GI1787583, Length=348, Percent_Identity=34.7701149425287, Blast_Score=203, Evalue=1e-53,
Organism=Escherichia coli, GI87081872, Length=235, Percent_Identity=42.5531914893617, Blast_Score=196, Evalue=3e-51,
Organism=Escherichia coli, GI87081858, Length=321, Percent_Identity=30.2180685358255, Blast_Score=144, Evalue=1e-35,
Organism=Escherichia coli, GI1789828, Length=250, Percent_Identity=32, Blast_Score=129, Evalue=4e-31,
Organism=Escherichia coli, GI1786599, Length=102, Percent_Identity=35.2941176470588, Blast_Score=74, Evalue=2e-14,
Organism=Escherichia coli, GI1786911, Length=102, Percent_Identity=31.3725490196078, Blast_Score=62, Evalue=5e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR011006
- InterPro:   IPR020441
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR001789 [H]

Pfam domain/function: PF02954 HTH_8; PF00072 Response_reg; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 49909; Mature: 49778

Theoretical pI: Translated: 6.61; Mature: 6.61

Prosite motif: PS50110 RESPONSE_REGULATORY ; PS00675 SIGMA54_INTERACT_1 ; PS00676 SIGMA54_INTERACT_2 ; PS50045 SIGMA54_INTERACT_4

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.8 %Met     (Translated Protein)
3.4 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSKILIIDDEVQIRSLLARMLGLEGYEVCQAGDCKAAIRQLEIQQPDVALCDVFLPDGNG
CCEEEEECCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCCCEEEEEEEECCCCC
VDLVLNIKKTAPNVEVILLTAHGNIPDGVQAIKNGAFDYITKGDDNNKIIPLISRAVEKA
EEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHH
KMNVRLEKLEKKVSQLYSFDSILGESKVLKEAVMLAQKVSVTDVPVLLTGETGTGKEVFA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHH
QAIHYNSKRSKQSFVAVNCSSFSKELLESEMFGHKAGSFTGALKDKKGLFEEANNGTIFL
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHCCCCCEEEH
DEIGEMAFELQAKLLRILETGEYIKIGDTKPTHVNVRIIAATNRNLTEEIKAGRFREDLF
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHHCCCHHHHHH
YRLSVFQVHLPALRERTGDIRILATAFAKSFSEKLSYTVNEMTPAFLHALEQQPWKGNIR
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
ELRNVIERSLIVCEGGHLDVCDLPLEIQNTHYECSDDNIGSFELAAMERRHIARVLEYTK
HHHHHHHHCEEEECCCCEEEECCCEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCC
GNKTETARLLKIGLTTLYRKIEEYKI
CCCHHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
SKILIIDDEVQIRSLLARMLGLEGYEVCQAGDCKAAIRQLEIQQPDVALCDVFLPDGNG
CEEEEECCCHHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHCCCCCCEEEEEEEECCCCC
VDLVLNIKKTAPNVEVILLTAHGNIPDGVQAIKNGAFDYITKGDDNNKIIPLISRAVEKA
EEEEEEEECCCCCEEEEEEEECCCCCHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHH
KMNVRLEKLEKKVSQLYSFDSILGESKVLKEAVMLAQKVSVTDVPVLLTGETGTGKEVFA
HHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCCHHHHH
QAIHYNSKRSKQSFVAVNCSSFSKELLESEMFGHKAGSFTGALKDKKGLFEEANNGTIFL
HHHHCCCCCCCCCEEEEEHHHHHHHHHHHHHHCCCCCCCCCCCCHHCCHHHCCCCCEEEH
DEIGEMAFELQAKLLRILETGEYIKIGDTKPTHVNVRIIAATNRNLTEEIKAGRFREDLF
HHHHHHHHHHHHHHHHHHCCCCEEEECCCCCCEEEEEEEEECCCCHHHHHHCCCHHHHHH
YRLSVFQVHLPALRERTGDIRILATAFAKSFSEKLSYTVNEMTPAFLHALEQQPWKGNIR
HHHHHHHHHHHHHHCCCCCEEEEHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCHH
ELRNVIERSLIVCEGGHLDVCDLPLEIQNTHYECSDDNIGSFELAAMERRHIARVLEYTK
HHHHHHHHCEEEECCCCEEEECCCEEECCCEEECCCCCCCCCHHHHHHHHHHHHHHHHCC
GNKTETARLLKIGLTTLYRKIEEYKI
CCCHHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9097040; 9278503; 8346225 [H]