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The map label for this gene is gpmA

Identifier: 29347070

GI number: 29347070

Start: 2051277

End: 2052023

Strand: Reverse

Name: gpmA

Synonym: BT_1660

Alternate gene names: 29347070

Gene position: 2052023-2051277 (Counterclockwise)

Preceding gene: 29347072

Following gene: 29347069

Centisome position: 32.78

GC content: 45.11

Gene sequence:

>747_bases
ATGAAAAAGATAGTATTACTTCGTCATGGAGAGAGTGCTTGGAACAAAGAAAACCGTTTCACAGGTTGGACGGATGTAGA
CCTGACGGAAAAGGGAGTTGCCGAAGCGGAAAAGGCAGGCGTCACGTTGAGGGAATATGGCTTCAACTTTGATAAAGCCT
ATACTTCTTATCTGAAAAGGGCAGTCAAAACCTTGAACTGCGTGCTTGATAAAATGAATCTGGACTGGATTCCCGTCGAG
AAGAGCTGGCGTCTGAATGAGAAGCATTACGGCGATTTGCAAGGACTCAATAAGGCGGAAACAGCCGAGAAATACGGAGA
AGAACAAGTGCTGATCTGGCGTCGCAGTTATGATATAGCTCCCAATCCGCTTTCCGAAAGCGATTTGAGAAATCCGCGTT
TCGATTATCGCTATCACGAAGTATCCGATGCGGAACTGCCGCGTACCGAATCATTAAAAGATACCATCGACCGTATTATG
CCGTACTGGGAGTCGGATATATTCCCGGCTTTAAAAGATGCGCATACCTTGCTGGTTGTCGCGCATGGCAATAGTCTGCG
AGGTATCATTAAGCATTTGAAACATATTTCTGATGAAGATATCATCAAACTGAATCTTCCTACTGCCGTTCCTTATGTAT
TCGAGTTCGACGAGAACCTGAATGTTGCCAATGATTACTTCCTGGGCAATCCGGAAGAAATTCGTAAGCTGATGGAAGCG
GTAGCCAATCAGGGGAAGAAAAAATAG

Upstream 100 bases:

>100_bases
AACCATCACTTTTAGGTATTGATACCTGCTGATTCTTTCGTGAACTTTGTAGAGAAACAAAATGTTGTATATATAAAAAG
AAGAAAGGAGACCATTAAGA

Downstream 100 bases:

>100_bases
CAGGCTTCATCGCCTGTATATAAATTGTTATACATTAAAAAAATAAAGTTATGAGTAAAGTAGTTGATTTATTAGGAGAT
AAGACCAGTTATTATCTGGA

Product: phosphoglyceromutase

Products: NA

Alternate protein names: BPG-dependent PGAM 2; PGAM 2; Phosphoglyceromutase 2; dPGM 2

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MKKIVLLRHGESAWNKENRFTGWTDVDLTEKGVAEAEKAGVTLREYGFNFDKAYTSYLKRAVKTLNCVLDKMNLDWIPVE
KSWRLNEKHYGDLQGLNKAETAEKYGEEQVLIWRRSYDIAPNPLSESDLRNPRFDYRYHEVSDAELPRTESLKDTIDRIM
PYWESDIFPALKDAHTLLVVAHGNSLRGIIKHLKHISDEDIIKLNLPTAVPYVFEFDENLNVANDYFLGNPEEIRKLMEA
VANQGKKK

Sequences:

>Translated_248_residues
MKKIVLLRHGESAWNKENRFTGWTDVDLTEKGVAEAEKAGVTLREYGFNFDKAYTSYLKRAVKTLNCVLDKMNLDWIPVE
KSWRLNEKHYGDLQGLNKAETAEKYGEEQVLIWRRSYDIAPNPLSESDLRNPRFDYRYHEVSDAELPRTESLKDTIDRIM
PYWESDIFPALKDAHTLLVVAHGNSLRGIIKHLKHISDEDIIKLNLPTAVPYVFEFDENLNVANDYFLGNPEEIRKLMEA
VANQGKKK
>Mature_248_residues
MKKIVLLRHGESAWNKENRFTGWTDVDLTEKGVAEAEKAGVTLREYGFNFDKAYTSYLKRAVKTLNCVLDKMNLDWIPVE
KSWRLNEKHYGDLQGLNKAETAEKYGEEQVLIWRRSYDIAPNPLSESDLRNPRFDYRYHEVSDAELPRTESLKDTIDRIM
PYWESDIFPALKDAHTLLVVAHGNSLRGIIKHLKHISDEDIIKLNLPTAVPYVFEFDENLNVANDYFLGNPEEIRKLMEA
VANQGKKK

Specific function: Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate

COG id: COG0588

COG function: function code G; Phosphoglycerate mutase 1

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily

Homologues:

Organism=Homo sapiens, GI4505753, Length=249, Percent_Identity=53.8152610441767, Blast_Score=271, Evalue=3e-73,
Organism=Homo sapiens, GI50593010, Length=252, Percent_Identity=51.1904761904762, Blast_Score=270, Evalue=6e-73,
Organism=Homo sapiens, GI71274132, Length=249, Percent_Identity=50.6024096385542, Blast_Score=250, Evalue=7e-67,
Organism=Homo sapiens, GI4502445, Length=252, Percent_Identity=47.6190476190476, Blast_Score=245, Evalue=2e-65,
Organism=Homo sapiens, GI40353764, Length=252, Percent_Identity=47.6190476190476, Blast_Score=245, Evalue=2e-65,
Organism=Homo sapiens, GI310129614, Length=161, Percent_Identity=54.6583850931677, Blast_Score=176, Evalue=2e-44,
Organism=Escherichia coli, GI1786970, Length=248, Percent_Identity=58.4677419354839, Blast_Score=299, Evalue=9e-83,
Organism=Saccharomyces cerevisiae, GI6322697, Length=247, Percent_Identity=51.417004048583, Blast_Score=250, Evalue=1e-67,
Organism=Saccharomyces cerevisiae, GI6324516, Length=295, Percent_Identity=28.135593220339, Blast_Score=130, Evalue=2e-31,
Organism=Saccharomyces cerevisiae, GI6320183, Length=296, Percent_Identity=30.4054054054054, Blast_Score=129, Evalue=5e-31,
Organism=Saccharomyces cerevisiae, GI6324857, Length=236, Percent_Identity=26.271186440678, Blast_Score=65, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24646216, Length=253, Percent_Identity=50.9881422924901, Blast_Score=263, Evalue=8e-71,
Organism=Drosophila melanogaster, GI85725270, Length=253, Percent_Identity=50.197628458498, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI85725272, Length=253, Percent_Identity=50.197628458498, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI24650981, Length=253, Percent_Identity=50.197628458498, Blast_Score=249, Evalue=2e-66,
Organism=Drosophila melanogaster, GI28571817, Length=252, Percent_Identity=39.2857142857143, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI28571815, Length=252, Percent_Identity=39.2857142857143, Blast_Score=184, Evalue=6e-47,
Organism=Drosophila melanogaster, GI24648979, Length=252, Percent_Identity=39.2857142857143, Blast_Score=183, Evalue=8e-47,

Paralogues:

None

Copy number: 960 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 40 Molecules/Cell In: Stationary Phase, Rich Media (Based on E. coli). [C]

Swissprot (AC and ID): GPMA2_BACTN (Q8A765)

Other databases:

- EMBL:   AE015928
- RefSeq:   NP_810573.1
- ProteinModelPortal:   Q8A765
- SMR:   Q8A765
- GeneID:   1075636
- GenomeReviews:   AE015928_GR
- KEGG:   bth:BT_1660
- NMPDR:   fig|226186.1.peg.1660
- HOGENOM:   HBG658938
- OMA:   TGWKDPD
- PhylomeDB:   Q8A765
- ProtClustDB:   PRK14115
- BioCyc:   BTHE226186:BT_1660-MONOMER
- BRENDA:   5.4.2.1
- GO:   GO:0006096
- HAMAP:   MF_01039
- InterPro:   IPR013078
- InterPro:   IPR001345
- InterPro:   IPR005952
- PANTHER:   PTHR11931
- SMART:   SM00855
- TIGRFAMs:   TIGR01258

Pfam domain/function: PF00300 PGAM

EC number: =5.4.2.1

Molecular weight: Translated: 28788; Mature: 28788

Theoretical pI: Translated: 6.18; Mature: 6.18

Prosite motif: PS00175 PG_MUTASE

Important sites: ACT_SITE 9-9 ACT_SITE 182-182

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
2.0 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
2.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKKIVLLRHGESAWNKENRFTGWTDVDLTEKGVAEAEKAGVTLREYGFNFDKAYTSYLKR
CCEEEEEECCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
AVKTLNCVLDKMNLDWIPVEKSWRLNEKHYGDLQGLNKAETAEKYGEEQVLIWRRSYDIA
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHCCCCHHHHHHHHCCCEEEEEEECCCCC
PNPLSESDLRNPRFDYRYHEVSDAELPRTESLKDTIDRIMPYWESDIFPALKDAHTLLVV
CCCCCHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEE
AHGNSLRGIIKHLKHISDEDIIKLNLPTAVPYVFEFDENLNVANDYFLGNPEEIRKLMEA
ECCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VANQGKKK
HHHCCCCC
>Mature Secondary Structure
MKKIVLLRHGESAWNKENRFTGWTDVDLTEKGVAEAEKAGVTLREYGFNFDKAYTSYLKR
CCEEEEEECCCHHCCCCCCCCCCCCCCCCHHHHHHHHHHCCCHHHHCCCHHHHHHHHHHH
AVKTLNCVLDKMNLDWIPVEKSWRLNEKHYGDLQGLNKAETAEKYGEEQVLIWRRSYDIA
HHHHHHHHHHHCCCCEEECCCCCCCCCCCCCHHCCCCHHHHHHHHCCCEEEEEEECCCCC
PNPLSESDLRNPRFDYRYHEVSDAELPRTESLKDTIDRIMPYWESDIFPALKDAHTLLVV
CCCCCHHHCCCCCCCCEECCCCCCCCCCCCHHHHHHHHHHHHHCCCCCHHHCCCEEEEEE
AHGNSLRGIIKHLKHISDEDIIKLNLPTAVPYVFEFDENLNVANDYFLGNPEEIRKLMEA
ECCCCHHHHHHHHHHCCCCCEEEEECCCCCCEEEEECCCCCCCCCCCCCCHHHHHHHHHH
VANQGKKK
HHHCCCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 12663928