Click here to switch to the map view.

The map label for this gene is galU [C]

Identifier: 29347043

GI number: 29347043

Start: 2019352

End: 2020095

Strand: Reverse

Name: galU [C]

Synonym: BT_1633

Alternate gene names: 29347043

Gene position: 2020095-2019352 (Counterclockwise)

Preceding gene: 29347044

Following gene: 29347042

Centisome position: 32.27

GC content: 46.64

Gene sequence:

>744_bases
ATGATATTTGCAGCCGGGTTGGGTAGCCGGCTGAAACCACTGACCGATACGATGCCCAAAGCCCTTGTTCCCGTGGCCGG
ACGTCCAATGCTGGAGCATGTGATTTTGAAACTGAAAGCTTCCGGTTTTACCGAAATAGTGATTAATATCCATCATTTCG
GTGAGCAGATTATTGATTTTCTGAAAGCTAACAATGATTTCGGACTGACGTTGCATATTTCCGACGAACGGGACCTGCTG
CTCGATACGGGGGGAGGAATCAGAAAAGCCCGTCGATTCTTTGAAAATTCCGATGAACCCTTCCTTGTGCATAATGTGGA
TATTCTTTCGGATATGAATCTGAAAGAACTGTATGACTTTCATTTGCGGAACGGAAGTGTAGCCACCTTGCTCGCCAGCC
GGCGTAAAACTTCCCGTTATCTGCTTTTTGATGCGGAACAAAGATTGTGCGGATGGATCAACAAAGATACGGGACAGGTG
AGGCCCGAAGGTTTCCTATATGATGAGTCGCTGTATAGAGAGTATGCCTTTAGCGGTATCCATGTTTTTTCGCCTGCTGT
CTTCCAGTTGATGGAAGTGCCGTGCTGGGAAGGCAAGTTCTCTATTATGGACTTTTATCTGGCTACCTGCGGGCAAACGG
ATTATTGCGGTTATCTTACGGAAAAGCTGGAACTGATTGATATCGGCAAGCCGGAGACGTTGGCACGGGCGGAAGAGTTT
TTAAGAGAGAATATAGTATCATGA

Upstream 100 bases:

>100_bases
TGGCAGAGCACCTGAACCGCAAATTTGGCGTGAAAGTGGAGCTGGTGCACCGCGAACAGAATATAGAACGTACTTTTGAG
GCAACTGTGTAATGAAAGCA

Downstream 100 bases:

>100_bases
GTATATTCGGGTAATTAGAGTTAATGAAAGGCGGAGATATTCGGAAACGGATATTGCCGCCTTTCTTTTTTTGTCTCGAA
AGTTGTCTGATAATGTCTGT

Product: mannose-1-phosphate guanyltransferase

Products: NA

Alternate protein names: UDP-N-acetylglucosamine pyrophosphorylase; N-acetylglucosamine-1-phosphate uridyltransferase; Glucosamine-1-phosphate N-acetyltransferase [H]

Number of amino acids: Translated: 247; Mature: 247

Protein sequence:

>247_residues
MIFAAGLGSRLKPLTDTMPKALVPVAGRPMLEHVILKLKASGFTEIVINIHHFGEQIIDFLKANNDFGLTLHISDERDLL
LDTGGGIRKARRFFENSDEPFLVHNVDILSDMNLKELYDFHLRNGSVATLLASRRKTSRYLLFDAEQRLCGWINKDTGQV
RPEGFLYDESLYREYAFSGIHVFSPAVFQLMEVPCWEGKFSIMDFYLATCGQTDYCGYLTEKLELIDIGKPETLARAEEF
LRENIVS

Sequences:

>Translated_247_residues
MIFAAGLGSRLKPLTDTMPKALVPVAGRPMLEHVILKLKASGFTEIVINIHHFGEQIIDFLKANNDFGLTLHISDERDLL
LDTGGGIRKARRFFENSDEPFLVHNVDILSDMNLKELYDFHLRNGSVATLLASRRKTSRYLLFDAEQRLCGWINKDTGQV
RPEGFLYDESLYREYAFSGIHVFSPAVFQLMEVPCWEGKFSIMDFYLATCGQTDYCGYLTEKLELIDIGKPETLARAEEF
LRENIVS
>Mature_247_residues
MIFAAGLGSRLKPLTDTMPKALVPVAGRPMLEHVILKLKASGFTEIVINIHHFGEQIIDFLKANNDFGLTLHISDERDLL
LDTGGGIRKARRFFENSDEPFLVHNVDILSDMNLKELYDFHLRNGSVATLLASRRKTSRYLLFDAEQRLCGWINKDTGQV
RPEGFLYDESLYREYAFSGIHVFSPAVFQLMEVPCWEGKFSIMDFYLATCGQTDYCGYLTEKLELIDIGKPETLARAEEF
LRENIVS

Specific function: Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetyl-glucosamine (UDP- GlcNAc). Responsible for the acetylation of GlcN-1-P to GlcNAc-1- P, and for the uridyl transfer from UTP to GlcNAc-1-P, to produce UDP-GlcN

COG id: COG1208

COG function: function code MJ; Nucleoside-diphosphate-sugar pyrophosphorylase involved in lipopolysaccharide biosynthesis/translation initiation factor 2B, gamma/epsilon subunits (eIF-2Bgamma/eIF-2Bepsilon)

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: In the C-terminal section; belongs to the transferase hexapeptide repeat family [H]

Homologues:

Organism=Homo sapiens, GI11761619, Length=200, Percent_Identity=25.5, Blast_Score=82, Evalue=6e-16,
Organism=Homo sapiens, GI11761621, Length=200, Percent_Identity=25.5, Blast_Score=81, Evalue=7e-16,
Organism=Caenorhabditis elegans, GI133931050, Length=151, Percent_Identity=32.4503311258278, Blast_Score=77, Evalue=8e-15,
Organism=Saccharomyces cerevisiae, GI6320148, Length=195, Percent_Identity=29.2307692307692, Blast_Score=88, Evalue=2e-18,
Organism=Drosophila melanogaster, GI21355443, Length=197, Percent_Identity=29.9492385786802, Blast_Score=88, Evalue=4e-18,
Organism=Drosophila melanogaster, GI24644084, Length=197, Percent_Identity=29.9492385786802, Blast_Score=88, Evalue=4e-18,

Paralogues:

None

Copy number: 120 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 140 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). 260 Molecules/Cell In: Growth Phase, Minimal Media (Based on E. coli). [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR005835
- InterPro:   IPR011004 [H]

Pfam domain/function: PF00483 NTP_transferase [H]

EC number: =2.7.7.23; =2.3.1.157 [H]

Molecular weight: Translated: 28135; Mature: 28135

Theoretical pI: Translated: 5.38; Mature: 5.38

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
4.0 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
4.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIFAAGLGSRLKPLTDTMPKALVPVAGRPMLEHVILKLKASGFTEIVINIHHFGEQIIDF
CEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
LKANNDFGLTLHISDERDLLLDTGGGIRKARRFFENSDEPFLVHNVDILSDMNLKELYDF
HHCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCEEEEECHHHCCCCHHHHHHH
HLRNGSVATLLASRRKTSRYLLFDAEQRLCGWINKDTGQVRPEGFLYDESLYREYAFSGI
HCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCC
HVFSPAVFQLMEVPCWEGKFSIMDFYLATCGQTDYCGYLTEKLELIDIGKPETLARAEEF
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCCHHHHHHHHH
LRENIVS
HHHHCCC
>Mature Secondary Structure
MIFAAGLGSRLKPLTDTMPKALVPVAGRPMLEHVILKLKASGFTEIVINIHHFGEQIIDF
CEEECCCCCCCCCHHHHHHHHHCCCCCCHHHHHHHHHHHCCCCEEEEEEHHHHHHHHHHH
LKANNDFGLTLHISDERDLLLDTGGGIRKARRFFENSDEPFLVHNVDILSDMNLKELYDF
HHCCCCCEEEEEECCCCCEEEECCCCHHHHHHHHCCCCCCEEEEECHHHCCCCHHHHHHH
HLRNGSVATLLASRRKTSRYLLFDAEQRLCGWINKDTGQVRPEGFLYDESLYREYAFSGI
HCCCCCHHHHHHHHCCCCEEEEEECHHHHHHHCCCCCCCCCCCCEEEHHHHHHHHHHCCC
HVFSPAVFQLMEVPCWEGKFSIMDFYLATCGQTDYCGYLTEKLELIDIGKPETLARAEEF
HHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCHHHHHHHCEEEEECCCCHHHHHHHHH
LRENIVS
HHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA