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The map label for this gene is cusR [H]

Identifier: 29346400

GI number: 29346400

Start: 1221693

End: 1222379

Strand: Reverse

Name: cusR [H]

Synonym: BT_0990

Alternate gene names: 29346400

Gene position: 1222379-1221693 (Counterclockwise)

Preceding gene: 29346402

Following gene: 29346399

Centisome position: 19.53

GC content: 41.78

Gene sequence:

>687_bases
ATGTACACAATACTAATTATAGAAGACGAACCCAGAGTGGCAAGTTTGCTGATGAACGGGCTGGAAGAAAATGGTTATCA
GACCATGGTAGCTTATGACGGATTAATGGGGCTGCGGCTTTTTCAGGCACATACGTTCGATCTGGTTATATCTGATATTG
TTCTGCCTAAGATGGACGGATTTGAGCTGACGAAAGAAATCCGTAAGTCCAATCCCCGTATTCCTATATTAATGTTGACG
GCATTAGGATCAACGAACGATAAGCTGGATGGTTTCGATGCCGGTGCAGACGACTATATGGTGAAGCCCTTTGATTTCAG
AGAGTTGAATGCCAGAATCAAAGTTCTATTGAAACGTGTCTCGGGAAATGTACCGGAATTGCCACAGGAACTTGTTTATG
CGGATCTGCGCATTGATCTTCAGCGGAAGGACGTAGAACGAAATAACGTTTCCATTAAACTTTCTCCGAAAGAATATAAC
CTGCTGTTATATATGGTCGAAAATGCCGAAAGAGTATTGAGCCGGGTAGAGATAGCGGAGAAAGTATGGAACACACATTT
TGATACGGGAACCAACTTCATTGATGTATATATCAACTACCTTCGCAAAAAGATAGACCGTAACTTTGAACCGAAACTTA
TTCATACCAAAGCAGGGATGGGTTTCATACTGACTGACAAATTATGA

Upstream 100 bases:

>100_bases
GCAAATATAGCAAATATAAAATGGTTTAAAAGAGTCATAAGTGAGGAATAATCATTATTTTTGTTTCGTTTTATAGATTC
AGATTAACGAGTTCTTTCCT

Downstream 100 bases:

>100_bases
AAATCCGGACAACGCTGACTCTGCAATATGCGGGCATTACAGCTGCGGTATTCTTCGCATTTGTCATAGCTGTCTATTAC
GTAAGCGAGCATTCGCGCAG

Product: two-component system response regulator

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MYTILIIEDEPRVASLLMNGLEENGYQTMVAYDGLMGLRLFQAHTFDLVISDIVLPKMDGFELTKEIRKSNPRIPILMLT
ALGSTNDKLDGFDAGADDYMVKPFDFRELNARIKVLLKRVSGNVPELPQELVYADLRIDLQRKDVERNNVSIKLSPKEYN
LLLYMVENAERVLSRVEIAEKVWNTHFDTGTNFIDVYINYLRKKIDRNFEPKLIHTKAGMGFILTDKL

Sequences:

>Translated_228_residues
MYTILIIEDEPRVASLLMNGLEENGYQTMVAYDGLMGLRLFQAHTFDLVISDIVLPKMDGFELTKEIRKSNPRIPILMLT
ALGSTNDKLDGFDAGADDYMVKPFDFRELNARIKVLLKRVSGNVPELPQELVYADLRIDLQRKDVERNNVSIKLSPKEYN
LLLYMVENAERVLSRVEIAEKVWNTHFDTGTNFIDVYINYLRKKIDRNFEPKLIHTKAGMGFILTDKL
>Mature_228_residues
MYTILIIEDEPRVASLLMNGLEENGYQTMVAYDGLMGLRLFQAHTFDLVISDIVLPKMDGFELTKEIRKSNPRIPILMLT
ALGSTNDKLDGFDAGADDYMVKPFDFRELNARIKVLLKRVSGNVPELPQELVYADLRIDLQRKDVERNNVSIKLSPKEYN
LLLYMVENAERVLSRVEIAEKVWNTHFDTGTNFIDVYINYLRKKIDRNFEPKLIHTKAGMGFILTDKL

Specific function: Member of the two-component regulatory system CusS/CusR. Activates the expression of cusCFBA in response to increasing levels of copper ions, and probably silver ions [H]

COG id: NA

COG function: NA

Gene ontology:

Cell location: Cytoplasmic [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 response regulatory domain [H]

Homologues:

Organism=Escherichia coli, GI1786784, Length=221, Percent_Identity=42.5339366515837, Blast_Score=182, Evalue=2e-47,
Organism=Escherichia coli, GI87082012, Length=219, Percent_Identity=39.7260273972603, Blast_Score=159, Evalue=1e-40,
Organism=Escherichia coli, GI1786911, Length=224, Percent_Identity=32.1428571428571, Blast_Score=130, Evalue=5e-32,
Organism=Escherichia coli, GI1789402, Length=224, Percent_Identity=32.5892857142857, Blast_Score=129, Evalue=2e-31,
Organism=Escherichia coli, GI1786599, Length=228, Percent_Identity=32.0175438596491, Blast_Score=122, Evalue=2e-29,
Organism=Escherichia coli, GI1789809, Length=230, Percent_Identity=30.4347826086957, Blast_Score=121, Evalue=4e-29,
Organism=Escherichia coli, GI1790552, Length=221, Percent_Identity=33.4841628959276, Blast_Score=116, Evalue=1e-27,
Organism=Escherichia coli, GI1790860, Length=224, Percent_Identity=32.5892857142857, Blast_Score=115, Evalue=2e-27,
Organism=Escherichia coli, GI1787375, Length=224, Percent_Identity=31.25, Blast_Score=111, Evalue=5e-26,
Organism=Escherichia coli, GI1788394, Length=220, Percent_Identity=32.7272727272727, Blast_Score=110, Evalue=1e-25,
Organism=Escherichia coli, GI1787229, Length=234, Percent_Identity=32.9059829059829, Blast_Score=103, Evalue=1e-23,
Organism=Escherichia coli, GI2367329, Length=230, Percent_Identity=30.8695652173913, Blast_Score=100, Evalue=1e-22,
Organism=Escherichia coli, GI1790863, Length=226, Percent_Identity=30.5309734513274, Blast_Score=93, Evalue=2e-20,
Organism=Escherichia coli, GI1788550, Length=107, Percent_Identity=37.3831775700935, Blast_Score=82, Evalue=2e-17,
Organism=Escherichia coli, GI1790437, Length=125, Percent_Identity=33.6, Blast_Score=81, Evalue=7e-17,
Organism=Escherichia coli, GI1788905, Length=153, Percent_Identity=32.0261437908497, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1788713, Length=114, Percent_Identity=35.0877192982456, Blast_Score=71, Evalue=6e-14,
Organism=Escherichia coli, GI145693157, Length=117, Percent_Identity=30.7692307692308, Blast_Score=69, Evalue=3e-13,
Organism=Escherichia coli, GI145693140, Length=233, Percent_Identity=26.6094420600858, Blast_Score=68, Evalue=4e-13,
Organism=Escherichia coli, GI1787487, Length=100, Percent_Identity=36, Blast_Score=67, Evalue=1e-12,
Organism=Escherichia coli, GI1790299, Length=111, Percent_Identity=28.8288288288288, Blast_Score=66, Evalue=2e-12,
Organism=Escherichia coli, GI1788191, Length=120, Percent_Identity=32.5, Blast_Score=63, Evalue=2e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR011006
- InterPro:   IPR001867
- InterPro:   IPR006291
- InterPro:   IPR001789
- InterPro:   IPR011991 [H]

Pfam domain/function: PF00072 Response_reg; PF00486 Trans_reg_C [H]

EC number: NA

Molecular weight: Translated: 26276; Mature: 26276

Theoretical pI: Translated: 5.43; Mature: 5.43

Prosite motif: PS50110 RESPONSE_REGULATORY

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
3.9 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
3.9 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MYTILIIEDEPRVASLLMNGLEENGYQTMVAYDGLMGLRLFQAHTFDLVISDIVLPKMDG
CEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCC
FELTKEIRKSNPRIPILMLTALGSTNDKLDGFDAGADDYMVKPFDFRELNARIKVLLKRV
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
SGNVPELPQELVYADLRIDLQRKDVERNNVSIKLSPKEYNLLLYMVENAERVLSRVEIAE
CCCCCCCCHHHHHHHHEEEEECCCCCCCCEEEEECCCCEEEEEEEECCHHHHHHHHHHHH
KVWNTHFDTGTNFIDVYINYLRKKIDRNFEPKLIHTKAGMGFILTDKL
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCC
>Mature Secondary Structure
MYTILIIEDEPRVASLLMNGLEENGYQTMVAYDGLMGLRLFQAHTFDLVISDIVLPKMDG
CEEEEEECCCCHHHHHHHHHHHCCCCEEEEEECCHHHHHHHHHHHHHHHHHHHHCCCCCC
FELTKEIRKSNPRIPILMLTALGSTNDKLDGFDAGADDYMVKPFDFRELNARIKVLLKRV
HHHHHHHHHCCCCCEEEEEEECCCCCCCCCCCCCCCCCCEECCCCHHHHHHHHHHHHHHH
SGNVPELPQELVYADLRIDLQRKDVERNNVSIKLSPKEYNLLLYMVENAERVLSRVEIAE
CCCCCCCCHHHHHHHHEEEEECCCCCCCCEEEEECCCCEEEEEEEECCHHHHHHHHHHHH
KVWNTHFDTGTNFIDVYINYLRKKIDRNFEPKLIHTKAGMGFILTDKL
HHHCCCCCCCCHHHHHHHHHHHHHHCCCCCCCEEEECCCCCEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]