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The map label for this gene is kbl [C]

Identifier: 29346280

GI number: 29346280

Start: 1069916

End: 1071100

Strand: Reverse

Name: kbl [C]

Synonym: BT_0870

Alternate gene names: 29346280

Gene position: 1071100-1069916 (Counterclockwise)

Preceding gene: 29346285

Following gene: 29346277

Centisome position: 17.11

GC content: 45.65

Gene sequence:

>1185_bases
ATGGGATTATTACAAGAGAAGTTAGCTAAGTACGACCTGCCACAGAAATTTATGGCACAGGGCGTTTACCCATATTTCCG
TGAGATTGAGGGAAAGCAGGGTACAGAAGTAGAAATGGGCGGACAACATGTGTTAATGTTCGGGTCCAATGCATACACTG
GCCTTACGGGAGATGAAAGAGTGATTGAAGCAGGTATCAAAGCCATGCGCAAATACGGTTCCGGTTGTGCCGGTTCACGT
TTTCTGAATGGTACGCTCGATCTTCATGTTCAACTTGAAAAAGAACTGGCAGCCTTTGTTGGCAAGGATGAAGCACTTTG
CTTCTCTACCGGTTTTACGGTTAATTCCGGAGTTATCTCATGCCTGACCGACCGAAATGATTATATAATATGTGATGACC
GTGACCATGCCTCTATCGTAGATGGCCGTCGTCTCTCCTTCTCACAGCAATTAAAATATAAGCACAACGATATGGCGGAT
CTGGAAAAGCAACTTCAGAAGTGCAATCCGGATTCAGTGAAACTGATCATAGTAGACGGTGTATTCTCTATGGAAGGTGA
CTTGGCAAACCTACCCGAAATCGTTCGCCTGAAACATAAATACAATGCTACTATCATGGTAGACGAAGCTCACGGTTTGG
GTGTATTCGGAAAACAGGGACGTGGTGTATGCGACCATTTCGGTCTGACACACGAAGTAGACCTGATCATGGGTACTTTC
AGTAAGTCACTGGCCTCTATCGGCGGTTTTATCGCTGCTGATTCTTCTATCATCAACTGGCTGCGACACAATGCACGTAC
TTATATTTTCAGTGCATCCAACACTCCGGCTGCAACAGCAGCTGCTCTGGAAGCGCTTCATATCATCCAGAATGAACCGG
AAAGACTGAACGCTCTGTGGGAAGCAACCAACTATGCTCTGAGACGTTTCCGTGAAGCAGGCTTCGAGATCGGTGCTACT
GAGTCTCCTATCATTCCTCTTTATGTACGCGATACGGAGAAGACTTTCATGGTTACTAAGTTAGCTTTCGACGAAGGTGT
ATTCATCAATCCGGTTATTCCGCCGGCATGTGCTCCGCAAGACACATTGGTACGCGTGGCATTGATGGCTACTCACACCA
AAGAACAAATAGACAGTGCTGTAGAAAAGTTAGTGAAAGCTTTCAAAGCTTTAGACCTTTTGTAA

Upstream 100 bases:

>100_bases
ATTTTGTTATCTTTGCCCCCTGTTTTAAACACTTGTTAAGATAAAAGGAAATTAGATCATCAGCGAATGATCTGAGTATG
AGTATAATAAATTATAATTC

Downstream 100 bases:

>100_bases
GCAGCATCTCTGAAAAGCTATAAAAAAGCTACTTTCCGAAAGACAAATCATCAGGAAAGTAGCTTTTTTAATTCTACAGC
AAACAAATTACTTCTGCTTT

Product: 8-amino-7-oxononanoate synthase

Products: NA

Alternate protein names: AONS/AKB ligase; 7-keto-8-amino-pelargonic acid synthase; 7-KAP synthase; KAPA synthase; 8-amino-7-ketopelargonate synthase; Alpha-oxoamine synthase; L-alanine--pimeloyl-CoA ligase [H]

Number of amino acids: Translated: 394; Mature: 393

Protein sequence:

>394_residues
MGLLQEKLAKYDLPQKFMAQGVYPYFREIEGKQGTEVEMGGQHVLMFGSNAYTGLTGDERVIEAGIKAMRKYGSGCAGSR
FLNGTLDLHVQLEKELAAFVGKDEALCFSTGFTVNSGVISCLTDRNDYIICDDRDHASIVDGRRLSFSQQLKYKHNDMAD
LEKQLQKCNPDSVKLIIVDGVFSMEGDLANLPEIVRLKHKYNATIMVDEAHGLGVFGKQGRGVCDHFGLTHEVDLIMGTF
SKSLASIGGFIAADSSIINWLRHNARTYIFSASNTPAATAAALEALHIIQNEPERLNALWEATNYALRRFREAGFEIGAT
ESPIIPLYVRDTEKTFMVTKLAFDEGVFINPVIPPACAPQDTLVRVALMATHTKEQIDSAVEKLVKAFKALDLL

Sequences:

>Translated_394_residues
MGLLQEKLAKYDLPQKFMAQGVYPYFREIEGKQGTEVEMGGQHVLMFGSNAYTGLTGDERVIEAGIKAMRKYGSGCAGSR
FLNGTLDLHVQLEKELAAFVGKDEALCFSTGFTVNSGVISCLTDRNDYIICDDRDHASIVDGRRLSFSQQLKYKHNDMAD
LEKQLQKCNPDSVKLIIVDGVFSMEGDLANLPEIVRLKHKYNATIMVDEAHGLGVFGKQGRGVCDHFGLTHEVDLIMGTF
SKSLASIGGFIAADSSIINWLRHNARTYIFSASNTPAATAAALEALHIIQNEPERLNALWEATNYALRRFREAGFEIGAT
ESPIIPLYVRDTEKTFMVTKLAFDEGVFINPVIPPACAPQDTLVRVALMATHTKEQIDSAVEKLVKAFKALDLL
>Mature_393_residues
GLLQEKLAKYDLPQKFMAQGVYPYFREIEGKQGTEVEMGGQHVLMFGSNAYTGLTGDERVIEAGIKAMRKYGSGCAGSRF
LNGTLDLHVQLEKELAAFVGKDEALCFSTGFTVNSGVISCLTDRNDYIICDDRDHASIVDGRRLSFSQQLKYKHNDMADL
EKQLQKCNPDSVKLIIVDGVFSMEGDLANLPEIVRLKHKYNATIMVDEAHGLGVFGKQGRGVCDHFGLTHEVDLIMGTFS
KSLASIGGFIAADSSIINWLRHNARTYIFSASNTPAATAAALEALHIIQNEPERLNALWEATNYALRRFREAGFEIGATE
SPIIPLYVRDTEKTFMVTKLAFDEGVFINPVIPPACAPQDTLVRVALMATHTKEQIDSAVEKLVKAFKALDLL

Specific function: Catalyzes the decarboxylative condensation of pimeloyl- CoA and L-alanine to produce 8-amino-7-oxononanoate (AON), coenzyme A and/or converts 2-amino-3-ketobutyrate to glycine and acetyl-CoA [H]

COG id: COG0156

COG function: function code H; 7-keto-8-aminopelargonate synthetase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family [H]

Homologues:

Organism=Homo sapiens, GI7657118, Length=373, Percent_Identity=32.4396782841823, Blast_Score=219, Evalue=2e-57,
Organism=Homo sapiens, GI284448556, Length=348, Percent_Identity=33.0459770114943, Blast_Score=214, Evalue=1e-55,
Organism=Homo sapiens, GI4758668, Length=365, Percent_Identity=34.2465753424658, Blast_Score=204, Evalue=2e-52,
Organism=Homo sapiens, GI119220554, Length=359, Percent_Identity=33.4261838440111, Blast_Score=194, Evalue=1e-49,
Organism=Homo sapiens, GI83977442, Length=378, Percent_Identity=29.6296296296296, Blast_Score=192, Evalue=6e-49,
Organism=Homo sapiens, GI83977440, Length=378, Percent_Identity=29.6296296296296, Blast_Score=192, Evalue=7e-49,
Organism=Homo sapiens, GI83977444, Length=378, Percent_Identity=29.6296296296296, Blast_Score=191, Evalue=8e-49,
Organism=Homo sapiens, GI4502025, Length=357, Percent_Identity=31.6526610644258, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI40316939, Length=357, Percent_Identity=31.6526610644258, Blast_Score=179, Evalue=4e-45,
Organism=Homo sapiens, GI5454084, Length=276, Percent_Identity=36.231884057971, Blast_Score=169, Evalue=6e-42,
Organism=Escherichia coli, GI1790046, Length=384, Percent_Identity=35.15625, Blast_Score=235, Evalue=3e-63,
Organism=Escherichia coli, GI1786993, Length=349, Percent_Identity=32.378223495702, Blast_Score=169, Evalue=2e-43,
Organism=Caenorhabditis elegans, GI71994529, Length=383, Percent_Identity=33.6814621409922, Blast_Score=233, Evalue=1e-61,
Organism=Caenorhabditis elegans, GI17560914, Length=393, Percent_Identity=30.7888040712468, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI17560912, Length=395, Percent_Identity=31.6455696202532, Blast_Score=189, Evalue=2e-48,
Organism=Caenorhabditis elegans, GI32566772, Length=369, Percent_Identity=31.7073170731707, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI71982625, Length=331, Percent_Identity=34.1389728096677, Blast_Score=179, Evalue=2e-45,
Organism=Caenorhabditis elegans, GI71982617, Length=331, Percent_Identity=34.1389728096677, Blast_Score=179, Evalue=2e-45,
Organism=Saccharomyces cerevisiae, GI6320267, Length=348, Percent_Identity=35.0574712643678, Blast_Score=201, Evalue=2e-52,
Organism=Saccharomyces cerevisiae, GI6320438, Length=422, Percent_Identity=27.4881516587678, Blast_Score=159, Evalue=5e-40,
Organism=Saccharomyces cerevisiae, GI6323954, Length=252, Percent_Identity=32.5396825396825, Blast_Score=141, Evalue=2e-34,
Organism=Drosophila melanogaster, GI24662918, Length=381, Percent_Identity=32.8083989501312, Blast_Score=231, Evalue=6e-61,
Organism=Drosophila melanogaster, GI17136286, Length=373, Percent_Identity=33.7801608579088, Blast_Score=186, Evalue=2e-47,
Organism=Drosophila melanogaster, GI24653280, Length=335, Percent_Identity=32.2388059701493, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24653276, Length=335, Percent_Identity=32.2388059701493, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI24653278, Length=335, Percent_Identity=32.2388059701493, Blast_Score=177, Evalue=1e-44,
Organism=Drosophila melanogaster, GI17137420, Length=384, Percent_Identity=28.6458333333333, Blast_Score=169, Evalue=3e-42,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR001917
- InterPro:   IPR004839
- InterPro:   IPR004723
- InterPro:   IPR010962
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00155 Aminotran_1_2 [H]

EC number: =2.3.1.29; =2.3.1.47 [H]

Molecular weight: Translated: 43464; Mature: 43333

Theoretical pI: Translated: 5.97; Mature: 5.97

Prosite motif: PS00599 AA_TRANSFER_CLASS_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
4.6 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.5 %Met     (Mature Protein)
4.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGLLQEKLAKYDLPQKFMAQGVYPYFREIEGKQGTEVEMGGQHVLMFGSNAYTGLTGDER
CCHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCCCCHH
VIEAGIKAMRKYGSGCAGSRFLNGTLDLHVQLEKELAAFVGKDEALCFSTGFTVNSGVIS
HHHHHHHHHHHHCCCCCCCEEECCEEEEEEEEHHHHHHHHCCCCEEEEECCCEECCCEEE
CLTDRNDYIICDDRDHASIVDGRRLSFSQQLKYKHNDMADLEKQLQKCNPDSVKLIIVDG
EEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEC
VFSMEGDLANLPEIVRLKHKYNATIMVDEAHGLGVFGKQGRGVCDHFGLTHEVDLIMGTF
EEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEHHHHHHHH
SKSLASIGGFIAADSSIINWLRHNARTYIFSASNTPAATAAALEALHIIQNEPERLNALW
HHHHHHHCCHHHCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
EATNYALRRFREAGFEIGATESPIIPLYVRDTEKTFMVTKLAFDEGVFINPVIPPACAPQ
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEECCCCCCCCCCH
DTLVRVALMATHTKEQIDSAVEKLVKAFKALDLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure 
GLLQEKLAKYDLPQKFMAQGVYPYFREIEGKQGTEVEMGGQHVLMFGSNAYTGLTGDER
CHHHHHHHHCCCCHHHHHCCCCHHHHHCCCCCCCEEEECCCEEEEECCCCCCCCCCCHH
VIEAGIKAMRKYGSGCAGSRFLNGTLDLHVQLEKELAAFVGKDEALCFSTGFTVNSGVIS
HHHHHHHHHHHHCCCCCCCEEECCEEEEEEEEHHHHHHHHCCCCEEEEECCCEECCCEEE
CLTDRNDYIICDDRDHASIVDGRRLSFSQQLKYKHNDMADLEKQLQKCNPDSVKLIIVDG
EEECCCCEEEECCCCCCCCCCCCCCCHHHHHHHCCCCHHHHHHHHHHCCCCCEEEEEEEC
VFSMEGDLANLPEIVRLKHKYNATIMVDEAHGLGVFGKQGRGVCDHFGLTHEVDLIMGTF
EEECCCCCCCCHHHHHHHHHCCEEEEEECCCCCCCCCCCCCCCHHHCCCCEEHHHHHHHH
SKSLASIGGFIAADSSIINWLRHNARTYIFSASNTPAATAAALEALHIIQNEPERLNALW
HHHHHHHCCHHHCCHHHHHHHHCCCEEEEEECCCCCHHHHHHHHHHHHHHCCHHHHHHHH
EATNYALRRFREAGFEIGATESPIIPLYVRDTEKTFMVTKLAFDEGVFINPVIPPACAPQ
HHHHHHHHHHHHCCCCCCCCCCCEEEEEEECCCCEEEEEEEECCCCEEECCCCCCCCCCH
DTLVRVALMATHTKEQIDSAVEKLVKAFKALDLL
HHHHHHHHHHHCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA