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The map label for this gene is uvrB [H]

Identifier: 29345980

GI number: 29345980

Start: 705641

End: 707674

Strand: Reverse

Name: uvrB [H]

Synonym: BT_0570

Alternate gene names: 29345980

Gene position: 707674-705641 (Counterclockwise)

Preceding gene: 29345986

Following gene: 29345978

Centisome position: 11.3

GC content: 46.51

Gene sequence:

>2034_bases
ATGAATTTTGAACTAACATCAGCTTACAAACCTACCGGGGATCAACCAGAAGCGATCGCCCAGCTTACTGAGGGGGTACT
TCAAGGAGTTCCCGCACAGACTTTATTGGGGGTTACCGGATCGGGAAAAACGTTCACCATCGCCAATGTGATCGCCAACA
TCAACAAGCCTACGTTGATCTTGAGCCACAACAAGACATTGGCTGCGCAGCTATACAGCGAGTTCAAGGGATTTTTCCCC
AATAACGCCGTAGAATATTACGTTTCATATTACGACTACTATCAGCCGGAAGCCTATCTGCCAAATTCAGATACCTATAT
AGAAAAGGATCTCGCCATCAATGACGAGATTGACAAGTTACGTCTCGCCGCTACCTCCTCCCTGCTTTCAGGCCGGAAAG
ATGTGGTAGTCGTTTCCTCAGTCTCCTGTATTTACGGTATGGGAAACCCGTCGGATTTCTATAAAAATGTAATCGAAATT
GAACGGGGGCGGATGCTTGACCGTAATGTTTTTCTGCGTCGTCTTGTGGACAGCCTGTATGTCCGTAATGATATCGATTT
GAATCGTGGCAACTTCCGCGTTAAAGGAGACACGGTCGACATTTTCCTTGCGTACTCGGACACTCTGCTTCGTGTCACTT
TCTGGGGAGACGAGATTGATGGGATAGAAGAAGTGGACCCGATTACCGGTGTGACTACCGCTCCTTTCGAAGCCTATAAG
ATCTATCCCGCCAATTTATTTATGACCACCAAGGAAGCTACTCTTCGTGCCATCCACGAAATAGAGGATGACTTAACCAA
ACAAGTAGCGTTCTTCGAATCTATCGGCAAAGAATATGAAGCGAAACGATTGTACGAGCGAGTTACGTATGACATGGAAA
TGATCCGGGAATTAGGGCACTGTTCCGGCATTGAGAATTATTCCCGTTATTTCGACGGTCGCGCTGCCGGCACCCGTCCT
TATTGCCTTCTCGATTTCTTCCCGGATGACTTTTTGCTGGTTATTGACGAAAGTCATGTAAGCGTGCCGCAGGTTCGCGC
CATGTATGGAGGCGACCGTGCCCGTAAAATCAATCTGGTAGAATATGGGTTCCGACTGCCTGCCGCAATGGACAACCGCC
CTCTGAAATTTGAAGAATTTGAGGAGATGACAAAACAAGTGATTTATGTCAGTGCTACCCCGGCAGAATATGAGCTGATA
CAATCGGAAGGGATCGTTGTAGAACAAGTGATCCGCCCTACCGGTCTGCTTGATCCTGTTATTGAAGTACGCCCGAGTCT
CAATCAAATTGACGACCTGATGGAAGAAATTCAGCTGCGTATCGAAAAAGAAGAACGGGTACTTGTAACGACACTTACGA
AACGTATGGCGGAAGAGCTGACAGAATACCTTCTCAACAATAATGTGAGATGTAACTATATCCATAGCGATGTGGATACA
TTAGAGCGTGTGAAGATCATGGATGACTTGAGACAAGGCGTTTATGACGTACTTATCGGTGTCAATCTGCTTCGTGAAGG
TCTTGACCTTCCGGAAGTATCCCTTGTCGCTATTCTCGATGCCGATAAGGAAGGCTTCCTCCGTTCGCATCGCTCATTGA
CCCAGACTGCAGGACGTGCTGCCCGTAATGTAAACGGAAAAGTAATCATGTATGCAGATAAAATAACAGACAGTATGCGG
CTTACGATCGATGAAACAAACCGTCGACGCGAGAAACAGCTCGCTTATAATGAAGCGAACGGCATCACCCCACAACAAAT
CAAGAAGGCGAGAAACTTGTCTGTATTTGGCAGTCCAGGTTCCGAAGCCGATGAGTTGCTGAAAGAAAAACACGCTTATG
TGGAACCTTCTTCACCTAATATCGCAGCCGACCCAATCGTACAATATATGAGCAAAGCTCAAATGGAAAAGAGCATAGAG
CGTACCCGCAAATTAATGCAGGAGGCCGCCAAAAAACTGGAATTTATCGAAGCTGCCCAATATCGGAATGAGCTGCTGAA
ACTGGAAGATTTGATGAAAGAAAAGTGGGGATAA

Upstream 100 bases:

>100_bases
CATGATATTAATATGTTGCAAAGTAAAGGATTTATTTGGAAAAATGATTTGTTATCTCAATTATTTTGCCGAATATTGCT
CCACTTTTTAGGATTTAACT

Downstream 100 bases:

>100_bases
ACGGCTTATAAATATCAATAAATCTATAAGAAACCCGAGCTTTTGCTAATTAGTGTTATAAAAACACCTATTTAAGAGAA
ATAATTTGCAGATTTCGCAA

Product: excinuclease ABC subunit B

Products: NA

Alternate protein names: Protein uvrB; Excinuclease ABC subunit B [H]

Number of amino acids: Translated: 677; Mature: 677

Protein sequence:

>677_residues
MNFELTSAYKPTGDQPEAIAQLTEGVLQGVPAQTLLGVTGSGKTFTIANVIANINKPTLILSHNKTLAAQLYSEFKGFFP
NNAVEYYVSYYDYYQPEAYLPNSDTYIEKDLAINDEIDKLRLAATSSLLSGRKDVVVVSSVSCIYGMGNPSDFYKNVIEI
ERGRMLDRNVFLRRLVDSLYVRNDIDLNRGNFRVKGDTVDIFLAYSDTLLRVTFWGDEIDGIEEVDPITGVTTAPFEAYK
IYPANLFMTTKEATLRAIHEIEDDLTKQVAFFESIGKEYEAKRLYERVTYDMEMIRELGHCSGIENYSRYFDGRAAGTRP
YCLLDFFPDDFLLVIDESHVSVPQVRAMYGGDRARKINLVEYGFRLPAAMDNRPLKFEEFEEMTKQVIYVSATPAEYELI
QSEGIVVEQVIRPTGLLDPVIEVRPSLNQIDDLMEEIQLRIEKEERVLVTTLTKRMAEELTEYLLNNNVRCNYIHSDVDT
LERVKIMDDLRQGVYDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSHRSLTQTAGRAARNVNGKVIMYADKITDSMR
LTIDETNRRREKQLAYNEANGITPQQIKKARNLSVFGSPGSEADELLKEKHAYVEPSSPNIAADPIVQYMSKAQMEKSIE
RTRKLMQEAAKKLEFIEAAQYRNELLKLEDLMKEKWG

Sequences:

>Translated_677_residues
MNFELTSAYKPTGDQPEAIAQLTEGVLQGVPAQTLLGVTGSGKTFTIANVIANINKPTLILSHNKTLAAQLYSEFKGFFP
NNAVEYYVSYYDYYQPEAYLPNSDTYIEKDLAINDEIDKLRLAATSSLLSGRKDVVVVSSVSCIYGMGNPSDFYKNVIEI
ERGRMLDRNVFLRRLVDSLYVRNDIDLNRGNFRVKGDTVDIFLAYSDTLLRVTFWGDEIDGIEEVDPITGVTTAPFEAYK
IYPANLFMTTKEATLRAIHEIEDDLTKQVAFFESIGKEYEAKRLYERVTYDMEMIRELGHCSGIENYSRYFDGRAAGTRP
YCLLDFFPDDFLLVIDESHVSVPQVRAMYGGDRARKINLVEYGFRLPAAMDNRPLKFEEFEEMTKQVIYVSATPAEYELI
QSEGIVVEQVIRPTGLLDPVIEVRPSLNQIDDLMEEIQLRIEKEERVLVTTLTKRMAEELTEYLLNNNVRCNYIHSDVDT
LERVKIMDDLRQGVYDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSHRSLTQTAGRAARNVNGKVIMYADKITDSMR
LTIDETNRRREKQLAYNEANGITPQQIKKARNLSVFGSPGSEADELLKEKHAYVEPSSPNIAADPIVQYMSKAQMEKSIE
RTRKLMQEAAKKLEFIEAAQYRNELLKLEDLMKEKWG
>Mature_677_residues
MNFELTSAYKPTGDQPEAIAQLTEGVLQGVPAQTLLGVTGSGKTFTIANVIANINKPTLILSHNKTLAAQLYSEFKGFFP
NNAVEYYVSYYDYYQPEAYLPNSDTYIEKDLAINDEIDKLRLAATSSLLSGRKDVVVVSSVSCIYGMGNPSDFYKNVIEI
ERGRMLDRNVFLRRLVDSLYVRNDIDLNRGNFRVKGDTVDIFLAYSDTLLRVTFWGDEIDGIEEVDPITGVTTAPFEAYK
IYPANLFMTTKEATLRAIHEIEDDLTKQVAFFESIGKEYEAKRLYERVTYDMEMIRELGHCSGIENYSRYFDGRAAGTRP
YCLLDFFPDDFLLVIDESHVSVPQVRAMYGGDRARKINLVEYGFRLPAAMDNRPLKFEEFEEMTKQVIYVSATPAEYELI
QSEGIVVEQVIRPTGLLDPVIEVRPSLNQIDDLMEEIQLRIEKEERVLVTTLTKRMAEELTEYLLNNNVRCNYIHSDVDT
LERVKIMDDLRQGVYDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSHRSLTQTAGRAARNVNGKVIMYADKITDSMR
LTIDETNRRREKQLAYNEANGITPQQIKKARNLSVFGSPGSEADELLKEKHAYVEPSSPNIAADPIVQYMSKAQMEKSIE
RTRKLMQEAAKKLEFIEAAQYRNELLKLEDLMKEKWG

Specific function: The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 uvrA and 2 uvrB subunits scans DNA for abnormalities. Upon binding of the uvrA(2)B(2) complex to a putative damaged site, the DNA

COG id: COG0556

COG function: function code L; Helicase subunit of the DNA excision repair complex

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 UVR domain [H]

Homologues:

Organism=Escherichia coli, GI1786996, Length=671, Percent_Identity=55.5886736214605, Blast_Score=726, Evalue=0.0,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR014001
- InterPro:   IPR001650
- InterPro:   IPR014021
- InterPro:   IPR006935
- InterPro:   IPR001943
- InterPro:   IPR004807
- InterPro:   IPR009055 [H]

Pfam domain/function: PF00271 Helicase_C; PF04851 ResIII [H]

EC number: NA

Molecular weight: Translated: 77114; Mature: 77114

Theoretical pI: Translated: 4.69; Mature: 4.69

Prosite motif: PS50151 UVR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.6 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
2.7 %Met     (Mature Protein)
3.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNFELTSAYKPTGDQPEAIAQLTEGVLQGVPAQTLLGVTGSGKTFTIANVIANINKPTLI
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEECCCCCEEEHHHHHHCCCCCEEE
LSHNKTLAAQLYSEFKGFFPNNAVEYYVSYYDYYQPEAYLPNSDTYIEKDLAINDEIDKL
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHH
RLAATSSLLSGRKDVVVVSSVSCIYGMGNPSDFYKNVIEIERGRMLDRNVFLRRLVDSLY
HHHHHHHHHCCCCCEEEEEECHHEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VRNDIDLNRGNFRVKGDTVDIFLAYSDTLLRVTFWGDEIDGIEEVDPITGVTTAPFEAYK
HCCCCCCCCCCEEEECCEEEEEEEECCEEEEEEEECCCCCCCHHCCCCCCCCCCCCCEEE
IYPANLFMTTKEATLRAIHEIEDDLTKQVAFFESIGKEYEAKRLYERVTYDMEMIRELGH
EEECEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CSGIENYSRYFDGRAAGTRPYCLLDFFPDDFLLVIDESHVSVPQVRAMYGGDRARKINLV
CCCCCHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEE
EYGFRLPAAMDNRPLKFEEFEEMTKQVIYVSATPAEYELIQSEGIVVEQVIRPTGLLDPV
EECCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHCCCCHHHHHHCCCCCCCHH
IEVRPSLNQIDDLMEEIQLRIEKEERVLVTTLTKRMAEELTEYLLNNNVRCNYIHSDVDT
HHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
LERVKIMDDLRQGVYDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSHRSLTQTAGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
ARNVNGKVIMYADKITDSMRLTIDETNRRREKQLAYNEANGITPQQIKKARNLSVFGSPG
HHCCCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCC
SEADELLKEKHAYVEPSSPNIAADPIVQYMSKAQMEKSIERTRKLMQEAAKKLEFIEAAQ
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRNELLKLEDLMKEKWG
HHHHHHHHHHHHHHHCC
>Mature Secondary Structure
MNFELTSAYKPTGDQPEAIAQLTEGVLQGVPAQTLLGVTGSGKTFTIANVIANINKPTLI
CCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCHHHHEEECCCCCEEEHHHHHHCCCCCEEE
LSHNKTLAAQLYSEFKGFFPNNAVEYYVSYYDYYQPEAYLPNSDTYIEKDLAINDEIDKL
EECCCHHHHHHHHHHHCCCCCCHHHHHHHHHHCCCCCCCCCCCCCEEEECCCCCCCHHHH
RLAATSSLLSGRKDVVVVSSVSCIYGMGNPSDFYKNVIEIERGRMLDRNVFLRRLVDSLY
HHHHHHHHHCCCCCEEEEEECHHEECCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHH
VRNDIDLNRGNFRVKGDTVDIFLAYSDTLLRVTFWGDEIDGIEEVDPITGVTTAPFEAYK
HCCCCCCCCCCEEEECCEEEEEEEECCEEEEEEEECCCCCCCHHCCCCCCCCCCCCCEEE
IYPANLFMTTKEATLRAIHEIEDDLTKQVAFFESIGKEYEAKRLYERVTYDMEMIRELGH
EEECEEEEECHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHC
CSGIENYSRYFDGRAAGTRPYCLLDFFPDDFLLVIDESHVSVPQVRAMYGGDRARKINLV
CCCCCHHHHHCCCCCCCCCCEEEEEECCCCEEEEEECCCCCCHHHHHHHCCCCCEEEEEE
EYGFRLPAAMDNRPLKFEEFEEMTKQVIYVSATPAEYELIQSEGIVVEQVIRPTGLLDPV
EECCCCCCCCCCCCCCHHHHHHHHHHEEEEECCCCHHHHHHCCCCHHHHHHCCCCCCCHH
IEVRPSLNQIDDLMEEIQLRIEKEERVLVTTLTKRMAEELTEYLLNNNVRCNYIHSDVDT
HHHCCCHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCCCCEEEEECCCHHH
LERVKIMDDLRQGVYDVLIGVNLLREGLDLPEVSLVAILDADKEGFLRSHRSLTQTAGRA
HHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCEEEEEEEECCHHHHHHHHHHHHHHHHHH
ARNVNGKVIMYADKITDSMRLTIDETNRRREKQLAYNEANGITPQQIKKARNLSVFGSPG
HHCCCCCEEEEECCCCCCEEEEEEHHHHHHHHHHHHHCCCCCCHHHHHHHCCCEEECCCC
SEADELLKEKHAYVEPSSPNIAADPIVQYMSKAQMEKSIERTRKLMQEAAKKLEFIEAAQ
CHHHHHHHHHHCCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
YRNELLKLEDLMKEKWG
HHHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: Hydrolase; Acting on ester bonds [C]

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: NA