Click here to switch to the map view.

The map label for this gene is trpR [H]

Identifier: 29144852

GI number: 29144852

Start: 4775748

End: 4776074

Strand: Direct

Name: trpR [H]

Synonym: t4622

Alternate gene names: 29144852

Gene position: 4775748-4776074 (Clockwise)

Preceding gene: 161486765

Following gene: 29144853

Centisome position: 99.66

GC content: 55.05

Gene sequence:

>327_bases
ATGACCCAGCATTCCCCTTATTCATCGGCTATCGCCGAACAACGTAATCAGGAGTGGCTTCGTTTTGTGGAGTTACTCCG
TCAGGCATATGCAGAGGATCTGCATCTGCCTTTATTACAACTGATGCTTACGCCGGACGAGCGTGAAGCGCTGGGAACGC
GCGTGCGCATTATTGAGGAGTTGCTGCGTGGCGAAATGAGCCAGCGCGAGTTGAAAACCGAGCTGGGGGCGGGCATCGCT
ACCATCACACGCGGGTCAAACAGCCTGAAATCCGCGCCGGTTGAACTGCGTCATTGGCTTGAGCAGATACTGCTGAAAAG
CGCCTGA

Upstream 100 bases:

>100_bases
AGAGGCCTTAATGAGCGACTCTGAGTGGCAGCGACGGTATTAATGCAGACGGGTTATGTTATCATTTGTACTCGTGTAAC
AGTACAAACGGCGGTATAAC

Downstream 100 bases:

>100_bases
TTTGCTCGTAGGCCGGATAAGACGAAGCGGCCATCCGGCAACATCGCCGCGAAATGCCTGATGGCGCTGTGCTTATCAGG
CCTACAACATAGCGCAAATA

Product: Trp operon repressor

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 108; Mature: 107

Protein sequence:

>108_residues
MTQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKTELGAGIA
TITRGSNSLKSAPVELRHWLEQILLKSA

Sequences:

>Translated_108_residues
MTQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKTELGAGIA
TITRGSNSLKSAPVELRHWLEQILLKSA
>Mature_107_residues
TQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEELLRGEMSQRELKTELGAGIAT
ITRGSNSLKSAPVELRHWLEQILLKSA

Specific function: This protein is an aporepressor. When complexed with L- tryptophan it binds the operator region of the trp operon (5'- ACTAGT-'3') and prevents the initiation of transcription. The complex also regulates trp repressor biosynthesis by binding to its regula

COG id: COG2973

COG function: function code K; Trp operon repressor

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the trpR family [H]

Homologues:

Organism=Escherichia coli, GI1790854, Length=107, Percent_Identity=84.1121495327103, Blast_Score=166, Evalue=3e-43,

Paralogues:

None

Copy number: 250-750 50-300 [C]

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000831
- InterPro:   IPR013335
- InterPro:   IPR010921
- ProDom:   PD012582 [H]

Pfam domain/function: PF01371 Trp_repressor [H]

EC number: NA

Molecular weight: Translated: 12392; Mature: 12261

Theoretical pI: Translated: 6.26; Mature: 6.26

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.0 %Cys     (Translated Protein)
2.8 %Met     (Translated Protein)
2.8 %Cys+Met (Translated Protein)
0.0 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
1.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEE
CCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LLRGEMSQRELKTELGAGIATITRGSNSLKSAPVELRHWLEQILLKSA
HHHCHHHHHHHHHHHCCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHCC
>Mature Secondary Structure 
TQHSPYSSAIAEQRNQEWLRFVELLRQAYAEDLHLPLLQLMLTPDEREALGTRVRIIEE
CCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHH
LLRGEMSQRELKTELGAGIATITRGSNSLKSAPVELRHWLEQILLKSA
HHHCHHHHHHHHHHHCCCHHHHHCCCCHHHHCCHHHHHHHHHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Alpha

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: DNA [C]

Specific reaction: Protein + DNA = Protein-DNA [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA