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The map label for this gene is prpR [H]

Identifier: 29142883

GI number: 29142883

Start: 2571825

End: 2573450

Strand: Direct

Name: prpR [H]

Synonym: t2497

Alternate gene names: 29142883

Gene position: 2571825-2573450 (Clockwise)

Preceding gene: 29142878

Following gene: 29142885

Centisome position: 53.67

GC content: 55.54

Gene sequence:

>1626_bases
ATGACGACTGCTCACAGCGCTCCGCGCGATAATAGCGATAAACCGGTGATCTGGACGGTCTCCGTAACGCGTCTATTCGA
ACTGTTTCGGGATATCAGCCTGGAATTCGATCATCTGGCGACCATCACGCCTATTCAACTCGGCTTTGAAAAGGCGGTGA
CCTACATTCGCAAAAAACTGGCGACCGAGCGCTGCGACGCGATTATCGCGGCGGGTTCGAACGGGGCCTATTTAAAAAGT
CGCCTGTCAATACCGGTGATCCTCATCAAGCCCAGCGGATTCGACGTATTACAGGCGCTGGCGAAAGCGGGAAAGCTCAC
CTCGTCTATCGGTATCGTGACCTATCAGGAGACCATTCCGACTTTACTTGCCTTTCAGAAAACGTTTCACCTCTGTCTTG
AACAGCGAAGCTATGTCACCGAAGAGGACGCGCGCGGGCAAATTAACGAACTTAAGGCCAACGGTATTGAGGCCGTCGTC
GGCGCGGGATTAATTACCGATCTGGCGGAAGAAGCGGGTATGACCGCCATCTTTATTTATTCCGCGGCGACCGTTCGTCA
GGCTTTTCATGATGCGCTGGATATGACCCGTCTGACACGGCGCCAGCGCGTGGATTACCCATCCGGCAAGGGATTACAAA
CCCGGTATGAACTGGGCGATATACGCGGCCAGTCGCCGCAAATGGAGCAGCTCCGCCAGACGATTACGCTCTATGCCCGC
TCCCGTGCGGCAGTGCTGATTCAGGGGGAAACAGGGACCGGAAAAGAGCTGGCGGCGCAGGCGATTCACCAGACGTTTTT
TCACCGCCAGCCTCACCGTCAGAATAAGCCATCCCCTCCCTTTGTCGCCGTCAATTGCGGCGCGATTACCGAGTCATTGC
TGGAGGCGGAACTGTTTGGTTATGAAGAGGGCGCGTTTACCGGTTCACGACGAGGAGGCCGGGCGGGGCTGTTTGAAATC
GCACACGGCGGCACGCTGTTTCTGGATGAAATCGGCGAAATGCCCTTGCCGTTACAAACCCGACTCTTGCGCGTACTGGA
GGAAAAAGCCGTCACTCGCGTCGGCGGACACCAACCGATCCCGGTGGATGTCCGGGTGATCAGCGCTACGCATTGCGATC
TGGATCGGGAGATAATGCAAGGACGTTTTCGCCCCGATCTCTTTTATCGCCTGAGTATTCTGCGTCTGACGCTTCCTCCT
TTGCGCGAGCGGCAGGCTGATATTTTGCCGCTGGCGGAAAGCTTTTTAAAACAGTCGCTGGCGGCGATGGAAATTCCGTT
TACCGAATCGATACGTCATGGATTGACACAGTGTCAGCCGCTTTTGCTGGCCTGGGGCTGGCCCGGTAATATTCGCGAAC
TGCGTAATATGATGGAGCGCCTGGCGCTTTTTTTAAGCGTCGATCCCGCACCAACGCTGGACAGGCAATTTATGCGGCAG
TTATTACCTGAGCTTATGGTGAACACAGCAGAGCTGACGCCTTCAACCGTGGATGCGCACACGTTACAGGATGTACTGGC
GCGCTTTAAGGGCGATAAGACCGCGGCGGCGCGTTATCTGGGGATTAGCCGCACCACTCTGTGGCGTCGTTTAAAAGCAG
GTGCCAAAGACCAGTCGGGTAATTAA

Upstream 100 bases:

>100_bases
GTCAGCTAACGTTTCATGAAACGAATCGCTCCGTTTCATTGCAACATTTATGAAACACGTTTAAAACAAAAAATCGCCCC
TTAAAGATGAACCTACTGCG

Downstream 100 bases:

>100_bases
GACAAATGACAGCGTCCTGAATGCCTGATGGCGCTACGTTTACTGCAGGCCGTCATCCGGCAAAACGGATGCCGGTTGCC
AGGAATAAAAATACCCGCCG

Product: propionate catabolism operon regulatory protein

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 541; Mature: 540

Protein sequence:

>541_residues
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKS
RLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPTLLAFQKTFHLCLEQRSYVTEEDARGQINELKANGIEAVV
GAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEI
AHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPP
LRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWGWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSGN

Sequences:

>Translated_541_residues
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKS
RLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPTLLAFQKTFHLCLEQRSYVTEEDARGQINELKANGIEAVV
GAGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEI
AHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPP
LRERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWGWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSGN
>Mature_540_residues
TTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKLATERCDAIIAAGSNGAYLKSR
LSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIPTLLAFQKTFHLCLEQRSYVTEEDARGQINELKANGIEAVVG
AGLITDLAEEAGMTAIFIYSAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYARS
RAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFGYEEGAFTGSRRGGRAGLFEIA
HGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPIPVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPL
RERQADILPLAESFLKQSLAAMEIPFTESIRHGLTQCQPLLLAWGWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQL
LPELMVNTAELTPSTVDAHTLQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSGN

Specific function: Involved in the transcriptional regulation of the propionate catabolism operon [H]

COG id: COG1221

COG function: function code KT; Transcriptional regulators containing an AAA-type ATPase domain and a DNA-binding domain

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 sigma-54 factor interaction domain [H]

Homologues:

Organism=Escherichia coli, GI1786524, Length=526, Percent_Identity=80.0380228136882, Blast_Score=840, Evalue=0.0,
Organism=Escherichia coli, GI1788550, Length=347, Percent_Identity=41.7867435158501, Blast_Score=244, Evalue=1e-65,
Organism=Escherichia coli, GI87082117, Length=354, Percent_Identity=44.0677966101695, Blast_Score=231, Evalue=8e-62,
Organism=Escherichia coli, GI1790437, Length=316, Percent_Identity=43.3544303797468, Blast_Score=229, Evalue=5e-61,
Organism=Escherichia coli, GI1788905, Length=317, Percent_Identity=42.9022082018927, Blast_Score=222, Evalue=4e-59,
Organism=Escherichia coli, GI1790299, Length=339, Percent_Identity=41.5929203539823, Blast_Score=221, Evalue=7e-59,
Organism=Escherichia coli, GI1789233, Length=332, Percent_Identity=40.6626506024096, Blast_Score=216, Evalue=3e-57,
Organism=Escherichia coli, GI87082152, Length=244, Percent_Identity=46.7213114754098, Blast_Score=198, Evalue=7e-52,
Organism=Escherichia coli, GI1789087, Length=344, Percent_Identity=40.1162790697674, Blast_Score=195, Evalue=6e-51,
Organism=Escherichia coli, GI87081872, Length=245, Percent_Identity=42.0408163265306, Blast_Score=182, Evalue=3e-47,
Organism=Escherichia coli, GI1787583, Length=329, Percent_Identity=32.8267477203647, Blast_Score=161, Evalue=1e-40,
Organism=Escherichia coli, GI87081858, Length=319, Percent_Identity=31.3479623824451, Blast_Score=138, Evalue=1e-33,
Organism=Escherichia coli, GI1789828, Length=282, Percent_Identity=33.6879432624113, Blast_Score=129, Evalue=5e-31,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003593
- InterPro:   IPR009057
- InterPro:   IPR002197
- InterPro:   IPR002078
- InterPro:   IPR012704
- InterPro:   IPR010524 [H]

Pfam domain/function: PF02954 HTH_8; PF06506 PrpR_N; PF00158 Sigma54_activat [H]

EC number: NA

Molecular weight: Translated: 60212; Mature: 60081

Theoretical pI: Translated: 8.88; Mature: 8.88

Prosite motif: PS00676 SIGMA54_INTERACT_2 ; PS00688 SIGMA54_INTERACT_3 ; PS50045 SIGMA54_INTERACT_4 ; PS00134 TRYPSIN_HIS

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
2.0 %Met     (Translated Protein)
3.0 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.9 %Met     (Mature Protein)
2.8 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MTTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKL
CCCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
ATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIP
HHHHHCEEEEECCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHCEEEEEHHHHH
TLLAFQKTFHLCLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIY
HHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHHHCC
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFG
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHC
YEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPI
CCCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSL
CEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
AAMEIPFTESIRHGLTQCQPLLLAWGWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
HHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSG
HHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCC
N
C
>Mature Secondary Structure 
TTAHSAPRDNSDKPVIWTVSVTRLFELFRDISLEFDHLATITPIQLGFEKAVTYIRKKL
CCCCCCCCCCCCCCEEEEEEHHHHHHHHHHCCCCHHHHCCCCHHHHHHHHHHHHHHHHH
ATERCDAIIAAGSNGAYLKSRLSIPVILIKPSGFDVLQALAKAGKLTSSIGIVTYQETIP
HHHHHCEEEEECCCCCCHHHCCCCEEEEECCCCHHHHHHHHHHCCHHHHCEEEEEHHHHH
TLLAFQKTFHLCLEQRSYVTEEDARGQINELKANGIEAVVGAGLITDLAEEAGMTAIFIY
HHHHHHHHHHHHHHHHHCCCCCHHCCCHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEE
SAATVRQAFHDALDMTRLTRRQRVDYPSGKGLQTRYELGDIRGQSPQMEQLRQTITLYAR
HHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCEEHHHHCCCCCCHHHHHHHHHHHHHCC
SRAAVLIQGETGTGKELAAQAIHQTFFHRQPHRQNKPSPPFVAVNCGAITESLLEAELFG
CCEEEEEECCCCCCHHHHHHHHHHHHHHCCCCCCCCCCCCEEEEECHHHHHHHHHHHHHC
YEEGAFTGSRRGGRAGLFEIAHGGTLFLDEIGEMPLPLQTRLLRVLEEKAVTRVGGHQPI
CCCCCCCCCCCCCCCCEEEECCCCEEEHHHHCCCCCCHHHHHHHHHHHHHHHHCCCCCCC
PVDVRVISATHCDLDREIMQGRFRPDLFYRLSILRLTLPPLRERQADILPLAESFLKQSL
CEEEEEEEECCCCCCHHHHCCCCCCCHHHHHHHHHHCCCCHHHHCCHHHHHHHHHHHHHH
AAMEIPFTESIRHGLTQCQPLLLAWGWPGNIRELRNMMERLALFLSVDPAPTLDRQFMRQ
HHHCCCCHHHHHHHHHHCCCEEEEECCCCCHHHHHHHHHHHHHHHCCCCCCCHHHHHHHH
LLPELMVNTAELTPSTVDAHTLQDVLARFKGDKTAAARYLGISRTTLWRRLKAGAKDQSG
HHHHHHHCHHHCCCCCCHHHHHHHHHHHHCCCHHHHHHHHCCHHHHHHHHHHCCCCCCCC
N
C

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9006051; 11677609 [H]