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The map label for this gene is proC [H]

Identifier: 29142864

GI number: 29142864

Start: 2549547

End: 2550356

Strand: Direct

Name: proC [H]

Synonym: t2478

Alternate gene names: 29142864

Gene position: 2549547-2550356 (Clockwise)

Preceding gene: 161486791

Following gene: 29142870

Centisome position: 53.2

GC content: 56.17

Gene sequence:

>810_bases
ATGGAGAAGAAAATCGGTTTTATTGGCTGCGGTAATATGGGCAAGGCTATTCTTGGCGGACTGATTGCCAGCGGTCAGGT
ACTTCCCGGCCAGATCTGGGTCTACACCCCCTCCCCCGATAAAGTTGCCGCCCTGCATGATCAGTACGGCATTAATGCGG
CGCAAAGCGCGCAGGAGGTCGCTCAGGTCGCGGATATCGTTTTCGGCGCGGTAAAACCGGGCATTATGGTGAAAGTGCTC
AGTGAAATCTCCTCCAGCCTGAACAAAGACTCGCTGGTGGTCTCTATCGCCGCAGGCGTAACGCTTGATCAGCTTGCGCG
CGCGCTGGGACACGACCGTAAAATCATTCGCGCTATGCCGAATACGCCGTCGCTGGTCAACGCAGGAATGACCTCCGTCA
CGCCCAACGCGCTGGTCACACCGGAAGATACGGCTGATGTGCTGAATATTTTCCGCTGCTTTGGCGAGGCGGAAGTGATT
GCTGAGCCGATGATCCATCCGGTGGTTGGCGTGAGCGGATCTTCGCCGGCCTATGTCTTTATGTTTATCGAGGCGATGGC
GGACGCTGCCGTTCTGGGCGGTATGCCTCGCGCTCAGGCTTATAAATTCGCCGCGCAGGCCGTCATGGGGTCGGCGAAAA
TAGTACTCGAAACCGGAAAGCATCCCGGCGAACTGAAAGATATGGTGTGCTCGCCTGGCGGAACGACGATTGAAGCCGTA
CGCGTTCTGGAAGAACGTGGCTTCCGCGCTGCGGTAATAGAAGCGATGACGAAATGTATGGAAAAATCAGAGGCGCTCAG
TAAATCCTGA

Upstream 100 bases:

>100_bases
GCTTTTGTCTTTCATCAAAGTGCTGTTTCTCCTTCTGCCCGTTTTCAATCCGCGTTAAGCTAACCATTCCCCATAACACA
CAAACATAGGGAGTGACGAG

Downstream 100 bases:

>100_bases
AGCCCGGCTGGACGTCATGCCGCCACTTCGGTGCGGTTACGTCCGGCATTCTTTGCTTTGTAAAGCGCCATATCCGCAGA
CTTTAACCATTCCCGATAAT

Product: pyrroline-5-carboxylate reductase

Products: NA

Alternate protein names: P5C reductase; P5CR [H]

Number of amino acids: Translated: 269; Mature: 269

Protein sequence:

>269_residues
MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQYGINAAQSAQEVAQVADIVFGAVKPGIMVKVL
SEISSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPSLVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVI
AEPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKIVLETGKHPGELKDMVCSPGGTTIEAV
RVLEERGFRAAVIEAMTKCMEKSEALSKS

Sequences:

>Translated_269_residues
MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQYGINAAQSAQEVAQVADIVFGAVKPGIMVKVL
SEISSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPSLVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVI
AEPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKIVLETGKHPGELKDMVCSPGGTTIEAV
RVLEERGFRAAVIEAMTKCMEKSEALSKS
>Mature_269_residues
MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQYGINAAQSAQEVAQVADIVFGAVKPGIMVKVL
SEISSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMPNTPSLVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVI
AEPMIHPVVGVSGSSPAYVFMFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKIVLETGKHPGELKDMVCSPGGTTIEAV
RVLEERGFRAAVIEAMTKCMEKSEALSKS

Specific function: Proline biosynthesis; third (last) step. [C]

COG id: COG0345

COG function: function code E; Pyrroline-5-carboxylate reductase

Gene ontology:

Cell location: Cytoplasm [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyrroline-5-carboxylate reductase family [H]

Homologues:

Organism=Homo sapiens, GI21361454, Length=266, Percent_Identity=37.593984962406, Blast_Score=167, Evalue=1e-41,
Organism=Homo sapiens, GI24797097, Length=266, Percent_Identity=37.593984962406, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI24797095, Length=266, Percent_Identity=37.593984962406, Blast_Score=166, Evalue=2e-41,
Organism=Homo sapiens, GI198041662, Length=266, Percent_Identity=34.5864661654135, Blast_Score=166, Evalue=2e-41,
Organism=Escherichia coli, GI1786585, Length=269, Percent_Identity=95.1672862453532, Blast_Score=529, Evalue=1e-151,
Organism=Caenorhabditis elegans, GI17569021, Length=265, Percent_Identity=40.7547169811321, Blast_Score=187, Evalue=6e-48,
Organism=Caenorhabditis elegans, GI17540664, Length=280, Percent_Identity=37.1428571428571, Blast_Score=148, Evalue=3e-36,
Organism=Saccharomyces cerevisiae, GI6320861, Length=278, Percent_Identity=26.6187050359712, Blast_Score=105, Evalue=5e-24,
Organism=Drosophila melanogaster, GI24648116, Length=277, Percent_Identity=38.9891696750903, Blast_Score=178, Evalue=3e-45,
Organism=Drosophila melanogaster, GI21358587, Length=265, Percent_Identity=38.8679245283019, Blast_Score=176, Evalue=2e-44,
Organism=Drosophila melanogaster, GI24647700, Length=169, Percent_Identity=40.2366863905325, Blast_Score=128, Evalue=4e-30,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008927
- InterPro:   IPR016040
- InterPro:   IPR004455
- InterPro:   IPR000304 [H]

Pfam domain/function: PF03807 F420_oxidored [H]

EC number: =1.5.1.2 [H]

Molecular weight: Translated: 28116; Mature: 28116

Theoretical pI: Translated: 6.13; Mature: 6.13

Prosite motif: PS00521 P5CR

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
4.8 %Met     (Translated Protein)
6.3 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
4.8 %Met     (Mature Protein)
6.3 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQYGINAAQSAQEV
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHH
AQVADIVFGAVKPGIMVKVLSEISSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHCCC
NTPSLVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIAEPMIHPVVGVSGSSPAYVF
CCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHH
MFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKIVLETGKHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCCCCHHHHH
RVLEERGFRAAVIEAMTKCMEKSEALSKS
HHHHHCCCHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MEKKIGFIGCGNMGKAILGGLIASGQVLPGQIWVYTPSPDKVAALHDQYGINAAQSAQEV
CCCCEEEEECCCHHHHHHHHHHHCCCCCCCEEEEECCCCCCHHHHHHHHCCCHHHHHHHH
AQVADIVFGAVKPGIMVKVLSEISSSLNKDSLVVSIAAGVTLDQLARALGHDRKIIRAMP
HHHHHHHHHHCCCHHHHHHHHHHHHHCCCCCEEEEEECCCCHHHHHHHHCCCCHHHHCCC
NTPSLVNAGMTSVTPNALVTPEDTADVLNIFRCFGEAEVIAEPMIHPVVGVSGSSPAYVF
CCCHHHHCCCCCCCCCCEECCCHHHHHHHHHHHHCCHHHHHHHHHHHHCCCCCCCCHHHH
MFIEAMADAAVLGGMPRAQAYKFAAQAVMGSAKIVLETGKHPGELKDMVCSPGGTTIEAV
HHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCEEEEECCCCCCHHHHHHCCCCCCHHHHH
RVLEERGFRAAVIEAMTKCMEKSEALSKS
HHHHHCCCHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 6296787; 9278503 [H]