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The map label for this gene is lolE [H]

Identifier: 29142135

GI number: 29142135

Start: 1765879

End: 1767123

Strand: Reverse

Name: lolE [H]

Synonym: t1701

Alternate gene names: 29142135

Gene position: 1767123-1765879 (Counterclockwise)

Preceding gene: 29142136

Following gene: 29142134

Centisome position: 36.88

GC content: 53.57

Gene sequence:

>1245_bases
ATGGCGTCGCCTTTATCATTGTTAATTGGCTTGCGTTTCAGCCGTGGACGGCGGCGCGGCGGTATGGTTTCGCTCATTTC
CGTCATTTCTACCATCGGTATCGCGCTGGGCGTGGCGGTGTTGATTGTCGGTTTAAGCGCGATGAACGGTTTCGAACGCG
AGTTGAATAACCGTATTCTGGCGGTGGTTCCACACGGGGAGATTGAAGCGGTCAATCAGCCGTGGACCAACTGGCGTGAA
GCGCTGGCAAAAGTGCAGAAGGTGCCGGGCATTGCCGCCGCCGCGCCGTATATCAATTTTACCGGCCTGGTAGAGAGCGG
GGCGAATTTGCGCGCCATTCAGGTTAAAGGCGTCGATCCTAAGCAAGAGCAGCAGCTTAGCGCGTTACCGTCATTTGTGC
AAAATCACGCCTGGGATCATTTCAAAGCGGGCGAGCAGCAGATCATTATCGGTAAAGGCGTCGCCGATGCGCTGAACGTG
AAACAGGGCGACTGGGTGTCCATCATGATCCCCAATGCGAATGCCGACCATAAGCTGCTCCAGCCCAAACGCGTGCGTTT
GCATGTCATCGGGATTCTGCAACTGAGCGGCCAGCTCGATCACAGCTTCGCCATGATCCCGCTTGAGGATGCGCAGCAGT
ATCTGGATATGGGGTCCAGCGTTTCCGGTATCGCGCTTAAAGTCCACGACGTGTTTAATGCGAACAAACTGGTGCGTGAT
GCGGGTGAAGTGACTAACAGCTATGTCTACATTAAGAGCTGGATCGGCACCTACGGCTATATGTATCGCGATATCCAGAT
GATTCGCGCCATTATGTATCTGGCGATGATTCTGGTGATCGGCGTGGCCTGTTTTAATATCGTTTCCACCTTAGTGATGG
CGGTAAAAGACAAAAGCGGCGACATTGCGGTATTAAGAACGCTGGGGGCGAAAGATGGTTTGATTCGTGCCATTTTCGTC
TGGTACGGACTACTGGCGGGCTTGCTGGGCAGCTTGATTGGCGTGGCGATCGGCGTTGTCGTTTCGCTTCAGCTTACCGC
CATTATTAATGGGATTGAAAAGGAGATCGGGCATCAGTTTTTGTCCGGCGATATCTATTTTATCGACTTCCTGCCATCCG
AATTACATTGGCTGGACGTTGTTTACGTACTGGTCACGGCGTTGTTGTTAAGCTTACTGGCGAGCTGGTATCCGGCGCGG
CGGGCGAGCAACATTGACCCTGCGCGAGTATTGAGCGGCCAGTAA

Upstream 100 bases:

>100_bases
TGGTGACTCACGATTTGCAACTGGCGAAACGTATGAGCCGCCAGCTTGAGATGCGCGATGGCCGCCTGACAGCGGAACTG
AGCCTGATGGGGGCTGAGTA

Downstream 100 bases:

>100_bases
TCGCGGAATATAAAAACAAGGAGCGGCGATGTATTACGGGTTTGACATTGGCGGAACAAAGATTGCGTTAGGCGTATTTG
ACTCAACGCGGCGGCTGCAG

Product: outer membrane-specific lipoprotein transporter subunit LolE

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 414; Mature: 413

Protein sequence:

>414_residues
MASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVNQPWTNWRE
ALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDPKQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNV
KQGDWVSIMIPNANADHKLLQPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFV
WYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKEIGHQFLSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPAR
RASNIDPARVLSGQ

Sequences:

>Translated_414_residues
MASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVNQPWTNWRE
ALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDPKQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNV
KQGDWVSIMIPNANADHKLLQPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFV
WYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKEIGHQFLSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPAR
RASNIDPARVLSGQ
>Mature_413_residues
ASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRILAVVPHGEIEAVNQPWTNWREA
LAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDPKQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNVK
QGDWVSIMIPNANADHKLLQPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRDA
GEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSGDIAVLRTLGAKDGLIRAIFVW
YGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKEIGHQFLSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPARR
ASNIDPARVLSGQ

Specific function: Part of an ATP-dependent transport system lolCDE responsible for the release of lipoproteins targeted to the outer membrane from the inner membrane. Such a release is dependent of the sorting-signal (absence of an Asp at position 2 of the mature lipoprote

COG id: COG4591

COG function: function code M; ABC-type transport system, involved in lipoprotein release, permease component

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the ABC-4 integral membrane protein family. LolC/E subfamily [H]

Homologues:

Organism=Escherichia coli, GI1787362, Length=414, Percent_Identity=92.512077294686, Blast_Score=720, Evalue=0.0,
Organism=Escherichia coli, GI1787360, Length=420, Percent_Identity=28.5714285714286, Blast_Score=144, Evalue=9e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR003838
- InterPro:   IPR011925
- InterPro:   IPR011926 [H]

Pfam domain/function: PF02687 FtsX [H]

EC number: NA

Molecular weight: Translated: 45040; Mature: 44909

Theoretical pI: Translated: 9.33; Mature: 9.33

Prosite motif: PS00027 HOMEOBOX_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.2 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
2.9 %Cys+Met (Translated Protein)
0.2 %Cys     (Mature Protein)
2.4 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRIL
CCCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEE
AVVPHGEIEAVNQPWTNWREALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDP
EEECCCCCEECCCCHHHHHHHHHHHHHCCCCCHHCCCCEEHHHHCCCCCEEEEEEECCCC
KQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNVKQGDWVSIMIPNANADHKLL
HHHHHHHHHHHHHHHCCCCHHCCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCCCC
QPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
CCCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEEHHHCHHHHHHH
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSG
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAVLRTLGAKDGLIRAIFVWYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKEIGHQF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPARRASNIDPARVLSGQ
HCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC
>Mature Secondary Structure 
ASPLSLLIGLRFSRGRRRGGMVSLISVISTIGIALGVAVLIVGLSAMNGFERELNNRIL
CCHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHCCCEE
AVVPHGEIEAVNQPWTNWREALAKVQKVPGIAAAAPYINFTGLVESGANLRAIQVKGVDP
EEECCCCCEECCCCHHHHHHHHHHHHHCCCCCHHCCCCEEHHHHCCCCCEEEEEEECCCC
KQEQQLSALPSFVQNHAWDHFKAGEQQIIIGKGVADALNVKQGDWVSIMIPNANADHKLL
HHHHHHHHHHHHHHHCCCCHHCCCCCEEEEECCCHHHCCCCCCCEEEEEECCCCCCCCCC
QPKRVRLHVIGILQLSGQLDHSFAMIPLEDAQQYLDMGSSVSGIALKVHDVFNANKLVRD
CCCCEEEEEEEEEEECCCCCCCEEEEEHHHHHHHHHCCCCCCCEEEEEEHHHCHHHHHHH
AGEVTNSYVYIKSWIGTYGYMYRDIQMIRAIMYLAMILVIGVACFNIVSTLVMAVKDKSG
HHHHHCCEEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCC
DIAVLRTLGAKDGLIRAIFVWYGLLAGLLGSLIGVAIGVVVSLQLTAIINGIEKEIGHQF
CEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LSGDIYFIDFLPSELHWLDVVYVLVTALLLSLLASWYPARRASNIDPARVLSGQ
HCCCEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHHCCHHHCCCCCHHHHCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 8905232; 9278503; 10783239 [H]