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The map label for this gene is glsA2 [H]

Identifier: 29141897

GI number: 29141897

Start: 1490901

End: 1491827

Strand: Direct

Name: glsA2 [H]

Synonym: t1446

Alternate gene names: 29141897

Gene position: 1490901-1491827 (Clockwise)

Preceding gene: 29141896

Following gene: 29141898

Centisome position: 31.11

GC content: 54.15

Gene sequence:

>927_bases
GTGGCCAGGGCCATGGATAATGCAATTTTAGAAACGATTTTACAGCGCGTTCGCCCCCTCATTGGCCAGGGCAAAGTAGC
TGACTATATTCCGGCATTAGCGTCCGTCGAGGGTTCAAAGCTGGGAATAGCGATTTGTACCGTGGACGGGCAGCATTATC
AGGCGGGCGATGCGCACGAACGCTTCTCTATTCAGTCTATTTCGAAAGTGCTCAGTCTGGTGATGGCGATGCGTCATTAT
CCGGAAGAGGAGATCTGGCAGCGTGTCGGAAAAGATCCTTCCGGCTCGCCGTTCAATTCGTTGGTTCAGTTAGAGATGGA
ACAAGGCATCCCGCGTAATCCATTTATTAATGCGGGCGCGCTGGTGGTATGCGACATGTTGCAAGGGCGGCTTAGCGCGC
CGCGTCAGCGGATGCTGGAAGTTGCGCGCGCGCTTTGCGGCGTATCGGATATTACATATGACGCTACGGTCGCGCGCTCT
GAATTTGAGCATTCCGCCCGTAACGCCGCTATTGCCTGGCTGATGAAATCATTCGGTAATTTTCATCATGATGTGCCTAC
CGTGTTGCAAAATTACTTCCACTACTGTGCGTTGAAAATGAGCTGCATGGAACTGGCGAGGACGTTTGTCTTTCTGGCGA
ATCAGGGCGAGGCGTTTCATCTCGACGAGCCGGTAGTTACCCCCATGCAGGCCCGGCAGATTAATGCGCTAATGGCGACC
AGCGGTATGTATCAGAATGCCGGCGAGTTTGCCTGGCGGGTGGGATTGCCCGCTAAATCCGGCGTGGGCGGCGGTATTGT
CGCCATTGTGCCGCATGAAATGGCGATTGCCGTCTGGAGTCCGGAGCTGGATCCTGCGGGAAACTCTCTGGCAGGTATCG
CCGCGCTTGAACAATTAACACAAACGTTAGGACGTTTGGTATACTGA

Upstream 100 bases:

>100_bases
GCAGACCGTCTGGAAGAACCGCGTCTAATCGCCCTGACGTCGCGTGGCGCCCTCTGCTATACTCGCAGGCCTTTTCAGAC
CTGCGAGCAAGGAGCATGTT

Downstream 100 bases:

>100_bases
TGAATGCGCTTGAACCGCTCTTTGCCCGCCTGGCGCGATCGACATTTCGTTCGCGCTTTCGTCTCGGGATAAAAGAAAGA
CAATATTGCTGGGATAAAGG

Product: glutaminase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 308; Mature: 307

Protein sequence:

>308_residues
MARAMDNAILETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTVDGQHYQAGDAHERFSIQSISKVLSLVMAMRHY
PEEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGALVVCDMLQGRLSAPRQRMLEVARALCGVSDITYDATVARS
EFEHSARNAAIAWLMKSFGNFHHDVPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTPMQARQINALMAT
SGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAALEQLTQTLGRLVY

Sequences:

>Translated_308_residues
MARAMDNAILETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTVDGQHYQAGDAHERFSIQSISKVLSLVMAMRHY
PEEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGALVVCDMLQGRLSAPRQRMLEVARALCGVSDITYDATVARS
EFEHSARNAAIAWLMKSFGNFHHDVPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTPMQARQINALMAT
SGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAALEQLTQTLGRLVY
>Mature_307_residues
ARAMDNAILETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTVDGQHYQAGDAHERFSIQSISKVLSLVMAMRHYP
EEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGALVVCDMLQGRLSAPRQRMLEVARALCGVSDITYDATVARSE
FEHSARNAAIAWLMKSFGNFHHDVPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTPMQARQINALMATS
GMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAALEQLTQTLGRLVY

Specific function: Unknown

COG id: COG2066

COG function: function code E; Glutaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the glutaminase family [H]

Homologues:

Organism=Homo sapiens, GI156104878, Length=274, Percent_Identity=38.3211678832117, Blast_Score=180, Evalue=2e-45,
Organism=Homo sapiens, GI20336214, Length=294, Percent_Identity=34.0136054421769, Blast_Score=159, Evalue=3e-39,
Organism=Escherichia coli, GI1787804, Length=308, Percent_Identity=90.9090909090909, Blast_Score=584, Evalue=1e-168,
Organism=Escherichia coli, GI1786693, Length=286, Percent_Identity=38.1118881118881, Blast_Score=187, Evalue=5e-49,
Organism=Caenorhabditis elegans, GI17507019, Length=293, Percent_Identity=37.2013651877133, Blast_Score=180, Evalue=8e-46,
Organism=Caenorhabditis elegans, GI193204073, Length=300, Percent_Identity=36.6666666666667, Blast_Score=176, Evalue=2e-44,
Organism=Caenorhabditis elegans, GI193204075, Length=302, Percent_Identity=36.4238410596026, Blast_Score=175, Evalue=3e-44,
Organism=Caenorhabditis elegans, GI17532727, Length=304, Percent_Identity=32.8947368421053, Blast_Score=169, Evalue=2e-42,
Organism=Drosophila melanogaster, GI281363241, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24653162, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI281363239, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=6e-45,
Organism=Drosophila melanogaster, GI24653156, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI24653164, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=7e-45,
Organism=Drosophila melanogaster, GI116008307, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24653158, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=8e-45,
Organism=Drosophila melanogaster, GI24653166, Length=285, Percent_Identity=35.4385964912281, Blast_Score=177, Evalue=9e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR012338
- InterPro:   IPR015868 [H]

Pfam domain/function: PF04960 Glutaminase [H]

EC number: =3.5.1.2 [H]

Molecular weight: Translated: 33627; Mature: 33496

Theoretical pI: Translated: 6.42; Mature: 6.42

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
4.5 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
4.2 %Met     (Mature Protein)
5.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MARAMDNAILETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTVDGQHYQAGDAHE
CCCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHH
RFSIQSISKVLSLVMAMRHYPEEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
LVVCDMLQGRLSAPRQRMLEVARALCGVSDITYDATVARSEFEHSARNAAIAWLMKSFGN
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FHHDVPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTPMQARQINALMAT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHH
SGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAALEQLT
CCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHH
QTLGRLVY
HHHHHHCC
>Mature Secondary Structure 
ARAMDNAILETILQRVRPLIGQGKVADYIPALASVEGSKLGIAICTVDGQHYQAGDAHE
CCHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHCCCCCCEEEEEEEECCCCCCCCCHHH
RFSIQSISKVLSLVMAMRHYPEEEIWQRVGKDPSGSPFNSLVQLEMEQGIPRNPFINAGA
HHHHHHHHHHHHHHHHHHHCCHHHHHHHHCCCCCCCCHHHHHHHHHHCCCCCCCCCCCCH
LVVCDMLQGRLSAPRQRMLEVARALCGVSDITYDATVARSEFEHSARNAAIAWLMKSFGN
HHHHHHHHHHHCCHHHHHHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHCC
FHHDVPTVLQNYFHYCALKMSCMELARTFVFLANQGEAFHLDEPVVTPMQARQINALMAT
CCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCEEECCCCCCCCHHHHHHHHHHHH
SGMYQNAGEFAWRVGLPAKSGVGGGIVAIVPHEMAIAVWSPELDPAGNSLAGIAALEQLT
CCCCCCCCCEEEEECCCCCCCCCCCEEEEECCCEEEEEECCCCCCCCCCHHHHHHHHHHH
QTLGRLVY
HHHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11206551; 11258796 [H]