BacMap

Definition	Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome.
Accession	NC_004631
Length	4,791,961

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The map label for this gene is ydfG

Identifier: 29141883

GI number: 29141883

Start: 1477079

End: 1477825

Strand: Reverse

Name: ydfG

Synonym: t1432

Alternate gene names: 29141883

Gene position: 1477825-1477079 (Counterclockwise)

Preceding gene: 29141886

Following gene: 29141882

Centisome position: 30.84

GC content: 53.68

Gene sequence:

>747_bases
ATGATCGTTTTAGTAACTGGAGCAACCGCAGGGTTTGGCGAGTGCATTGCACGCCGTTTTGTTGAGAATGGACATAAAGT
CATTGCCACGGGACGTCGTCATGAACGCCTGCAAGCGTTAAAAGATGAGCTTGGCGAGAACGTATTGACCGCCCAACTGG
ACGTGCGCAACCGCGCGGCCATCGAAGAGATGATGGCCTCTCTGCCTGCGCAGTGGCGCGATATTGATGTGCTGGTCAAT
AACGCCGGTCTGGCGCTGGGTCTTGAACCGGCGCATAAAGCCAGCGTAGAAGACTGGGAAACTATGATCGATACTAATAA
TAAAGGCTTAATTTATATGACCCGCGCCGTGCTGCCAGGAATGGTCGAACGTAATCGCGGTCATATCATTAACATCGGTT
CAACCGCCGGCAGTTGGCCTTATGCTGGTGGCAACGTCTATGGCGCGACGAAAGCCTTTGTGCGCCAGTTTAGCCTGAAT
TTGCGCACGGATTTACACGGCACGGCGGTTCGCGTGACCGACATTGAACCGGGTCTGGTTGGCGGCACCGAGTTTTCCAG
CGTCCGTTTCAAAGGCGACGATGAGAAAGCGGGTAAAACCTACGAAAATACCACCGCGCTCACGCCAGAAGACATTACCG
AAGCGGTATGGTGGGTGGCCACACTCCCCGCGCATGTGAATATTAATACCGTTGAAATGATGCCTGTTACCCAATCCTTC
GCAGGGCTCAGCGTCCACCGTAGCTAA

Upstream 100 bases:

>100_bases
TTCCCCCTATGCTGACCGCAACCGTGTTAACCAGGATTACCCTTTCATAAACGCCGCGTGCTATGGTAATACAACACAAA
AAGCGTTGAGGAACTGTGTG

Downstream 100 bases:

>100_bases
GGGGTTATACCCGGTCTGCGGGCCGGGTAATCCCTGGCAAACGTATCTGCAACCAGAAACATGATCGGTATAGACCGCCA
CGGAAAAGTGGTAGAGTATC

Product: 3-hydroxy acid dehydrogenase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 248; Mature: 248

Protein sequence:

>248_residues
MIVLVTGATAGFGECIARRFVENGHKVIATGRRHERLQALKDELGENVLTAQLDVRNRAAIEEMMASLPAQWRDIDVLVN
NAGLALGLEPAHKASVEDWETMIDTNNKGLIYMTRAVLPGMVERNRGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLN
LRTDLHGTAVRVTDIEPGLVGGTEFSSVRFKGDDEKAGKTYENTTALTPEDITEAVWWVATLPAHVNINTVEMMPVTQSF
AGLSVHRS

Sequences:

>Translated_248_residues
MIVLVTGATAGFGECIARRFVENGHKVIATGRRHERLQALKDELGENVLTAQLDVRNRAAIEEMMASLPAQWRDIDVLVN
NAGLALGLEPAHKASVEDWETMIDTNNKGLIYMTRAVLPGMVERNRGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLN
LRTDLHGTAVRVTDIEPGLVGGTEFSSVRFKGDDEKAGKTYENTTALTPEDITEAVWWVATLPAHVNINTVEMMPVTQSF
AGLSVHRS
>Mature_248_residues
MIVLVTGATAGFGECIARRFVENGHKVIATGRRHERLQALKDELGENVLTAQLDVRNRAAIEEMMASLPAQWRDIDVLVN
NAGLALGLEPAHKASVEDWETMIDTNNKGLIYMTRAVLPGMVERNRGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLN
LRTDLHGTAVRVTDIEPGLVGGTEFSSVRFKGDDEKAGKTYENTTALTPEDITEAVWWVATLPAHVNINTVEMMPVTQSF
AGLSVHRS

Specific function: Catalyzes the NADP-dependent oxidation of L-allo- threonine and L-serine

COG id: COG4221

COG function: function code R; Short-chain alcohol dehydrogenase of unknown specificity

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the short-chain dehydrogenases/reductases (SDR) family

Homologues:

Organism=Homo sapiens, GI109715829, Length=248, Percent_Identity=35.0806451612903, Blast_Score=132, Evalue=2e-31,
Organism=Homo sapiens, GI7657478, Length=263, Percent_Identity=29.277566539924, Blast_Score=91, Evalue=9e-19,
Organism=Homo sapiens, GI7705855, Length=206, Percent_Identity=30.5825242718447, Blast_Score=91, Evalue=1e-18,
Organism=Homo sapiens, GI40548397, Length=184, Percent_Identity=34.7826086956522, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI214010158, Length=184, Percent_Identity=34.7826086956522, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI214010156, Length=184, Percent_Identity=34.7826086956522, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22758144, Length=184, Percent_Identity=34.7826086956522, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI22507405, Length=183, Percent_Identity=34.9726775956284, Blast_Score=89, Evalue=3e-18,
Organism=Homo sapiens, GI150247226, Length=195, Percent_Identity=32.8205128205128, Blast_Score=89, Evalue=4e-18,
Organism=Homo sapiens, GI19923817, Length=188, Percent_Identity=29.2553191489362, Blast_Score=86, Evalue=2e-17,
Organism=Homo sapiens, GI20149619, Length=193, Percent_Identity=29.5336787564767, Blast_Score=86, Evalue=4e-17,
Organism=Homo sapiens, GI7706318, Length=190, Percent_Identity=31.5789473684211, Blast_Score=82, Evalue=3e-16,
Organism=Homo sapiens, GI157739938, Length=187, Percent_Identity=27.2727272727273, Blast_Score=80, Evalue=1e-15,
Organism=Homo sapiens, GI4557649, Length=179, Percent_Identity=29.0502793296089, Blast_Score=77, Evalue=1e-14,
Organism=Homo sapiens, GI32483357, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI19743808, Length=183, Percent_Identity=30.0546448087432, Blast_Score=75, Evalue=8e-14,
Organism=Homo sapiens, GI4758504, Length=202, Percent_Identity=27.2277227722772, Blast_Score=73, Evalue=3e-13,
Organism=Homo sapiens, GI4503817, Length=183, Percent_Identity=27.8688524590164, Blast_Score=72, Evalue=4e-13,
Organism=Homo sapiens, GI44680136, Length=184, Percent_Identity=29.3478260869565, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI44680133, Length=184, Percent_Identity=29.3478260869565, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI17738292, Length=184, Percent_Identity=29.3478260869565, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI226371731, Length=185, Percent_Identity=27.5675675675676, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI50726952, Length=185, Percent_Identity=28.6486486486486, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI119392083, Length=198, Percent_Identity=28.7878787878788, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI40254992, Length=180, Percent_Identity=26.6666666666667, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI5031737, Length=197, Percent_Identity=27.4111675126904, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4504503, Length=181, Percent_Identity=25.9668508287293, Blast_Score=65, Evalue=4e-11,
Organism=Homo sapiens, GI33667109, Length=190, Percent_Identity=27.3684210526316, Blast_Score=65, Evalue=8e-11,
Organism=Escherichia coli, GI1787820, Length=248, Percent_Identity=87.9032258064516, Blast_Score=462, Evalue=1e-132,
Organism=Escherichia coli, GI1787335, Length=197, Percent_Identity=33.502538071066, Blast_Score=104, Evalue=5e-24,
Organism=Escherichia coli, GI87082100, Length=181, Percent_Identity=34.2541436464088, Blast_Score=80, Evalue=1e-16,
Organism=Escherichia coli, GI1786812, Length=240, Percent_Identity=25.8333333333333, Blast_Score=72, Evalue=3e-14,
Organism=Escherichia coli, GI1790717, Length=179, Percent_Identity=26.8156424581006, Blast_Score=63, Evalue=2e-11,
Organism=Caenorhabditis elegans, GI17559104, Length=245, Percent_Identity=28.5714285714286, Blast_Score=95, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI17562910, Length=238, Percent_Identity=27.3109243697479, Blast_Score=87, Evalue=8e-18,
Organism=Caenorhabditis elegans, GI17560332, Length=241, Percent_Identity=29.045643153527, Blast_Score=87, Evalue=1e-17,
Organism=Caenorhabditis elegans, GI71994600, Length=236, Percent_Identity=25.8474576271186, Blast_Score=84, Evalue=6e-17,
Organism=Caenorhabditis elegans, GI17538480, Length=240, Percent_Identity=26.6666666666667, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI71994604, Length=234, Percent_Identity=26.9230769230769, Blast_Score=84, Evalue=7e-17,
Organism=Caenorhabditis elegans, GI17551412, Length=247, Percent_Identity=27.9352226720648, Blast_Score=81, Evalue=4e-16,
Organism=Caenorhabditis elegans, GI25152911, Length=215, Percent_Identity=31.1627906976744, Blast_Score=78, Evalue=5e-15,
Organism=Caenorhabditis elegans, GI17562908, Length=187, Percent_Identity=28.8770053475936, Blast_Score=77, Evalue=8e-15,
Organism=Caenorhabditis elegans, GI17560150, Length=186, Percent_Identity=29.0322580645161, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI17544670, Length=243, Percent_Identity=25.5144032921811, Blast_Score=77, Evalue=9e-15,
Organism=Caenorhabditis elegans, GI193204405, Length=221, Percent_Identity=28.0542986425339, Blast_Score=76, Evalue=1e-14,
Organism=Caenorhabditis elegans, GI17565030, Length=241, Percent_Identity=27.8008298755187, Blast_Score=75, Evalue=4e-14,
Organism=Caenorhabditis elegans, GI17562904, Length=189, Percent_Identity=30.1587301587302, Blast_Score=74, Evalue=5e-14,
Organism=Caenorhabditis elegans, GI17563726, Length=240, Percent_Identity=27.5, Blast_Score=73, Evalue=1e-13,
Organism=Caenorhabditis elegans, GI72000259, Length=238, Percent_Identity=28.5714285714286, Blast_Score=72, Evalue=2e-13,
Organism=Caenorhabditis elegans, GI17538486, Length=196, Percent_Identity=27.5510204081633, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17560676, Length=200, Percent_Identity=27, Blast_Score=72, Evalue=3e-13,
Organism=Caenorhabditis elegans, GI17562990, Length=187, Percent_Identity=27.2727272727273, Blast_Score=72, Evalue=4e-13,
Organism=Caenorhabditis elegans, GI17560176, Length=188, Percent_Identity=28.7234042553192, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI17562906, Length=190, Percent_Identity=26.8421052631579, Blast_Score=71, Evalue=6e-13,
Organism=Caenorhabditis elegans, GI193203117, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI193203115, Length=195, Percent_Identity=27.6923076923077, Blast_Score=67, Evalue=9e-12,
Organism=Caenorhabditis elegans, GI212646214, Length=222, Percent_Identity=27.027027027027, Blast_Score=67, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17560220, Length=190, Percent_Identity=27.3684210526316, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17531453, Length=187, Percent_Identity=27.807486631016, Blast_Score=66, Evalue=1e-11,
Organism=Caenorhabditis elegans, GI17557780, Length=186, Percent_Identity=27.4193548387097, Blast_Score=65, Evalue=3e-11,
Organism=Caenorhabditis elegans, GI17508895, Length=152, Percent_Identity=28.9473684210526, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI17564282, Length=152, Percent_Identity=28.2894736842105, Blast_Score=64, Evalue=7e-11,
Organism=Caenorhabditis elegans, GI115534694, Length=179, Percent_Identity=30.1675977653631, Blast_Score=64, Evalue=9e-11,
Organism=Saccharomyces cerevisiae, GI6323882, Length=245, Percent_Identity=38.7755102040816, Blast_Score=166, Evalue=2e-42,
Organism=Saccharomyces cerevisiae, GI6322227, Length=190, Percent_Identity=27.3684210526316, Blast_Score=79, Evalue=1e-15,
Organism=Saccharomyces cerevisiae, GI6322067, Length=176, Percent_Identity=30.1136363636364, Blast_Score=72, Evalue=1e-13,
Organism=Saccharomyces cerevisiae, GI6319635, Length=204, Percent_Identity=27.9411764705882, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI116007236, Length=253, Percent_Identity=28.8537549407115, Blast_Score=112, Evalue=3e-25,
Organism=Drosophila melanogaster, GI21358495, Length=223, Percent_Identity=30.4932735426009, Blast_Score=102, Evalue=2e-22,
Organism=Drosophila melanogaster, GI23397609, Length=180, Percent_Identity=34.4444444444444, Blast_Score=100, Evalue=1e-21,
Organism=Drosophila melanogaster, GI24643142, Length=179, Percent_Identity=32.4022346368715, Blast_Score=96, Evalue=2e-20,
Organism=Drosophila melanogaster, GI281364494, Length=252, Percent_Identity=27.7777777777778, Blast_Score=95, Evalue=3e-20,
Organism=Drosophila melanogaster, GI28571526, Length=231, Percent_Identity=29.4372294372294, Blast_Score=92, Evalue=2e-19,
Organism=Drosophila melanogaster, GI24640442, Length=194, Percent_Identity=30.9278350515464, Blast_Score=92, Evalue=5e-19,
Organism=Drosophila melanogaster, GI24641388, Length=252, Percent_Identity=28.968253968254, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24663911, Length=252, Percent_Identity=26.5873015873016, Blast_Score=87, Evalue=1e-17,
Organism=Drosophila melanogaster, GI24648693, Length=254, Percent_Identity=29.5275590551181, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI21355889, Length=254, Percent_Identity=29.5275590551181, Blast_Score=85, Evalue=5e-17,
Organism=Drosophila melanogaster, GI28571387, Length=252, Percent_Identity=27.7777777777778, Blast_Score=82, Evalue=3e-16,
Organism=Drosophila melanogaster, GI116007238, Length=186, Percent_Identity=29.5698924731183, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI161076933, Length=181, Percent_Identity=29.8342541436464, Blast_Score=82, Evalue=4e-16,
Organism=Drosophila melanogaster, GI24584748, Length=181, Percent_Identity=29.8342541436464, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI21357041, Length=183, Percent_Identity=27.8688524590164, Blast_Score=81, Evalue=5e-16,
Organism=Drosophila melanogaster, GI116007234, Length=253, Percent_Identity=28.4584980237154, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24641232, Length=257, Percent_Identity=27.2373540856031, Blast_Score=80, Evalue=1e-15,
Organism=Drosophila melanogaster, GI24644339, Length=183, Percent_Identity=28.4153005464481, Blast_Score=77, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28574402, Length=191, Percent_Identity=29.3193717277487, Blast_Score=73, Evalue=2e-13,
Organism=Drosophila melanogaster, GI24584744, Length=191, Percent_Identity=29.3193717277487, Blast_Score=72, Evalue=3e-13,
Organism=Drosophila melanogaster, GI17737361, Length=191, Percent_Identity=29.3193717277487, Blast_Score=70, Evalue=2e-12,
Organism=Drosophila melanogaster, GI24580925, Length=226, Percent_Identity=26.1061946902655, Blast_Score=69, Evalue=3e-12,
Organism=Drosophila melanogaster, GI24648944, Length=243, Percent_Identity=26.7489711934156, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI24584752, Length=186, Percent_Identity=27.4193548387097, Blast_Score=67, Evalue=1e-11,
Organism=Drosophila melanogaster, GI21355631, Length=181, Percent_Identity=27.6243093922652, Blast_Score=64, Evalue=6e-11,

Paralogues:

None

Copy number: 1300 Molecules/Cell In: Growth-Phase, Minimal-Media (Based on E. coli). [C]

Swissprot (AC and ID): YDFG_SALTI (P69935)

Other databases:

- EMBL:   AL627270
- EMBL:   AE014613
- RefSeq:   NP_455969.1
- RefSeq:   NP_805225.1
- ProteinModelPortal:   P69935
- SMR:   P69935
- PRIDE:   P69935
- GeneID:   1070868
- GeneID:   1247931
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t1432
- KEGG:   sty:STY1550
- HOGENOM:   HBG750976
- OMA:   GSIAGRQ
- ProtClustDB:   PRK10538
- BioCyc:   SENT209261:T1432-MONOMER
- BioCyc:   SENT220341:STY1550-MONOMER
- GO:   GO:0005488
- InterPro:   IPR002198
- InterPro:   IPR002347
- InterPro:   IPR016040
- InterPro:   IPR020904
- Gene3D:   G3DSA:3.40.50.720
- PANTHER:   PTHR19410
- PRINTS:   PR00081
- PRINTS:   PR00080

Pfam domain/function: PF00106 adh_short

EC number: 1.-.-.- [C]

Molecular weight: Translated: 27043; Mature: 27043

Theoretical pI: Translated: 6.16; Mature: 6.16

Prosite motif: PS00061 ADH_SHORT

Important sites: ACT_SITE 147-147 BINDING 134-134

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
3.2 %Met     (Translated Protein)
3.6 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
3.2 %Met     (Mature Protein)
3.6 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MIVLVTGATAGFGECIARRFVENGHKVIATGRRHERLQALKDELGENVLTAQLDVRNRAA
CEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHHHH
IEEMMASLPAQWRDIDVLVNNAGLALGLEPAHKASVEDWETMIDTNNKGLIYMTRAVLPG
HHHHHHHCCCCCCEEEEEEECCCEEEECCCCHHCCHHHHHHHHCCCCCCEEEEHHHHCCH
MVERNRGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLNLRTDLHGTAVRVTDIEPGLV
HHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCEEEEEECCCCCC
GGTEFSSVRFKGDDEKAGKTYENTTALTPEDITEAVWWVATLPAHVNINTVEMMPVTQSF
CCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCEEEEEEECCHHH
AGLSVHRS
CCEEEECC
>Mature Secondary Structure
MIVLVTGATAGFGECIARRFVENGHKVIATGRRHERLQALKDELGENVLTAQLDVRNRAA
CEEEEECCCCCHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHHHCCCEEEEEECCHHHHH
IEEMMASLPAQWRDIDVLVNNAGLALGLEPAHKASVEDWETMIDTNNKGLIYMTRAVLPG
HHHHHHHCCCCCCEEEEEEECCCEEEECCCCHHCCHHHHHHHHCCCCCCEEEEHHHHCCH
MVERNRGHIINIGSTAGSWPYAGGNVYGATKAFVRQFSLNLRTDLHGTAVRVTDIEPGLV
HHHCCCCCEEEECCCCCCCCCCCCCCCHHHHHHHHHHHCCCEECCCCCEEEEEECCCCCC
GGTEFSSVRFKGDDEKAGKTYENTTALTPEDITEAVWWVATLPAHVNINTVEMMPVTQSF
CCCCCCEEEECCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCEECCEEEEEEECCHHH
AGLSVHRS
CCEEEECC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504