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The map label for this gene is tppB

Identifier: 29141779

GI number: 29141779

Start: 1380626

End: 1382131

Strand: Reverse

Name: tppB

Synonym: t1320

Alternate gene names: 29141779

Gene position: 1382131-1380626 (Counterclockwise)

Preceding gene: 29141780

Following gene: 29141778

Centisome position: 28.84

GC content: 53.05

Gene sequence:

>1506_bases
GTGTCTACTGCAAACAAAAAACCAACTGAAAGCGTCAGTTTGAACGCTTTCAAACAACCGAAGGCGTTCTATCTAATCTT
CTCGATAGAGTTATGGGAGCGTTTTGGTTATTACGGCCTGCAAGGCATTATGGCCGTCTACCTGGTAAAACAACTGGGTA
TGTCAGAAGCGGATTCCATCACCCTTTTCTCTTCCTTCAGTGCGCTGGTGTACGGCCTGGTCGCCATTGGCGGTTGGTTA
GGTGATAAAATTCTGGGCACCAAACGCGTTATTATGCTGGGTGCCGTGGTGCTGGCTATCGGTTATGCGCTGGTCGCATG
GTCTGGTCATGACGCTGGCATCGTCTATATGGGCATGGCGGCTATCGCTGTGGGTAATGGTCTGTTTAAAGCTAACCCGT
CTTCCCTGCTGTCTACCTGTTACGCGAAGGACGATCCGCGTCTCGACGGCGCATTTACGATGTATTATATGTCCGTCAAC
ATCGGCTCCTTCTTCTCTATGCTGGCGACGCCGTGGCTGGCGGCGCGTTATGGCTGGAGCACCGCGTTTGCGCTTAGCGT
CGTCGGTATGCTGATAACCGTCGTTAACTTTGCTTTCTGCCAGCGCTGGGTGAAAAGCTACGGTTCCAAACCCGACTTTG
AACCGATCAACTTCCGTAATCTGCTGCTGACAATCGTGGGTATTGTCGTTCTGATTGCGGTCGCCACCTGGCTGCTGCAC
AACCAGGATATCGCGCGTATGGTGCTGGGCGTAATCGCTCTTGGCATCGTCATTATTTTCGGTAAAGAAGCGTTTTCCAT
GCACGGCGCGGCTCGCCGTAAAATGATCGTCGCCTTTATTTTGATGCTGCAGGCGATTATCTTCTTCGTACTGTACAGCC
AGATGCCGACGTCGCTGAACTTCTTTGCCATTCGTAACGTCGAGCACTCTATTCTCGGTATCGCGTTCGAACCGGAACAG
TATCAGGCGCTGAACCCATTCTGGATCATTACCGGCAGCCCGATTCTGGCCGCTATTTATAACAGGATGGGCGATACGCT
GCCGATGCCGATGAAATTCGCCATTGGTATGGTGCTGTGTTCCGGCGCGTTCCTGATTCTGCCGCTGGGCGCCAAATTTG
CGAACGATGCCGGCATCGTATCCGTAAACTGGCTGATCGCAAGCTACGGCCTGCAAAGTATCGGTGAGCTGATGATCTCC
GGTCTGGGCCTGGCAATGGTCGCACAGTTGGTTCCGCAGCGTCTGATGGGCTTCATCATGGGTAGCTGGTTCCTGACAAC
GGCAGGCGCTAACATCATCGGCGGTTATGTCGCCAACCTGATGGCTGTGCCGAGCGACGTGACTGACCCACTGATGTCCC
TAGAAGTCTATGGTCGCGTATTTATGCAGATTGGCATAGCAACCGCCGTTATCGCCGTCCTGATGCTGCTGACAGCGCCT
AAGCTGAACCGTATGACCCAGGACGATGATACCGCTGAAAAAGGCTCTAAAGCCGCTACAGTTTAA

Upstream 100 bases:

>100_bases
ACCTGCCGTTTCCCCTCCAATATAACAATCGGACGGATGAGTCTGACTCATCACGCGCCAGACAATCCCTGTTAATACGG
GGCGTAAAAAAGAGGTAAAA

Downstream 100 bases:

>100_bases
TTTTCCGGGAAACAACATTCAGGCCGCTAACTGTGCGTTAGCGGCTTTTTTTTTGCTCGTCCCCGCACTACCATACTTTA
AACCTCAGCAAAAAGGAGTT

Product: tripeptide transporter permease

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 501; Mature: 500

Protein sequence:

>501_residues
MSTANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVN
IGSFFSMLATPWLAARYGWSTAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLH
NQDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAFEPEQ
YQALNPFWIITGSPILAAIYNRMGDTLPMPMKFAIGMVLCSGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAP
KLNRMTQDDDTAEKGSKAATV

Sequences:

>Translated_501_residues
MSTANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWL
GDKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVN
IGSFFSMLATPWLAARYGWSTAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLH
NQDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAFEPEQ
YQALNPFWIITGSPILAAIYNRMGDTLPMPMKFAIGMVLCSGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMIS
GLGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAP
KLNRMTQDDDTAEKGSKAATV
>Mature_500_residues
STANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSITLFSSFSALVYGLVAIGGWLG
DKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMAAIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVNI
GSFFSMLATPWLAARYGWSTAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLHN
QDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLNFFAIRNVEHSILGIAFEPEQY
QALNPFWIITGSPILAAIYNRMGDTLPMPMKFAIGMVLCSGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMISG
LGLAMVAQLVPQRLMGFIMGSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAPK
LNRMTQDDDTAEKGSKAATV

Specific function: Proton-dependent permease that transports di- and tripeptides

COG id: COG3104

COG function: function code E; Dipeptide/tripeptide permease

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein (Potential)

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the PTR2/POT transporter (TC 2.A.17) family. DtpA subfamily

Homologues:

Organism=Homo sapiens, GI4827008, Length=387, Percent_Identity=22.4806201550388, Blast_Score=72, Evalue=1e-12,
Organism=Escherichia coli, GI1787922, Length=487, Percent_Identity=91.3757700205339, Blast_Score=921, Evalue=0.0,
Organism=Escherichia coli, GI1789911, Length=487, Percent_Identity=50.9240246406571, Blast_Score=511, Evalue=1e-146,
Organism=Escherichia coli, GI1790572, Length=471, Percent_Identity=30.3609341825902, Blast_Score=192, Evalue=5e-50,
Organism=Escherichia coli, GI1786927, Length=460, Percent_Identity=28.0434782608696, Blast_Score=176, Evalue=3e-45,
Organism=Caenorhabditis elegans, GI17541704, Length=395, Percent_Identity=23.2911392405063, Blast_Score=81, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI71987453, Length=368, Percent_Identity=23.0978260869565, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI24639585, Length=354, Percent_Identity=26.271186440678, Blast_Score=88, Evalue=2e-17,
Organism=Drosophila melanogaster, GI24639581, Length=363, Percent_Identity=25.068870523416, Blast_Score=86, Evalue=6e-17,
Organism=Drosophila melanogaster, GI24639583, Length=345, Percent_Identity=26.0869565217391, Blast_Score=85, Evalue=1e-16,
Organism=Drosophila melanogaster, GI28571098, Length=367, Percent_Identity=25.3405994550409, Blast_Score=79, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571102, Length=367, Percent_Identity=25.0681198910082, Blast_Score=78, Evalue=1e-14,
Organism=Drosophila melanogaster, GI28571100, Length=367, Percent_Identity=25.0681198910082, Blast_Score=78, Evalue=1e-14,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): DTPA_SALTI (Q8Z6Q5)

Other databases:

- EMBL:   AL627271
- EMBL:   AE014613
- RefSeq:   NP_456078.1
- RefSeq:   NP_805121.1
- ProteinModelPortal:   Q8Z6Q5
- GeneID:   1070745
- GeneID:   1248044
- GenomeReviews:   AE014613_GR
- GenomeReviews:   AL513382_GR
- KEGG:   stt:t1320
- KEGG:   sty:STY1670
- HOGENOM:   HBG586603
- OMA:   VFFVLYS
- ProtClustDB:   PRK09584
- BioCyc:   SENT209261:T1320-MONOMER
- BioCyc:   SENT220341:STY1670-MONOMER
- HAMAP:   MF_01878
- InterPro:   IPR020846
- InterPro:   IPR016196
- InterPro:   IPR000109
- InterPro:   IPR005279
- InterPro:   IPR018456
- PANTHER:   PTHR11654:SF6
- TIGRFAMs:   TIGR00924

Pfam domain/function: PF00854 PTR2; SSF103473 MFS_gen_substrate_transporter

EC number: NA

Molecular weight: Translated: 54328; Mature: 54197

Theoretical pI: Translated: 9.08; Mature: 9.08

Prosite motif: PS50850 MFS; PS01022 PTR2_1; PS01023 PTR2_2; PS00778 HIS_ACID_PHOSPHAT_2

Important sites: NA

Signals:

None

Transmembrane regions:

HASH(0xc55e4d8)-; HASH(0xe4cc0ec)-; HASH(0xdfc1b24)-; HASH(0xde043e4)-; HASH(0xe5285cc)-; HASH(0xe3b6db0)-; HASH(0xe4d3440)-; HASH(0xe57aee0)-; HASH(0xe22d3f8)-; HASH(0xe1a7130)-; HASH(0xe3e53f8)-; HASH(0xe17a94c)-; HASH(0xe56a494)-; HASH(0xe4e87f0)-;

Cys/Met content:

0.6 %Cys     (Translated Protein)
5.6 %Met     (Translated Protein)
6.2 %Cys+Met (Translated Protein)
0.6 %Cys     (Mature Protein)
5.4 %Met     (Mature Protein)
6.0 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSTANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC
TLFSSFSALVYGLVAIGGWLGDKILGTKRVIMLGAVVLAIGYALVAWSGHDAGIVYMGMA
HHHHHHHHHHHHHHHHHHHHHHHHHCHHHHHHHHHHHHHHHHHHHEECCCCCCHHHHHHH
AIAVGNGLFKANPSSLLSTCYAKDDPRLDGAFTMYYMSVNIGSFFSMLATPWLAARYGWS
HHHHCCCCCCCCHHHHHHHHHCCCCCCCCCEEEEEEEEECHHHHHHHHHHHHHHHHCCCH
TAFALSVVGMLITVVNFAFCQRWVKSYGSKPDFEPINFRNLLLTIVGIVVLIAVATWLLH
HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHHHHHHHHHC
NQDIARMVLGVIALGIVIIFGKEAFSMHGAARRKMIVAFILMLQAIIFFVLYSQMPTSLN
CHHHHHHHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCE
FFAIRNVEHSILGIAFEPEQYQALNPFWIITGSPILAAIYNRMGDTLPMPMKFAIGMVLC
EEEEECCCHHHEEEEECCHHHCCCCCEEEEECCHHHHHHHHHHCCCCCCCHHHHHHHHHH
SGAFLILPLGAKFANDAGIVSVNWLIASYGLQSIGELMISGLGLAMVAQLVPQRLMGFIM
CCCCEEEECCCCCCCCCCEEEHHHHHHHHHHHHHHHHHHHCCHHHHHHHHHHHHHHHHHH
GSWFLTTAGANIIGGYVANLMAVPSDVTDPLMSLEVYGRVFMQIGIATAVIAVLMLLTAP
HHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHCCC
KLNRMTQDDDTAEKGSKAATV
HHCCCCCCCCHHHCCCCCCCH
>Mature Secondary Structure 
STANKKPTESVSLNAFKQPKAFYLIFSIELWERFGYYGLQGIMAVYLVKQLGMSEADSI
CCCCCCCCCCCCCCCCCCCCEEEEEEEHHHHHHCCHHHHHHHHHHHHHHHHCCCCCCCC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HHCCCCCCCCHHHCCCCCCCH

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504