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The map label for this gene is pdxY [H]

Identifier: 29141777

GI number: 29141777

Start: 1379227

End: 1379913

Strand: Direct

Name: pdxY [H]

Synonym: t1318

Alternate gene names: 29141777

Gene position: 1379227-1379913 (Clockwise)

Preceding gene: 29141776

Following gene: 161486806

Centisome position: 28.78

GC content: 54.44

Gene sequence:

>687_bases
ATGAAGAATATCCTCGCTATCCAGTCCCATGTTGTTTTCGGACATGCGGGCAACAGCGCCGCCGAATTTCCCATGCGCCG
TCTTGGCGCGAATGTTTGGCCGCTGAATACCGTTCAGTTTTCTAACCACACGCAATATGGTAAATGGACCGGCTGTGTCA
TGCCGCCCAGCCATCTGACTGAGATTGTCCAGGGGATTGCGGACATTGGCCAGTTAGCGCACTGCGACGCCGTACTTAGC
GGTTACCTGGGATCTGCCGAGCAGGGAGAACACATTCTCGGTATTGTGCGCCAGGTTAAAGCAGCAAATCCGCAGGCAAA
ATATTTCTGCGATCCCGTGATGGGGCATCCGGAAAAGGGTTGTATCGTGGCGCCTGGCGTCGCAGAGTTCCATGTGCGTT
ATGCGCTACCCGCCAGCGATATTATCGCGCCTAACCTGATTGAACTGGAAATTCTCAGCAAACATAGCGTGAATAATGTG
AATGACGCCGTGCAGGTGGCGCGAGAACTGATTGCTCAGGGGCCAGAAATTGTACTGGTAAAACATCTCGCCCGCGCCGG
TTACAGTTCAGAACGCTTTGAAATGCTGCTGGTGACAGCGCAGGAAGCCTGGCATATTAGCCGTCCGCTGGTGGATTTCG
GCTCACGTCAGCCGGTTGGCGCTACAGCGAGCTATCCGGCAACATGA

Upstream 100 bases:

>100_bases
GTCGCGGCAAAAAGAACTATTGTCTGATTTGCTGGAAATAAGGCATTAAGTAACAGGGAGTGAGAAATCACTCCCTTATT
TTTGATGTTCAGGTAAAAAA

Downstream 100 bases:

>100_bases
CATTAATTCAGTCCTTCCGCTTTAAGCGCTGCCGCAACGGTCGGTCTTTTTGCGACACGCTGCATATAACTTTCAATATG
CGTTGACCCGTCCATATTCA

Product: pyridoxamine kinase

Products: NA

Alternate protein names: PM kinase [H]

Number of amino acids: Translated: 228; Mature: 228

Protein sequence:

>228_residues
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIADIGQLAHCDAVLS
GYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKGCIVAPGVAEFHVRYALPASDIIAPNLIELEILSKHSVNNV
NDAVQVARELIAQGPEIVLVKHLARAGYSSERFEMLLVTAQEAWHISRPLVDFGSRQPVGATASYPAT

Sequences:

>Translated_228_residues
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIADIGQLAHCDAVLS
GYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKGCIVAPGVAEFHVRYALPASDIIAPNLIELEILSKHSVNNV
NDAVQVARELIAQGPEIVLVKHLARAGYSSERFEMLLVTAQEAWHISRPLVDFGSRQPVGATASYPAT
>Mature_228_residues
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLTEIVQGIADIGQLAHCDAVLS
GYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKGCIVAPGVAEFHVRYALPASDIIAPNLIELEILSKHSVNNV
NDAVQVARELIAQGPEIVLVKHLARAGYSSERFEMLLVTAQEAWHISRPLVDFGSRQPVGATASYPAT

Specific function: Phosphorylates B6 vitamers; functions in a salvage pathway. Uses pyridoxamine [H]

COG id: COG2240

COG function: function code H; Pyridoxal/pyridoxine/pyridoxamine kinase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the pyridoxine kinase family [H]

Homologues:

Organism=Homo sapiens, GI4505701, Length=180, Percent_Identity=35.5555555555556, Blast_Score=121, Evalue=6e-28,
Organism=Escherichia coli, GI1787924, Length=220, Percent_Identity=90.4545454545455, Blast_Score=419, Evalue=1e-119,
Organism=Escherichia coli, GI1788758, Length=205, Percent_Identity=29.2682926829268, Blast_Score=100, Evalue=7e-23,
Organism=Caenorhabditis elegans, GI17507759, Length=182, Percent_Identity=32.967032967033, Blast_Score=100, Evalue=9e-22,
Organism=Caenorhabditis elegans, GI17507757, Length=192, Percent_Identity=31.7708333333333, Blast_Score=96, Evalue=2e-20,
Organism=Saccharomyces cerevisiae, GI6324354, Length=177, Percent_Identity=35.5932203389831, Blast_Score=100, Evalue=1e-22,
Organism=Saccharomyces cerevisiae, GI6320806, Length=157, Percent_Identity=40.7643312101911, Blast_Score=95, Evalue=1e-20,
Organism=Drosophila melanogaster, GI45553007, Length=160, Percent_Identity=37.5, Blast_Score=110, Evalue=5e-25,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR013749
- InterPro:   IPR004625 [H]

Pfam domain/function: PF08543 Phos_pyr_kin [H]

EC number: =2.7.1.35 [H]

Molecular weight: Translated: 24662; Mature: 24662

Theoretical pI: Translated: 6.91; Mature: 6.91

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.8 %Cys     (Translated Protein)
2.2 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.8 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.9 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLT
CCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCHHHHH
EIVQGIADIGQLAHCDAVLSGYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
CIVAPGVAEFHVRYALPASDIIAPNLIELEILSKHSVNNVNDAVQVARELIAQGPEIVLV
CEECCCHHHEEEEEECCHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEHH
KHLARAGYSSERFEMLLVTAQEAWHISRPLVDFGSRQPVGATASYPAT
HHHHHCCCCCCCEEEEEEECHHHHHHCCCHHHCCCCCCCCCCCCCCCC
>Mature Secondary Structure
MKNILAIQSHVVFGHAGNSAAEFPMRRLGANVWPLNTVQFSNHTQYGKWTGCVMPPSHLT
CCCEEEEEEEEEEECCCCCHHHHHHHHHCCCCCCCCEEEECCCCCCCCEECCCCCHHHHH
EIVQGIADIGQLAHCDAVLSGYLGSAEQGEHILGIVRQVKAANPQAKYFCDPVMGHPEKG
HHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHCCCCCCCEEECCCCCCCCCC
CIVAPGVAEFHVRYALPASDIIAPNLIELEILSKHSVNNVNDAVQVARELIAQGPEIVLV
CEECCCHHHEEEEEECCHHHCCCCCEEEEEEECCCCCCCHHHHHHHHHHHHHCCCCEEHH
KHLARAGYSSERFEMLLVTAQEAWHISRPLVDFGSRQPVGATASYPAT
HHHHHCCCCCCCEEEEEEECHHHHHHCCCHHHCCCCCCCCCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 11677608; 12644504 [H]