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The map label for this gene is lysP [H]

Identifier: 29141165

GI number: 29141165

Start: 737999

End: 739468

Strand: Direct

Name: lysP [H]

Synonym: t0655

Alternate gene names: 29141165

Gene position: 737999-739468 (Clockwise)

Preceding gene: 29141164

Following gene: 29141166

Centisome position: 15.4

GC content: 53.54

Gene sequence:

>1470_bases
ATGGGTTCCAAAACTAAAACCACAGAAGCGCCCGCGCTACGTCGCGAATTAAAGGCGCGTCACCTGACGATGATTGCCAT
TGGCGGCTCCATCGGGACAGGTCTTTTCGTTGCATCTGGTGCGACAATTTCTCTGGCGGGGCCAGGCGGCGCGCTGTTTT
CTTATATTCTGATTGGTTTGATGGTCTACTTCCTGATGACCAGTCTTGGCGAGCTGGCGGCCTATATGCCGGTATCTGGC
TCGTTTGCGACATATGGTCAGAACTATGTGGAAGAAGGCTTTGGTTTCGCGCTGGGCTGGAACTACTGGTACAACTGGGC
GGTGACTATCGCTGTTGACCTGGTTGCCGCACAATTGGTGATGGGCTGGTGGTTCCCGGACACGCCGGGCTGGATCTGGA
GCGCGCTATTCCTCTGCGTCATTTTCTTGCTGAACTACATTTCTGTACGCGGTTTTGGCGAGGCGGAGTACTGGTTCTCG
TTAATTAAAGTCGCGACCGTTATTATCTTCATCATCGTTGGCGTAGCGATGATTATCGGCATCTTTAAAGGTGTCGAGCC
GGTCGGCTGGAGCAACTGGACGACGGGCGATGCGCCTTTCGCTGGCGGTTTTGCGGCAATGATTGGCGTCGCGATGATCG
TGGGCTTCTCTTTCCAGGGAACTGAGCTGATTGGTATTGCCGCCGGGGAATCTGAAAACCCGGAGAAGAATATTCCGCGC
GCGGTGCGTCAGGTGTTCTGGCGTATTCTGCTGTTTTATGTTTTCGCGATTTTGATTATCAGCCTGATCATTCCTTATAC
CGATCCAAACCTGCTGCGTAACGACGTCAAAGACATTAGCGTCAGTCCGTTTACCTTAGTGTTCCAGCATGCGGGCTTGT
TGTCTGCGGCGGCGATAATGAATGCGGTTATCCTGACGGCGGTACTGTCTGCGGGTAACTCCGGGATGTATGCCTCGACC
CGTATGCTCTACACCCTGGCCTGTGACGGTAAGGCCCCGCGTATTTTTGCGAAATTGTCCCGCGGCGGCGTACCGCGCAA
TGCGCTTTATGCCACCACCGTGATTGCCGGTCTTTGCTTTTTGACCTCAATGTTCGGCAACCAGACGGTCTATCTGTGGC
TGTTGAACACCTCCGGTATGACGGGCTTCATCGCCTGGCTGGGGATTGCCATTAGCCATTATCGCTTCCGTCGCGGTTAC
GTGTTACAAGGGTATGATGTGAATGATTTGCCGTACCGTTCCGGGTTCTTCCCGCTGGGGCCGATTTTCGCCTTTGTACT
GTGCCTGATTATTACGTTGGGGCAGAACTATGAAGCGTTCCTGAAAGATACCATCGACTGGGGCGGCGTCGCGGCGACCT
ATATCGGTATTCCGCTGTTCCTGCTTATCTGGTTCGGCTACAAGCTGATAAAAGGCACGCATTTCGTGCGCTATAGCGAA
ATGCACTTCCCGGAACGCGTTAAAAAGTAA

Upstream 100 bases:

>100_bases
CCGGTCATGAAGGTCTCTTATAACCGCGCATTTGTGTCGGAAGGATAGTATTTCGTCTGTTACAATCGCGCCTCATTTTT
TGGATGGATAGCATTTTCAC

Downstream 100 bases:

>100_bases
CGTAATATTCTCGTCATAGGCCGGATAAGGCTTTATGCCGCCATCCGGCACGGACTGCCTGAACCTGACCCTTCTAACCC
TCTCATTCGAGAGGGTTTTT

Product: lysine transporter

Products: Proton [Cytoplasm]; L-lysine [Cytoplasm] [C]

Alternate protein names: NA

Number of amino acids: Translated: 489; Mature: 488

Protein sequence:

>489_residues
MGSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISLAGPGGALFSYILIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFS
LIKVATVIIFIIVGVAMIIGIFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGYDVNDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSE
MHFPERVKK

Sequences:

>Translated_489_residues
MGSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISLAGPGGALFSYILIGLMVYFLMTSLGELAAYMPVSG
SFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFS
LIKVATVIIFIIVGVAMIIGIFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
AVRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYAST
RMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGY
VLQGYDVNDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSE
MHFPERVKK
>Mature_488_residues
GSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISLAGPGGALFSYILIGLMVYFLMTSLGELAAYMPVSGS
FATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLVMGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFSL
IKVATVIIFIIVGVAMIIGIFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPRA
VRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIMNAVILTAVLSAGNSGMYASTR
MLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCFLTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYV
LQGYDVNDLPYRSGFFPLGPIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSEM
HFPERVKK

Specific function: Permease that is involved in the transport across the cytoplasmic membrane of lysine [H]

COG id: COG0833

COG function: function code E; Amino acid transporters

Gene ontology:

Cell location: Cell inner membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the amino acid-polyamine-organocation (APC) superfamily. Amino acid transporter (AAT) (TC 2.A.3.1) family [H]

Homologues:

Organism=Homo sapiens, GI110347453, Length=366, Percent_Identity=24.3169398907104, Blast_Score=70, Evalue=4e-12,
Organism=Escherichia coli, GI1788480, Length=489, Percent_Identity=94.2740286298569, Blast_Score=932, Evalue=0.0,
Organism=Escherichia coli, GI87081708, Length=485, Percent_Identity=38.5567010309278, Blast_Score=326, Evalue=2e-90,
Organism=Escherichia coli, GI48994972, Length=435, Percent_Identity=38.8505747126437, Blast_Score=281, Evalue=8e-77,
Organism=Escherichia coli, GI1786789, Length=418, Percent_Identity=37.5598086124402, Blast_Score=268, Evalue=6e-73,
Organism=Escherichia coli, GI1786302, Length=408, Percent_Identity=35.7843137254902, Blast_Score=254, Evalue=6e-69,
Organism=Escherichia coli, GI1790653, Length=402, Percent_Identity=36.318407960199, Blast_Score=243, Evalue=2e-65,
Organism=Escherichia coli, GI1789017, Length=409, Percent_Identity=34.2298288508557, Blast_Score=236, Evalue=2e-63,
Organism=Escherichia coli, GI1786602, Length=418, Percent_Identity=37.5598086124402, Blast_Score=231, Evalue=6e-62,
Organism=Escherichia coli, GI87081915, Length=389, Percent_Identity=34.1902313624679, Blast_Score=224, Evalue=8e-60,
Organism=Escherichia coli, GI87081869, Length=395, Percent_Identity=23.7974683544304, Blast_Score=82, Evalue=6e-17,
Organism=Escherichia coli, GI87082250, Length=234, Percent_Identity=28.6324786324786, Blast_Score=65, Evalue=8e-12,
Organism=Escherichia coli, GI87082023, Length=335, Percent_Identity=24.1791044776119, Blast_Score=65, Evalue=1e-11,
Organism=Saccharomyces cerevisiae, GI6320772, Length=480, Percent_Identity=37.2916666666667, Blast_Score=322, Evalue=7e-89,
Organism=Saccharomyces cerevisiae, GI6324990, Length=488, Percent_Identity=35.2459016393443, Blast_Score=311, Evalue=1e-85,
Organism=Saccharomyces cerevisiae, GI6324061, Length=478, Percent_Identity=34.9372384937238, Blast_Score=300, Evalue=3e-82,
Organism=Saccharomyces cerevisiae, GI6324059, Length=478, Percent_Identity=35.9832635983264, Blast_Score=289, Evalue=6e-79,
Organism=Saccharomyces cerevisiae, GI6322892, Length=475, Percent_Identity=36.6315789473684, Blast_Score=288, Evalue=2e-78,
Organism=Saccharomyces cerevisiae, GI6324924, Length=484, Percent_Identity=33.8842975206612, Blast_Score=277, Evalue=3e-75,
Organism=Saccharomyces cerevisiae, GI6321629, Length=492, Percent_Identity=30.6910569105691, Blast_Score=260, Evalue=4e-70,
Organism=Saccharomyces cerevisiae, GI6324553, Length=429, Percent_Identity=35.6643356643357, Blast_Score=258, Evalue=2e-69,
Organism=Saccharomyces cerevisiae, GI6319824, Length=470, Percent_Identity=29.1489361702128, Blast_Score=237, Evalue=3e-63,
Organism=Saccharomyces cerevisiae, GI6322967, Length=468, Percent_Identity=30.982905982906, Blast_Score=229, Evalue=9e-61,
Organism=Saccharomyces cerevisiae, GI6321053, Length=479, Percent_Identity=29.0187891440501, Blast_Score=228, Evalue=2e-60,
Organism=Saccharomyces cerevisiae, GI6320717, Length=480, Percent_Identity=27.7083333333333, Blast_Score=226, Evalue=6e-60,
Organism=Saccharomyces cerevisiae, GI6319543, Length=475, Percent_Identity=29.2631578947368, Blast_Score=218, Evalue=2e-57,
Organism=Saccharomyces cerevisiae, GI6319542, Length=470, Percent_Identity=27.4468085106383, Blast_Score=217, Evalue=3e-57,
Organism=Saccharomyces cerevisiae, GI6320251, Length=470, Percent_Identity=27.0212765957447, Blast_Score=216, Evalue=8e-57,
Organism=Saccharomyces cerevisiae, GI6324981, Length=490, Percent_Identity=31.6326530612245, Blast_Score=213, Evalue=4e-56,
Organism=Saccharomyces cerevisiae, GI6319608, Length=496, Percent_Identity=27.6209677419355, Blast_Score=203, Evalue=6e-53,
Organism=Saccharomyces cerevisiae, GI6320364, Length=558, Percent_Identity=26.1648745519713, Blast_Score=178, Evalue=2e-45,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004841
- InterPro:   IPR002293
- InterPro:   IPR004840 [H]

Pfam domain/function: PF00324 AA_permease [H]

EC number: NA

Molecular weight: Translated: 53670; Mature: 53539

Theoretical pI: Translated: 9.05; Mature: 9.05

Prosite motif: PS00218 AMINO_ACID_PERMEASE_1

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.8 %Cys     (Translated Protein)
3.1 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
0.8 %Cys     (Mature Protein)
2.9 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MGSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISLAGPGGALFSYILIGL
CCCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEEEECCCCHHHHHHHHHHH
MVYFLMTSLGELAAYMPVSGSFATYGQNYVEEGFGFALGWNYWYNWAVTIAVDLVAAQLV
HHHHHHHHHHHHHHHCCCCCCHHHHCHHHHHHCCCEEEECHHHHHHHHHHHHHHHHHHHH
MGWWFPDTPGWIWSALFLCVIFLLNYISVRGFGEAEYWFSLIKVATVIIFIIVGVAMIIG
HHCCCCCCCHHHHHHHHHHHHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHH
IFKGVEPVGWSNWTTGDAPFAGGFAAMIGVAMIVGFSFQGTELIGIAAGESENPEKNIPR
HHHCCCCCCCCCCCCCCCCCCCHHHHHHHHHHHHCCCCCCCEEEEEECCCCCCCHHHHHH
AVRQVFWRILLFYVFAILIISLIIPYTDPNLLRNDVKDISVSPFTLVFQHAGLLSAAAIM
HHHHHHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHH
NAVILTAVLSAGNSGMYASTRMLYTLACDGKAPRIFAKLSRGGVPRNALYATTVIAGLCF
HHHHHHHHHHCCCCCCEEHHEEEEEEEECCCCCHHHHHHHCCCCCCHHHHHHHHHHHHHH
LTSMFGNQTVYLWLLNTSGMTGFIAWLGIAISHYRFRRGYVLQGYDVNDLPYRSGFFPLG
HHHHHCCCEEEEEEEECCCCHHHHHHHHHHHHHHHHHCCEEEECCCCCCCCCCCCCCCHH
PIFAFVLCLIITLGQNYEAFLKDTIDWGGVAATYIGIPLFLLIWFGYKLIKGTHFVRYSE
HHHHHHHHHHHHHCCCHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHHHHHCCCCEEEECC
MHFPERVKK
CCCHHHHCC
>Mature Secondary Structure 
GSKTKTTEAPALRRELKARHLTMIAIGGSIGTGLFVASGATISLAGPGGALFSYILIGL
CCCCCCCCCHHHHHHHHHHHEEEEEECCCCCCCEEEECCCEEEECCCCHHHHHHHHHHH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CCCHHHHCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: Proton [Periplasm]; L-lysine [Periplasm] [C]

Specific reaction: Proton [Periplasm] + L-lysine [Periplasm] = Proton [Cytoplasm] + L-lysine [Cytoplasm] [C]

General reaction: NA

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 1315732; 9278503; 7551055 [H]