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The map label for this gene is ada [H]

Identifier: 29141113

GI number: 29141113

Start: 683567

End: 684628

Strand: Direct

Name: ada [H]

Synonym: t0599

Alternate gene names: 29141113

Gene position: 683567-684628 (Clockwise)

Preceding gene: 29141112

Following gene: 29141114

Centisome position: 14.26

GC content: 60.92

Gene sequence:

>1062_bases
ATGATGAAAAAAGCGTTACTTACCGATGATGAATGCTGGCTGCGGGTGCAGGCGCGCGATGCCAGCGCGGATGGGCGTTT
CGTTTTTGCAGTGCGAACCACTGGCGTTTTTTGCCGCCCTTCTTGTCGCTCGAAGCGGGCGTTACGTAAAAATGTTCGCT
TTTTTGCCAACGCGCAGCAGGCGCTGGACGCCGGTTTTCGCCCCTGCAAGCGCTGTCAGCCGGATAATGCGCGCGCGCAG
CAACGGCGGTTGGATAAGATTGCCTGCGCCTGCCGTTTACTTGAGCAGGAGACGCCGGTAACGCTGGCGTCTCTGGCGCA
GGCGGTGGCAATGAGTCCGTTTCATCTGCACCGTTTGTTTAAAGCGAGCACCGGAATGACGCCGAAAGGGTGGCAGCAGG
CGTGGCGCGCCCGGCGGCTGCGTGAGGCGTTGGCGAAAGGAGAGCCGATCACGGCGGCTATTTACCGCGCCGGCTTCCCG
GATAGCAGTAGCTACTATCGTCATGCCGACCAGACGCTGGGCATGACGGCAAAACAGTTTCGCAAAGGCGGCGATAATGT
CTCCGTTCGCTATGCGCTGACGGACTGGGTTTACGGACGGTGCCTGGTGGCGGAGAGCGGGCGGGGGATTTGCGCGATTC
TCCCCGGTGATAGCGACGATGCGCTACTGGCCGAATTACACACCCTTTTCCCGGCGGCCCGCCACGAACCTGCTGACGCG
CCTTTTCAGCAACGGGTGCGGCAGGTTGCCGCGGCTATCAACACACGCGATGTGCTGCTCTCGTTGCCGCTGGATATCCA
GGGAACCGCGTTTCAACAGCAGGTCTGGCAGGCGTTATGCGCGATTCCCTGCGGCGAAACCGTAAGCTATCAACAGCTTG
CCGCGACTATCGGCAAACCCACGGCAGTACGCGCGGTCGCCAGCGCGTGCGGCGCGAATAAACTGGCGATGGTGATCCCG
TGTCATCGGGTCGTGCGTCGCGATGGCGCGCTCTCCGGTTATCGTTGGGGCGTGCGTCGAAAAGCGCAGCTATTAAAGCG
AGAAGCGCAAAAAGAGGAGTAG

Upstream 100 bases:

>100_bases
TGGTGAGCGATAAGAATTAAAACGCAAGATTACGGGTTTTTGTGGGCGGATTTACGGACACACTGCATGTAAGCAAGCAC
TATGCTTAATGAAGGAGTCT

Downstream 100 bases:

>100_bases
CAATGCTGGATCTGTTTGCTGATGAAGCGCCCTGGCAAGAGCCCCTGGCGCCTGGCGCGGTGGTGTTGCGCCGCTTTGCG
TTTCGCGCGGCGCAGTCGCT

Product: ADA regulatory protein

Products: NA

Alternate protein names: Regulatory protein of adaptative response; O-6-methylguanine-DNA alkyltransferase [H]

Number of amino acids: Translated: 353; Mature: 353

Protein sequence:

>353_residues
MMKKALLTDDECWLRVQARDASADGRFVFAVRTTGVFCRPSCRSKRALRKNVRFFANAQQALDAGFRPCKRCQPDNARAQ
QRRLDKIACACRLLEQETPVTLASLAQAVAMSPFHLHRLFKASTGMTPKGWQQAWRARRLREALAKGEPITAAIYRAGFP
DSSSYYRHADQTLGMTAKQFRKGGDNVSVRYALTDWVYGRCLVAESGRGICAILPGDSDDALLAELHTLFPAARHEPADA
PFQQRVRQVAAAINTRDVLLSLPLDIQGTAFQQQVWQALCAIPCGETVSYQQLAATIGKPTAVRAVASACGANKLAMVIP
CHRVVRRDGALSGYRWGVRRKAQLLKREAQKEE

Sequences:

>Translated_353_residues
MMKKALLTDDECWLRVQARDASADGRFVFAVRTTGVFCRPSCRSKRALRKNVRFFANAQQALDAGFRPCKRCQPDNARAQ
QRRLDKIACACRLLEQETPVTLASLAQAVAMSPFHLHRLFKASTGMTPKGWQQAWRARRLREALAKGEPITAAIYRAGFP
DSSSYYRHADQTLGMTAKQFRKGGDNVSVRYALTDWVYGRCLVAESGRGICAILPGDSDDALLAELHTLFPAARHEPADA
PFQQRVRQVAAAINTRDVLLSLPLDIQGTAFQQQVWQALCAIPCGETVSYQQLAATIGKPTAVRAVASACGANKLAMVIP
CHRVVRRDGALSGYRWGVRRKAQLLKREAQKEE
>Mature_353_residues
MMKKALLTDDECWLRVQARDASADGRFVFAVRTTGVFCRPSCRSKRALRKNVRFFANAQQALDAGFRPCKRCQPDNARAQ
QRRLDKIACACRLLEQETPVTLASLAQAVAMSPFHLHRLFKASTGMTPKGWQQAWRARRLREALAKGEPITAAIYRAGFP
DSSSYYRHADQTLGMTAKQFRKGGDNVSVRYALTDWVYGRCLVAESGRGICAILPGDSDDALLAELHTLFPAARHEPADA
PFQQRVRQVAAAINTRDVLLSLPLDIQGTAFQQQVWQALCAIPCGETVSYQQLAATIGKPTAVRAVASACGANKLAMVIP
CHRVVRRDGALSGYRWGVRRKAQLLKREAQKEE

Specific function: The methylated ADA protein acts as a positive regulator of its own synthesis, as well as that of other proteins. The transcription-activating function of the ADA protein resides in its N-terminus. It activates the transcription of alkA, alkB and aidB [H]

COG id: COG2169

COG function: function code F; Adenosine deaminase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 1 HTH araC/xylS-type DNA-binding domain [H]

Homologues:

Organism=Homo sapiens, GI197304670, Length=92, Percent_Identity=41.304347826087, Blast_Score=70, Evalue=2e-12,
Organism=Escherichia coli, GI1788542, Length=353, Percent_Identity=74.5042492917847, Blast_Score=543, Evalue=1e-156,
Organism=Escherichia coli, GI1787596, Length=93, Percent_Identity=46.2365591397849, Blast_Score=100, Evalue=2e-22,
Organism=Caenorhabditis elegans, GI115533070, Length=128, Percent_Identity=45.3125, Blast_Score=108, Evalue=5e-24,
Organism=Caenorhabditis elegans, GI115533068, Length=128, Percent_Identity=45.3125, Blast_Score=107, Evalue=7e-24,
Organism=Saccharomyces cerevisiae, GI6320001, Length=91, Percent_Identity=43.956043956044, Blast_Score=96, Evalue=1e-20,
Organism=Drosophila melanogaster, GI17137554, Length=180, Percent_Identity=37.2222222222222, Blast_Score=81, Evalue=1e-15,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR004026
- InterPro:   IPR016221
- InterPro:   IPR009057
- InterPro:   IPR012287
- InterPro:   IPR018062
- InterPro:   IPR018060
- InterPro:   IPR001497
- InterPro:   IPR014048
- InterPro:   IPR008332
- InterPro:   IPR011991 [H]

Pfam domain/function: PF02805 Ada_Zn_binding; PF01035 DNA_binding_1; PF00165 HTH_AraC; PF02870 Methyltransf_1N [H]

EC number: =2.1.1.63 [H]

Molecular weight: Translated: 39145; Mature: 39145

Theoretical pI: Translated: 10.45; Mature: 10.45

Prosite motif: PS00041 HTH_ARAC_FAMILY_1 ; PS01124 HTH_ARAC_FAMILY_2 ; PS00374 MGMT

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

3.7 %Cys     (Translated Protein)
1.7 %Met     (Translated Protein)
5.4 %Cys+Met (Translated Protein)
3.7 %Cys     (Mature Protein)
1.7 %Met     (Mature Protein)
5.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMKKALLTDDECWLRVQARDASADGRFVFAVRTTGVFCRPSCRSKRALRKNVRFFANAQQ
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHH
ALDAGFRPCKRCQPDNARAQQRRLDKIACACRLLEQETPVTLASLAQAVAMSPFHLHRLF
HHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
KASTGMTPKGWQQAWRARRLREALAKGEPITAAIYRAGFPDSSSYYRHADQTLGMTAKQF
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHH
RKGGDNVSVRYALTDWVYGRCLVAESGRGICAILPGDSDDALLAELHTLFPAARHEPADA
HCCCCCEEEEEEEHHHHHCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PFQQRVRQVAAAINTRDVLLSLPLDIQGTAFQQQVWQALCAIPCGETVSYQQLAATIGKP
CHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
TAVRAVASACGANKLAMVIPCHRVVRRDGALSGYRWGVRRKAQLLKREAQKEE
HHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMKKALLTDDECWLRVQARDASADGRFVFAVRTTGVFCRPSCRSKRALRKNVRFFANAQQ
CCCCCCCCCCCCEEEEEECCCCCCCCEEEEEECCCEEECCCHHHHHHHHHHHHHHHHHHH
ALDAGFRPCKRCQPDNARAQQRRLDKIACACRLLEQETPVTLASLAQAVAMSPFHLHRLF
HHHHCCCHHHCCCCCCHHHHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHCCHHHHHHHH
KASTGMTPKGWQQAWRARRLREALAKGEPITAAIYRAGFPDSSSYYRHADQTLGMTAKQF
HHHCCCCCHHHHHHHHHHHHHHHHHCCCCCEEEEEECCCCCCCHHHHHHHHHHCCCHHHH
RKGGDNVSVRYALTDWVYGRCLVAESGRGICAILPGDSDDALLAELHTLFPAARHEPADA
HCCCCCEEEEEEEHHHHHCEEEEEECCCCEEEEECCCCCHHHHHHHHHHHHHHCCCCCCC
PFQQRVRQVAAAINTRDVLLSLPLDIQGTAFQQQVWQALCAIPCGETVSYQQLAATIGKP
CHHHHHHHHHHHHCCCCEEEECCCCCCCCHHHHHHHHHHHCCCCCCCCHHHHHHHHHCCC
TAVRAVASACGANKLAMVIPCHRVVRRDGALSGYRWGVRRKAQLLKREAQKEE
HHHHHHHHHCCCCCEEEEEHHHHHHHHCCCCCCHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Unstructured

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: 1904855; 11677609 [H]