BacMap

Definition	Salmonella enterica subsp. enterica serovar Typhi str. Ty2 chromosome, complete genome.
Accession	NC_004631
Length	4,791,961

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The map label for this gene is caiD [H]

Identifier: 29140613

GI number: 29140613

Start: 81533

End: 82318

Strand: Reverse

Name: caiD [H]

Synonym: t0071

Alternate gene names: 29140613

Gene position: 82318-81533 (Counterclockwise)

Preceding gene: 29140614

Following gene: 29140612

Centisome position: 1.72

GC content: 56.49

Gene sequence:

>786_bases
ATGAGTGAGTCATTACATCTGACCCGTAACGGCCCGATCCTGGAAATTACCCTCGACCGACCTAAAGCGAATGCCATTGA
TGCGAAAACCAGTTTTGCGATGGGTGAAGCTTTTCTTAATTTCCGTGACGACCCGGAATTACGCGTAGCAATCATTACCG
GCGGCGGGGAGAAATTCTTTTCTGCGGGCTGGGACTTAAAAGCGGCAGCGGAAGGTGAAGCGCCGGATGCCGATTTTGGT
CCCGGCGGCTTTGCCGGTTTAACCGAAATATTTGACCTCGATAAGCCGGTTATCGCCGCGGTGAACGGCTACGCATTTGG
TGGCGGTTTTGAGCTGGCGCTGGCGGCAGACTTTATTGTCTGCGCCGAAAACGCCAGCTTCGCGCTGCCGGAAGCCAAGC
TCGGCATCGTGCCTGACAGCGGCGGCGTATTGCGTCTGCCTAAGCTGCTGCCACCGGCTATCGTCAACGAAATGGTAATG
ACCGGCAGACGAATGAGCGCCGAAGAAGCGCTGCGTTGGGGGATCGTGAACCGCGTTGTCAGCCAGAGCGAACTGATGGA
GAGCGCGCGCGAACTGGCGCAACAACTGGTCAATAGCGCTCCGCTGGCTATCGCGGCGCTGAAAGAGATTTATCGCGCGA
CCAGTGAAATGCCGGTTGAAGAAGGCTACCGCTACATCCGCAGCGGCGTGCTGAAACATTATCCGTCGGTACTGCATTCA
GAAGATGCGCTCGAAGGACCGCAGGCATTTGCCGAAAAACGCGCTCCGGTGTGGAAAGGTCGTTAA

Upstream 100 bases:

>100_bases
TGCCACGCAACTGTTCAGGAAAAATAATCAAAAAAAATCTGAAATAAACCTTCCGGCAGGAATCCCTCCCGCCGGGAAAC
TATTTATCTGGAGATGAACT

Downstream 100 bases:

>100_bases
TGTGACTATGCCGGATGGCGCTTCGCTTATCCGGCCTACAACACATGCACAACCGTAGGCCGGATAAGGTATTTACGCCG
CCATCCGACAAAAAAAAACC

Product: carnitinyl-CoA dehydratase

Products: L-Carnitine.; L-carnitinyl-CoA [C]

Alternate protein names: Crotonobetainyl-CoA hydratase [H]

Number of amino acids: Translated: 261; Mature: 260

Protein sequence:

>261_residues
MSESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFFSAGWDLKAAAEGEAPDADFG
PGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVM
TGRRMSAEEALRWGIVNRVVSQSELMESARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHS
EDALEGPQAFAEKRAPVWKGR

Sequences:

>Translated_261_residues
MSESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFFSAGWDLKAAAEGEAPDADFG
PGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVM
TGRRMSAEEALRWGIVNRVVSQSELMESARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHS
EDALEGPQAFAEKRAPVWKGR
>Mature_260_residues
SESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFFSAGWDLKAAAEGEAPDADFGP
GGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIVCAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVMT
GRRMSAEEALRWGIVNRVVSQSELMESARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHSE
DALEGPQAFAEKRAPVWKGR

Specific function: Catalyzes the reversible dehydration of L-carnitinyl-CoA to crotonobetainyl-CoA [H]

COG id: COG1024

COG function: function code I; Enoyl-CoA hydratase/carnithine racemase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the enoyl-CoA hydratase/isomerase family [H]

Homologues:

Organism=Homo sapiens, GI194097323, Length=252, Percent_Identity=35.7142857142857, Blast_Score=145, Evalue=5e-35,
Organism=Homo sapiens, GI70995211, Length=268, Percent_Identity=32.8358208955224, Blast_Score=114, Evalue=9e-26,
Organism=Homo sapiens, GI31542718, Length=250, Percent_Identity=30.8, Blast_Score=97, Evalue=2e-20,
Organism=Homo sapiens, GI68989263, Length=187, Percent_Identity=35.8288770053476, Blast_Score=93, Evalue=2e-19,
Organism=Homo sapiens, GI150378541, Length=254, Percent_Identity=30.3149606299213, Blast_Score=88, Evalue=9e-18,
Organism=Homo sapiens, GI37594469, Length=227, Percent_Identity=29.0748898678414, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI37594471, Length=227, Percent_Identity=29.0748898678414, Blast_Score=85, Evalue=7e-17,
Organism=Homo sapiens, GI4502327, Length=242, Percent_Identity=30.5785123966942, Blast_Score=81, Evalue=1e-15,
Organism=Homo sapiens, GI260274832, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI45643119, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI260275230, Length=225, Percent_Identity=28, Blast_Score=77, Evalue=2e-14,
Organism=Homo sapiens, GI157694516, Length=218, Percent_Identity=26.1467889908257, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI213417737, Length=218, Percent_Identity=26.1467889908257, Blast_Score=70, Evalue=1e-12,
Organism=Homo sapiens, GI221136756, Length=135, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI221136753, Length=135, Percent_Identity=28.1481481481481, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI221307494, Length=136, Percent_Identity=27.9411764705882, Blast_Score=69, Evalue=4e-12,
Organism=Homo sapiens, GI20127408, Length=88, Percent_Identity=36.3636363636364, Blast_Score=69, Evalue=5e-12,
Organism=Homo sapiens, GI157694520, Length=182, Percent_Identity=27.4725274725275, Blast_Score=67, Evalue=1e-11,
Organism=Homo sapiens, GI261878539, Length=98, Percent_Identity=39.7959183673469, Blast_Score=67, Evalue=2e-11,
Organism=Homo sapiens, GI4757966, Length=128, Percent_Identity=27.34375, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI51538581, Length=128, Percent_Identity=27.34375, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI25453481, Length=128, Percent_Identity=27.34375, Blast_Score=66, Evalue=3e-11,
Organism=Homo sapiens, GI51538573, Length=128, Percent_Identity=27.34375, Blast_Score=66, Evalue=3e-11,
Organism=Escherichia coli, GI221142681, Length=261, Percent_Identity=93.4865900383142, Blast_Score=497, Evalue=1e-142,
Organism=Escherichia coli, GI1787659, Length=264, Percent_Identity=36.7424242424242, Blast_Score=147, Evalue=1e-36,
Organism=Escherichia coli, GI1788682, Length=190, Percent_Identity=36.8421052631579, Blast_Score=106, Evalue=1e-24,
Organism=Escherichia coli, GI87082183, Length=218, Percent_Identity=31.651376146789, Blast_Score=103, Evalue=2e-23,
Organism=Escherichia coli, GI1790281, Length=263, Percent_Identity=28.8973384030418, Blast_Score=95, Evalue=6e-21,
Organism=Escherichia coli, GI1787660, Length=261, Percent_Identity=29.5019157088123, Blast_Score=94, Evalue=1e-20,
Organism=Escherichia coli, GI1788597, Length=248, Percent_Identity=28.2258064516129, Blast_Score=92, Evalue=3e-20,
Organism=Caenorhabditis elegans, GI25145438, Length=258, Percent_Identity=34.4961240310078, Blast_Score=142, Evalue=2e-34,
Organism=Caenorhabditis elegans, GI17554946, Length=247, Percent_Identity=33.1983805668016, Blast_Score=137, Evalue=4e-33,
Organism=Caenorhabditis elegans, GI17560910, Length=249, Percent_Identity=29.3172690763052, Blast_Score=121, Evalue=3e-28,
Organism=Caenorhabditis elegans, GI17540714, Length=195, Percent_Identity=31.2820512820513, Blast_Score=99, Evalue=2e-21,
Organism=Caenorhabditis elegans, GI17534483, Length=257, Percent_Identity=27.6264591439689, Blast_Score=98, Evalue=5e-21,
Organism=Caenorhabditis elegans, GI17558304, Length=173, Percent_Identity=30.635838150289, Blast_Score=89, Evalue=2e-18,
Organism=Caenorhabditis elegans, GI17536985, Length=265, Percent_Identity=25.2830188679245, Blast_Score=88, Evalue=4e-18,
Organism=Caenorhabditis elegans, GI17549921, Length=217, Percent_Identity=26.7281105990783, Blast_Score=84, Evalue=8e-17,
Organism=Caenorhabditis elegans, GI17540306, Length=256, Percent_Identity=28.125, Blast_Score=84, Evalue=9e-17,
Organism=Caenorhabditis elegans, GI17535521, Length=220, Percent_Identity=27.2727272727273, Blast_Score=81, Evalue=6e-16,
Organism=Caenorhabditis elegans, GI25144276, Length=218, Percent_Identity=30.7339449541284, Blast_Score=80, Evalue=1e-15,
Organism=Caenorhabditis elegans, GI17508953, Length=218, Percent_Identity=30.7339449541284, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI17508951, Length=218, Percent_Identity=30.7339449541284, Blast_Score=79, Evalue=2e-15,
Organism=Caenorhabditis elegans, GI25144157, Length=208, Percent_Identity=27.4038461538462, Blast_Score=69, Evalue=2e-12,
Organism=Caenorhabditis elegans, GI25144160, Length=208, Percent_Identity=27.4038461538462, Blast_Score=69, Evalue=2e-12,
Organism=Saccharomyces cerevisiae, GI6320241, Length=182, Percent_Identity=26.9230769230769, Blast_Score=67, Evalue=2e-12,
Organism=Drosophila melanogaster, GI20129971, Length=240, Percent_Identity=34.5833333333333, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653477, Length=240, Percent_Identity=34.5833333333333, Blast_Score=132, Evalue=2e-31,
Organism=Drosophila melanogaster, GI24653139, Length=272, Percent_Identity=34.5588235294118, Blast_Score=127, Evalue=9e-30,
Organism=Drosophila melanogaster, GI19922422, Length=277, Percent_Identity=28.158844765343, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19920382, Length=230, Percent_Identity=28.695652173913, Blast_Score=94, Evalue=1e-19,
Organism=Drosophila melanogaster, GI21357171, Length=220, Percent_Identity=30.9090909090909, Blast_Score=90, Evalue=1e-18,
Organism=Drosophila melanogaster, GI24650670, Length=282, Percent_Identity=28.0141843971631, Blast_Score=83, Evalue=2e-16,
Organism=Drosophila melanogaster, GI24654903, Length=187, Percent_Identity=29.4117647058824, Blast_Score=78, Evalue=5e-15,
Organism=Drosophila melanogaster, GI19921000, Length=186, Percent_Identity=30.1075268817204, Blast_Score=68, Evalue=5e-12,
Organism=Drosophila melanogaster, GI24583077, Length=186, Percent_Identity=30.1075268817204, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583079, Length=186, Percent_Identity=30.1075268817204, Blast_Score=68, Evalue=7e-12,
Organism=Drosophila melanogaster, GI24583165, Length=217, Percent_Identity=24.8847926267281, Blast_Score=66, Evalue=3e-11,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR022852
- InterPro:   IPR014748
- InterPro:   IPR001753
- InterPro:   IPR018376 [H]

Pfam domain/function: PF00378 ECH [H]

EC number: 4.2.1.- [C]

Molecular weight: Translated: 28076; Mature: 27945

Theoretical pI: Translated: 4.66; Mature: 4.66

Prosite motif: PS00166 ENOYL_COA_HYDRATASE

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.4 %Cys     (Translated Protein)
2.7 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
0.4 %Cys     (Mature Protein)
2.3 %Met     (Mature Protein)
2.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFF
CCCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHH
SAGWDLKAAAEGEAPDADFGPGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIV
HCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCEEECCCEEHHHHHCEEE
CAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVMTGRRMSAEEALRWGIVNRVV
EECCCCEECCCCCEEEECCCCCEEECCHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SQSELMESARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
EDALEGPQAFAEKRAPVWKGR
CHHCCCHHHHHHHCCCCCCCC
>Mature Secondary Structure 
SESLHLTRNGPILEITLDRPKANAIDAKTSFAMGEAFLNFRDDPELRVAIITGGGEKFF
CCCEEEECCCCEEEEEECCCCCCCCCCHHHHHHHHHHHCCCCCCCEEEEEEECCCHHHH
SAGWDLKAAAEGEAPDADFGPGGFAGLTEIFDLDKPVIAAVNGYAFGGGFELALAADFIV
HCCCCCEECCCCCCCCCCCCCCCHHHHHHHHHCCCCCEEEECCEEECCCEEHHHHHCEEE
CAENASFALPEAKLGIVPDSGGVLRLPKLLPPAIVNEMVMTGRRMSAEEALRWGIVNRVV
EECCCCEECCCCCEEEECCCCCEEECCHHCCHHHHHHHHHCCCCCCHHHHHHHHHHHHHH
SQSELMESARELAQQLVNSAPLAIAALKEIYRATSEMPVEEGYRYIRSGVLKHYPSVLHS
HHHHHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHCC
EDALEGPQAFAEKRAPVWKGR
CHHCCCHHHHHHHCCCCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: D-Carnitine; D-carnitinyl-CoA [C]

Specific reaction: D-Carnitine = L-Carnitine. D-carnitinyl-CoA = L-carnitinyl-CoA [C]

General reaction: Isomerases [C]

Inhibitor: NA

Structure determination priority: 10.0

TargetDB status: NA

Availability: NA

References: NA