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The map label for this gene is copA [H]

Identifier: 28572954

GI number: 28572954

Start: 921486

End: 923636

Strand: Reverse

Name: copA [H]

Synonym: TW813

Alternate gene names: 28572954

Gene position: 923636-921486 (Counterclockwise)

Preceding gene: 28572955

Following gene: 28572953

Centisome position: 99.75

GC content: 52.3

Gene sequence:

>2151_bases
GTGGCGGAACCGTCAATTATTAGGCTTTATATATCCGGCATGACCTGTGCGTCGTGTGCGAGAGAAATCGAGAAGAAGCT
AAAGAATCGCGGTATATCTGCCAGTGTAGATTTTGCCACGGGGTCTGCTCTTTTGACGGCCCCCAGGGGTTTTAACCTGC
AAAAAGCAATTGAGGTGGTAAGGGGCGCGGGGTACACCGCGACACCCCGGAGGGTCTATTCGCAGGCTGTGAGGCTGCGG
AACCTCTTGGTGTCTATAGCCTTGGCCGTGCCGGTTATTGTCATCTCAATGCTGATGTCCACCTCTGTGCTTCTTTCGAT
TTTTCCCTCTATTCTGTTTTGGCGTTTCTTGGTGTTTGTGCTTGCAACCCCTGTGGTTATTTTCTCGGCCTGGCCTTTTT
ATAGATCCTGTTTGAGACGCCTGTCTCGTTTTGGTGTAACAATGGACACATTGATTAGCCTGGGCGTGTGTGTTACCTAT
GTTTGGTCGGTCTGGGTTCTTTTTTCGAGCATTGGCCACCCCAATGATTACGATGAACAGAGTCTTTATTTTGAGGCTTC
CGTTAGTATTGTAGTTTTTGCCTCCGTTGGCCGCTATCTTGAGGCAAAAGTAAAGGCCAAACAGGGCCTTGCCCTTGAGT
CTCTTGTAAAACTCGCGCCAAAAACAGCTACTCTGGCTGGCACCCTCGAAAAGGTGTTAACCGAGAACCTGAGAGCTGGA
GACAGGGTGGTTATTTACCCCGGGGAGCGAGTTCCTGCCGACGCACGAATTGTAGAGGGCGGTTCTGATGTTGATCTTTC
TTTCCTGACCGGCTGCAGCATTCCGTCCCGGGTCTCGATTGGGGATACCCTTGCCTCTGGGGCTATGAACCTGACGGGTA
ATCTTACGGCAGAGGTGGTTCGAGTTGGTTCGGACACAGAGCTTTCGCGCCTGATATCGCTTGTTCAGCGCGCGCAGAAA
CCCAAGCTTGTGCGGGTTGCAGACAGGGTTTCTGGTGTTTTTGTCCCCGTGGTATTGATTTTGTCTCTTGTTACGCTTTT
TGCTCACTGGGTCGTTACGGACAGTCTGGCCGGTAGCCTTTCTGCCGCTGTTGCAGTTCTTGTGATTGCGTGTCCGTGTG
CCCTCGGCCTGGCAACCCCAATGGCTATTTTGTCTGGCATGCTTCGAGGATTACAGCTTGGTATTCTGATTCGCTCAACA
AGCGCCTTGGAATCCAGACTTAGCGTGGTTGTTTTGGACAAGACAGGAACGCTTACCGAGAACAGGGTGTCTCTGAGCAA
ACTAATACCCGCACCCGGTCAAGACGTGAATGATCTTCTGCGTCTTTCTGCATCACTTGAGGCCGGAAGTGAACATCCAT
TGGCGCGCGCTGTTGTTATGGCGGCTAAGGATAAAGGTCTTGTGCTGGAGAGCTTTTCGGACTTTGAAAACCACCCAGGC
TTTGGCGTGACCGGGAAAGTTGCCGGCCGGGATATCCTGGTTGGCCGCCTTGGATGGGCCGGGAAAACCCCCAATAAGAT
GCCCGACTGGATGTCAGGGCGTGACATAAGCCACGGAACTGTTATTGTCTGGGGAGGTAAAGTTCGAGGGGTTTTTGTTT
TTGACAGCCCACTGAGACCCACAAGCCCAAGGGGTGTTGCCCTGTTGTCAGGAATGGGATTAAAGGTTATTCTTGCCACG
GGAGATGGCGGGTTTGCCGCGACAAATGCTGCCGAGAGCTGCGGAATTAAGACCGTCGTTGCAGACGCGAAGCCGGCCGA
TAAACTTGAGCTCGTTCGATCCCTGCAGGCCCGCAAGGATCGCGTTGCTATGGTTGGGGATGGCATTAACGATGCTGCCG
CACTCGCCGCCGCGGATGTTGGCATTGCCATGGCTAGCGGGACCGACTTGGCGTTTGATAGATCGGATATTGCGGTTATG
TCAAGCGACTTAATTGGCGTTGTTGATGGCATTAGACTCTCAAGAAAGACGCGGAGGGTGGTAAAACAAAATCTTTTTTG
GGCATTTGCCTACAACACCGCAGGCATTCCTGTCGCGTCTGTTGGTTTATTGAGCCCGATGATTGCAAGTCTGGCTATGG
CCCTTTCTAGCCTGTTTGTTGTTGGCAACAGCCTTCGTATAAGGAAGTTCCAGCCTACAACACCCCTCTAG

Upstream 100 bases:

>100_bases
GTGTTGGGCCTAGCAGACATGTTGTGTTATCAAACCCTTGACCGGCTTTTCTGTGCGGTCAACGATTGTGCCGTAGACCG
GGGGTGCCTTTGGGGTTTTA

Downstream 100 bases:

>100_bases
CGCATACCGGTTCCTGCACACCCCGCTCAGCGGTTGTAGTATGGTTGTTGTGTTCTTGTGCCGCCCGCTTTTTTGGGTGG
AGCTTGTTTCTTTTGGGTTT

Product: metal cation-transporting ATPase

Products: ADP; Orthophosphate. [C]

Alternate protein names: Protein CopA [H]

Number of amino acids: Translated: 716; Mature: 715

Protein sequence:

>716_residues
MAEPSIIRLYISGMTCASCAREIEKKLKNRGISASVDFATGSALLTAPRGFNLQKAIEVVRGAGYTATPRRVYSQAVRLR
NLLVSIALAVPVIVISMLMSTSVLLSIFPSILFWRFLVFVLATPVVIFSAWPFYRSCLRRLSRFGVTMDTLISLGVCVTY
VWSVWVLFSSIGHPNDYDEQSLYFEASVSIVVFASVGRYLEAKVKAKQGLALESLVKLAPKTATLAGTLEKVLTENLRAG
DRVVIYPGERVPADARIVEGGSDVDLSFLTGCSIPSRVSIGDTLASGAMNLTGNLTAEVVRVGSDTELSRLISLVQRAQK
PKLVRVADRVSGVFVPVVLILSLVTLFAHWVVTDSLAGSLSAAVAVLVIACPCALGLATPMAILSGMLRGLQLGILIRST
SALESRLSVVVLDKTGTLTENRVSLSKLIPAPGQDVNDLLRLSASLEAGSEHPLARAVVMAAKDKGLVLESFSDFENHPG
FGVTGKVAGRDILVGRLGWAGKTPNKMPDWMSGRDISHGTVIVWGGKVRGVFVFDSPLRPTSPRGVALLSGMGLKVILAT
GDGGFAATNAAESCGIKTVVADAKPADKLELVRSLQARKDRVAMVGDGINDAAALAAADVGIAMASGTDLAFDRSDIAVM
SSDLIGVVDGIRLSRKTRRVVKQNLFWAFAYNTAGIPVASVGLLSPMIASLAMALSSLFVVGNSLRIRKFQPTTPL

Sequences:

>Translated_716_residues
MAEPSIIRLYISGMTCASCAREIEKKLKNRGISASVDFATGSALLTAPRGFNLQKAIEVVRGAGYTATPRRVYSQAVRLR
NLLVSIALAVPVIVISMLMSTSVLLSIFPSILFWRFLVFVLATPVVIFSAWPFYRSCLRRLSRFGVTMDTLISLGVCVTY
VWSVWVLFSSIGHPNDYDEQSLYFEASVSIVVFASVGRYLEAKVKAKQGLALESLVKLAPKTATLAGTLEKVLTENLRAG
DRVVIYPGERVPADARIVEGGSDVDLSFLTGCSIPSRVSIGDTLASGAMNLTGNLTAEVVRVGSDTELSRLISLVQRAQK
PKLVRVADRVSGVFVPVVLILSLVTLFAHWVVTDSLAGSLSAAVAVLVIACPCALGLATPMAILSGMLRGLQLGILIRST
SALESRLSVVVLDKTGTLTENRVSLSKLIPAPGQDVNDLLRLSASLEAGSEHPLARAVVMAAKDKGLVLESFSDFENHPG
FGVTGKVAGRDILVGRLGWAGKTPNKMPDWMSGRDISHGTVIVWGGKVRGVFVFDSPLRPTSPRGVALLSGMGLKVILAT
GDGGFAATNAAESCGIKTVVADAKPADKLELVRSLQARKDRVAMVGDGINDAAALAAADVGIAMASGTDLAFDRSDIAVM
SSDLIGVVDGIRLSRKTRRVVKQNLFWAFAYNTAGIPVASVGLLSPMIASLAMALSSLFVVGNSLRIRKFQPTTPL
>Mature_715_residues
AEPSIIRLYISGMTCASCAREIEKKLKNRGISASVDFATGSALLTAPRGFNLQKAIEVVRGAGYTATPRRVYSQAVRLRN
LLVSIALAVPVIVISMLMSTSVLLSIFPSILFWRFLVFVLATPVVIFSAWPFYRSCLRRLSRFGVTMDTLISLGVCVTYV
WSVWVLFSSIGHPNDYDEQSLYFEASVSIVVFASVGRYLEAKVKAKQGLALESLVKLAPKTATLAGTLEKVLTENLRAGD
RVVIYPGERVPADARIVEGGSDVDLSFLTGCSIPSRVSIGDTLASGAMNLTGNLTAEVVRVGSDTELSRLISLVQRAQKP
KLVRVADRVSGVFVPVVLILSLVTLFAHWVVTDSLAGSLSAAVAVLVIACPCALGLATPMAILSGMLRGLQLGILIRSTS
ALESRLSVVVLDKTGTLTENRVSLSKLIPAPGQDVNDLLRLSASLEAGSEHPLARAVVMAAKDKGLVLESFSDFENHPGF
GVTGKVAGRDILVGRLGWAGKTPNKMPDWMSGRDISHGTVIVWGGKVRGVFVFDSPLRPTSPRGVALLSGMGLKVILATG
DGGFAATNAAESCGIKTVVADAKPADKLELVRSLQARKDRVAMVGDGINDAAALAAADVGIAMASGTDLAFDRSDIAVMS
SDLIGVVDGIRLSRKTRRVVKQNLFWAFAYNTAGIPVASVGLLSPMIASLAMALSSLFVVGNSLRIRKFQPTTPL

Specific function: Involved in copper export [H]

COG id: COG2217

COG function: function code P; Cation transport ATPase

Gene ontology:

Cell location: Cell membrane; Multi-pass membrane protein [H]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Contains 2 HMA domains [H]

Homologues:

Organism=Homo sapiens, GI115529486, Length=825, Percent_Identity=29.6969696969697, Blast_Score=321, Evalue=2e-87,
Organism=Homo sapiens, GI55743071, Length=788, Percent_Identity=30.8375634517766, Blast_Score=315, Evalue=9e-86,
Organism=Homo sapiens, GI55743073, Length=545, Percent_Identity=31.1926605504587, Blast_Score=214, Evalue=3e-55,
Organism=Homo sapiens, GI48762687, Length=265, Percent_Identity=25.2830188679245, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI48762689, Length=265, Percent_Identity=25.2830188679245, Blast_Score=67, Evalue=7e-11,
Organism=Homo sapiens, GI48762685, Length=265, Percent_Identity=25.2830188679245, Blast_Score=67, Evalue=9e-11,
Organism=Homo sapiens, GI48762691, Length=265, Percent_Identity=25.2830188679245, Blast_Score=66, Evalue=9e-11,
Organism=Escherichia coli, GI1786691, Length=742, Percent_Identity=36.3881401617251, Blast_Score=352, Evalue=3e-98,
Organism=Escherichia coli, GI1789879, Length=725, Percent_Identity=30.3448275862069, Blast_Score=234, Evalue=1e-62,
Organism=Escherichia coli, GI1786914, Length=511, Percent_Identity=29.1585127201566, Blast_Score=145, Evalue=8e-36,
Organism=Caenorhabditis elegans, GI17556548, Length=797, Percent_Identity=31.7440401505646, Blast_Score=288, Evalue=7e-78,
Organism=Saccharomyces cerevisiae, GI6320475, Length=703, Percent_Identity=31.7211948790896, Blast_Score=280, Evalue=7e-76,
Organism=Saccharomyces cerevisiae, GI6319772, Length=631, Percent_Identity=26.3074484944533, Blast_Score=206, Evalue=1e-53,
Organism=Saccharomyces cerevisiae, GI6325221, Length=546, Percent_Identity=26.1904761904762, Blast_Score=97, Evalue=1e-20,
Organism=Saccharomyces cerevisiae, GI6321430, Length=533, Percent_Identity=25.891181988743, Blast_Score=94, Evalue=8e-20,
Organism=Saccharomyces cerevisiae, GI6321432, Length=159, Percent_Identity=31.4465408805031, Blast_Score=66, Evalue=2e-11,
Organism=Drosophila melanogaster, GI221329854, Length=519, Percent_Identity=31.5992292870906, Blast_Score=192, Evalue=6e-49,
Organism=Drosophila melanogaster, GI24668704, Length=246, Percent_Identity=26.0162601626016, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI24668708, Length=246, Percent_Identity=26.0162601626016, Blast_Score=66, Evalue=9e-11,
Organism=Drosophila melanogaster, GI281366617, Length=246, Percent_Identity=26.0162601626016, Blast_Score=66, Evalue=1e-10,
Organism=Drosophila melanogaster, GI161085803, Length=246, Percent_Identity=26.0162601626016, Blast_Score=66, Evalue=1e-10,
Organism=Drosophila melanogaster, GI24668696, Length=246, Percent_Identity=26.0162601626016, Blast_Score=66, Evalue=1e-10,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR008250
- InterPro:   IPR006403
- InterPro:   IPR006416
- InterPro:   IPR001757
- InterPro:   IPR018303
- InterPro:   IPR006122
- InterPro:   IPR005834
- InterPro:   IPR023214
- InterPro:   IPR017969
- InterPro:   IPR006121 [H]

Pfam domain/function: PF00122 E1-E2_ATPase; PF00403 HMA; PF00702 Hydrolase [H]

EC number: 3.6.3.4 [C]

Molecular weight: Translated: 75971; Mature: 75840

Theoretical pI: Translated: 10.19; Mature: 10.19

Prosite motif: PS00154 ATPASE_E1_E2 ; PS50846 HMA_2 ; PS01229 COF_2

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.1 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.5 %Cys+Met (Translated Protein)
1.1 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.4 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MAEPSIIRLYISGMTCASCAREIEKKLKNRGISASVDFATGSALLTAPRGFNLQKAIEVV
CCCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCHHHHHHHH
RGAGYTATPRRVYSQAVRLRNLLVSIALAVPVIVISMLMSTSVLLSIFPSILFWRFLVFV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATPVVIFSAWPFYRSCLRRLSRFGVTMDTLISLGVCVTYVWSVWVLFSSIGHPNDYDEQ
HHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SLYFEASVSIVVFASVGRYLEAKVKAKQGLALESLVKLAPKTATLAGTLEKVLTENLRAG
CEEEEECEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DRVVIYPGERVPADARIVEGGSDVDLSFLTGCSIPSRVSIGDTLASGAMNLTGNLTAEVV
CEEEEECCCCCCCCCEEECCCCCCCCHHEECCCCCCCCCCCHHHHCCCCCCCCCCEEEEE
RVGSDTELSRLISLVQRAQKPKLVRVADRVSGVFVPVVLILSLVTLFAHWVVTDSLAGSL
ECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAVAVLVIACPCALGLATPMAILSGMLRGLQLGILIRSTSALESRLSVVVLDKTGTLTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHHHHCCCEEEEEECCCCCCC
NRVSLSKLIPAPGQDVNDLLRLSASLEAGSEHPLARAVVMAAKDKGLVLESFSDFENHPG
CHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCEECCHHHHCCCCC
FGVTGKVAGRDILVGRLGWAGKTPNKMPDWMSGRDISHGTVIVWGGKVRGVFVFDSPLRP
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCC
TSPRGVALLSGMGLKVILATGDGGFAATNAAESCGIKTVVADAKPADKLELVRSLQARKD
CCCCCEEEEECCCEEEEEEECCCCCEECCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHC
RVAMVGDGINDAAALAAADVGIAMASGTDLAFDRSDIAVMSSDLIGVVDGIRLSRKTRRV
CEEEECCCCCHHHHHHHHHHCEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
VKQNLFWAFAYNTAGIPVASVGLLSPMIASLAMALSSLFVVGNSLRIRKFQPTTPL
HHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC
>Mature Secondary Structure 
AEPSIIRLYISGMTCASCAREIEKKLKNRGISASVDFATGSALLTAPRGFNLQKAIEVV
CCCCEEEEEECCCCHHHHHHHHHHHHHHCCCCEEEEECCCCEEEECCCCCCHHHHHHHH
RGAGYTATPRRVYSQAVRLRNLLVSIALAVPVIVISMLMSTSVLLSIFPSILFWRFLVFV
HCCCCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
LATPVVIFSAWPFYRSCLRRLSRFGVTMDTLISLGVCVTYVWSVWVLFSSIGHPNDYDEQ
HHHHHHHHCCCHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCCCC
SLYFEASVSIVVFASVGRYLEAKVKAKQGLALESLVKLAPKTATLAGTLEKVLTENLRAG
CEEEEECEEEEEEEHHHHHHHHHHHHHCCCHHHHHHHHCCCHHHHHHHHHHHHHHHCCCC
DRVVIYPGERVPADARIVEGGSDVDLSFLTGCSIPSRVSIGDTLASGAMNLTGNLTAEVV
CEEEEECCCCCCCCCEEECCCCCCCCHHEECCCCCCCCCCCHHHHCCCCCCCCCCEEEEE
RVGSDTELSRLISLVQRAQKPKLVRVADRVSGVFVPVVLILSLVTLFAHWVVTDSLAGSL
ECCCCHHHHHHHHHHHHHCCCCHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHH
SAAVAVLVIACPCALGLATPMAILSGMLRGLQLGILIRSTSALESRLSVVVLDKTGTLTE
HHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEEEEECHHHHHCCCEEEEEECCCCCCC
NRVSLSKLIPAPGQDVNDLLRLSASLEAGSEHPLARAVVMAAKDKGLVLESFSDFENHPG
CHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCHHHHHHHEECCCCCEECCHHHHCCCCC
FGVTGKVAGRDILVGRLGWAGKTPNKMPDWMSGRDISHGTVIVWGGKVRGVFVFDSPLRP
CCCCCCCCCCEEEEEECCCCCCCCCCCCCCCCCCCCCCCEEEEECCCEEEEEEECCCCCC
TSPRGVALLSGMGLKVILATGDGGFAATNAAESCGIKTVVADAKPADKLELVRSLQARKD
CCCCCEEEEECCCEEEEEEECCCCCEECCCHHHCCCEEEEECCCCHHHHHHHHHHHHHHC
RVAMVGDGINDAAALAAADVGIAMASGTDLAFDRSDIAVMSSDLIGVVDGIRLSRKTRRV
CEEEECCCCCHHHHHHHHHHCEEEECCCCCEECCCCHHHHHHHHHHHHHHHHHHHHHHHH
VKQNLFWAFAYNTAGIPVASVGLLSPMIASLAMALSSLFVVGNSLRIRKFQPTTPL
HHHHCEEEEEECCCCCCHHHHHHHHHHHHHHHHHHHHHHHHCCCEEEEEECCCCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: Cu [C]

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: ATP; H2O [C]

Specific reaction: ATP + H2O = ADP + Orthophosphate. [C]

General reaction: Phosphorous acid anhydride hydrolysis [C]

Inhibitor: NA

Structure determination priority: 6.0

TargetDB status: NA

Availability: NA

References: 9384377; 12644235; 11922674; 12590580 [H]