| Definition | Tropheryma whipplei TW08/27, complete genome. |
|---|---|
| Accession | NC_004551 |
| Length | 925,938 |
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The map label for this gene is metT [H]
Identifier: 28572756
GI number: 28572756
Start: 691441
End: 693909
Strand: Reverse
Name: metT [H]
Synonym: TW610
Alternate gene names: 28572756
Gene position: 693909-691441 (Counterclockwise)
Preceding gene: 28572757
Following gene: 28572755
Centisome position: 74.94
GC content: 46.29
Gene sequence:
>2469_bases ATGTTATTCGGGACCATTCTCGGTTATCCCAGATTGGGTCCGCGAAGAGAGTTGAGAGATTATCTTTATTCCTATTGGCA GGGAAAAATATCCGAAGAAGTTCTCGAGGAAAAAACCCGTCTACTCCGCGAGGAAACGCATCGAAGATTAATTCTCCTCG GCCTTTCTGCCGAGAATTATTCTATCCCAGAATCGTTCTCGTACTACGATCATGTTCTGGATGCTGCGGTTCATGTTGGA GCTGTGCCAAGTCGTTTTTCATGGCTTTTGAATGATGGAATAGTTGATCTAAATGCGTATTTCACCCTTGCCAGGGGTGA TCGCTCGCTTGCCCCTCTTGAATCCTTAAGATACTTTGGGTCAAGTTATCACTATCTAGTTCCTGAGATTGATGGCAATA CACATTTCGCACTTACCTCACACAGGGTTATTACGCAGTTTGAACAGGCAAAACAGGCCGGGGTAAATGTTAGGCCAACC ATTCTTGGACCCGTTTCACTTCTTATGATGTCTAGGTCTCACGGTCCTAATGCAATTAATCCGATTGAGCGCTTGCAAGA TCTTGTGCCCGTTTATTCGGAATTGTTTGAAAAACTTTATAATTCTGGCTGCAAATTTGTCCAAGTCGATGAGCCGGCTG TGACTCACAACACCTTCGGTATACAAAAATCCCAGGAGCTCCTTGTTGATGCGTATAAATTCTTGTCATCGCGGAAACTA CGCCCAGAGATTCTCGTTGCAATGTCTTATGGAAATGCTGCTGATCAGGTTGATGCATTAGCTACGACTGGCGTAGAGGC TATGGCATTTAACCTTATTGATGGAGCTGTGCCATTTGCAAATCCATCCTTGGCAGATAAGGCCCTTTTTGGAGGGGTTA TCGATGGCAGAAATATTTGGCGCGGCGATCTAGCAGCGGCGTATTACAAGCTTGAGAGATTGCGTGAACTCAGTGGCAAT GTTGTTGCTTCAACATCAGCTTCACTTTTCCACTTACCTCTCTCCCTTGACACTGAAGACCTTGGCGATCACCTAAAGGA ATGGCTTGCCTTTGCAGATGAAAAAGTCAGACAGGTTATGATCCTTGCAAGAGGTCTGGAGTATGGGGTGGGGTGCATAT ATGAACATCTCGATTCTGCAGCAAATTCACTATCCGACAGAATGACTACCCCCGGCGTGCGTGTCGAAGAAGTGAGACAA GCGTTGCAGGACCTCGGTGAGTCTGACTTTTGCCGCCCCCCGCGTGAACAGCAACAGGGCTGCAATCATGCGAGTCTGCC AATTCTTCCAATGGTAGGTATCGGTGAATTTTCCGATGGCACACCTTTTGTTAACAACGATGGTATACCAAATAACAACC CCCAGGCAGCAATCAGTTTCCAGGAAGATCTAGATATTCTGGCCGTTCAAAGGCTGGGAGATATTGATCCTATACAACGT TTCGCCTCTCGTATGCATGGATTTGCGATAACGCATAATGGATGGGTTCAGAGCATAGGGCCACACAGTGTCTGTCCGCC TATTCTATGGGGTGACGTCTCTCGCATAACCCCCATGTCGTCATGGATAGAATACACTCAAACCCTTACCGAGAAGTCTG TAAAACCGGTTTTACCGGGACCATTAACCCTTTTAATGTCATGTTTTGTACGCGAGGATCAGCCGTTTCAGGAAACAGCC CAGCAAATAGCCATTGCCATACGTGATGATATAGCCGATTTACAACGCTCCGGAATAAGAGCTATTCAGATTGATGAACC CGCCTTGGAAGAGTTTTTATCAATATATGACAATGCACGCTACTGTGCGCCGCAGGTATTTAGACTGGCCACATCAAGCG CTAAACCTGAGGTCCAGATACACCTCCACCTGCGCCCTCCAAATCTTGTTGAAACAATTGACATAATAAATGACCTTGAT GCGGATGTAATTAGTGCCGAGATTGTGCCGTACACTTTCGGTTTACCCGCCCAGAAATGCCTGATGGAAATAAGACGTCG AATTCCTCTTTGCTTGTATTTCCATGATGCGAATTTTTCCAGAATGCCCAGCGTTGATGAGTGTCGATACTTGATTGATA CGCTTGTAAGAGATGTGGATGGCGCCACACTTGCCAAGCAGTTTGATGACATGCACATTGCTGGCTTTACCGCAGGGTGT GCATTCACGGCCATTAATCCACGGGATATCTGCGTGCCCAGGGCGGATGATGCTGGAATCCCGTCGCTTGGATCTGGCGC AGATCATACACTAGAGCGTCAAAAAGCTACTTACATACCTGGCGGTATACATAACCTCTGGATAGGTCTTATATACTCAC ATTCGGGCTATAACGCATTTGTTTATGACAGCGCTTATATGAGGGACATATATATCGGGAATGAACTCCAATTCGTGAAG AATATGACACAGGCAGTCTTACTACTTAGGAAGGAGTTTACATCACCCCAAAAGGCCCTATCTGCTTGA
Upstream 100 bases:
>100_bases GCGATGTGATAGCATTCCTCCGGTCTTGACGAGGTGTTTTCGGCAATGTAGCACACTTGTTTTATTATGGTCGCAGCTTG CCTGGTTCTAAGGAGTTTTT
Downstream 100 bases:
>100_bases GTTTATGTTACGCAAATAGGTTTCTCTACCCCCTTGTTTCATGAGCAGCTTAACTAAGCTTAGTCAACAGCCAGTATCGT AAGCCACAACAGGGCAAGGG
Product: 5-methyltetrahydropteroyltriglutamate-- homocysteine S-methyltransferase
Products: NA
Alternate protein names: Cobalamin-independent methionine synthase; Methionine synthase, vitamin-B12 independent isozyme [H]
Number of amino acids: Translated: 822; Mature: 822
Protein sequence:
>822_residues MLFGTILGYPRLGPRRELRDYLYSYWQGKISEEVLEEKTRLLREETHRRLILLGLSAENYSIPESFSYYDHVLDAAVHVG AVPSRFSWLLNDGIVDLNAYFTLARGDRSLAPLESLRYFGSSYHYLVPEIDGNTHFALTSHRVITQFEQAKQAGVNVRPT ILGPVSLLMMSRSHGPNAINPIERLQDLVPVYSELFEKLYNSGCKFVQVDEPAVTHNTFGIQKSQELLVDAYKFLSSRKL RPEILVAMSYGNAADQVDALATTGVEAMAFNLIDGAVPFANPSLADKALFGGVIDGRNIWRGDLAAAYYKLERLRELSGN VVASTSASLFHLPLSLDTEDLGDHLKEWLAFADEKVRQVMILARGLEYGVGCIYEHLDSAANSLSDRMTTPGVRVEEVRQ ALQDLGESDFCRPPREQQQGCNHASLPILPMVGIGEFSDGTPFVNNDGIPNNNPQAAISFQEDLDILAVQRLGDIDPIQR FASRMHGFAITHNGWVQSIGPHSVCPPILWGDVSRITPMSSWIEYTQTLTEKSVKPVLPGPLTLLMSCFVREDQPFQETA QQIAIAIRDDIADLQRSGIRAIQIDEPALEEFLSIYDNARYCAPQVFRLATSSAKPEVQIHLHLRPPNLVETIDIINDLD ADVISAEIVPYTFGLPAQKCLMEIRRRIPLCLYFHDANFSRMPSVDECRYLIDTLVRDVDGATLAKQFDDMHIAGFTAGC AFTAINPRDICVPRADDAGIPSLGSGADHTLERQKATYIPGGIHNLWIGLIYSHSGYNAFVYDSAYMRDIYIGNELQFVK NMTQAVLLLRKEFTSPQKALSA
Sequences:
>Translated_822_residues MLFGTILGYPRLGPRRELRDYLYSYWQGKISEEVLEEKTRLLREETHRRLILLGLSAENYSIPESFSYYDHVLDAAVHVG AVPSRFSWLLNDGIVDLNAYFTLARGDRSLAPLESLRYFGSSYHYLVPEIDGNTHFALTSHRVITQFEQAKQAGVNVRPT ILGPVSLLMMSRSHGPNAINPIERLQDLVPVYSELFEKLYNSGCKFVQVDEPAVTHNTFGIQKSQELLVDAYKFLSSRKL RPEILVAMSYGNAADQVDALATTGVEAMAFNLIDGAVPFANPSLADKALFGGVIDGRNIWRGDLAAAYYKLERLRELSGN VVASTSASLFHLPLSLDTEDLGDHLKEWLAFADEKVRQVMILARGLEYGVGCIYEHLDSAANSLSDRMTTPGVRVEEVRQ ALQDLGESDFCRPPREQQQGCNHASLPILPMVGIGEFSDGTPFVNNDGIPNNNPQAAISFQEDLDILAVQRLGDIDPIQR FASRMHGFAITHNGWVQSIGPHSVCPPILWGDVSRITPMSSWIEYTQTLTEKSVKPVLPGPLTLLMSCFVREDQPFQETA QQIAIAIRDDIADLQRSGIRAIQIDEPALEEFLSIYDNARYCAPQVFRLATSSAKPEVQIHLHLRPPNLVETIDIINDLD ADVISAEIVPYTFGLPAQKCLMEIRRRIPLCLYFHDANFSRMPSVDECRYLIDTLVRDVDGATLAKQFDDMHIAGFTAGC AFTAINPRDICVPRADDAGIPSLGSGADHTLERQKATYIPGGIHNLWIGLIYSHSGYNAFVYDSAYMRDIYIGNELQFVK NMTQAVLLLRKEFTSPQKALSA >Mature_822_residues MLFGTILGYPRLGPRRELRDYLYSYWQGKISEEVLEEKTRLLREETHRRLILLGLSAENYSIPESFSYYDHVLDAAVHVG AVPSRFSWLLNDGIVDLNAYFTLARGDRSLAPLESLRYFGSSYHYLVPEIDGNTHFALTSHRVITQFEQAKQAGVNVRPT ILGPVSLLMMSRSHGPNAINPIERLQDLVPVYSELFEKLYNSGCKFVQVDEPAVTHNTFGIQKSQELLVDAYKFLSSRKL RPEILVAMSYGNAADQVDALATTGVEAMAFNLIDGAVPFANPSLADKALFGGVIDGRNIWRGDLAAAYYKLERLRELSGN VVASTSASLFHLPLSLDTEDLGDHLKEWLAFADEKVRQVMILARGLEYGVGCIYEHLDSAANSLSDRMTTPGVRVEEVRQ ALQDLGESDFCRPPREQQQGCNHASLPILPMVGIGEFSDGTPFVNNDGIPNNNPQAAISFQEDLDILAVQRLGDIDPIQR FASRMHGFAITHNGWVQSIGPHSVCPPILWGDVSRITPMSSWIEYTQTLTEKSVKPVLPGPLTLLMSCFVREDQPFQETA QQIAIAIRDDIADLQRSGIRAIQIDEPALEEFLSIYDNARYCAPQVFRLATSSAKPEVQIHLHLRPPNLVETIDIINDLD ADVISAEIVPYTFGLPAQKCLMEIRRRIPLCLYFHDANFSRMPSVDECRYLIDTLVRDVDGATLAKQFDDMHIAGFTAGC AFTAINPRDICVPRADDAGIPSLGSGADHTLERQKATYIPGGIHNLWIGLIYSHSGYNAFVYDSAYMRDIYIGNELQFVK NMTQAVLLLRKEFTSPQKALSA
Specific function: Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation [H]
COG id: COG0620
COG function: function code E; Methionine synthase II (cobalamin-independent)
Gene ontology:
Cell location: Cytoplasm [C]
Metaboloic importance: Unknown [C]
Operon status: Not Known
Operon components: None
Similarity: Belongs to the vitamin-B12 independent methionine synthase family [H]
Homologues:
Organism=Escherichia coli, GI2367304, Length=681, Percent_Identity=32.15859030837, Blast_Score=305, Evalue=6e-84, Organism=Saccharomyces cerevisiae, GI6320936, Length=745, Percent_Identity=30.3355704697987, Blast_Score=291, Evalue=4e-79,
Paralogues:
None
Copy number: 45,000 Molecules/Cell In: Glucose minimal media [C]
Swissprot (AC and ID): NA
Other databases:
- InterPro: IPR013215 - InterPro: IPR006276 - InterPro: IPR002629 [H]
Pfam domain/function: PF08267 Meth_synt_1; PF01717 Meth_synt_2 [H]
EC number: =2.1.1.14 [H]
Molecular weight: Translated: 91677; Mature: 91677
Theoretical pI: Translated: 5.08; Mature: 5.08
Prosite motif: NA
Important sites: NA
Signals:
None
Transmembrane regions:
None
Cys/Met content:
1.5 %Cys (Translated Protein) 1.9 %Met (Translated Protein) 3.4 %Cys+Met (Translated Protein) 1.5 %Cys (Mature Protein) 1.9 %Met (Mature Protein) 3.4 %Cys+Met (Mature Protein)
Secondary structure:
>Translated Secondary Structure MLFGTILGYPRLGPRRELRDYLYSYWQGKISEEVLEEKTRLLREETHRRLILLGLSAENY CCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC SIPESFSYYDHVLDAAVHVGAVPSRFSWLLNDGIVDLNAYFTLARGDRSLAPLESLRYFG CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHC SSYHYLVPEIDGNTHFALTSHRVITQFEQAKQAGVNVRPTILGPVSLLMMSRSHGPNAIN CCCEEEEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCC PIERLQDLVPVYSELFEKLYNSGCKFVQVDEPAVTHNTFGIQKSQELLVDAYKFLSSRKL HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHHHHHHHHHHHCCCC RPEILVAMSYGNAADQVDALATTGVEAMAFNLIDGAVPFANPSLADKALFGGVIDGRNIW CCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCC RGDLAAAYYKLERLRELSGNVVASTSASLFHLPLSLDTEDLGDHLKEWLAFADEKVRQVM HHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH ILARGLEYGVGCIYEHLDSAANSLSDRMTTPGVRVEEVRQALQDLGESDFCRPPREQQQG HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCC CNHASLPILPMVGIGEFSDGTPFVNNDGIPNNNPQAAISFQEDLDILAVQRLGDIDPIQR CCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCHHHHHHHHCCCCCHHHH FASRMHGFAITHNGWVQSIGPHSVCPPILWGDVSRITPMSSWIEYTQTLTEKSVKPVLPG HHHHHCCEEEEECCCCCCCCCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCCC PLTLLMSCFVREDQPFQETAQQIAIAIRDDIADLQRSGIRAIQIDEPALEEFLSIYDNAR HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCC YCAPQVFRLATSSAKPEVQIHLHLRPPNLVETIDIINDLDADVISAEIVPYTFGLPAQKC HHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHEEECEECCCCHHHH LMEIRRRIPLCLYFHDANFSRMPSVDECRYLIDTLVRDVDGATLAKQFDDMHIAGFTAGC HHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCC AFTAINPRDICVPRADDAGIPSLGSGADHTLERQKATYIPGGIHNLWIGLIYSHSGYNAF EEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHEEEEEECCCCEEE VYDSAYMRDIYIGNELQFVKNMTQAVLLLRKEFTSPQKALSA EECCHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHCC >Mature Secondary Structure MLFGTILGYPRLGPRRELRDYLYSYWQGKISEEVLEEKTRLLREETHRRLILLGLSAENY CCCCCCCCCCCCCCHHHHHHHHHHHHCCCHHHHHHHHHHHHHHHHCCCEEEEEEECCCCC SIPESFSYYDHVLDAAVHVGAVPSRFSWLLNDGIVDLNAYFTLARGDRSLAPLESLRYFG CCCCCHHHHHHHHHHHHHHCCCHHHHHHHHCCCEEEEEEEEEEECCCCCCCHHHHHHHHC SSYHYLVPEIDGNTHFALTSHRVITQFEQAKQAGVNVRPTILGPVSLLMMSRSHGPNAIN CCCEEEEEEECCCEEEEEECHHHHHHHHHHHHCCCCCCCHHHHHHHHHHHHCCCCCCCCC PIERLQDLVPVYSELFEKLYNSGCKFVQVDEPAVTHNTFGIQKSQELLVDAYKFLSSRKL HHHHHHHHHHHHHHHHHHHHHCCCCEEEECCCCEECCCCCCCHHHHHHHHHHHHHHCCCC RPEILVAMSYGNAADQVDALATTGVEAMAFNLIDGAVPFANPSLADKALFGGVIDGRNIW CCEEEEEEECCCCHHHHHHHHHCCHHHHHHHHHHCCCCCCCCCHHHHHHHCCCCCCCCCC RGDLAAAYYKLERLRELSGNVVASTSASLFHLPLSLDTEDLGDHLKEWLAFADEKVRQVM HHHHHHHHHHHHHHHHHCCCEEEECCCEEEEEECCCCHHHHHHHHHHHHHHHHHHHHHHH ILARGLEYGVGCIYEHLDSAANSLSDRMTTPGVRVEEVRQALQDLGESDFCRPPREQQQG HHHHHHHHHHHHHHHHHHHHHHHHHHHCCCCCCCHHHHHHHHHHCCCCCCCCCCHHHHCC CNHASLPILPMVGIGEFSDGTPFVNNDGIPNNNPQAAISFQEDLDILAVQRLGDIDPIQR CCCCCCCCEEECCCCCCCCCCCCCCCCCCCCCCCCEEEEHHHCHHHHHHHHCCCCCHHHH FASRMHGFAITHNGWVQSIGPHSVCPPILWGDVSRITPMSSWIEYTQTLTEKSVKPVLPG HHHHHCCEEEEECCCCCCCCCCCCCCCHHHCCHHHCCHHHHHHHHHHHHHHHCCCCCCCC PLTLLMSCFVREDQPFQETAQQIAIAIRDDIADLQRSGIRAIQIDEPALEEFLSIYDNAR HHHHHHHHHHCCCCCHHHHHHHHHHHHHHHHHHHHHCCCEEEEECCHHHHHHHHHHCCCC YCAPQVFRLATSSAKPEVQIHLHLRPPNLVETIDIINDLDADVISAEIVPYTFGLPAQKC HHHHHHHHHHHCCCCCEEEEEEEECCCCHHHHHHHHHHCCHHHHHHEEECEECCCCHHHH LMEIRRRIPLCLYFHDANFSRMPSVDECRYLIDTLVRDVDGATLAKQFDDMHIAGFTAGC HHHHHHCCCEEEEEECCCCCCCCCHHHHHHHHHHHHHHCCCHHHHHHHCCCEEEEEECCC AFTAINPRDICVPRADDAGIPSLGSGADHTLERQKATYIPGGIHNLWIGLIYSHSGYNAF EEEECCCCCCEEECCCCCCCCCCCCCCCHHHHHHCCCCCCCCHHHHHEEEEEECCCCEEE VYDSAYMRDIYIGNELQFVKNMTQAVLLLRKEFTSPQKALSA EECCHHHEEEEECCHHHHHHHHHHHHHHHHHHCCCHHHHHCC
PDB accession: NA
Resolution: NA
Structure class: Unstructured
Cofactors: NA
Metal ions: NA
Kcat value (1/min): NA
Specific activity: NA
Km value (mM): NA
Substrates: NA
Specific reaction: NA
General reaction: NA
Inhibitor: NA
Structure determination priority: 9.0
TargetDB status: NA
Availability: NA
References: NA