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The map label for this gene is fabF [H]

Identifier: 28572668

GI number: 28572668

Start: 558467

End: 559702

Strand: Direct

Name: fabF [H]

Synonym: TW519

Alternate gene names: 28572668

Gene position: 558467-559702 (Clockwise)

Preceding gene: 28572667

Following gene: 28572679

Centisome position: 60.31

GC content: 49.68

Gene sequence:

>1236_bases
TTGTCCAGACAAGTTGTTGTTACAGGTCTAGGCGTTTGTTGTCCCCTTGGGATCGGGACTGAACTGGCCTGGCAGGCGCT
CCTGGATGGCGAGAGTGGTGTTCGTACCCTGCCCGATCGGTGCACCAAAGGGTTTGATTTGCCGGTGACTTTTGCTGGAC
TGGTACCTGATGGCGTGGAGGATTTGCTCGCGCGTACTGAAGTAAATAGGCTCGATAGGGCAGGTCAGATTTCTCTTATT
GCAGCACGACAAGCAGTGGAAGACGCGGGAGATATAAAACAAAATCCTGAGAGAACGGCTGTTAGTTGGGGCACTGGGAT
AGGTTGTATAAATACCGTCTTGAGTGCATGGGATAGGCTTGCCGAGAAGGGCCCAGGTCGTGTGTTGCCAATGACCGTGC
CAATGCTCATGCCAAACGCCCCTGCGGTGGCTGTTGGGATGAAGATGCAGGCGAGGGCTGGTATTCACACCTCGGTAAGT
GCTTGCGCTGCATCAACTGAGTCAATTGCTGTTGGATTCGACATGATTCGATCTAATAAGGCTGATGTTGTTATTGCGGG
AGGTAGTGAGTCGGCCATAAATCCTCTCACCATTTCAGCTTTTGCCAGCCTGTCTGCCCTGTCGACCTATTCCGGTAATC
CTGAGCATGCATCGAGACCCTTTTCTAAGAATCGCGATGGCTTTGTTGTATCTGAAGGCGCTGCGGTCTTGATTTTAGAA
GAAAAGACCCGCGCCAAAGCAAGGGGTGCAAAAATATATGCCGAAATCTCGGGTGCGCTTTTTAATAGTGATGCGCATCA
TATTACTGCGCCTGAGCCAGACGGAAAGATGGCAACAACTGCCATGAGGAACACCCTTAAAATGGGCGGGCTCTCACCTG
AGGAAATAACATACGTTAATGCACACGCTACAGCCACTATTCTGGGCGATATAAGTGAATATAAGGCCCTTCTTGCTCTA
TTCGAAGATCACCTGGCAAATGTATATGTCTCTGCCACAAAGGCATCAACAGGACATTTGCTTGGCGGTGCTGGTGCCTT
GGAAGCTGTATTTACCGTTAAGGCCGTTTCTGAGTCAATAATCCCTCCAACAATTAACTGTGATGAACAAGACCCGGATA
TACAACTGAGAATTCAAAGGCAGCCCAAAAAGCTTTCTCGACCGTTTGCAGCAATCAGTAATTCGTTTGGCTTTGGGGGT
CACAATGCGGTTGTTGCATTTACGCCAACCGACTGA

Upstream 100 bases:

>100_bases
TGCTGAGGAGAAGTACGGTATAGAAATTCCCGACGATAAGGTCAGGGAATTGCGTACGGTGGGTGATGCCGTTGACTTTA
TTATTGCTGCCAAGGCATAA

Downstream 100 bases:

>100_bases
ACTGGACTTCTTCAAAATCTCGTCTCTAAACAACCATATAATGCCAATCACGTAGTGCTATATTGTCATGCACTGTCGAT
TCTTCTTATTTATGCGTAGG

Product: 3-oxoacyl-[acyl-carrier-protein] synthase II

Products: NA

Alternate protein names: 3-oxoacyl-[acyl-carrier-protein] synthase II; Beta-ketoacyl-ACP synthase II; KAS II [H]

Number of amino acids: Translated: 411; Mature: 410

Protein sequence:

>411_residues
MSRQVVVTGLGVCCPLGIGTELAWQALLDGESGVRTLPDRCTKGFDLPVTFAGLVPDGVEDLLARTEVNRLDRAGQISLI
AARQAVEDAGDIKQNPERTAVSWGTGIGCINTVLSAWDRLAEKGPGRVLPMTVPMLMPNAPAVAVGMKMQARAGIHTSVS
ACAASTESIAVGFDMIRSNKADVVIAGGSESAINPLTISAFASLSALSTYSGNPEHASRPFSKNRDGFVVSEGAAVLILE
EKTRAKARGAKIYAEISGALFNSDAHHITAPEPDGKMATTAMRNTLKMGGLSPEEITYVNAHATATILGDISEYKALLAL
FEDHLANVYVSATKASTGHLLGGAGALEAVFTVKAVSESIIPPTINCDEQDPDIQLRIQRQPKKLSRPFAAISNSFGFGG
HNAVVAFTPTD

Sequences:

>Translated_411_residues
MSRQVVVTGLGVCCPLGIGTELAWQALLDGESGVRTLPDRCTKGFDLPVTFAGLVPDGVEDLLARTEVNRLDRAGQISLI
AARQAVEDAGDIKQNPERTAVSWGTGIGCINTVLSAWDRLAEKGPGRVLPMTVPMLMPNAPAVAVGMKMQARAGIHTSVS
ACAASTESIAVGFDMIRSNKADVVIAGGSESAINPLTISAFASLSALSTYSGNPEHASRPFSKNRDGFVVSEGAAVLILE
EKTRAKARGAKIYAEISGALFNSDAHHITAPEPDGKMATTAMRNTLKMGGLSPEEITYVNAHATATILGDISEYKALLAL
FEDHLANVYVSATKASTGHLLGGAGALEAVFTVKAVSESIIPPTINCDEQDPDIQLRIQRQPKKLSRPFAAISNSFGFGG
HNAVVAFTPTD
>Mature_410_residues
SRQVVVTGLGVCCPLGIGTELAWQALLDGESGVRTLPDRCTKGFDLPVTFAGLVPDGVEDLLARTEVNRLDRAGQISLIA
ARQAVEDAGDIKQNPERTAVSWGTGIGCINTVLSAWDRLAEKGPGRVLPMTVPMLMPNAPAVAVGMKMQARAGIHTSVSA
CAASTESIAVGFDMIRSNKADVVIAGGSESAINPLTISAFASLSALSTYSGNPEHASRPFSKNRDGFVVSEGAAVLILEE
KTRAKARGAKIYAEISGALFNSDAHHITAPEPDGKMATTAMRNTLKMGGLSPEEITYVNAHATATILGDISEYKALLALF
EDHLANVYVSATKASTGHLLGGAGALEAVFTVKAVSESIIPPTINCDEQDPDIQLRIQRQPKKLSRPFAAISNSFGFGGH
NAVVAFTPTD

Specific function: Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Has a preference for short chain acid substrates [H]

COG id: COG0304

COG function: function code IQ; 3-oxoacyl-(acyl-carrier-protein) synthase

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Non_Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the beta-ketoacyl-ACP synthases family [H]

Homologues:

Organism=Homo sapiens, GI8923559, Length=418, Percent_Identity=39.4736842105263, Blast_Score=287, Evalue=1e-77,
Organism=Homo sapiens, GI223972627, Length=147, Percent_Identity=48.9795918367347, Blast_Score=140, Evalue=2e-33,
Organism=Homo sapiens, GI41872631, Length=259, Percent_Identity=25.8687258687259, Blast_Score=86, Evalue=9e-17,
Organism=Escherichia coli, GI1787337, Length=409, Percent_Identity=38.8753056234719, Blast_Score=251, Evalue=6e-68,
Organism=Escherichia coli, GI1788663, Length=414, Percent_Identity=33.3333333333333, Blast_Score=170, Evalue=1e-43,
Organism=Caenorhabditis elegans, GI71983541, Length=407, Percent_Identity=33.6609336609337, Blast_Score=219, Evalue=3e-57,
Organism=Caenorhabditis elegans, GI71983535, Length=257, Percent_Identity=37.7431906614786, Blast_Score=171, Evalue=7e-43,
Organism=Caenorhabditis elegans, GI212642053, Length=423, Percent_Identity=23.8770685579196, Blast_Score=97, Evalue=1e-20,
Organism=Caenorhabditis elegans, GI17550940, Length=259, Percent_Identity=28.1853281853282, Blast_Score=72, Evalue=5e-13,
Organism=Saccharomyces cerevisiae, GI6320904, Length=442, Percent_Identity=31.6742081447964, Blast_Score=211, Evalue=2e-55,
Organism=Drosophila melanogaster, GI24644341, Length=417, Percent_Identity=39.8081534772182, Blast_Score=271, Evalue=8e-73,
Organism=Drosophila melanogaster, GI221330659, Length=439, Percent_Identity=25.7403189066059, Blast_Score=106, Evalue=2e-23,
Organism=Drosophila melanogaster, GI19920632, Length=439, Percent_Identity=25.7403189066059, Blast_Score=106, Evalue=3e-23,
Organism=Drosophila melanogaster, GI24581345, Length=256, Percent_Identity=25, Blast_Score=83, Evalue=3e-16,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR017568
- InterPro:   IPR000794
- InterPro:   IPR018201
- InterPro:   IPR014031
- InterPro:   IPR014030
- InterPro:   IPR016039
- InterPro:   IPR016038 [H]

Pfam domain/function: PF00109 ketoacyl-synt; PF02801 Ketoacyl-synt_C [H]

EC number: =2.3.1.179 [H]

Molecular weight: Translated: 43081; Mature: 42949

Theoretical pI: Translated: 6.11; Mature: 6.11

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.5 %Cys     (Translated Protein)
2.4 %Met     (Translated Protein)
3.9 %Cys+Met (Translated Protein)
1.5 %Cys     (Mature Protein)
2.2 %Met     (Mature Protein)
3.7 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MSRQVVVTGLGVCCPLGIGTELAWQALLDGESGVRTLPDRCTKGFDLPVTFAGLVPDGVE
CCCEEEEECCHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEECCCCCCHH
DLLARTEVNRLDRAGQISLIAARQAVEDAGDIKQNPERTAVSWGTGIGCINTVLSAWDRL
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHH
AEKGPGRVLPMTVPMLMPNAPAVAVGMKMQARAGIHTSVSACAASTESIAVGFDMIRSNK
HHCCCCEEEEEEEHEECCCCCEEEECCEEHHCCCCCHHHHHHHCCCCCEEEHHHHHHCCC
ADVVIAGGSESAINPLTISAFASLSALSTYSGNPEHASRPFSKNRDGFVVSEGAAVLILE
CCEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEECCCEEEEEE
EKTRAKARGAKIYAEISGALFNSDAHHITAPEPDGKMATTAMRNTLKMGGLSPEEITYVN
CCHHHHHCCCEEEEEECCCEECCCCCEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEEEE
AHATATILGDISEYKALLALFEDHLANVYVSATKASTGHLLGGAGALEAVFTVKAVSESI
CCEEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHCC
IPPTINCDEQDPDIQLRIQRQPKKLSRPFAAISNSFGFGGHNAVVAFTPTD
CCCCCCCCCCCCCEEEEEECCCHHHHCCHHHHHCCCCCCCCCEEEEEECCC
>Mature Secondary Structure 
SRQVVVTGLGVCCPLGIGTELAWQALLDGESGVRTLPDRCTKGFDLPVTFAGLVPDGVE
CCEEEEECCHHHCCCCCCHHHHHHHHHCCCCCCCCCHHHHCCCCCCCEEEECCCCCCHH
DLLARTEVNRLDRAGQISLIAARQAVEDAGDIKQNPERTAVSWGTGIGCINTVLSAWDRL
HHHHHHHHHHHCCCCCEEEEHHHHHHHHHHCCCCCCCCCEEECCCCHHHHHHHHHHHHHH
AEKGPGRVLPMTVPMLMPNAPAVAVGMKMQARAGIHTSVSACAASTESIAVGFDMIRSNK
HHCCCCEEEEEEEHEECCCCCEEEECCEEHHCCCCCHHHHHHHCCCCCEEEHHHHHHCCC
ADVVIAGGSESAINPLTISAFASLSALSTYSGNPEHASRPFSKNRDGFVVSEGAAVLILE
CCEEEECCCCCCCCCEEHHHHHHHHHHHHCCCCHHHCCCCCCCCCCCEEEECCCEEEEEE
EKTRAKARGAKIYAEISGALFNSDAHHITAPEPDGKMATTAMRNTLKMGGLSPEEITYVN
CCHHHHHCCCEEEEEECCCEECCCCCEEECCCCCCCHHHHHHHHHHHHCCCCHHHEEEEE
AHATATILGDISEYKALLALFEDHLANVYVSATKASTGHLLGGAGALEAVFTVKAVSESI
CCEEEEEEHHHHHHHHHHHHHHHHHHEEEEEEECCCCCCEECCCHHHHHHHHHHHHHHCC
IPPTINCDEQDPDIQLRIQRQPKKLSRPFAAISNSFGFGGHNAVVAFTPTD
CCCCCCCCCCCCCEEEEEECCCHHHHCCHHHHHCCCCCCCCCEEEEEECCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 8905231; 11152607 [H]