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The map label for this gene is iscS1 [H]

Identifier: 28572506

GI number: 28572506

Start: 384742

End: 385893

Strand: Direct

Name: iscS1 [H]

Synonym: TW352

Alternate gene names: 28572506

Gene position: 384742-385893 (Clockwise)

Preceding gene: 28572505

Following gene: 28572507

Centisome position: 41.55

GC content: 46.01

Gene sequence:

>1152_bases
TTGATGTTCGGTACTTATCTAGACTATGCTGCTCATGCCCCCTTGATGCCTGAAGCTGCCGCTGTTTATCAGCAGTTTTG
CAATATGCCCGGCAATGCTTCTTCATCGCATTTCTATGGCAGGCATATGCGTGCTGTTATTGAAAAGGCAAAAGAAGGAA
TCCTCGCTGCACTAAACGCTCCACCCGGGACGGAAGTTTCCTTTACAAGCGGTGGAACAGAATCTATCAATACCTGTATA
TATGGGACATATCTATTCAGAAATTCTTTTGTTAGTCATATAAACGATGGGAATATCAGCAAAAAGATTATTCTGGCCAA
TCCTGCAGATCACACGGCGCAGCTCAGCAGTATAAAGAGTTTGCCTTATGCCGAGATAGTATGGCTGCCGATTGATAAAT
ATGCAAGGGTGCTTCCCGATAGCCTCGAGCAGGCAATACTGCAGAAGGATCCAAATAAAATTGCTCTTTTTGCCTGCACG
TGGGTTAATAGCGAGCTCGGTACGATCTCTCCAGTTTATGACTACGCCAGGATATGTCAAACATATGATATTCCTGTCCA
CATTGATTCCGTTGCGGCAACCAGTTTAATTGATTTTTCGCGACTGGTTGGGAAAGTTTCTCTCTCAATTGCAGGTCACA
AAATTGGAGCACCCCCCGGCACAGGTGCCATTTTGTCATCATTCTCGTTTCCACCACTTTTACGAGGTGGGAATCAACAA
AGACTCAGGTCTGGGTCGGTGGATCCGCTTGGTTCAACATCCCTGTCTATTGCATTAAACAGGAAAGTTCAATCTTTGAG
GGCATTGCGACAGCGCTTGGTCGAAGTGGTTTTGTCTGCCGTTCCAGAGGCAGTTGTAAATTCTGACACTCAGGACAGTA
GTGACGCAATTCTTAATGTTTCGTTTCCCGGCTGTTCATCTGACACGCTGCTTTATCTGTTCGATGAGGCAAAAATAGCT
ATCTCATCCGGTTCCGCCTGCCATTCCGGGGTTATTCAGCCATCACATGTCATGAGCGCGGTGGGCCTCAAGCCAGATTT
GGCAAAGGCAACACTCCGGTTTTCCCTTGGCTGGGCTAGTACATTTGATGACATAGAGGTACTGTCCCAAAATCTTGGTG
ACATATACAAAAAGGCTTTGATCGCGAAATAA

Upstream 100 bases:

>100_bases
ACTCTAGCCAGCTTTTGTTCTACATTCCTACTGTTGGGTCGAATGAGAGAATAGCTCTTTTGGGCTTTACTCGGGGGATT
GCCTCTGCCAGAGAAGTGCG

Downstream 100 bases:

>100_bases
ATTCACGTATAGAGTATTACCTGTGAAGGTCTTGGCTGCTATGAGTGGCGGTGTCGATTCCGCCGTCGCCGCCGCGCGTG
CGGTAGATATGGGTCACGAT

Product: aminotransferase

Products: NA

Alternate protein names: NA

Number of amino acids: Translated: 383; Mature: 383

Protein sequence:

>383_residues
MMFGTYLDYAAHAPLMPEAAAVYQQFCNMPGNASSSHFYGRHMRAVIEKAKEGILAALNAPPGTEVSFTSGGTESINTCI
YGTYLFRNSFVSHINDGNISKKIILANPADHTAQLSSIKSLPYAEIVWLPIDKYARVLPDSLEQAILQKDPNKIALFACT
WVNSELGTISPVYDYARICQTYDIPVHIDSVAATSLIDFSRLVGKVSLSIAGHKIGAPPGTGAILSSFSFPPLLRGGNQQ
RLRSGSVDPLGSTSLSIALNRKVQSLRALRQRLVEVVLSAVPEAVVNSDTQDSSDAILNVSFPGCSSDTLLYLFDEAKIA
ISSGSACHSGVIQPSHVMSAVGLKPDLAKATLRFSLGWASTFDDIEVLSQNLGDIYKKALIAK

Sequences:

>Translated_383_residues
MMFGTYLDYAAHAPLMPEAAAVYQQFCNMPGNASSSHFYGRHMRAVIEKAKEGILAALNAPPGTEVSFTSGGTESINTCI
YGTYLFRNSFVSHINDGNISKKIILANPADHTAQLSSIKSLPYAEIVWLPIDKYARVLPDSLEQAILQKDPNKIALFACT
WVNSELGTISPVYDYARICQTYDIPVHIDSVAATSLIDFSRLVGKVSLSIAGHKIGAPPGTGAILSSFSFPPLLRGGNQQ
RLRSGSVDPLGSTSLSIALNRKVQSLRALRQRLVEVVLSAVPEAVVNSDTQDSSDAILNVSFPGCSSDTLLYLFDEAKIA
ISSGSACHSGVIQPSHVMSAVGLKPDLAKATLRFSLGWASTFDDIEVLSQNLGDIYKKALIAK
>Mature_383_residues
MMFGTYLDYAAHAPLMPEAAAVYQQFCNMPGNASSSHFYGRHMRAVIEKAKEGILAALNAPPGTEVSFTSGGTESINTCI
YGTYLFRNSFVSHINDGNISKKIILANPADHTAQLSSIKSLPYAEIVWLPIDKYARVLPDSLEQAILQKDPNKIALFACT
WVNSELGTISPVYDYARICQTYDIPVHIDSVAATSLIDFSRLVGKVSLSIAGHKIGAPPGTGAILSSFSFPPLLRGGNQQ
RLRSGSVDPLGSTSLSIALNRKVQSLRALRQRLVEVVLSAVPEAVVNSDTQDSSDAILNVSFPGCSSDTLLYLFDEAKIA
ISSGSACHSGVIQPSHVMSAVGLKPDLAKATLRFSLGWASTFDDIEVLSQNLGDIYKKALIAK

Specific function: Catalyzes the removal of elemental sulfur from cysteine to produce alanine [H]

COG id: COG1104

COG function: function code E; Cysteine sulfinate desulfinase/cysteine desulfurase and related enzymes

Gene ontology:

Cell location: Cytoplasm [C]

Metaboloic importance: Unknown [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily [H]

Homologues:

Organism=Homo sapiens, GI32307132, Length=378, Percent_Identity=31.2169312169312, Blast_Score=156, Evalue=4e-38,
Organism=Homo sapiens, GI156713448, Length=408, Percent_Identity=25.7352941176471, Blast_Score=79, Evalue=7e-15,
Organism=Escherichia coli, GI48994898, Length=389, Percent_Identity=30.0771208226221, Blast_Score=146, Evalue=2e-36,
Organism=Caenorhabditis elegans, GI25143064, Length=378, Percent_Identity=29.8941798941799, Blast_Score=142, Evalue=3e-34,
Organism=Saccharomyces cerevisiae, GI6319831, Length=397, Percent_Identity=30.2267002518892, Blast_Score=137, Evalue=3e-33,
Organism=Drosophila melanogaster, GI20129463, Length=378, Percent_Identity=29.3650793650794, Blast_Score=150, Evalue=1e-36,

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000192
- InterPro:   IPR020578
- InterPro:   IPR016454
- InterPro:   IPR015424
- InterPro:   IPR015421
- InterPro:   IPR015422 [H]

Pfam domain/function: PF00266 Aminotran_5 [H]

EC number: =2.8.1.7 [H]

Molecular weight: Translated: 41112; Mature: 41112

Theoretical pI: Translated: 7.25; Mature: 7.25

Prosite motif: NA

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

1.6 %Cys     (Translated Protein)
1.6 %Met     (Translated Protein)
3.1 %Cys+Met (Translated Protein)
1.6 %Cys     (Mature Protein)
1.6 %Met     (Mature Protein)
3.1 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MMFGTYLDYAAHAPLMPEAAAVYQQFCNMPGNASSSHFYGRHMRAVIEKAKEGILAALNA
CCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECC
PPGTEVSFTSGGTESINTCIYGTYLFRNSFVSHINDGNISKKIILANPADHTAQLSSIKS
CCCCEEEECCCCCCCCHHHEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCC
LPYAEIVWLPIDKYARVLPDSLEQAILQKDPNKIALFACTWVNSELGTISPVYDYARICQ
CCCEEEEEEEHHHHHHHCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHH
TYDIPVHIDSVAATSLIDFSRLVGKVSLSIAGHKIGAPPGTGAILSSFSFPPLLRGGNQQ
HCCCCEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHCCCCCHHHCCCCHH
RLRSGSVDPLGSTSLSIALNRKVQSLRALRQRLVEVVLSAVPEAVVNSDTQDSSDAILNV
HHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEE
SFPGCSSDTLLYLFDEAKIAISSGSACHSGVIQPSHVMSAVGLKPDLAKATLRFSLGWAS
ECCCCCCCCEEEEEECCEEEEECCCCHHCCCCCHHHHHHHHCCCCCHHHHEEEEECCCCC
TFDDIEVLSQNLGDIYKKALIAK
CHHHHHHHHHHHHHHHHHHHCCC
>Mature Secondary Structure
MMFGTYLDYAAHAPLMPEAAAVYQQFCNMPGNASSSHFYGRHMRAVIEKAKEGILAALNA
CCCCCHHHHHHCCCCCHHHHHHHHHHHCCCCCCCCCCHHHHHHHHHHHHHHCCEEEEECC
PPGTEVSFTSGGTESINTCIYGTYLFRNSFVSHINDGNISKKIILANPADHTAQLSSIKS
CCCCEEEECCCCCCCCHHHEEHHHHHHHHHHHHCCCCCCCEEEEEECCCCHHHHHHHHCC
LPYAEIVWLPIDKYARVLPDSLEQAILQKDPNKIALFACTWVNSELGTISPVYDYARICQ
CCCEEEEEEEHHHHHHHCHHHHHHHHHHCCCCEEEEEEEEEECCCCCCCCHHHHHHHHHH
TYDIPVHIDSVAATSLIDFSRLVGKVSLSIAGHKIGAPPGTGAILSSFSFPPLLRGGNQQ
HCCCCEEECHHHHHHHHHHHHHHHHHEEEECCCCCCCCCCCCHHHHCCCCCHHHCCCCHH
RLRSGSVDPLGSTSLSIALNRKVQSLRALRQRLVEVVLSAVPEAVVNSDTQDSSDAILNV
HHHCCCCCCCCCCEEEEEHHHHHHHHHHHHHHHHHHHHHHCCHHHHCCCCCCCCCCEEEE
SFPGCSSDTLLYLFDEAKIAISSGSACHSGVIQPSHVMSAVGLKPDLAKATLRFSLGWAS
ECCCCCCCCEEEEEECCEEEEECCCCHHCCCCCHHHHHHHHCCCCCHHHHEEEEECCCCC
TFDDIEVLSQNLGDIYKKALIAK
CHHHHHHHHHHHHHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 9.0

TargetDB status: NA

Availability: NA

References: 9384377 [H]