Click here to switch to the map view.

The map label for this gene is sipS [H]

Identifier: 28572465

GI number: 28572465

Start: 344025

End: 344717

Strand: Direct

Name: sipS [H]

Synonym: TW309

Alternate gene names: 28572465

Gene position: 344025-344717 (Clockwise)

Preceding gene: 28572464

Following gene: 28572466

Centisome position: 37.15

GC content: 46.75

Gene sequence:

>693_bases
GTGAATGTCGTGCTTCACTCTTCTTTGCGTTCCTTATGGGAAAAGTTTCGTGGCACCCTGTTTACACTTCTTGTTGTCGT
TACGATCGTCGTTATTGTAAGGACATTTCTCTTCGGCGTTTACTATATACCGTCGGGGTCGATGCTGAACACCCTGCAGT
TGGGTGATCGGATATTTGTAAGTCGCCTCCACCCCACGCTGTTTCCACTAAAGAGGGGTGATGTGGTTGTCTTTCGGGAC
AAGAATCACTGGATTCCCGATGATGATACTAGTTCTCGGTCAGGTTTGCTGGATTTGATTCTTGGCTTTATTGAGGGCAG
AGAGCCCCATAAGCTTCTAATAAAGCGAGTTATTGGTTTACCTGGTGATAGGGTTACTTGCTGCAGCGAAGCGGGCCGGA
TTGTTGTGAACGGTAGGGAGCTAGACGAGACCCCTTACCTGTATGATGCAACACCCCCGGCAAGCAGTATAGTCTTCGAT
GTTGTTATACCTGAAGGTCGTTTGTGGGTTATGGGAGATAACCGAAATAATTCAGCTGATTCTCGTTTGCATATTGGGTT
GCCAGGAGGTGGGTTTGTTCCAATTGCTGATGTTGTTGGCAGGGCACTCCTGGTGTTTTGGCCTTTTGGTCATTGGAAGA
TTCTTCATAACTATCATGACAGTACTTTCAAAGGTGTTTCGAGAGTTTCCTGA

Upstream 100 bases:

>100_bases
GGATAGAGGTTGTTACCAAGGGAAGTGTTCGCCGTGCGAAGCTGTACTACATTCGCAAGCTTAGGGGTAAAAAGGCAAAG
GTCAAACAGAAGCGTGAACT

Downstream 100 bases:

>100_bases
TTTAGGATTCACGGTAAGTGTTTGACGAAAAATTGTTTTGTATCAGATCTGGTTTTTGTCGGATATAACGCCCTTCTCGT
GGGTATTTGACCTAGACAAG

Product: signal peptidase I

Products: NA

Alternate protein names: SPase I; Leader peptidase I [H]

Number of amino acids: Translated: 230; Mature: 230

Protein sequence:

>230_residues
MNVVLHSSLRSLWEKFRGTLFTLLVVVTIVVIVRTFLFGVYYIPSGSMLNTLQLGDRIFVSRLHPTLFPLKRGDVVVFRD
KNHWIPDDDTSSRSGLLDLILGFIEGREPHKLLIKRVIGLPGDRVTCCSEAGRIVVNGRELDETPYLYDATPPASSIVFD
VVIPEGRLWVMGDNRNNSADSRLHIGLPGGGFVPIADVVGRALLVFWPFGHWKILHNYHDSTFKGVSRVS

Sequences:

>Translated_230_residues
MNVVLHSSLRSLWEKFRGTLFTLLVVVTIVVIVRTFLFGVYYIPSGSMLNTLQLGDRIFVSRLHPTLFPLKRGDVVVFRD
KNHWIPDDDTSSRSGLLDLILGFIEGREPHKLLIKRVIGLPGDRVTCCSEAGRIVVNGRELDETPYLYDATPPASSIVFD
VVIPEGRLWVMGDNRNNSADSRLHIGLPGGGFVPIADVVGRALLVFWPFGHWKILHNYHDSTFKGVSRVS
>Mature_230_residues
MNVVLHSSLRSLWEKFRGTLFTLLVVVTIVVIVRTFLFGVYYIPSGSMLNTLQLGDRIFVSRLHPTLFPLKRGDVVVFRD
KNHWIPDDDTSSRSGLLDLILGFIEGREPHKLLIKRVIGLPGDRVTCCSEAGRIVVNGRELDETPYLYDATPPASSIVFD
VVIPEGRLWVMGDNRNNSADSRLHIGLPGGGFVPIADVVGRALLVFWPFGHWKILHNYHDSTFKGVSRVS

Specific function: Unknown

COG id: COG0681

COG function: function code U; Signal peptidase I

Gene ontology:

Cell location: Cell membrane; Single-pass type II membrane protein [H]

Metaboloic importance: Essential [C]

Operon status: Not Known

Operon components: None

Similarity: Belongs to the peptidase S26 family [H]

Homologues:

None

Paralogues:

None

Copy number: NA

Swissprot (AC and ID): NA

Other databases:

- InterPro:   IPR000223
- InterPro:   IPR019758
- InterPro:   IPR019756
- InterPro:   IPR019759
- InterPro:   IPR015927
- InterPro:   IPR011056 [H]

Pfam domain/function: PF00717 Peptidase_S24 [H]

EC number: =3.4.21.89 [H]

Molecular weight: Translated: 25777; Mature: 25777

Theoretical pI: Translated: 9.13; Mature: 9.13

Prosite motif: PS00761 SPASE_I_3

Important sites: NA

Signals:

None

Transmembrane regions:

None

Cys/Met content:

0.9 %Cys     (Translated Protein)
1.3 %Met     (Translated Protein)
2.2 %Cys+Met (Translated Protein)
0.9 %Cys     (Mature Protein)
1.3 %Met     (Mature Protein)
2.2 %Cys+Met (Mature Protein)

Secondary structure:

>Translated Secondary Structure
MNVVLHSSLRSLWEKFRGTLFTLLVVVTIVVIVRTFLFGVYYIPSGSMLNTLQLGDRIFV
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHCHHHHH
SRLHPTLFPLKRGDVVVFRDKNHWIPDDDTSSRSGLLDLILGFIEGREPHKLLIKRVIGL
HHHCCHHCEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCC
PGDRVTCCSEAGRIVVNGRELDETPYLYDATPPASSIVFDVVIPEGRLWVMGDNRNNSAD
CCCCEEEHHHCCEEEEECCCCCCCCEEEECCCCCCCEEEEEEECCCEEEEEECCCCCCCC
SRLHIGLPGGGFVPIADVVGRALLVFWPFGHWKILHNYHDSTFKGVSRVS
CEEEEECCCCCCEEHHHHHCCEEEEEECCCCEEEEECCCCHHHHHHHCCC
>Mature Secondary Structure
MNVVLHSSLRSLWEKFRGTLFTLLVVVTIVVIVRTFLFGVYYIPSGSMLNTLQLGDRIFV
CCEEEHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHHEEECCCCCEEHHHHHCHHHHH
SRLHPTLFPLKRGDVVVFRDKNHWIPDDDTSSRSGLLDLILGFIEGREPHKLLIKRVIGL
HHHCCHHCEECCCCEEEEECCCCCCCCCCCCCCCHHHHHHHHHHCCCCHHHHHHHHHHCC
PGDRVTCCSEAGRIVVNGRELDETPYLYDATPPASSIVFDVVIPEGRLWVMGDNRNNSAD
CCCCEEEHHHCCEEEEECCCCCCCCEEEECCCCCCCEEEEEEECCCEEEEEECCCCCCCC
SRLHIGLPGGGFVPIADVVGRALLVFWPFGHWKILHNYHDSTFKGVSRVS
CEEEEECCCCCCEEHHHHHCCEEEEEECCCCEEEEECCCCHHHHHHHCCC

PDB accession: NA

Resolution: NA

Structure class: Alpha Beta

Cofactors: NA

Metal ions: NA

Kcat value (1/min): NA

Specific activity: NA

Km value (mM): NA

Substrates: NA

Specific reaction: NA

General reaction: NA

Inhibitor: NA

Structure determination priority: 7.0

TargetDB status: NA

Availability: NA

References: 9634230; 12218036 [H]